Abstract：
:Alterations in the brain that contribute to the development of epilepsy, also called epileptogenesis, are not well understood, which makes it difficult to develop strategies for preventing epilepsy. Here we have studied the role of the CRE binding transcription factors, cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER), in the development of epilepsy following pilocarpine induced status epilepticus (SE) in mice. Following SE, ICER mRNA and protein are increased in neurons. The increase in ICER, however, is not necessary for neuronal injury following SE as pilocarpine treatment induces equivalent neuronal injury in pyramidal neurons of wild type and CREM/ICER null mice. Following SE, the CREM/ICER null mice develop a more severe epileptic phenotype experiencing approximately threefold more frequent spontaneous seizures. Together these data suggest that the increase in ICER mRNA following SE may have a role in suppressing the severity of epilepsy.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Porter BE,Lund IV,Varodayan FP,Wallace RW,Blendy JAdoi
10.1016/j.neuroscience.2007.10.064subject
Has Abstractpub_date
2008-03-27 00:00:00pages
829-36issue
3eissn
0306-4522issn
1873-7544pii
S0306-4522(08)00022-5journal_volume
152pub_type
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