On the significance of subterritories in the "accumbens" part of the rat ventral striatum.

Abstract:

:Although many workers have appreciated the striking cytologic and neurochemical similarities of neostriatum, accumbens and olfactory tubercle, a compelling case for regarding these areas as territories in a striatal complex awaited the arguments made by Heimer and his colleagues based on their investigations of connections. A number of recent papers support this viewpoint and extend it with the characterization of three accumbal subterritories: core, shell and rostral pole. The case for separate classifications of systems traversing the accumbens has become more compelling with each study that demonstrates connectional, cytoarchitectural and neurochemical specificity conforming to the boundaries separating the core and its downstream targets from the shell and its projection fields. Furthermore, its apparent composite of core-like and shell-like characteristics distinguishes the rostral pole as yet another unique subterritory. Differences in compartmental organization distinguish the accumbens and neostriatum. The available data are consistent with the periventricular and rostrolateral enkephalin-rich zones being ventralmost parts of the neostriatal patch and matrix compartments, respectively. The accumbal cell cluster compartment, on the other hand, appears to be a separate entity, with connectional and neurochemical features that are dissimilar to both patch and matrix of neostriatum. Boundaries between the accumbens and caudate-putamen remain elusive, and the point of view that such boundaries do not exist but, rather, are represented by "transition zones" must to a large degree reflect the reality. Likewise, it is important to acknowledge that the boundaries between accumbal subterritories are not necessarily distinct or observed faithfully by all of the afferent systems. "Transition zones" appear to be particularly significant organizational features in rostral and lateral parts of the accumbens. Interestingly, histochemically distinct cell clusters tend to be numerous in boundary regions between adjacent territories and subterritories. The predominant organizational pattern appears to be one in which the core, shell and rostral pole engage different forebrain systems that possibly subserve entirely different functions mediated by distantly related mechanisms. In this regard, it is of paramount interest that the processing of information conveyed to the accumbens by diverse cortical and subcortical inputs occurs within distinct and perhaps very different dopaminergic environments in the core, shell and rostral pole (e.g., see Refs 24, 34, 90, 110).

journal_name

Neuroscience

journal_title

Neuroscience

authors

Zahm DS,Brog JS

doi

10.1016/0306-4522(92)90202-d

keywords:

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

751-67

issue

4

eissn

0306-4522

issn

1873-7544

pii

0306-4522(92)90202-D

journal_volume

50

pub_type

杂志文章,评审
  • Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy.

    abstract::Ecstasy (3,4-methylenedioxymethamphetamine; MDMA) has potent CNS stimulant effects. Besides the acute effects of MDMA, such as psychomotor activation, euphoria, decreased appetite, and hyperthermia, long-term damage of dopaminergic and serotonergic nerve terminals in multiple brain areas have also been reported. Altho...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.12.027

    authors: Alvaro AR,Martins J,Costa AC,Fernandes E,Carvalho F,Ambrósio AF,Cavadas C

    更新日期:2008-03-03 00:00:00

  • Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes.

    abstract::Rat brain synaptosomes were isolated to study the effects of protein kinase inhibitors (sphingosine, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, N-(6-aminohexyl)-5-chloro-1-naphtalenesulfonamide, staurosporine) on Ca2+-dependent and Ca2+-independent [14C]GABA release. The Ca2+-dependent [14C]GABA re...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00599-x

    authors: Storchak LG,Pozdnyakova NG,Himmelreich NH

    更新日期:1998-08-01 00:00:00

  • Role of nitric oxide in the ethylcholine aziridinium model of delayed apoptotic neurodegeneration in vivo and in vitro.

    abstract::The involvement of nitric oxide in neurodegenerative processes still remains incompletely characterized. Although nitric oxide has been reported to be an important mediator in neuronal degeneration in different models of cell death involving NMDA-receptor activation, increasing evidence for protective mechanisms has b...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(99)00599-0

    authors: Lautenschlager M,Onufriev MV,Gulyaeva NV,Harms C,Freyer D,Sehmsdorf U,Ruscher K,Moiseeva YV,Arnswald A,Victorov I,Dirnagl U,Weber JR,Hörtnagl H

    更新日期:2000-01-01 00:00:00

  • Dysregulation of p53 and Parkin Induce Mitochondrial Dysfunction and Leads to the Diabetic Neuropathic Pain.

    abstract::p53 and parkin are involved in mitochondrial quality control. The present study aimed to characterize the functional significance of parkin/p53 in the development of mitochondrial dysfunction and the pathophysiology of neuropathic pain in type I diabetes. Type I diabetes was induced in mice (N = 170) using streptozoto...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.07.045

    authors: Yamashita A,Matsuoka Y,Matsuda M,Kawai K,Sawa T,Amaya F

    更新日期:2019-09-15 00:00:00

  • Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat.

    abstract::Midbrain dopamine neurons in the ventral tegmental area, substantia nigra and retrorubral field play key roles in reward processing, learning and memory, and movement. Within these midbrain regions and admixed with the dopamine neurons, are also substantial populations of GABAergic neurons that regulate dopamine neuro...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.01.046

    authors: Nair-Roberts RG,Chatelain-Badie SD,Benson E,White-Cooper H,Bolam JP,Ungless MA

    更新日期:2008-04-09 00:00:00

  • Etomidate uniquely modulates the desensitization of recombinant α1β3δ GABA(A) receptors.

    abstract::Central GABA(A) receptors mediate GABAergic phasic and tonic inhibition. While synaptic αβγ GABA(A) receptors primarily mediate phasic inhibition, extrasynaptic αβδ receptors play an important role in mediating tonic inhibition. Etomidate is a general anesthetic that produces its effects by enhancing GABA(A) receptor ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.05.051

    authors: Liu K,Jounaidi Y,Forman SA,Feng HJ

    更新日期:2015-08-06 00:00:00

  • The presence of the APP(swe) mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation.

    abstract::Neuroinflammation, and elevated levels of inflammatory proteins, such as tumor necrosis factor-alpha, and the deposition of beta-amyloid may interact to contribute to the pathogenesis of Alzheimer's disease. We reproduced a component of the neuroinflammatory state within the basal forebrain cholinergic system, a regio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2004.01.050

    authors: Wenk GL,McGann-Gramling K,Hauss-Wegrzyniak B

    更新日期:2004-01-01 00:00:00

  • Developmental study of the distribution of hypoxia-induced factor-1 alpha and microtubule-associated protein 2 in children's brainstem: comparison between controls and cases with signs of perinatal hypoxia.

    abstract::Perinatal asphyxia and hypoxia are common causes of morbidity in neonates. Prenatal birth associated with hypoxemia often results in several disorders because of the lack of oxygen in the brain. Survival rates from perinatal hypoxia have improved, but appropriate treatments for recovery are still limited, with great i...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.04.018

    authors: Coveñas R,González-Fuentes J,Rivas-Infante E,Lagartos-Donate MJ,Cebada-Sánchez S,Arroyo-Jiménez MM,Insausti R,Marcos P

    更新日期:2014-06-20 00:00:00

  • N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy.

    abstract::Most patients with temporal lobe epilepsy (TLE), the most common type of epilepsy, show pronounced loss of neurons in limbic brain regions, including the hippocampus. The massive neurodegeneration in the hippocampus is known as hippocampal sclerosis, and is considered one of the hallmarks of this type of difficult-to-...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(03)00027-7

    authors: Brandt C,Potschka H,Löscher W,Ebert U

    更新日期:2003-01-01 00:00:00

  • Exposure to a conditioned aversive environment interferes with long-term potentiation induction in the fimbria-CA3 pathway.

    abstract::The effect of re-exposure of rats to an aversive environment on the induction of long-term potentiation was investigated in the CA3 region 3 and 12 h after contextual conditioning. Electro-physiological recordings showed that re-exposure of rats to the conditioning chamber produced a significant and long-lasting decre...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00285-6

    authors: Garcia R,Tocco G,Baudry M,Thompson RF

    更新日期:1998-01-01 00:00:00

  • Expression of nerve growth factor in astrocytes of the hippocampal CA1 area following transient forebrain ischemia.

    abstract::We have examined by immunoassay and immunohistochemistry, the expression of nerve growth factor in the rat hippocampus, one to 28 days after transient forebrain ischemia. In the CA1 area, the overall level of nerve growth factor expression remained constant over the first three days of reperfusion while it increased b...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00612-5

    authors: Gottlieb M,Matute C

    更新日期:1999-01-01 00:00:00

  • Effect of tricyclodecan-9-yl potassium xanthate (D609) on phospholipid metabolism and cell death during oxygen-glucose deprivation in PC12 cells.

    abstract::Alterations in lipid metabolism play an integral role in neuronal death in cerebral ischemia. Here we used an in vitro model, oxygen-glucose deprivation (OGD) of rat pheochromocytoma (PC12) cells, and analyzed changes in phosphatidylcholine (PC) and sphingomyelin (SM) metabolism. OGD (4-8 h) of PC12 cells triggered a ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.02.022

    authors: Larsen EC,Hatcher JF,Adibhatla RM

    更新日期:2007-05-25 00:00:00

  • Effects of acoustic startle stimuli on interceptive action.

    abstract::In reaction time (RT) tasks, presentation of a startling acoustic stimulus (SAS) together with a visual imperative stimulus can dramatically reduce RT while leaving response execution unchanged. It has been suggested that a prepared motor response program is triggered early by the SAS but is not otherwise affected. Mo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.06.029

    authors: Tresilian JR,Plooy AM

    更新日期:2006-10-13 00:00:00

  • Control of slow oscillations in the thalamocortical neuron: a computer model.

    abstract::We investigated computer models of a single thalamocortical neuron to assess the interaction of intrinsic voltage-sensitive channels and cortical synaptic input in producing the range of oscillation frequencies observed in these cells in vivo. A morphologically detailed model with Hodgkin-Huxley-like ion channels demo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)83006-5

    authors: Lytton WW,Destexhe A,Sejnowski TJ

    更新日期:1996-02-01 00:00:00

  • Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex.

    abstract::Serotonin induces 'spontaneous' (non-electrically evoked) excitatory postsynaptic currents in layer V pyramidal neurons in the prefrontal cortex. This is likely due to a serotonin2A receptor-mediated focal release of glutamate onto apical dendrites. In addition, activation of the serotonin2A receptor selectively enhan...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00170-1

    authors: Stutzmann GE,Marek GJ,Aghajanian GK

    更新日期:2001-01-01 00:00:00

  • Chemically defined feedback connections from infragranular layers of sensory association cortices in the rat.

    abstract::The primary visual (V1), auditory (AI), and somatosensory (SI) cortices are reciprocally connected with their respective sensory association cortices. In the rat, we have previously demonstrated that some of the connections arising from the secondary somatosensory (SII) and parietal insular (PA) cortices and terminati...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2003.08.056

    authors: Bai WZ,Ishida M,Arimatsu Y

    更新日期:2004-01-01 00:00:00

  • Involvement of glutamatergic and GABAergic transmission in MK-801-increased gamma band oscillation power in rat cortical electroencephalograms.

    abstract::Hypofunction of the N-methyl-D-aspartic acid receptor (NMDAr) has been considered to play a crucial role in the pathophysiology of schizophrenia. In rodent electroencephalogram (EEG) studies, non-competitive NMDAr antagonists have been reported to produce aberrant basal gamma band oscillation (GBO), as observed in sch...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.08.047

    authors: Hiyoshi T,Kambe D,Karasawa J,Chaki S

    更新日期:2014-11-07 00:00:00

  • Tract-based analysis of white matter degeneration in Alzheimer's disease.

    abstract::Although much prior work has focused on the known cortical pathology that defines Alzheimer's disease (AD) histologically, recent work has additionally demonstrated substantial damage to the cerebral white matter in this condition. While there is large evidence of diffuse damage to the white matter in AD, it is unclea...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.05.049

    authors: Lee SH,Coutu JP,Wilkens P,Yendiki A,Rosas HD,Salat DH,Alzheimer’s disease Neuroimaging Initiative (ADNI).

    更新日期:2015-08-20 00:00:00

  • Epigenetic Dysregulation of Dopaminergic System by Maternal Cafeteria Diet During Early Postnatal Development.

    abstract::Dopamine is a neurotransmitter crucial for motor, motivational, and reward-related functions. Our aim was to determine the effect of a palatable maternal diet on the transcriptional regulation of dopaminergic-related genes during perinatal development of rat offspring. For that, female offspring from dams fed with a c...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.09.016

    authors: Rossetti MF,Schumacher R,Gastiazoro MP,Lazzarino GP,Andreoli MF,Stoker C,Varayoud J,Ramos JG

    更新日期:2020-01-01 00:00:00

  • Cholecystokinin-immunopositive basket and Schaffer collateral-associated interneurones target different domains of pyramidal cells in the CA1 area of the rat hippocampus.

    abstract::Two types of GABAergic interneurone are known to express cholecystokinin-related peptides in the isocortex: basket cells, which preferentially innervate the somata and proximal dendrites of pyramidal cells; and double bouquet cells, which innervate distal dendrites and dendritic spines. In the hippocampus, cholecystok...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00440-7

    authors: Cope DW,Maccaferri G,Márton LF,Roberts JD,Cobden PM,Somogyi P

    更新日期:2002-01-01 00:00:00

  • A stable brain from unstable components: Emerging concepts and implications for neural computation.

    abstract::Neuroscientists have often described the adult brain in similar terms to an electronic circuit board- dependent on fixed, precise connectivity. However, with the advent of technologies allowing chronic measurements of neural structure and function, the emerging picture is that neural networks undergo significant remod...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2017.06.005

    authors: Chambers AR,Rumpel S

    更新日期:2017-08-15 00:00:00

  • The relation between transmitter release and Ca2+ entry at the mouse motor nerve terminal: role of stochastic factors causing heterogeneity.

    abstract::The relation between quantal transmitter release and presynaptic Ca2+/Ba2+ entry at the mouse neuromuscular junction was studied, making use of the finding that in the presence of Ba2+ trains of nerve stimuli or brief nerve terminal depolarizations elicit "tails" of raised miniature end-plate potential frequency (fm) ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90305-l

    authors: Quastel DM,Guan YY,Saint DA

    更新日期:1992-12-01 00:00:00

  • Role of GABA in the extraocular motor nuclei of the cat: a postembedding immunocytochemical study.

    abstract::The GABAergic innervation of the extraocular motor nuclei in the cat was evaluated using postembedding immunocytochemical techniques. The characterization of GABA-immunoreactive terminals in the oculomotor nucleus was carried out at the light and electron microscopic levels. GABA-immunopositive puncta suggestive of bo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90529-b

    authors: de la Cruz RR,Pastor AM,Martínez-Guijarro FJ,López-García C,Delgado-García JM

    更新日期:1992-12-01 00:00:00

  • The differential synaptic organization of the spinal and lemniscal projections to the ventrobasal complex of the rat thalamus. Evidence for convergence of the two systems upon single thalamic neurons.

    abstract::The synaptic organization of terminals originating either from the spinal cord (spinothalamic) or from the dorsal column nuclei (lemniscal) was investigated in the ventrobasal complex of the rat thalamus. Wheatgerm agglutinin conjugated to horseradish peroxidase was used as an anterogradely transported axonal tracer, ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)92970-8

    authors: Ma W,Peschanski M,Ralston HJ 3rd

    更新日期:1987-09-01 00:00:00

  • Vagal modulation of responses elicited by stimulation of the aortic depressor nerve in neurons of the rostral ventrolateral medulla oblongata in the rat.

    abstract::Stimulation of cervical vagal afferents inhibits central sympathetic outflows in part by inhibiting the ongoing activity of putative baroreceptive neurons in the rostral ventrolateral medulla oblongata. The aim of the present study was to examine the electrophysiological characteristics of vagal responses and their in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(99)00041-x

    authors: Zagon A,Rocha I,Ishizuka K,Spyer KM

    更新日期:1999-01-01 00:00:00

  • Anterograde horseradish peroxidase tracing and immunohistochemistry of trigeminal ganglion tooth pulp neurons after dental nerve lesions in the rat.

    abstract::The peripheral reorganization of pulpal nerves after tooth injury was studied, in the rat, with anterograde horseradish peroxidase tracing techniques, and combined retrograde Fluorogold tracing and immunohistochemistry was employed to examine the effects of inferior alveolar nerve lesions or tooth injury on some cytoc...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(91)90434-p

    authors: Fried K,Arvidsson J,Robertson B,Pfaller K

    更新日期:1991-01-01 00:00:00

  • Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity.

    abstract::Brain iron accumulation and oxidative stress are common features of many neurodegenerative diseases, and could be due in part to increased iron influx across the blood-brain interface. The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.04.008

    authors: Loke SY,Siddiqi NJ,Alhomida AS,Kim HC,Ong WY

    更新日期:2013-08-15 00:00:00

  • A key role for the caudoventral pontine tegmentum in the simultaneous generation of eye saccades in bursts and associated ponto-geniculo-occipital waves during paradoxical sleep in the cat.

    abstract::Ponto-geniculo-occipital waves and rapid eye movements (eye saccades) are two prominent phasic events of paradoxical sleep which occur in conjunction. Although they have been studied intensively, the neuronal link between these two events is still poorly understood. On the basis of our previous results, combining brai...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00045-1

    authors: Vanni-Mercier G,Debilly G

    更新日期:1998-09-01 00:00:00

  • The T-type calcium channel antagonist Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.

    abstract::The role of T-type calcium channels in brain diseases such as absence epilepsy and neuropathic pain has been studied extensively. However, less is known regarding the involvement of T-type channels in cognition and behavior. Prepulse inhibition (PPI) is a measure of sensorimotor gating which is a basic process whereby...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.06.035

    authors: Marks WN,Greba Q,Cain SM,Snutch TP,Howland JG

    更新日期:2016-09-22 00:00:00

  • Molecular profile of reactive astrocytes--implications for their role in neurologic disease.

    abstract::The central nervous system responds to diverse neurologic injuries with a vigorous activation of astrocytes. While this phenomenon is found in many different species, its function is obscure. Understanding the molecular profile characteristic of reactive astrocytes should help define their function. The purpose of thi...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/0306-4522(93)90380-x

    authors: Eddleston M,Mucke L

    更新日期:1993-05-01 00:00:00