Morphological and neurochemical differentiation of large granular layer interneurons in the adult rat cerebellum.

abstract：:Stimulus-induced pattern of bioelectric activity in human neocortical tissue was investigated by use of the voltage sensitive dye RH795 and a fast optical recording system. During control conditions stimulation of layer I evoked activity predominantly in supragranular layers showing a spatial extent of up to 3000 micr...

journal_title：Neuroscience

authors： Straub H,Kuhnt U,Höhling JM,Köhling R,Gorji A,Kuhlmann D,Tuxhorn I,Ebner A,Wolf P,Pannek HW,Lahl R,Speckmann EJ

更新日期：2003-01-01 00:00:00

abstract：:Pathological narcissism is often characterized by arrogant behavior, a lack of empathy, and willingness to exploit other individuals. Generally, individuals with high levels of narcissism are more likely to suffer mental disorders. However, the brain structural basis of individual pathological narcissism trait among h...

journal_title：Neuroscience

authors： Mao Y,Sang N,Wang Y,Hou X,Huang H,Wei D,Zhang J,Qiu J

更新日期：2016-07-22 00:00:00

abstract：:Several studies suggest that hypothalamic cocaine- and amphetamine-regulated transcript (CART) may interact with the hypothalamic-pituitary-adrenal (HPA) axis in the control of neuroendocrine function and may also participate in cardiovascular regulation. Therefore, this study aimed to evaluate, in experimental models...

journal_title：Neuroscience

authors： Ruginsk SG,Uchoa ET,Elias LL,Antunes-Rodrigues J,Llewellyn-Smith IJ

更新日期：2011-07-14 00:00:00

abstract：:Antagonists acting at the 5-hydroxytryptamine3 receptor are potent anti-emetic agents in cases of cytotoxic- and radiation-induced vomiting, and binding sites for these compounds have been described in brainstem areas known to be involved in mediation of nausea and vomiting. We have used autoradiography to examine the...

journal_title：Neuroscience

authors： Leslie RA,Reynolds DJ,Andrews PL,Grahame-Smith DG,Davis CJ,Harvey JM

更新日期：1990-01-01 00:00:00

abstract：:Solid pieces of cerebellar primordia taken from 12-day-old C57BL embryos were implanted into the cerebellar parenchyma of 3- to 4-month-old "Purkinje cell degeneration" mutant mice and analysed 2-3 months later. Purkinje cell replacement was followed by means of immunocytochemistry with antisera against either cyclic ...

journal_title：Neuroscience

authors： Sotelo C,Alvarado-Mallart RM

更新日期：1987-01-01 00:00:00

abstract：:Stepping over an obstacle is preceded by a center of pressure (CoP) shift, termed anticipatory postural adjustments (APAs). It provides an acceleration of the center of mass forward and laterally prior to step initiation. The APAs are characterized in the lateral direction by a force exerted by the moving leg onto the...

journal_title：Neuroscience

authors： Ruget H,Blouin J,Teasdale N,Mouchnino L

更新日期：2008-08-26 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of morbidity and mortality world-wide and can result in persistent cognitive, sensory and behavioral dysfunction. Understanding the time course of TBI-induced pathology is essential to effective treatment outcomes. We induced TBI in rats using an impact acceleration method...

journal_title：Neuroscience

authors： Allitt BJ,Iva P,Yan EB,Rajan R

更新日期：2016-10-15 00:00:00

abstract：:NESP55 (neuroendocrine secretory protein of M(r) 55000) is a novel member of the chromogranin family. In the present study, we have investigated the distribution, axonal transport and proteolytic processing of NESP55 in the peripheral nervous system. The amount of NESP55 immunoreactivity in adrenal gland was more than...

journal_title：Neuroscience

authors： Li JY,Lovisetti-Scamihorn P,Fischer-Colbrie R,Winkler H,Dahlström A,Department of Anatomy and Cell Biology, University of Göteborg, Sweden. jiayi.li@anatcell.gu.se.

更新日期：2002-01-01 00:00:00

abstract：:It is commonly recognized that physical exercise positively affects several CNS regions and improves cognitive abilities. For example, exercise is associated with an increase in neurogenesis and facilitation of long-term potentiation in the hippocampus. Conversely, animal models for depression are associated with a de...

journal_title：Neuroscience

authors： Dahlin E,Andersson M,Thorén A,Hanse E,Seth H

更新日期：2019-06-01 00:00:00

abstract：:The medial thalamus contains abundant mu-opioid receptors and is activated by acute morphine administration. However, the role of the medial thalamus in the rewarding effects of morphine is unclear. The present study examined whether mu-opioid receptors of the medial thalamus influenced the acquisition and expression ...

journal_title：Neuroscience

authors： Guo N,Garcia MM,Taylor BK,Zadina JE,Harlan RE

更新日期：2008-02-19 00:00:00

abstract：:Immunoreactive nerve cell bodies and fibres in the intestine have been examined using three antibody preparations raised against 5-hydroxytryptamine. Cross reactivity studies indicate that the substance localized was an hydroxylated indoleamine. In the guinea-pig small intestine, nerve cell bodies were located in the ...

journal_title：Neuroscience

authors： Costa M,Furness JB,Cuello AC,Verhofstad AA,Steinbusch HW,Elde RP

更新日期：1982-02-01 00:00:00

abstract：:Stimulus exposure duration in emotion perception research is often chosen pragmatically; however, little work exists on the consequences of stimulus duration for the processing of emotional faces. We utilized the spatiotemporal resolution capabilities of magnetoencephalography (MEG) to characterize early implicit proc...

journal_title：Neuroscience

authors： Kouptsova JE,Leung RC,Taylor MJ

更新日期：2017-01-26 00:00:00

abstract：:Emerging evidence indicates that the expression of trophic factors in the brain is regulated in an activity-dependent manner, which suggests an involvement of trophic factors in events controlled by input activity. We have investigated the possibility that visual sensory input impacts the expression of basic fibroblas...

journal_title：Neuroscience

authors： Gómez-Pinilla F,Choi J,Ryba EA

更新日期：1999-01-01 00:00:00

abstract：:The hypocretin/orexin system regulates, among other things, sleep and energy homeostasis. The system is likely regulated by both homeostatic and circadian mechanisms. Little is known about local differences in the regulation of hypocretin activity. The aim of this study was to establish an optimized peptide quantifica...

journal_title：Neuroscience

authors： Justinussen JL,Holm A,Kornum BR

更新日期：2015-12-03 00:00:00

abstract：:Recombinant human erythropoietin (EPO) has been successfully tested as neuroprotectant in brain injury models. The first large clinical trial with stroke patients, however, revealed negative results. Reasons are manifold and may include side-effects such as thrombotic complications or interactions with other medicatio...

journal_title：Neuroscience

authors： Rahimi Nedjat M,Wähmann M,Bächli H,Güresir E,Vatter H,Raabe A,Heimann A,Kempski O,Alessandri B

更新日期：2013-05-15 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons and leads to death a few years after symptom onset. Despite its high morbidity and mortality, its underlying pathogenic mechanisms still remain poorly understood. Although there is increasing evidence for sign...

journal_title：Neuroscience

authors： Konsolaki E,Koropouli E,Tsape E,Pothakos K,Zagoraiou L

更新日期：2020-12-01 00:00:00

abstract：:It is becoming clear that the detection and integration of synaptic input and its conversion into an output signal in cortical neurons are strongly influenced by background synaptic activity or "noise." The majority of this noise results from the spontaneous release of synaptic transmitters, interacting with ligand-ga...

journal_title：Neuroscience

authors： Greenhill SD,Jones RS

更新日期：2007-07-29 00:00:00

abstract：:The encoding of reward-predictive stimuli by neurons in the nucleus accumbens (NAcc) depends on integrated synaptic activity from the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) afferent inputs. In a previous study, we found that single electrical stimulation pulses applied to the BLA facilitate mPF...

journal_title：Neuroscience

authors： McGinty VB,Grace AA

更新日期：2009-09-15 00:00:00

abstract：:Hippocampal neurogenesis and associated cognitive behaviors are regulated by a number of factors including stress, inflammation, and exercise. However, the interplay between these factors remains relatively unexplored, especially across the lifespan. In the current study, the effect of social isolation stress during t...

journal_title：Neuroscience

authors： Hueston CM,Cryan JF,Nolan YM

更新日期：2017-12-04 00:00:00

abstract：:The rostral ventromedial medulla contains three physiologically defined classes of pain-modulating neuron that project to the spinal and trigeminal dorsal horns. OFF cells contribute to anti-nociceptive processes, ON cells contribute to pro-nociceptive processes (i.e. hyperalgesia) and neutral cells tonically modulate...

journal_title：Neuroscience

authors： Hirakawa N,Tershner SA,Fields HL,Manning BH

更新日期：2000-01-01 00:00:00

abstract：:The tachykinin peptide substance P (SP) is expressed by many interneurons and some projection neurons in the superficial dorsal horn of the spinal cord. We have recently shown that SP-expressing excitatory interneurons in lamina II correspond largely to a morphological class known as radial cells. However, little is k...

journal_title：Neuroscience

authors： Polgár E,Bell AM,Gutierrez-Mecinas M,Dickie AC,Akar O,Costreie M,Watanabe M,Todd AJ

更新日期：2020-12-01 00:00:00

abstract：:Brain iron accumulation and oxidative stress are common features of many neurodegenerative diseases, and could be due in part to increased iron influx across the blood-brain interface. The iron transport protein, divalent metal transporter 1 (DMT1) is found in reactive astrocytes of the lesioned hippocampal CA fields ...

journal_title：Neuroscience

authors： Loke SY,Siddiqi NJ,Alhomida AS,Kim HC,Ong WY

更新日期：2013-08-15 00:00:00

abstract：:Ascorbate is an antioxidant vitamin that is found in high concentrations in the brain which seems to have neuroprotective properties in some experimental models of excitotoxic neurological disorders, including convulsive behavior and reactive species-related damage. In this study we tested whether ascorbate (30, 100 o...

journal_title：Neuroscience

authors： Schneider Oliveira M,Flávia Furian A,Freire Royes LF,Rechia Fighera M,de Carvalho Myskiw J,Gindri Fiorenza N,Mello CF

更新日期：2004-01-01 00:00:00

abstract：:Cholesterol is an essential substance for maintaining normal structure and function of the brain. But unfortunately, a long-term high-cholesterol diet can lead to a variety of pathological changes of the brain such as β-amyloid (Aβ) accumulation, Tau hyperphosphorylation, reactive gliosis, neuroinflammation, neuronal ...

journal_title：Neuroscience

authors： Chen YL,Wang LM,Chen Y,Gao JY,Marshall C,Cai ZY,Hu G,Xiao M

更新日期：2016-03-01 00:00:00

abstract：:Brain connectivity studies have reported that functional networks change with older age. We aim to (1) investigate whether electroencephalography (EEG) data can be used to distinguish between individual functional networks of young and old adults; and (2) identify the functional connections that contribute to this cla...

journal_title：Neuroscience

authors： Moezzi B,Pratti LM,Hordacre B,Graetz L,Berryman C,Lavrencic LM,Ridding MC,Keage HAD,McDonnell MD,Goldsworthy MR

更新日期：2019-12-01 00:00:00

abstract：:Androgens are known to affect cognitive and mnemonic aspects of spatial processing. The cholinergic system is thought to play an important role in cognition and memory, but little is known about the interaction between androgen and cholinergic neurons. The present study focused on the effects of testosterone on the ch...

journal_title：Neuroscience

authors： Nakamura N,Fujita H,Kawata M

更新日期：2002-01-01 00:00:00

abstract：:Recent advances in multiple areas of research have contributed to the identification of several pathophysiological factors underlying obsessive-compulsive disorder (OCD). In particular, the glutamate transporter gene SLC1A1 has been associated with the diagnosis of OCD. Immunological and infectious studies have report...

journal_title：Neuroscience

authors： Rotge JY,Aouizerate B,Tignol J,Bioulac B,Burbaud P,Guehl D

更新日期：2010-01-20 00:00:00

abstract：:The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for...

journal_title：Neuroscience

authors： Ji L,Wang Y,Zhu D,Liu W,Shi J

更新日期：2015-10-01 00:00:00

abstract：:Functional imaging studies have implicated the hippocampus and parahippocampal gyrus in cue-guided spatial navigation, but also many other regions. Furthermore, little is known about de-activations that take place during performance of navigation tasks, something that is of interest given that the hippocampus is a com...

journal_title：Neuroscience

authors： Salgado-Pineda P,Landin-Romero R,Pomes A,Spanlang B,Sarró S,Salvador R,Slater M,McKenna PJ,Pomarol-Clotet E

更新日期：2017-09-01 00:00:00

abstract：:In a previous study it has been demonstrated that fear conditioning is associated with a long-lasting potentiation of parallel fiber to Purkinje cell synaptic transmission in vermal lobules V and VI. Since modifications of intrinsic membrane properties have been suggested to mediate some forms of memory processes, we ...

journal_title：Neuroscience

authors： Zhu L,Scelfo B,Tempia F,Sacchetti B,Strata P

更新日期：2006-07-07 00:00:00