Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus.

abstract：:Neurotoxicity of (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist for metabotropic glutamate receptors negatively coupled to adenylyl cyclase, was investigated in vivo by the intraventricular administration in the rat, compared with that of (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-C...

journal_title：Neuroscience

authors： Kwak S,Miyamoto M,Ishida M,Shinozaki H

更新日期：1996-08-01 00:00:00

abstract：:Beta-amyloid (Aβ) deposition and neuroinflammation are involved in Alzheimer's disease (AD)-type neurodegeneration with cognitive deficits. Phosphodiesterase-5 (PDE5) inhibitors have recently been studied as a potential target for cognitive enhancement by reducing inflammatory responses and Aβ levels. The present stud...

journal_title：Neuroscience

authors： Yin C,Deng Y,Gao J,Li X,Liu Y,Gong Q

更新日期：2016-07-22 00:00:00

abstract：:Lamina I of the spinal dorsal horn contains a diverse mixture of neurons. Among these, a group of giant neurons (Waldeyer cells) has long been recognized. In this study we have used immunocytochemistry to characterize a population of Waldeyer cells which were identified by the presence of high levels of the glycine re...

journal_title：Neuroscience

authors： Puskár Z,Polgár E,Todd AJ

更新日期：2001-01-01 00:00:00

abstract：:Urocortin, a novel 40 amino acid neuropeptide, is a member of the corticotropin-releasing factor family. With 45% homology to corticotropin-releasing factor, urocortin binds with similar affinity to the corticotropin-releasing factor- and corticotropin-releasing factor-2 receptors and may play a role in modulating man...

journal_title：Neuroscience

authors： Morin SM,Ling N,Liu XJ,Kahl SD,Gehlert DR

更新日期：1999-01-01 00:00:00

abstract：:Recently evidence has accumulated that schizophrenia can arise from primary synaptic defects involving structural proteins particularly, microtubule associated proteins. Previous experiments have demonstrated that a STOP (stable tubule only peptide) gene deletion in mice leads to a phenotype mimicking some aspects of ...

journal_title：Neuroscience

authors： Bégou M,Volle J,Bertrand JB,Brun P,Job D,Schweitzer A,Saoud M,D'Amato T,Andrieux A,Suaud-Chagny MF

更新日期：2008-11-11 00:00:00

abstract：:To examine the effect of glucose on the cerebral metabolism of glutamine, rat brain slices were incubated with 5mM [3-(13)C]glutamine without and with 5mM unlabeled glucose. Tissue plus medium extracts were analyzed by using enzymatic and (13)C NMR techniques and fluxes through the enzymatic steps involved were calcul...

journal_title：Neuroscience

authors： El Hage M,Baverel G,Conjard-Duplany A,Martin G

更新日期：2013-09-17 00:00:00

abstract：:Ubiquitination is a post-translational modification that can dynamically alter the function, degradation and transport of a protein, as well as its interaction with other proteins, and activity of an enzyme. Dysfunctional ubiquitination is detrimental to normal cellular functions, and can result in severe diseases. Ov...

journal_title：Neuroscience

authors： Zhu J,Tsai NP

更新日期：2020-01-21 00:00:00

abstract：:The amygdalar basolateral nuclear complex (BLC) is a cortex-like structure that receives inputs from many cortical areas. It has long been assumed that cortico-amygdalar projections, as well as inter-areal intracortical connections, arise from cortical pyramidal cells. However, recent studies have shown that GABAergic...

journal_title：Neuroscience

authors： McDonald AJ,Zaric V

更新日期：2015-05-21 00:00:00

abstract：:The projections of the nucleus of the diagonal band of Broca and of the substantia innominata to the cerebral cortex were studied in the rat, using the anterograde transport of wheat germ agglutinin conjugated with horseradish peroxidase. Following diagonal band injections, fibers were observed ascending in the septum...

journal_title：Neuroscience

authors： Lamour Y,Dutar P,Jobert A

更新日期：1984-06-01 00:00:00

abstract：:Phenomics is an emerging transdiscipline dedicated to the systematic study of phenotypes on a genome-wide scale. New methods for high-throughput genotyping have changed the priority for biomedical research to phenotyping, but the human phenome is vast and its dimensionality remains unknown. Phenomics research strategi...

journal_title：Neuroscience

authors： Bilder RM,Sabb FW,Cannon TD,London ED,Jentsch JD,Parker DS,Poldrack RA,Evans C,Freimer NB

更新日期：2009-11-24 00:00:00

abstract：:The present study was designed to clarify an intensity-dependent effect of prenatal stress on the morphological development of hippocampal neurons in rats. In addition, the involvement of receptors for glucocorticoids, i.e. mineralocorticoid receptors and glucocorticoid receptors, in stress-induced changes in the morp...

journal_title：Neuroscience

authors： Fujioka A,Fujioka T,Ishida Y,Maekawa T,Nakamura S

更新日期：2006-08-25 00:00:00

abstract：:Opioid binding sites were localized in cryostat sections of guinea-pig brain by in vitro autoradiography using (-)-[3H]bremazocine. Quantification of binding sites in gray matter was accomplished using standard samples of tritium mixed in brain gray matter. The binding sites in fiber tracts were quantified using stand...

journal_title：Neuroscience

authors： Foote RW

更新日期：1987-01-01 00:00:00

abstract：:Regulation of adult hippocampal neurogenesis in mice responds to behavioral stimuli, including physical activity (RUN) and the exposure to enriched environments (ENR). If studied after days or weeks, these stimuli and the pathological stimulus of kainic acid-induced seizures (KA) show differential effects on different...

journal_title：Neuroscience

authors： Steiner B,Zurborg S,Hörster H,Fabel K,Kempermann G

更新日期：2008-06-23 00:00:00

abstract：:Long-term treatment with diazepam, a full allosteric modulator of the GABA(A) receptor, results in tolerance to its anticonvulsant effects, whereas an equipotent treatment with the partial allosteric modulator imidazenil does not produce tolerance. Use of subunit-specific antibodies linked to gold particles allowed an...

journal_title：Neuroscience

authors： Pesold C,Caruncho HJ,Impagnatiello F,Berg MJ,Fritschy JM,Guidotti A,Costa E

更新日期：1997-07-01 00:00:00

abstract：:Considerable effort has been directed toward the development of methods to selectively activate specific subtypes of neurons. Focus has been placed on the heterologous expression of proteins that are capable of exciting neurons in which they are expressed. Here we describe the heterologous expression of the invertebra...

journal_title：Neuroscience

authors： Schanuel SM,Bell KA,Henderson SC,McQuiston AR

更新日期：2008-08-13 00:00:00

abstract：:Aversive experiences in early life are thought to dispose to psychopathologies such as mood or anxiety disorders. In a two-hit stress model, we assessed the effects of juvenile and/or adult stress on the 5-HT-mediated modulation of synaptic inhibition of ventral dentate gyrus granule cells. Combined but not single str...

journal_title：Neuroscience

authors： Gruber D,Gilling KE,Albrecht A,Bartsch JC,Çalışkan G,Richter-Levin G,Stork O,Heinemann U,Behr J

更新日期：2015-05-07 00:00:00

abstract：:Western diets are high in fat and sucrose and can influence behavior and gut microbiota. There is growing evidence that altering the microbiome can influence the brain and behavior. This study was designed to determine whether diet-induced changes in the gut microbiota could contribute to alterations in anxiety, memor...

journal_title：Neuroscience

authors： Magnusson KR,Hauck L,Jeffrey BM,Elias V,Humphrey A,Nath R,Perrone A,Bermudez LE

更新日期：2015-08-06 00:00:00

abstract：:Huntington's disease is a progressive, inherited neurodegenerative disorder characterized by the loss of subsets of neurons primarily in the striatum. In this study, we assessed the neuroprotective effect of lithium against striatal lesion formation in a rat model of Huntington's disease in which quinolinic acid was u...

journal_title：Neuroscience

authors： Wei H,Qin ZH,Senatorov VV,Wei W,Wang Y,Qian Y,Chuang DM

更新日期：2001-01-01 00:00:00

abstract：:The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating. Recent data have shown that amphetamine (AMPH) is rewarding to prairie voles as it induces conditioned place preferences. Further, repeated treatment with AMPH impairs social bonding in adult prairie vol...

journal_title：Neuroscience

authors： Fukushiro DF,Olivera A,Liu Y,Wang Z

更新日期：2015-10-29 00:00:00

abstract：:Neurons in the region of dorsomedial hypothalamus are involved in the organization of the physiological responses to emotional stress. We have recently shown that the cardiovascular response evoked by activation of dorsomedial hypothalamus neurons is largely dependent on a synaptic relay with the lateral/dorsolateral ...

journal_title：Neuroscience

authors： da Silva LG Jr,Menezes RC,Villela DC,Fontes MA

更新日期：2006-01-01 00:00:00

abstract：:While the effects of progesterone in the CNS, like those of estrogen, have generally been considered within the context of reproductive function, growing evidence supports its importance in regulating non-reproductive functions including cognition and affect. In addition, progesterone has well-described protective eff...

journal_title：Neuroscience

authors： Singh M,Su C

更新日期：2013-06-03 00:00:00

abstract：:Parkinson's disease (PD) is a common movement disorder. Alpha-synuclein (α-synuclein) plays a critical role in PD. In this study, we evaluated the level of central nervous system (CNS)-derived exosomal α-synuclein in serum, which may be regarded as a specific peripheral biomarker for PD. We recruited patients with PD ...

journal_title：Neuroscience

authors： Si X,Tian J,Chen Y,Yan Y,Pu J,Zhang B

更新日期：2019-08-10 00:00:00

abstract：:In some brain regions, previous studies reported the frequent coexistence between neuronal nitric oxide synthase (nNOS) and somatostatin (SOM). In the hippocampus, nNOS and SOM were mainly expressed in GABAergic nonprincipal neurons. Here we estimated the immunocytochemical colocalization of nNOS and SOM in the mouse ...

journal_title：Neuroscience

authors： Jinno S,Kosaka T

更新日期：2004-01-01 00:00:00

abstract：:Vagal afferents ascending from the gastrointestinal tract synapse on neurons in the nucleus of the solitary tract. Although these neurons constitute a significant proportion of solitary tract cells their firing behaviour and synaptic properties are not documented. Since gastrointestinal tract afferent termination site...

journal_title：Neuroscience

authors： Paton JF,Li YW,Deuchars J,Kasparov S

更新日期：2000-01-01 00:00:00

abstract：:Single steps in different directions are often used for postural corrections. However, our knowledge about the neural mechanisms underlying their generation is scarce. This study was aimed to characterize the corrective steps generated in response to disturbances of the basic body configuration caused by forward, back...

journal_title：Neuroscience

authors： Hsu LJ,Zelenin PV,Lyalka VF,Vemula MG,Orlovsky GN,Deliagina TG

更新日期：2017-04-07 00:00:00

abstract：:The acute self-stimulation of the medial forebrain bundle was reported to induce the expression of c-Fos, the protein product of c-fos, an immediate early gene, in the central nervous system. In the present study, we examined regional changes in c-Fos expression in several reward-related areas of rat brain in response...

journal_title：Neuroscience

authors： Nakahara D,Ishida Y,Nakamura M,Kuwahara I,Todaka K,Nishimori T

更新日期：1999-03-01 00:00:00

abstract：:The development of mechanisms of neurotransmitter release is an important component in the formation of functional synaptic connections. Synaptic neurotransmitter release can be modulated by nitric oxide, a compound shown to have a variety of physiologic functions in the nervous system. The goal of this study was to d...

journal_title：Neuroscience

authors： Sporns O,Jenkinson S

更新日期：1997-10-01 00:00:00

abstract：:alpha-Calcitonin gene-related peptide expression in alpha-motoneurons is regulated by spinal cord transection, axotomy and testosterone, but to date there are no studies which examine the regulation of cholecystokinin expression in motoneurons. In the present study, we compared the regulation of preprocholecystokinin ...

journal_title：Neuroscience

authors： Popper P,Abelson L,Micevych PE

更新日期：1992-11-01 00:00:00

abstract：:In the present study the effect of cocaine on thymidine, uridine and leucine incorporation was assessed in primary cortical glial and C6 glioma cells. Cocaine exposure for 24 h inhibited thymidine and uridine incorporation in cortical glial and C6 glioma cells. However, the effect of cocaine on uridine incorporation w...

journal_title：Neuroscience

authors： Garg UC,Turndorf H,Bansinath M

更新日期：1993-11-01 00:00:00

abstract：:Ochratoxin A (OTA), a mycotoxin and widespread food contaminant, is known for its patent nephrotoxicity and potential neurotoxicity. Previous observations in vitro showed that in the CNS, glial cells were particularly sensitive to OTA. In the search for the molecular mechanisms underlying OTA neurotoxicity, we investi...

journal_title：Neuroscience

authors： Zurich MG,Lengacher S,Braissant O,Monnet-Tschudi F,Pellerin L,Honegger P

更新日期：2005-01-01 00:00:00