Differential expression of ryanodine receptors in the rat cochlea.

abstract：:Previous research has implicated hippocampal rhythmical slow activity in the mechanisms of action of the anxiolytic drugs. In this study ethanol and a putative ethanol antagonist, Ro 15-4513, were investigated with reticular elicitation of rhythmical slow activity. Doses of ethanol between 0.6 and 3.1 g/kg were used. ...

journal_title：Neuroscience

authors： Coop CF,McNaughton N,Warnock K,Laverty R

更新日期：1990-01-01 00:00:00

abstract：:It has been hypothesized [Colpaert, F.C., 1994. In: Briley, M., Marien, M. (Eds.), Noradrenergic Mechanisms in Parkinson's Disease. CRC Press, Boca Raton, FL, pp. 225-254] that a deficiency in the noradrenergic system originating from the locus coeruleus is a decisive factor in the progression of central neurodegenera...

journal_title：Neuroscience

authors： Debeir T,Marien M,Chopin P,Martel JC,Colpaert F,Raisman-Vozari R

更新日期：2002-01-01 00:00:00

abstract：:Nitric oxide is thought to play an important role in multiple forms of use-dependent synaptic plasticity, including that which follows noxious peripheral stimulation. This suggests that development of nociception-induced neuroplasticity should be impaired in transgenic animals lacking the neuronal form of nitric oxide...

journal_title：Neuroscience

authors： Crosby G,Marota JJ,Huang PL

更新日期：1995-12-01 00:00:00

abstract：:Fathers play a substantial role in infant care in a small but significant number of mammalian species, including humans. However, the neural circuitry controlling paternal behavior is much less understood than its female counterpart. In order to characterize brain areas activated by paternal care, male California mice...

journal_title：Neuroscience

authors： de Jong TR,Measor KR,Chauke M,Harris BN,Saltzman W

更新日期：2010-09-01 00:00:00

abstract：:Accumulated evidence suggests that the single transmembrane domain insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/M6P or IGF-II receptor) plays an important role in the intracellular trafficking of lysosomal enzymes and endocytosis-mediated degradation of insulin like growth factor (IGF-II). Howeve...

journal_title：Neuroscience

authors： Amritraj A,Rauw G,Baker GB,Kar S

更新日期：2010-10-27 00:00:00

abstract：:We reported previously that sensory neurons isolated from mice with a heterozygous mutation of the Nf1 gene (Nf1+/-) exhibited greater excitability and increased sodium current densities compared with wildtype mice. This raises the question as to whether the increased current density resulted from post-translational m...

journal_title：Neuroscience

authors： Hodgdon KE,Hingtgen CM,Nicol GD

更新日期：2012-03-29 00:00:00

abstract：:Properties of excitatory synaptic responses in fast-spiking interneurons (FSIs) and pyramidal neurons (PNs) are different; however, the mechanisms and determinants of this diversity have not been fully investigated. In the present study, voltage-clamp recording of miniature excitatory post-synaptic currents (mEPSCs) w...

journal_title：Neuroscience

authors： Malkin SL,Kim KK,Tikhonov DB,Magazanik LG,Zaitsev AV

更新日期：2015-08-20 00:00:00

abstract：:Resilience, a personality construct that reflects capacities to persevere, maintain a positive outlook and/or thrive despite ongoing stressors, has emerged as an important focus of research on chronic pain (CP). Although behavior studies have found more resilient persons with CP experience less pain-related dysfunctio...

journal_title：Neuroscience

authors： You B,Jackson T

更新日期：2021-01-21 00:00:00

abstract：:The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens. Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of ho...

journal_title：Neuroscience

authors： Song C,Merali Z,Anisman H

更新日期：1999-01-01 00:00:00

abstract：:Insulin-like growth factor-I elicits a long-term depression of the glutamate-induced GABA release in the adult rat cerebellum that lasts at least several hours. We studied whether protein kinase C and nitric oxide may be involved in this effect of insulin-like growth factor-I on GABA release since both signalling path...

journal_title：Neuroscience

authors： Castro-Alamancos MA,Arevalo MA,Torres-Aleman I

更新日期：1996-02-01 00:00:00

abstract：:Calcineurin (PP2B) is a Ca(2+)-dependent protein phosphatase enriched in the brain that takes part in intracellular signaling pathways regulating synaptic plasticity and neuronal functions. Calcineurin-dependent pathways are important for complex brain functions such as learning and memory. More recently, they have be...

journal_title：Neuroscience

authors： Crozatier C,Farley S,Mansuy IM,Dumas S,Giros B,Tzavara ET

更新日期：2007-02-23 00:00:00

abstract：:Some glutamatergic synapses in the mammalian central nervous system exhibit high levels of free ionic zinc in their synaptic vesicles. The precise role of this vesicular zinc remains obscure, despite suggestive evidence for zinc as a neuromodulator. As a step towards elucidating the role of free zinc in the brain we h...

journal_title：Neuroscience

authors： Budde T,Minta A,White JA,Kay AR

更新日期：1997-07-01 00:00:00

abstract：:Paclitaxel is one of the most commonly used anti-neoplastic drugs for the treatment of solid tumors. Unfortunately, its use is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. However, there are few clinically available drugs or...

journal_title：Neuroscience

authors： Kiya T,Kawamata T,Namiki A,Yamakage M

更新日期：2011-02-03 00:00:00

abstract：:Both systemic and intrathecal capsaicin release and deplete substance P from primary sensory afferents and induce prolonged chemical and thermal analgesia. Given the existence of efferents containing substance P together with a pain-inhibitory serotoninergic pathway, the present study investigated the effects of intra...

journal_title：Neuroscience

authors： Bodnar RJ,Kirchgessner A,Nilaver G,Mulhern J,Zimmerman EA

更新日期：1982-03-01 00:00:00

abstract：:We previously showed that magnesium sulfate (MS) has systemic antinociceptive and local peripheral pronociceptive effects. The role of transient receptor potential (TRP) channels and acid-sensing ion channels (ASICs) in the mechanism of action of MS has not been investigated in detail. The aim of this study was to exp...

journal_title：Neuroscience

authors： Srebro D,Vučković S,Prostran M

更新日期：2016-12-17 00:00:00

abstract：:In the present study the effect of cocaine on thymidine, uridine and leucine incorporation was assessed in primary cortical glial and C6 glioma cells. Cocaine exposure for 24 h inhibited thymidine and uridine incorporation in cortical glial and C6 glioma cells. However, the effect of cocaine on uridine incorporation w...

journal_title：Neuroscience

authors： Garg UC,Turndorf H,Bansinath M

更新日期：1993-11-01 00:00:00

abstract：:The roles of acetylcholine and dynorphin (1-13) in the presynaptic control of the release of [3H]dopamine continuously synthesized from [3H]tyrosine were examined in a prominent striosomal enriched area and in an adjacent matrix enriched area of the cat caudate nucleus. This was achieved using microsuperfusion devices...

journal_title：Neuroscience

authors： Gauchy C,Desban M,Krebs MO,Glowinski J,Kemel ML

更新日期：1991-01-01 00:00:00

abstract：:The capacity of neural stem cells (NSC) to generate different types of neurons and glia depends on the action of intrinsic determinants and extracellular signals. Here, we isolated adult olfactory bulb stem cells (aOBSC) that express nestin, RC2 and Sox2, and that have the capacity to generate neurons possessing matur...

journal_title：Neuroscience

authors： Vergaño-Vera E,Méndez-Gómez HR,Hurtado-Chong A,Cigudosa JC,Vicario-Abejón C

更新日期：2009-08-04 00:00:00

abstract：:Although many workers have appreciated the striking cytologic and neurochemical similarities of neostriatum, accumbens and olfactory tubercle, a compelling case for regarding these areas as territories in a striatal complex awaited the arguments made by Heimer and his colleagues based on their investigations of connec...

journal_title：Neuroscience

authors： Zahm DS,Brog JS

更新日期：1992-10-01 00:00:00

abstract：:Several lines of evidence suggest that integrin receptors play a pivotal role in consolidation of long-term potentiation (LTP), but which of the many integrin dimers are involved remains to be discovered. The present study used an LTP reversal paradigm to test if alpha3 integrins make an important contribution. Functi...

journal_title：Neuroscience

authors： Kramár EA,Bernard JA,Gall CM,Lynch G

更新日期：2002-01-01 00:00:00

abstract：:In order to determine which types of spinal neuron produce c-fos in response to noxious stimulation, we have combined pre-embedding detection of c-fos-like immunoreactivity with post-embedding immunocytochemistry using antibodies against GABA and glycine, 2 h after subcutaneous injection of formalin into a hindpaw of ...

journal_title：Neuroscience

authors： Todd AJ,Spike RC,Brodbelt AR,Price RF,Shehab SA

更新日期：1994-12-01 00:00:00

abstract：:Morphine (opiate agonist) produced a dose-dependent decrease in the spontaneous motility of 5- and 9-day chick embryos. Naloxone (opiate antagonist) appeared to reverse competitively the inhibition of motility caused by morphine. The effects of morphine on spontaneous motility in 5-day embryos were also reversed stere...

journal_title：Neuroscience

authors： Maderdrut JL,Reitzel JL,Okado N,Oppenheim RW

更新日期：1985-10-01 00:00:00

abstract：:In Parkinson's disease, subthalamic nucleus (STN) neurons burst fire with increased periodicity and synchrony. This may entail abnormal release of glutamate, the major source of which in STN is cortical afferents. Indeed, the cortico-subthalamic pathway is implicated in the emergence of excessive oscillations, which a...

journal_title：Neuroscience

authors： Yamawaki N,Magill PJ,Woodhall GL,Hall SD,Stanford IM

更新日期：2012-02-17 00:00:00

abstract：:Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that re...

journal_title：Neuroscience

authors： Zhu YY,Jing L,Duan TT,Yuan Q,Cao J,Zhou QX,Xu L

更新日期：2013-10-10 00:00:00

abstract：:The central nervous system responds to diverse neurologic injuries with a vigorous activation of astrocytes. While this phenomenon is found in many different species, its function is obscure. Understanding the molecular profile characteristic of reactive astrocytes should help define their function. The purpose of thi...

journal_title：Neuroscience

authors： Eddleston M,Mucke L

更新日期：1993-05-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) produce widespread and complex effects on neocortex excitability. We studied how heteromeric nAChRs regulate inhibitory post-synaptic currents (IPSCs), in fast-spiking (FS) layer V neurons of the mouse frontal area 2 (Fr2). In the presence of blockers of ionotropic glutamate ...

journal_title：Neuroscience

authors： Aracri P,Meneghini S,Coatti A,Amadeo A,Becchetti A

更新日期：2017-01-06 00:00:00

abstract：:Stress has long been associated with the development of neuropsychiatric and neurological disorders. The effects of stress vary depending upon the age during which the stress is incurred, the duration and severity of the stressor, and can further be influenced by levels of circulating gonadal hormones. To date, the ma...

journal_title：Neuroscience

authors： Bath KG,Schilit A,Lee FS

更新日期：2013-06-03 00:00:00

abstract：:GABAergic neurons are coextensive with cholinergic neurons in the medial septum-diagonal band complex. Serial sectioning, sequential staining and double immunofluorescence techniques employing antibodies to glutamate decarboxylase and choline acetyltransferase revealed the distribution of these transmitter-specific ne...

journal_title：Neuroscience

authors： Brashear HR,Zaborszky L,Heimer L

更新日期：1986-02-01 00:00:00

abstract：:Estrogen is likely involved in the gender specific differences in coping with stress. Activation of catecholamine (CA) biosynthetic enzyme gene expression in central and peripheral CA systems plays a key role in response to stress and in regulation of the cardiovascular system. Here we examined whether estradiol can m...

journal_title：Neuroscience

authors： Serova LI,Maharjan S,Sabban EL

更新日期：2005-01-01 00:00:00

abstract：:Our working hypothesis is that brain neurotrophins and brain Na(+),K(+)-ATPase may be strongly associated with the occurrence of depression in animals subjected to chronic unpredictable mild stress (CUMS). Still, we believe that chrysin, a natural and bioactive flavonoid found in honey and some plants, can provide sat...

journal_title：Neuroscience

authors： Filho CB,Jesse CR,Donato F,Giacomeli R,Del Fabbro L,da Silva Antunes M,de Gomes MG,Goes AT,Boeira SP,Prigol M,Souza LC

更新日期：2015-03-19 00:00:00