Emergence of a functional coupling between inositol-1,4,5-trisphosphate receptors and calcium channels in developing neocortical neurons.

abstract：:Dopamine-mediated behaviors and certain biochemical and molecular events associated with these behaviors were examined following continuous infusion of the D1 dopamine agonist SKF38393 or the D2 dopamine agonist quinpirole into mice for six days. SKF38393 produced a transient grooming behavior while quinpirole initial...

journal_title：Neuroscience

authors： Chen JF,Aloyo VJ,Weiss B

更新日期：1993-06-01 00:00:00

abstract：:Despite extensive investigations into the mechanisms of aerobic respiration in mitochondria, the spontaneous metabolic activity of individual cells within a whole animal has not been observed in real time. Consequently, little is known about whether and how the level of mitochondrial energy metabolism is regulated in ...

journal_title：Neuroscience

authors： Kazama H,Ichikawa A,Kohsaka H,Morimoto-Tanifuji T,Nose A

更新日期：2008-03-03 00:00:00

abstract：:Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vome...

journal_title：Neuroscience

authors： Bakker J,Baum MJ,Slob AK

更新日期：1996-09-01 00:00:00

abstract：:Foetal mouse hippocampal primordia from mice homozygous for the Thy-1.1 allele were transplanted into the hippocampal region of adult histocompatible mice, homozygous for the Thy-1.2 allele. After survival periods of two months to one year the transplants consisted of a discrete tissue mass, well fused with the host, ...

journal_title：Neuroscience

authors： Zhou CF,Raisman G,Morris RJ

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:High-mobility group box 1 (HMGB1), an active receptor for advanced glycation endproducts (RAGE), functions as a potent proinflammatory cytokine-like factor that contributes to the pathogenesis of vasculature. Diabetes mellitus (DM) is associated with accelerated development of both microvascular and macrovasc...

journal_title：Neuroscience

authors： Ye X,Chopp M,Liu X,Zacharek A,Cui X,Yan T,Roberts C,Chen J

更新日期：2011-09-08 00:00:00

abstract：:Alzheimer's disease (AD), the most prominent form of dementia in elderly, is a yet incurable degenerative neurological illness characterized by memory loss. Here, we used an AD rat model to investigate the in vivo efficacy of caprospinol, a disease-modifying steroid developed on the concept that reduced synthesis of 2...

journal_title：Neuroscience

authors： Lecanu L,Rammouz G,McCourty A,Sidahmed EK,Greeson J,Papadopoulos V

更新日期：2010-01-20 00:00:00

abstract：:In synaptosomes prepared from dentate gyrus, activation of the metabotropic glutamate receptor by the specific agonist, trans-1-amino-cyclopentyl-1,3-dicarboxylate, increases release of glutamate in the presence of a low concentration of arachidonic acid. A similar interaction between trans-1-amino-cyclopentyl-1,3-dic...

journal_title：Neuroscience

authors： McGahon B,Lynch MA

更新日期：1996-06-01 00:00:00

abstract：:Even simple behaviors of vertebrates are typically generated by the concerted action of large numbers of brain cells. However, the mechanisms by which groups of neurons work together as functional populations to guide behavior remain largely unknown. One of the major model systems for exploring these mechanisms has be...

journal_title：Neuroscience

authors： Crish SD,Dengler-Crish CM,Comer CM

更新日期：2006-01-01 00:00:00

abstract：:According to the simulation theory, the internal simulation of a movement (imagined movement, IM) and its execution (actual movement, AM) are based on the same motor representations. The brain uses these representations for controlling action. The specific objective of this study was to investigate the updating proces...

journal_title：Neuroscience

authors： Chabeauti PY,Assaiante C,Vaugoyeau M

更新日期：2012-10-11 00:00:00

abstract：:Chronic administration of mu-opioid receptor agonists is known to produce adaptive changes within noradrenergic neurons of the locus coeruleus. Although mu-opioid receptors are densely expressed by locus coeruleus neurons, the effects of acute and chronic administration of agonists on the subcellular distribution of m...

journal_title：Neuroscience

authors： Van Bockstaele EJ,Commons KG

更新日期：2001-01-01 00:00:00

abstract：:Investigation of the integrity of the ryanodine receptor in Alzheimer's disease is important because it plays a critical role in the regulation of calcium release from the endoplasmic reticulum in brain, impairment of which is believed to contribute to the pathogenesis of Alzheimer's disease. The present study compare...

journal_title：Neuroscience

authors： Kelliher M,Fastbom J,Cowburn RF,Bonkale W,Ohm TG,Ravid R,Sorrentino V,O'Neill C

更新日期：1999-01-01 00:00:00

abstract：:Chronic, but not acute, exposure to minimal electroconvulsive shock (ECS) has been shown to decrease vulnerability to neuronal cell death, without itself causing neuronal damage. One potential mechanism for the neuroprotective effect of ECS is the increase in fibroblast growth factor-2 (FGF-2) which occurs after chron...

journal_title：Neuroscience

authors： Kondratyev A,Ved R,Gale K

更新日期：2002-01-01 00:00:00

abstract：:Properties of excitatory synaptic responses in fast-spiking interneurons (FSIs) and pyramidal neurons (PNs) are different; however, the mechanisms and determinants of this diversity have not been fully investigated. In the present study, voltage-clamp recording of miniature excitatory post-synaptic currents (mEPSCs) w...

journal_title：Neuroscience

authors： Malkin SL,Kim KK,Tikhonov DB,Magazanik LG,Zaitsev AV

更新日期：2015-08-20 00:00:00

abstract：:Midbrain dopamine neurons are critical in mediating the rewarding effects of opiates in dependent rats, as well as modulating some manifestations of opiate withdrawal. Morphine is known to excite dopamine neurons and thereby facilitate forebrain dopamine transmission through inhibition of GABA neurons. Cholinergic neu...

journal_title：Neuroscience

authors： Miller AD,Forster GL,Yeomans JS,Blaha CD

更新日期：2005-01-01 00:00:00

abstract：:Incubation of the rat sensory neuron-derived cell line ND7 in serum-free medium results in the arrest of mitosis and the appearance of numerous neuronal processes. During this differentiation event, secretory granule components such as chromogranins, neuropeptide Y and the C-flanking peptide of pro-neuropeptide Y move...

journal_title：Neuroscience

authors： Wheatley SC,Suburo AM,Horn DA,Vucicevic V,Terenghi G,Polak JM,Latchman DS

更新日期：1992-12-01 00:00:00

abstract：:GABA(B) receptors are G-protein-coupled receptors mediating the slow onset and prolonged synaptic actions of GABA in the CNS. The recent cloning of two genes, GABA(B1) and GABA(B2), has revealed a novel requirement for GABA(B) receptor signalling. Studies have demonstrated that the two receptor subunits associate as a...

journal_title：Neuroscience

authors： Charles KJ,Evans ML,Robbins MJ,Calver AR,Leslie RA,Pangalos MN

更新日期：2001-01-01 00:00:00

abstract：:κ opioid receptor agonists produce aversive effects in rodents, however the underlying mechanisms remain unclear. Activation of p38 mitogen-activated protein kinase (MAPK) has been discovered to play a critical role in the modulation of affective behaviors. The present study was undertaken to detect the possible invol...

journal_title：Neuroscience

authors： Zan GY,Wang Q,Wang YJ,Chen JC,Wu X,Yang CH,Chai JR,Li M,Liu Y,Hu XW,Shu XH,Liu JG

更新日期：2016-04-21 00:00:00

abstract：:Amphetamine induces a pronounced rotation directed ipsilateral to the lesion and lasting about 2 h in rats bearing a unilateral lesion of the nigrostriatal dopaminergic pathway. Implantation of embryonic dopaminergic neurons into the lesioned striatum leads to a compensation of this rotation. However, graft-bearing an...

journal_title：Neuroscience

authors： Herman JP,Rouge-Pont F,Le Moal M,Abrous DN

更新日期：1993-04-01 00:00:00

abstract：:The striatum, which processes cortical information for behavioral output, is a key target of Huntington's disease (HD), an autosomal dominant condition characterized by cognitive decline and progressive loss of motor control. Increasing evidence implicates deficient glutamate uptake caused by a down-regulation of GLT1...

journal_title：Neuroscience

authors： Miller BR,Dorner JL,Shou M,Sari Y,Barton SJ,Sengelaub DR,Kennedy RT,Rebec GV

更新日期：2008-04-22 00:00:00

abstract：:There are declines in the protein expression of the NR2B (mouse epsilon2) and NR1 (mouse zeta1) subunits of the N-methyl-D-aspartate (NMDA) receptor in the cerebral cortex and hippocampus during aging in C57BL/6 mice. This study was designed to determine if there is a greater effect of aging on subunit expression and ...

journal_title：Neuroscience

authors： Zhao X,Rosenke R,Kronemann D,Brim B,Das SR,Dunah AW,Magnusson KR

更新日期：2009-09-15 00:00:00

abstract：:Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated...

journal_title：Neuroscience

authors： Poulter MO,Padjen AL

更新日期：1995-09-01 00:00:00

abstract：:Electrophysiological records of unit activity were used to compare the effects of excitotoxic pallidal lesions and 6-hydroxydopamine-induced damage to the midbrain dopaminergic neurons on the discharge rates and patterns of the subthalamic neurons. Removal of the pallidal input induced a slight, but statistically sign...

journal_title：Neuroscience

authors： Hassani OK,Mouroux M,Féger J

更新日期：1996-05-01 00:00:00

abstract：:Estrogen exerts many of its receptor-mediated neuroprotective functions through the activation of various intracellular signal transduction pathways including the mitogen activating protein kinase (MAPK), phospho inositol-3 kinase and protein kinase C pathways. Here we have used a hippocampal slice culture model of ka...

journal_title：Neuroscience

authors： Goodenough S,Schleusner D,Pietrzik C,Skutella T,Behl C

更新日期：2005-01-01 00:00:00

abstract：:A histochemical stain to detect cobalt in cells was used to investigate the ionic basis of heat transduction in mammalian primary afferent neurons. Cultured dorsal root ganglion neurons from the adult rat were exposed to 10-min heat stimuli in an extracellular solution containing cobalt ions. When accumulated intracel...

journal_title：Neuroscience

authors： Reichling DB,Barratt L,Levine JD

更新日期：1997-03-01 00:00:00

abstract：:The after-effects of locomotor stimulation are a transient facilitation of locomotor initiation (the priming effect), and a transient increase in hippocampal rhythmic slow activity in the 3-6 Hz band of the theta range. The similar time course of the two effects suggests that hippocampal 3-6 Hz activity may be linked ...

journal_title：Neuroscience

authors： Sinnamon HM

更新日期：2000-01-01 00:00:00

abstract：:A variety of postmortem brain studies and clinical investigations have provided evidence that reduced serotonin neurotransmission is associated with suicidal behavior and depression, and several serotonergic parameters have been found to be altered in the prefrontal cortex of suicide victims. However, the integrity of...

journal_title：Neuroscience

authors： Austin MC,Whitehead RE,Edgar CL,Janosky JE,Lewis DA

更新日期：2002-01-01 00:00:00

abstract：:The ventromedial spinal cord of mammals contains a neural network known as the locomotor central pattern generator (CPG) which underlies the basic generation and coordination of muscle activity during walking. To understand how this neural network operates, it is necessary to identify, characterize, and map connectivi...

journal_title：Neuroscience

authors： Griener A,Dyck J,Gosgnach S

更新日期：2013-10-10 00:00:00

abstract：:In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells. Five different muscarinic receptor subtypes (M(1)-M(5)) have been identi...

journal_title：Neuroscience

authors： Iino S,Nojyo Y

更新日期：2006-01-01 00:00:00

abstract：:Spumiform basement membrane degeneration (sbmd) is a specific kind of aberration present in the capillaries of the midbrain periaqueductal gray (PAG) region of the senescent hamster. These capillaries, separated by the ependymal cell layer, are bordering the Sylvian cerebral aqueduct. The aqueduct, connecting the 3rd ...

journal_title：Neuroscience

authors： Gerrits PO,Kortekaas R,de Weerd H,Luiten PG,van der Want JJ,Veening JG

更新日期：2013-01-03 00:00:00

abstract：:The occurrence of neuropeptide Y-like immunoreactivity in the adrenal gland was investigated by means of radioimmunoassay, chromatography and immunohistochemistry. The adrenal levels of neuropeptide Y-like immunoreactivity varied considerably between species with lowest amounts in the rat and highest in the cow where ...

journal_title：Neuroscience

authors： de Quidt ME,Emson PC

更新日期：1986-11-01 00:00:00