Functional Compensation and Mechanism of Choline Acetyltransferase in the Treatment of Cognitive Deficits in Aged Dementia Mice.

abstract：:Addition of the excitatory amino acids l-glutamate, l-aspartate and their analogues kainate and N-methyl-d-aspartate to incubated slices of adult rat cerebellum led to large increases in cyclic GMP levels. The order of apparent potencies was kainate greater than N-methyl-d-aspartate greater than glutamate and aspartat...

journal_title：Neuroscience

authors： Garthwaite J

更新日期：1982-10-01 00:00:00

abstract：:Arachidonic acid (20:4) is a component of membrane lipids that has been implicated as a messenger both in physiological and pathophysiological processes, including ischemic injury and synaptic plasticity. In order to clarify direct trophic or toxic effects of arachidonic acid on central neurons, primary cultures of ra...

journal_title：Neuroscience

authors： Okuda S,Saito H,Katsuki H

更新日期：1994-12-01 00:00:00

abstract：:The synaptic events underlying the excitation of neurons in the rat's dorsal nucleus of the lateral lemniscus were studied by whole-cell patch-clamp recordings in a brain slice preparation of the auditory midbrain. Both current-clamp and voltage-clamp data were obtained with the brain slice submerged in artificial cer...

journal_title：Neuroscience

authors： Fu XW,Brezden BL,Kelly JB,Wu SH

更新日期：1997-06-01 00:00:00

abstract：:Within the dorsomedial hypothalamus (DMH), cholecystokinin (CCK) has been proposed to modulate neuropeptide Y (NPY) signaling to affect food intake. However, the neural circuitry underlying the actions of this CCK-NPY signaling system in the controls of food intake has yet to be determined. We sought to characterize t...

journal_title：Neuroscience

authors： Chen J,Scott KA,Zhao Z,Moran TH,Bi S

更新日期：2008-03-03 00:00:00

abstract：:Two volatile agents, isoflurane and sevoflurane have similar anesthetic properties but different potencies; this allows the discrimination between anesthetic potency and other properties on the protective mechanisms of volatile anesthesia. Two times the minimal alveolar concentration of an anesthetic is approximately ...

journal_title：Neuroscience

authors： Wang J,Meng F,Cottrell JE,Kass IS

更新日期：2006-07-07 00:00:00

abstract：:In stroke-prone spontaneously hypertensive rats (SHRSP/Izm), ischemia induces swelling of astrocytes, a process that subsequently leads to neuronal death. Following ischemic insult, arginine vasopressin (AVP) can induce edema and l-serine released by astrocytes supports the survival of neuronal cells. The purpose of t...

journal_title：Neuroscience

authors： Yamagata K,Yamamoto M,Kawakami K,Ohara H,Nabika T

更新日期：2014-05-16 00:00:00

abstract：:Dopamine (DA) axons and receptors have recently been identified in the primate thalamus, including the mediodorsal thalamic nucleus (MD). In order to determine whether the DA innervation of the primate MD shares the anatomical features of the mesocortical or nigrostriatal DA projections, we performed tract-tracing and...

journal_title：Neuroscience

authors： Melchitzky DS,Erickson SL,Lewis DA

更新日期：2006-12-28 00:00:00

abstract：:In the brain of young (two weeks old) rats, angiotensin II receptors (AT2 receptors) are found in brain nuclei which receive and integrate direct visual input from the retina, the suprachiasmatic nuclei (containing only AT1 receptors), the lateral geniculate nuclei (containing AT2 receptors) and the superior colliculu...

journal_title：Neuroscience

authors： Michels KM,Heemskerk FM,Saavedra JM

更新日期：1994-02-01 00:00:00

abstract：:We investigated immunohistochemically the cellular localization of multifunctional type II Ca2+/calmodulin-dependent protein kinase in the rat basal ganglia and intrastriatal grafts derived from fetal striatal primordia, in comparison with that of calcineurin, a reliable marker for striatal medium-sized spinous neuron...

journal_title：Neuroscience

authors： Goto S,Yamada K,Oyama T,Korematsu K,Nagahiro S,Ushio Y,Fukunaga K,Miyamoto E,Hofer W

更新日期：1994-10-01 00:00:00

abstract：:The purpose of the following experiments was to describe some of the neurochemical changes that occur in the basal ganglia of rats exposed chronically to a classical neuroleptic, fluphenazine, and to relate these changes to extrapyramidal motor dysfunction. For these studies a combination of behavioural, receptor auto...

journal_title：Neuroscience

authors： Johnson AE,Liminga U,Lidén A,Lindefors N,Gunne LM,Wiesel FA

更新日期：1994-12-01 00:00:00

abstract：:Previous research has demonstrated antidepressant-like effects in rodents upon intracerebral inhibition of histone deacetylases (HDACs). Such effects have been reported for local HDAC inhibition in the nucleus accumbens, hippocampus, and amygdala. However, the effect of HDAC inhibition within the medial prefrontal cor...

journal_title：Neuroscience

authors： Covington HE 3rd,Maze I,Vialou V,Nestler EJ

更新日期：2015-07-09 00:00:00

abstract：:The area postrema has been implicated as a major station for the processing of visceral sensory information, involved primarily in eliciting rapid homeostatic responses to fluid and nutrient imbalances. Yet the precise relationship of efferent projections from the area postrema to medullary motor and relay nuclei invo...

journal_title：Neuroscience

authors： Cunningham ET Jr,Miselis RR,Sawchenko PE

更新日期：1994-02-01 00:00:00

abstract：:The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The metabotropic glutamate receptors first d...

journal_title：Neuroscience

authors： Birse EF,Eaton SA,Jane DE,Jones PL,Porter RH,Pook PC,Sunter DC,Udvarhelyi PM,Wharton B,Roberts PJ

更新日期：1993-02-01 00:00:00

abstract：:The duration of long-term potentiation in the dentate gyrus of awake rats was examined following systematic manipulation of the number of stimulus trains delivered. This was correlated with the induction of immediate early genes in separate groups of animals given identical stimulus regimes. Following 10 trains of sti...

journal_title：Neuroscience

authors： Abraham WC,Mason SE,Demmer J,Williams JM,Richardson CL,Tate WP,Lawlor PA,Dragunow M

更新日期：1993-10-01 00:00:00

abstract：:Intracellular recordings were made from neurons in a rat locus coeruleus slice preparation in vitro. A postsynaptic potential was evoked by electrical stimulation of afferents to the neurons. CI-977 ([5R-(5a,7a,8b)]-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec -8-yl[-4-benzofuranacetamide monohydrochloride) cause...

journal_title：Neuroscience

authors： Pinnock RD

更新日期：1992-01-01 00:00:00

abstract：:During early embryonic development, the olfactory placode is the source of different cell types migrating toward the telencephalic vesicle. Among these cell types are the ensheathing cells, the luteinizing hormone-releasing hormone-producing cells and the olfactory marker protein-immunoreactive cells. We have identifi...

journal_title：Neuroscience

authors： De Carlos JA,López-Mascaraque L,Valverde F

更新日期：1995-10-01 00:00:00

abstract：:A significant decline in executive system function mediated by the prefrontal cortex (PFC) often occurs with normal aging. In vitro slice studies have shown that layer 2/3 pyramidal cells in the monkey PFC exhibit increased action potential (AP) firing rates which may, in part, contribute to this decline. Given that l...

journal_title：Neuroscience

authors： Luebke JI,Chang YM

更新日期：2007-12-12 00:00:00

abstract：:Regular physical exercise has been described as a good strategy for prevention or reduction of musculoskeletal pain. The Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) has been investigated as a promising target for the control of inflammatory pain. Therefore, the aim of this study was to evaluate whether ac...

journal_title：Neuroscience

authors： de Azambuja G,Botasso Gomes B,Messias LHD,Aquino BM,Jorge CO,Manchado-Gobatto FB,Oliveira-Fusaro MCG

更新日期：2020-02-10 00:00:00

abstract：:Local cerebral glucose utilization was assessed during whisker stimulation by 2-deoxyglucose autoradiography. Whisker stimulation increased local cerebral glucose utilization in brainstem, thalamus and whisker sensory cortex in normal rats. Whereas whisker stimulation increased glucose metabolism in brainstem, whisker...

journal_title：Neuroscience

authors： Ciricillo SP,Hill MP,Gonzalez MF,Smalley S,Morton MT,Sharp FR

更新日期：1994-04-01 00:00:00

abstract：:Response inhibition is a central aspect of cognitive control. Usually, response inhibition is examined using information from a single sensory modality. Yet, evidence suggests that conflicts between information from different modalities affect response inhibition. It is, however, crucial to consider that there are mod...

journal_title：Neuroscience

authors： Friedrich J,Beste C

更新日期：2019-07-01 00:00:00

abstract：:Several genetic mutations affecting the development and function of mammalian hair cells have been shown to cause deafness but not vestibular defects, most likely because vestibular deficits are sometimes centrally compensated. The study of hair cell physiology is thus a powerful direct approach to ascertain the funct...

journal_title：Neuroscience

authors： Tavazzani E,Spaiardi P,Zampini V,Contini D,Manca M,Russo G,Prigioni I,Marcotti W,Masetto S

更新日期：2016-07-22 00:00:00

abstract：:The mutant mice tottering, leaner and the compound heterozygous tottering/leaner exhibit varying degrees of several abnormal neurological phenotypes including petit mal-like epilepsy, ataxia and an intermittent myoclonus-like movement disorder. Aberrant expression of tyrosine hydroxylase in cerebellar Purkinje cells o...

journal_title：Neuroscience

authors： Abbott LC,Isaacs KR,Heckroth JA

更新日期：1996-03-01 00:00:00

abstract：:Neurotoxicity of (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist for metabotropic glutamate receptors negatively coupled to adenylyl cyclase, was investigated in vivo by the intraventricular administration in the rat, compared with that of (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-C...

journal_title：Neuroscience

authors： Kwak S,Miyamoto M,Ishida M,Shinozaki H

更新日期：1996-08-01 00:00:00

abstract：:It was investigated whether grafts of the suprachiasmatic nucleus could re-instate circadian rhythmicity in the absence of its endogenous vasopressin production and whether the restored rhythm would have the long period length of the donor. Grafts of 17-days-old vasopressin-deficient homozygous Brattleboro rat fetuses...

journal_title：Neuroscience

authors： Boer GJ,van Esseveldt KE,van der Geest BA,Duindam H,Rietveld WJ

更新日期：1999-03-01 00:00:00

abstract：:The cellular origin and degree of collateralization of the subcortical afferents to the caudate nucleus and the putamen in squirrel monkeys (Saimiri sciureus) were studied using the following combinations of fluorescent retrograde tracers: Evans blue and DAPI-Primuline, Fast blue and Nuclear yellow, True blue and Nucl...

journal_title：Neuroscience

authors： Parent A,Mackey A,De Bellefeuille L

更新日期：1983-12-01 00:00:00

abstract：:In this study, we performed in situ hybridization analysis of the expression pattern of two growth-associated proteins, stathmin and SCG10, in the hippocampus after unilateral lesion of the perforant pathway, the main excitatory input from the entorhinal cortex to the hippocampus. Stathmin is one of the major neural-e...

journal_title：Neuroscience

authors： Bräuer AU,Savaskan NE,Plaschke M,Ninnemann O,Nitsch R

更新日期：2001-01-01 00:00:00

abstract：:Endomorphin 2 (EM2) plays essential roles in regulating nociceptive transmission within the spinal dorsal horn, where EM2-immunopositive (EM2-IP) fibers and terminals are densely encountered. However, the origins of these EM2-IP structures are still obscure. Unilateral primary sensory afferents disruption (lumbar 3-6 ...

journal_title：Neuroscience

authors： Hui R,Wang W,Chen T,Lü BC,Li H,Zhang T,Wu SX,Li YQ

更新日期：2010-08-11 00:00:00

abstract：:Rett syndrome (RTT), a disorder caused almost exclusively by mutations in the X-linked gene, MECP2, has a phenotype thought to be primarily of neurological origin. Disruption of Mecp2 in mice results in a prominent RTT-like phenotype. One of the consequences of MeCP2 absence in the brain is altered functional and stru...

journal_title：Neuroscience

authors： Weng SM,McLeod F,Bailey ME,Cobb SR

更新日期：2011-04-28 00:00:00

abstract：:In rodents, chronic intermittent ethanol vapor exposure (CIE) produces alcohol dependence, alters the structure and activity of pyramidal neurons and decreases the number of oligodendroglial progenitors in the medial prefrontal cortex (mPFC). In this study, adult Wistar rats were exposed to seven weeks of CIE and were...

journal_title：Neuroscience

authors： Navarro AI,Mandyam CD

更新日期：2015-05-07 00:00:00

abstract：:Prolonged stress triggers neuroinflammation, which plays a significant role in the development of depression; however, stressed people do not always suffer from depression because of individual differences in stress vulnerability. Negative cognitive bias (NCB) toward pessimistic judgment often underlies depressive epi...

journal_title：Neuroscience

authors： Ito N,Sasaki K,Takemoto H,Kobayashi Y,Isoda H,Odaguchi H

更新日期：2020-09-01 00:00:00