Increased vulnerability of septal cholinergic neurons to partial loss of target neurons in aged rats.

abstract：:Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the...

journal_title：Neuroscience

authors： Zibman S,Shpak G,Wagner S

更新日期：2011-08-25 00:00:00

abstract：:The cellular localization of preprosomatostatin mRNA in the rat brain and sensory ganglia has been examined in detail using a newly developed highly sensitive non-radioactive in situ hybridization histochemistry procedure. An alkaline phosphatase labelled anti-sense 30mer oligodeoxynucleotide probe was used for detect...

journal_title：Neuroscience

authors： Kiyama H,Emson PC

更新日期：1990-01-01 00:00:00

abstract：:Despite extensive investigations into the mechanisms of aerobic respiration in mitochondria, the spontaneous metabolic activity of individual cells within a whole animal has not been observed in real time. Consequently, little is known about whether and how the level of mitochondrial energy metabolism is regulated in ...

journal_title：Neuroscience

authors： Kazama H,Ichikawa A,Kohsaka H,Morimoto-Tanifuji T,Nose A

更新日期：2008-03-03 00:00:00

abstract：:In unanesthetized cats it has been found that pyramidal volleys elicited upon medullary pyramidal tract stimulation were capable of modifying the discharge of 41% of intracerebellar nuclear cells, via pontocerebellar systems impinging predominantly on the lateral cerebellar cortex. The incidence of responsive cells wa...

journal_title：Neuroscience

authors： Giuffrida R,Licata F,Li Volsi G,Perciavalle V,Urbano A

更新日期：1983-06-01 00:00:00

abstract：:The clinical course of the degenerative motor neuron disorder amyotrophic lateral sclerosis (ALS) is closely related to hypoxia. The normal response to hypoxia involves two pathways in particular: the hypoxia inducible factor 1α (HIF-1α) pathway (which notably controls the synthesis of vascular endothelial growth fact...

journal_title：Neuroscience

authors： Moreau C,Gosset P,Kluza J,Brunaud-Danel V,Lassalle P,Marchetti P,Defebvre L,Destée A,Devos D

更新日期：2011-01-13 00:00:00

abstract：:This article argues how dopamine controls working memory and how the dysregulation of the dopaminergic system is related to schizophrenia. In the dorsolateral prefrontal cortex, which is the principal part of the working memory system, recurrent excitation is subtly balanced with intracortical inhibition. A potent con...

journal_title：Neuroscience

authors： Tanaka S

更新日期：2006-04-28 00:00:00

abstract：:The primary aim of this study was to investigate the effect of different training types and secondary to test gender differences on the training-related cortical plasticity induced by three different tongue-training paradigms: (1) therapeutic tongue exercises (TTE), (2) playing computer games with the tongue using the...

journal_title：Neuroscience

authors： Kothari M,Svensson P,Jensen J,Kjærsgaard A,Jeonghee K,Nielsen JF,Ghovanloo M,Baad-Hansen L

更新日期：2013-08-29 00:00:00

abstract：:The effect of intracranial microdialysis on brain glucose metabolism in control and kainic acid-treated rats was assessed by semi-quantitative [14C]2-deoxyglucose autoradiography. A dialysis fiber loop was implanted into the piriform cortex or a horizontal Vita fiber into the hippocampus, and 24 h later, fibers were p...

journal_title：Neuroscience

authors： Chastain JE Jr,Samson F,Nelson SR,Pazdernik TL

更新日期：1990-01-01 00:00:00

abstract：:It has recently been demonstrated that alpha-bungarotoxin receptors, which behave as functional nicotinic receptors, are present in chick CNS. In this paper, we report the purification and characterization of a functional alpha-bungarotoxin receptor from chick cerebellum, a nervous tissue in which a clear inhibition o...

journal_title：Neuroscience

authors： Gotti C,Hanke W,Schlue WR,Briscini L,Moretti M,Clementi F

更新日期：1992-09-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is an established technique that can modulate excitability of the motor cortex and corticospinal tract, beyond the duration of the stimulation itself. More recently, a newer repetitive technique, known as I-wave periodicity TMS (iTMS) has been purported to show incre...

journal_title：Neuroscience

authors： Kidgell DJ,Mason J,Frazer A,Pearce AJ

更新日期：2016-05-13 00:00:00

abstract：:Many of the different morphological types of interneurons in mammalian neocortex are presumed to be inhibitory, but to date, conclusive functional data have been lacking. Using paired intracellular recordings in slices of adult rat somatosensory cortex, we present a sparsely spiny, burst firing interneuron that elicit...

journal_title：Neuroscience

authors： Deuchars J,Thomson AM

更新日期：1995-04-01 00:00:00

abstract：:Laminar organization is a fundamental cytoarchitecture in mammalian CNS and a striking feature of the neocortex. ER81, a transcription factor, has recently been utilized as a marker of cells in the layer 5 of the neocortex. We further pursued the distribution of ER81 to investigate the identity of the ER81-expressing ...

journal_title：Neuroscience

authors： Yoneshima H,Yamasaki S,Voelker CC,Molnár Z,Christophe E,Audinat E,Takemoto M,Nishiwaki M,Tsuji S,Fujita I,Yamamoto N

更新日期：2006-01-01 00:00:00

abstract：:The effect of the intrathecal administration of the catecholaminergic neurotoxin 6-hydroxydopamine, or of hemisection of the spinal cord at the Cl level, on the density of alpha 2-adrenoceptors and on the norepinephrine, dopamine, and serotonin content in the cat lumbar spinal enlargement was determined 2, 7 or 21 day...

journal_title：Neuroscience

authors： Howe JR,Yaksh TL,Tyce GM

更新日期：1987-05-01 00:00:00

abstract：:Interactions between the hippocampus and the prefrontal cortex (PFC) are of major interest in the neurobiology of psychiatric and neurodegenerative disorders and are central to many experimental rodent models. Non-invasive imaging techniques offer a translatable approach to probing this system if homologous features c...

journal_title：Neuroscience

authors： Schwarz AJ,Gass N,Sartorius A,Zheng L,Spedding M,Schenker E,Risterucci C,Meyer-Lindenberg A,Weber-Fahr W

更新日期：2013-01-03 00:00:00

abstract：:Blocking activity with intraocular tetrodotoxin prevents the sharpening of the retinotectal map formed during regeneration of the optic nerve. If (under normal conditions) the initially diffuse map sharpens because of correlated activity in neighboring but not distant ganglion cells, then sharpening should also be pre...

journal_title：Neuroscience

authors： Schmidt JT,Eisele LE

更新日期：1985-02-01 00:00:00

abstract：:We have examined the relationship between brain-derived neurotrophic factor gene expression in the hippocampus and memory retention as well as long-term potentiation of rats. One-way inhibitory avoidance learning was adopted as the behavioural paradigm. Results revealed that brain-derived neurotrophic factor messenger...

journal_title：Neuroscience

authors： Ma YL,Wang HL,Wu HC,Wei CL,Lee EH

更新日期：1998-02-01 00:00:00

abstract：:Inflammatory damage following ICH is often attributed to microglia/macrophage activation. In many diseases, IL-4 has been proven to switch microglia/macrophages from the pro-inflammatory to the anti-inflammatory subtype. However, the role and underlying mechanism of IL-4 in ICH, especially in neuroprotection, remain u...

journal_title：Neuroscience

authors： He Y,Gao Y,Zhang Q,Zhou G,Cao F,Yao S

更新日期：2020-06-15 00:00:00

abstract：:Estrogen is likely involved in the gender specific differences in coping with stress. Activation of catecholamine (CA) biosynthetic enzyme gene expression in central and peripheral CA systems plays a key role in response to stress and in regulation of the cardiovascular system. Here we examined whether estradiol can m...

journal_title：Neuroscience

authors： Serova LI,Maharjan S,Sabban EL

更新日期：2005-01-01 00:00:00

abstract：:Rat cerebellar granule cells, when subjected to a glucose-free environment for 4 h, developed extensive degeneration of neuronal cell bodies and their associated neurite network over the following 24 h. This neuronal damage was quantitated with a colorimetric assay using the metabolic dye 3-(4,5-dimethylthiazol-2-yl)-...

journal_title：Neuroscience

authors： Facci L,Leon A,Skaper SD

更新日期：1990-01-01 00:00:00

abstract：:Calcineurin (PP2B) is a Ca(2+)-dependent protein phosphatase enriched in the brain that takes part in intracellular signaling pathways regulating synaptic plasticity and neuronal functions. Calcineurin-dependent pathways are important for complex brain functions such as learning and memory. More recently, they have be...

journal_title：Neuroscience

authors： Crozatier C,Farley S,Mansuy IM,Dumas S,Giros B,Tzavara ET

更新日期：2007-02-23 00:00:00

abstract：:Besides formation of neurofibrillary tangles and neuron loss, the Alzheimer's disease brain is characterized by neuritic plaques consisting of beta-amyloid peptide deposits and impaired neurotransmission. The proteins Munc18a, Munc18-interacting protein 1 and Munc18-interacting protein 2 mediate exocytosis and decreas...

journal_title：Neuroscience

authors： Jacobs EH,Williams RJ,Francis PT

更新日期：2006-01-01 00:00:00

abstract：:Anatomical and electrophysiological evidence has contributed to the hypothesis that microzones in the mammalian flocculus are organized to reflect control of eye movements in the planes of semicircular canals. Adult male Long-Evans rats received iontophoretic injections of FluoroGold and/or tetramethylrhodamine dextra...

journal_title：Neuroscience

authors： Balaban CD,Schuerger RJ,Porter JD

更新日期：2000-01-01 00:00:00

abstract：:Pain is processed in a large neural network that partially overlaps structures involved in emotion processing. Despite the fact that pain and emotion are known to share neural regions and interact in numerous clinical conditions, relatively little is known about the interaction of pain and emotion at the neural level....

journal_title：Neuroscience

authors： Orenius TI,Raij TT,Nuortimo A,Näätänen P,Lipsanen J,Karlsson H

更新日期：2017-05-04 00:00:00

abstract：:Intracerebroventricular (i.c.v.) injection of kynurenic acid (KYNA) had sedative and hypnotic effects during stress in neonatal chicks. However, its mechanism has not been clarified. KYNA is an endogenous antagonist of the α7 nicotinic acetylcholine (α7nACh) receptor and N-methyl-d-aspartate (NMDA) receptor. Therefore...

journal_title：Neuroscience

authors： Yoshida J,Shigemura A,Ogino Y,Denbow DM,Furuse M

更新日期：2013-09-17 00:00:00

abstract：:Inward rectifier potassium currents and calcium-dependent potassium currents have been studied in cultured embryonic mouse motoneurons. Sustained unitary inward rectifier potassium currents were recorded from cell-attached patches and the channel conductance was dependent on external K+ concentration with a value of 2...

journal_title：Neuroscience

authors： McLarnon JG,Kim SU,Michikawa M,Xu R

更新日期：1995-01-01 00:00:00

abstract：:There is increasing evidence that alterations in the focus of attention result in changes in neural responding at the most peripheral levels of the auditory system. To date, however, those studies have not ruled out differences in task demands or overall arousal in explaining differences in responding across intermoda...

journal_title：Neuroscience

authors： Srinivasan S,Keil A,Stratis K,Woodruff Carr KL,Smith DW

更新日期：2012-10-25 00:00:00

abstract：:Normal adult cerebellar Purkinje cells in the rat rarely express low-affinity nerve growth factor receptor immunoreactivity. However, intense anti-low-affinity nerve growth factor receptor immunostaining was observed as early as one day after a lesion of the cerebellar cortex. Low-affinity nerve growth factor receptor...

journal_title：Neuroscience

authors： Martínez-Murillo R,Caro L,Nieto-Sampedro M

更新日期：1993-02-01 00:00:00

abstract：:Neurosteroids are synthesized de novo in the brain and the cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated that the rat Purkinje cell actively produces progesterone de novo from cholesterol only during neonatal life and progesterone promotes dendritic growth, spinogenesis and ...

journal_title：Neuroscience

authors： Sakamoto H,Ukena K,Takemori H,Okamoto M,Kawata M,Tsutsui K

更新日期：2004-01-01 00:00:00

abstract：:Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by the presence of extracellular plaques composed of amyloid β (Aβ) peptides and intracellular tau aggregates. The plaques are surrounded by microglia, the brain's resident immune cells, which likely participate in the clearanc...

journal_title：Neuroscience

authors： Gyoneva S,Swanger SA,Zhang J,Weinshenker D,Traynelis SF

更新日期：2016-08-25 00:00:00

abstract：:The effects of steroid hormones on glutamate neurotoxicity were examined in cultured spinal cord neurons. The extent of neuronal damage, produced by glutamate exposure for 15 min, was estimated based on the activity of lactate dehydrogenase released from degenerated neurons to the media during 24 h of post-exposure in...

journal_title：Neuroscience

authors： Ogata T,Nakamura Y,Tsuji K,Shibata T,Kataoka K

更新日期：1993-07-01 00:00:00