Abstract：
:Glutathione S-transferase (GST)-pi is a cytosolic isoenzyme used as a marker for mature oligodendrocytes in the mammalian brain. However, the cellular properties of GST-pi-immunoreactive [GST-pi (+)] cells in adult brain are not completely understood. We immunohistochemically demonstrated the existence of two subtypes of GST-pi (+) cells in the cerebral cortex of adult rats: one subtype exhibited GST-pi in the cytoplasm (C-type cells), while the other did mainly in the nucleus (N-type cells). The GST-pi (+) C-type cells were also immunopositive for 2',3'-cyclic nucleotide 3'-phosphodiesterase and RIP, indicating that they were mature oligodendrocytes, while the GST-pi (+) N-type cells expressed NG2, indicating that they were oligodendrocyte progenitor cells. Furthermore, observation of the fate of newly-generated cells by 5-bromodeoxyuridine-labeling revealed that the GST-pi (+) N-type cells differentiated into C-type cells. These findings indicate translocation of GST-pi from the nucleus to the cytoplasm during oligodendrocyte maturation.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Tamura Y,Kataoka Y,Cui Y,Takamori Y,Watanabe Y,Yamada Hdoi
10.1016/j.neuroscience.2007.06.026subject
Has Abstractpub_date
2007-08-24 00:00:00pages
535-40issue
2eissn
0306-4522issn
1873-7544pii
S0306-4522(07)00779-8journal_volume
148pub_type
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