A Scj1p homolog and folding catalysts present in dog pancreas microsomes.

abstract：:The albumin gene family arose in a series of duplication events which gave rise to symmetry in its structure. The four genes are tandemly linked on human chromosome 4q in the order: 5'ALB-5'AFP-5'ALF-5'DBP-centromere, and their introns display a symmetrical and repetitive pattern that is shared by members of the gene ...

journal_title：Biological chemistry

authors： Nishio H,Hamdi HK,Dugaiczyk A

更新日期：1999-12-01 00:00:00

abstract：:Glycoconjugates have a whole spectrum of biological roles, from those that appear trivial to those that are crucial. Results accumulated in the past years indicate they might also play an important role in the response to stress, a complex physiological response of the human organism to various threats. We have recent...

journal_title：Biological chemistry

authors： Lauc G,Peter-Katalinić J,Dabelić S,Flögel M

更新日期：1999-04-01 00:00:00

abstract：:Latent episomal genomes of Epstein-Barr virus, a human gammaherpesvirus, represent a suitable model system for studying replication and methylation of chromosomal DNA in mammals. We analyzed the methylation patterns of CpG dinucleotides in the latent origin of DNA replication of Epstein-Barr virus using automated fluo...

journal_title：Biological chemistry

authors： Salamon D,Takacs M,Myöhänen S,Marcsek Z,Berencsi G,Minarovits J

更新日期：2000-02-01 00:00:00

abstract：:Hsp70 chaperone systems play an essential role in the life cycle of many proteins not only in an hostile environment but also under normal growth conditions. In the course of evolution the diversification of functions was accompanied by an amplification of components of the Hsp70 system. Here strategies are reviewed h...

journal_title：Biological chemistry

authors： Mayer MP,Bukau B

更新日期：1998-03-01 00:00:00

abstract：:Recent evidence suggests that epidermal growth factor receptor (EGFR)-dependent signaling contributes to liver cell proliferation, as well as to apoptotic liver cell death, and represents an important regulator of hepatic regeneration. This article summarizes recent findings on the molecular mechanisms involved in EGF...

journal_title：Biological chemistry

authors： Reinehr R,Häussinger D

更新日期：2009-10-01 00:00:00

abstract：:Meprins are zinc-endopeptidases of the astacin family, which are expressed as membrane-bound or secreted forms in renal and intestinal brush-border membranes of mouse, rat and man. There are two types of meprin subunits, alpha and beta, which form disulfide-bonded homo- and heterodimers; further oligomerization is med...

journal_title：Biological chemistry

authors： Becker C,Kruse MN,Slotty KA,Köhler D,Harris JR,Rösmann S,Sterchi EE,Stöcker W

更新日期：2003-05-01 00:00:00

abstract：:The transcription of the fatty acid synthase (FAS) gene is regulated by the sterol status of the cell via cleavage of the sterol regulatory element-binding protein (SREBP). When human HepG2 hepatoma cells were cotransfected with an expression plasmid for mature SREBP-1a together with FAS promoter/reporter constructs s...

journal_title：Biological chemistry

authors： Wolf SS,Roder K,Sickinger S,Schweizer M

更新日期：2001-07-01 00:00:00

abstract：:Human pro-matrix metalloproteinase 3 (proMMP-3) lacking the N-terminal 34 amino acids and the C-terminal hemopexin-like domain was expressed in E. coli and used to investigate the process of proenzyme activation and its interaction with an endogenous inhibitor TIMP-1 during activation. The truncated precursor was puri...

journal_title：Biological chemistry

authors： Suzuki K,Kan CC,Hung W,Gehring MR,Brew K,Nagase H

更新日期：1998-02-01 00:00:00

abstract：:DEAD-box proteins disrupt or remodel RNA and protein/RNA complexes at the expense of ATP. The catalytic core is composed of two flexibly connected RecA-like domains. The N-terminal domain contains most of the motifs involved in nucleotide binding and serves as a minimalistic model for helicase/nucleotide interactions....

journal_title：Biological chemistry

authors： Strohmeier J,Hertel I,Diederichsen U,Rudolph MG,Klostermeier D

更新日期：2011-04-01 00:00:00

abstract：:The conversion of the cellular isoform of the prion protein (PrP(C)) into the pathologic isoform (PrP(Sc)) is the key event in prion diseases. To study the conversion process, an in vitro system based on varying the concentration of low amounts of sodium dodecyl sulfate (SDS) has been employed. In the present study, t...

journal_title：Biological chemistry

authors： Stöhr J,Elfrink K,Weinmann N,Wille H,Willbold D,Birkmann E,Riesner D

更新日期：2011-05-01 00:00:00

abstract：:Cancer cells are relatively resistant to endoplasmic reticulum (ER) stress-induced apoptosis. However, the underlying mechanisms remain largely unclear. We observed that the microRNAs miR-221/222 are associated with apoptosis regulation under ER stress in human hepatocellular carcinoma (HCC) cells. Induction of ER str...

journal_title：Biological chemistry

authors： Dai R,Li J,Liu Y,Yan D,Chen S,Duan C,Liu X,He T,Li H

更新日期：2010-07-01 00:00:00

abstract：:The glutamyl endopeptidase family of enzymes from staphylococci has been shown to be important virulence determinants of pathogenic family members, such as Staphylococcus aureus. Previous studies have identified the N-terminus and residues from positions 185-195 as potentially important regions that determine the acti...

journal_title：Biological chemistry

authors： Ono T,Ohara-Nemoto Y,Shimoyama Y,Okawara H,Kobayakawa T,Baba TT,Kimura S,Nemoto TK

更新日期：2010-10-01 00:00:00

abstract：:The physiological roles of the intracellular iron and redox regulatory systems are intimately linked. Iron is an essential trace element for most organisms, yet elevated cellular iron levels are a potent generator and amplifier of reactive oxygen species and redox stress. Proteins binding iron or iron-sulfur (Fe/S) cl...

journal_title：Biological chemistry

authors： Mühlenhoff U,Braymer JJ,Christ S,Rietzschel N,Uzarska MA,Weiler BD,Lill R

更新日期：2020-11-26 00:00:00

abstract：:In this review, we discuss how time-resolved Fourier transform infrared (FTIR) spectroscopy is used to understand how GTP hydrolysis is catalyzed by small GTPases and their cognate GTPase-activating proteins (GAPs). By interaction with small GTPases, GAPs regulate important signal transduction pathways and transport m...

journal_title：Biological chemistry

authors： Kötting C,Gerwert K

更新日期：2015-02-01 00:00:00

abstract：:Coxsackievirus B3 (CVB-3) is a plus-strand RNA virus that is believed to be the most common causal agent of viral myocarditis. Since no specific treatment for CVB-3 infections is available to date, we and others have recently started to develop RNA interference (RNAi) approaches to prevent virus propagation. Here we d...

journal_title：Biological chemistry

authors： Werk D,Schubert S,Lindig V,Grunert HP,Zeichhardt H,Erdmann VA,Kurreck J

更新日期：2005-09-01 00:00:00

abstract：:We developed a novel method for the simultaneous extraction and analysis of total tissue RNA and DNA to quantify the RNA and DNA oxidation products 8-oxo-7,8-dihydroguanosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine using HPLC coupled to electrochemical detection (HPLC-ECD). The protein denaturing agents guanidine thio...

journal_title：Biological chemistry

authors： Hofer T,Seo AY,Prudencio M,Leeuwenburgh C

更新日期：2006-01-01 00:00:00

abstract：:Bacterial infections often upregulate the plasma kinin-forming cascade of the host (the 'contact system') which is triggered by adsorption of high molecular mass kininogen (HK), coagulation factor XII (FXII) and prekallikrein (pHPK) on the host or pathogen cell surfaces. A possible activation of the contact system upo...

journal_title：Biological chemistry

authors： Karkowska-Kuleta J,Kozik A,Rapala-Kozik M

更新日期：2010-01-01 00:00:00

abstract：:[NiFe] hydrogenases catalyze reversible hydrogen production/consumption. The active site of [NiFe] hydrogenases contains a complex NiFe(CN)2CO center, and the biosynthesis/maturation of these enzymes is a complex and dynamic process, primarily involving six Hyp proteins (HypABCDEF). HypA and HypB are involved in the N...

journal_title：Biological chemistry

authors： Watanabe S,Sasaki D,Tominaga T,Miki K

更新日期：2012-09-08 00:00:00

abstract：:The evolution of a highly developed nervous system is mirrored by the ability of individual neurons to develop increased morphological complexity. As microtubules (MTs) are crucially involved in neuronal development, we tested the hypothesis that the evolution of complexity is driven by an increasing capacity of the M...

journal_title：Biological chemistry

authors： Trushina NI,Mulkidjanian AY,Brandt R

更新日期：2019-08-27 00:00:00

abstract：:Abstract Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed ...

journal_title：Biological chemistry

authors： Petrovic S,Leskovac A,Kotur-Stevuljevic J,Joksic J,Guc-Scekic M,Vujic D,Joksic G

更新日期：2011-07-01 00:00:00

abstract：:Small-angle scattering (SAS) of X-rays and neutrons reveals low-resolution structures of biological macromolecules in solution. With the recent experimental and methodological advances, SAS became a unique tool for characterising biological systems. The method covers an extremely broad range of molecule sizes (from a ...

journal_title：Biological chemistry

authors： Svergun DI

更新日期：2010-07-01 00:00:00

abstract：:Rhomboids are ubiquitous intramembrane serine proteases that cleave transmembrane substrates. Their functions include growth factor signaling, mitochondrial homeostasis, and parasite invasion. A recent study revealed that the Escherichia coli rhomboid protease EcGlpG is essential for its extraintestinal pathogenic col...

journal_title：Biological chemistry

authors： Arutyunova E,Jiang Z,Yang J,Kulepa AN,Young HS,Verhelst S,O'Donoghue AJ,Lemieux MJ

更新日期：2018-11-27 00:00:00

abstract：:Seven purified proteins may be combined to reconstitute regulated, promoter-dependent RNA polymerase II transcription: five general transcription factors, Mediator, and RNA polymerase II. The entire system has been conserved across species from yeast to humans. The structure of RNA polymerase II, consisting of 10 poly...

journal_title：Biological chemistry

authors： Kornberg RD

更新日期：2001-08-01 00:00:00

abstract：:Selective adhesion of fungal cells to one another and to foreign surfaces is fundamental for the development of multicellular growth forms and the successful colonization of substrates and host organisms. Accordingly, fungi possess diverse cell wall-associated adhesins, mostly large glycoproteins, which present N-term...

journal_title：Biological chemistry

authors： Essen LO,Vogt MS,Mösch HU

更新日期：2020-11-26 00:00:00

abstract：:We have investigated the methylation status of the repeat unit of the human ribosomal RNA genes in lung cancer. Using a Southern blot analysis approach we have determined that the non-transcribed region of these genes was generally heavily methylated, while the transcribed region was not methylated in either tumor or ...

journal_title：Biological chemistry

authors： Shiraishi M,Sekiguchi A,Chuu YH,Sekiya T

更新日期：1999-01-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a 185 amino acid residue helical cytokine with various biological activities (e. g. B cell development, acute phase reaction). We have investigated the role of the 168-185 C-terminal region of IL-6 in the induction of fibrinogen synthesis and expression of junB mRNA using synthetic peptides cor...

journal_title：Biological chemistry

authors： Igaz P,Bösze S,Tóth S,Falus A,Hudecz F

更新日期：2001-04-01 00:00:00

abstract：:The major enzymatic activity of the ribosome is the catalysis of peptide bond formation. The active site -- the peptidyl transferase center -- is composed of ribosomal RNA (rRNA), and interactions between rRNA and the reactants, peptidyl-tRNA and aminoacyl-tRNA, are crucial for the reaction to proceed rapidly and effi...

journal_title：Biological chemistry

authors： Beringer M,Rodnina MV

更新日期：2007-07-01 00:00:00

abstract：:A controlled interaction of materials with their surrounding biological environment is of great interest in many fields. Multifunctional coatings aim to provide simultaneous modulation of several biological signals. They can consist of various combinations of bioactive, and bioinert components as well as of reporter m...

journal_title：Biological chemistry

authors： Pagel M,Beck-Sickinger AG

更新日期：2017-01-01 00:00:00

abstract：:The stress-activated protein kinase p38/SAPK2 is known to regulate the activity of transcription factors and to control expression of several genes at the transcriptional or post-transcriptional level. In order to identify genes whose expression is under the control of p38/SAPK2 activity, we have compared the mRNA lev...

journal_title：Biological chemistry

authors： Rolli-Derkinderen M,Gaestel M

更新日期：2000-03-01 00:00:00

abstract：:Most excitatory synaptic transmissions in the central nervous system are mediated by the neurotransmitter glutamate. Binding of glutamate released from the presynaptic membrane causes glutamate receptors in the postsynaptic membrane to open, which results in a transient depolarization of the postsynaptic membrane. The...

journal_title：Biological chemistry

authors： Nakagawa T,Cheng Y,Sheng M,Walz T

更新日期：2006-02-01 00:00:00