Genetic organization of the Escherichia coli K10 capsule gene cluster: identification and characterization of two conserved regions in group III capsule gene clusters encoding polysaccharide transport functions.

Abstract:

:Analysis of the Escherichia coli K10 capsule gene cluster identified two regions, regions 1 and 3, conserved between different group III capsule gene clusters. Region 1 encodes homologues of KpsD, KpsM, KpsT, and KpsE proteins, and region 3 encodes homologues of the KpsC and KpsS proteins. An rfaH mutation abolished K10 capsule production, suggesting that expression of the K10 capsule was regulated by RfaH in a manner analogous to group II capsule gene clusters. An IS3 element and a phiR73-like prophage, both of which may have played a role in the acquisition of group III capsule gene clusters, were detected flanking the K10 capsule genes.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Clarke BR,Pearce R,Roberts IS

doi

10.1128/JB.181.7.2279-2285.1999

keywords:

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

2279-85

issue

7

eissn

0021-9193

issn

1098-5530

journal_volume

181

pub_type

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