Prognosis of primary hepatic lymphoma: A US population-based analysis.

abstract：:Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most importan...

journal_title：Translational oncology

authors： Ribatti D,Nico B,Ruggieri S,Tamma R,Simone G,Mangia A

更新日期：2016-10-01 00:00:00

abstract：:DNA damage has been associated with prostate cancer risk. Men who were referred for initial prostate biopsy for elevated prostate-specific antigen or abnormal digital rectal examination are often found with no cancer but have a higher risk of developing prostate cancer than the general population of men in their lifet...

journal_title：Translational oncology

authors： Wu JD,Lin DW,Page ST,Lundgren AD,True LD,Plymate SR

更新日期：2009-03-01 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) provide clinical benefits to the lung cancer patients with epidermal growth factor receptor (EGFR) mutations. However, non-invasively determine EGFR mutation status in patients before targeted therapy remains a challenge. This study aimed to develop and validate a nomogram for preoper...

journal_title：Translational oncology

authors： Zhang G,Zhang J,Cao Y,Zhao Z,Li S,Deng L,Zhou J

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Angiogenesis plays an important role in pancreas cancer pathobiology. Pancreatic tumor cells secrete vascular endothelial growth factor (VEGF), activating endothelial cell protein kinase C beta (PKCbeta) that phosphorylates GSK3beta to suppress apoptosis and promote endothelial cell proliferation and microvesse...

journal_title：Translational oncology

authors： Spalding AC,Zeitlin BD,Wilder-Romans K,Davis ME,Nor JE,Lawrence TS,Ben-Josef E

更新日期：2008-12-01 00:00:00

abstract：:Oral mucositis (OM) is a serious side effect of cancer chemotherapy. The pathobiology of oral mucositis remains incompletely understood due to lack of appropriate models which recapitulate the human condition. Existing rodent models are intraperitoneal and require radiation, chemical or mechanical injury to the chemot...

journal_title：Translational oncology

authors： Bertolini M,Sobue T,Thompson A,Dongari-Bagtzoglou A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph ...

journal_title：Translational oncology

authors： Oltedal S,Kørner H,Aasprong OG,Hussain I,Tjensvoll K,Smaaland R,Søreide JA,Søreide K,Lothe RA,Heikkilä R,Gilje B,Nordgård O

更新日期：2018-04-01 00:00:00

abstract：:Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on pr...

journal_title：Translational oncology

authors： Lima AR,Bastos Mde L,Carvalho M,Guedes de Pinho P

更新日期：2016-08-01 00:00:00

abstract：:Phosphatidylserine (PS) is normally intracellular but becomes exposed on the luminal surface of vascular endothelial cells in tumors. It also becomes exposed on tumors cells responding to therapy. In the present study, we optically imaged exposed PS in vivo using PGN635, a novel monoclonal antibody that binds PS. The ...

journal_title：Translational oncology

authors： Zhao D,Stafford JH,Zhou H,Thorpe PE

更新日期：2011-12-01 00:00:00

abstract：:Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and mitochondrial DNA (mtDNA) damage, reflects how hypoxic conditions connect to cancer-induced systemi...

journal_title：Translational oncology

authors： Bousquet PA,Meltzer S,Sønstevold L,Esbensen Y,Dueland S,Flatmark K,Sitter B,Bathen TF,Seierstad T,Redalen KR,Eide L,Ree AH

更新日期：2019-01-01 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death in women worldwide. Incurable metastatic breast disease presents a major clinical challenge and is the main cause of breast cancer-related death. The epithelial-mesenchymal transition (EMT) is a critical early promoter of metastasis. In the present study, we id...

journal_title：Translational oncology

authors： Wen XF,Chen M,Wu Y,Chen MN,Glogowska A,Klonisch T,Zhang GJ

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD:Various bioinformatics tools were u...

journal_title：Translational oncology

authors： Ni H,Sun H,Zheng M,Bian T,Liu J,Li X,Zhang J,Liu Y

更新日期：2021-01-01 00:00:00

abstract：:Migration is a complex process that, besides its various physiological functions in embryogenesis and adult tissues, plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the involvement and collaboration of Akt, focal adhesion kinase (FAK), and Src kinases in migration and invasivene...

journal_title：Translational oncology

authors： Turecková J,Vojtechová M,Krausová M,Sloncová E,Korínek V

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis. METHODS:A retrospective, multicenter study on 80 surgical samples from mCRC patients treated in first line with bevaciz...

journal_title：Translational oncology

authors： Iorio J,Lastraioli E,Tofani L,Petroni G,Antonuzzo L,Messerini L,Perrone G,Caputo D,Francesconi M,Amato MM,Cadei M,Arcangeli G,Villanacci V,Boni L,Coppola R,Di Costanzo F,Arcangeli A

更新日期：2020-03-01 00:00:00

abstract：:The purpose of this study was to investigate the usefulness of photoacoustic imaging (PAI) for spatiotemporal mapping of tumor hemodynamics in a rabbit model of head and neck carcinoma. Shope cottontail rabbit papilloma virus associated VX2 carcinomas were established in adult male New Zealand White rabbits (n = 9) by...

journal_title：Translational oncology

authors： Rich LJ,Sexton S,Curtin L,Seshadri M

更新日期：2017-10-01 00:00:00

abstract：:Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch t...

journal_title：Translational oncology

authors： Castillo-Pichardo L,Humphries-Bickley T,De La Parra C,Forestier-Roman I,Martinez-Ferrer M,Hernandez E,Vlaar C,Ferrer-Acosta Y,Washington AV,Cubano LA,Rodriguez-Orengo J,Dharmawardhane S

更新日期：2014-10-24 00:00:00

abstract：:Checkpoint with FHA and RING finger domains (CHFR) was first recognized as an early mitotic checkpoint protein that delayed the cell cycle in response to microtubule-targeting drugs. It is an E3 ubiquitin ligase that ubiquitinates target proteins to direct them to the proteasome for degradation or to alter their activ...

journal_title：Translational oncology

authors： Privette LM,Petty EM

更新日期：2008-07-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are membrane receptors that play a vital role in various biological processes, in particular, cell survival, cell proliferation, and cell differentiation. These cellular processes are composed of multitiered signaling cascades of kinases starting from ligand binding to extracellular do...

journal_title：Translational oncology

authors： Chaiyawat P,Klangjorhor J,Settakorn J,Champattanachai V,Phanphaisarn A,Teeyakasem P,Svasti J,Pruksakorn D

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory res...

journal_title：Translational oncology

authors： Liu X,Sun X,Liu J,Kong P,Chen S,Zhan Y,Xu D

更新日期：2015-08-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most altered in cancer, leading to a range of cellular responses including enhanced proliferation, survival, and metabolism, and is thus an attractive target for anticancer drug development. Stimulation of the PI3K pathway can be initiated by alterat...

journal_title：Translational oncology

authors： Nguyen QD,Perumal M,Waldman TA,Aboagye EO

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:In gastric adenocarcinoma (GC), the major tumor suppressor genes (TSGs) such as p16, PTEN, Rb, E-cadherin, and p53, may play important roles in various regulatory pathways and in tumor suppression. This study evaluated the loss of heterozygosity (LOH) of microsatellite and protein expression of 5 TSGs and the r...

journal_title：Translational oncology

authors： Choi WH,Lee S,Cho S

更新日期：2018-02-01 00:00:00

abstract：:Intestinal commensal bacteria have recently been shown to trigger macrophages to produce diffusible clastogens (or chromosome-breaking factors) through a bystander effect (BSE) that mediates DNA damage and induces chromosomal instability in neighboring cells. Colon macrophages appear central to colon carcinogenesis an...

journal_title：Translational oncology

authors： Yang Y,Wang X,Huycke T,Moore DR,Lightfoot SA,Huycke MM

更新日期：2013-10-01 00:00:00

abstract：:In HNSCC, protein- and mRNA-expression of the antileukoproteinase SLPI are significantly inverse correlated with HPV-infection suggesting that elevated expression of SLPI protects against HPV-infections. Moreover, SLPI-expression is up-regulated in HNSCC-patients reporting a smoking habit. Here, we investigate the des...

journal_title：Translational oncology

authors： Quabius ES,Loehr J,Haaser D,Günther V,Maass N,Röcken C,Mathiak M,Alkatout I,Hoffmann M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

journal_title：Translational oncology

authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

更新日期：2020-12-01 00:00:00

abstract：:Clinical trials using anti-vascular endothelial growth factor /(VEGF) molecules induce a modest improvement in overall survival, measurable in weeks to just a few months, and tumors respond differently to these agents. In this review article, we have exposed some tumor characteristics and processes that may impair the...

journal_title：Translational oncology

authors： Ribatti D,Annese T,Ruggieri S,Tamma R,Crivellato E

更新日期：2019-07-01 00:00:00

abstract：:The presence of circulating tumor cells (CTCs) in the blood of cancer patients may guide the use of therapy. We investigated how to evaluate a reduction in the number of CTCs after administration of therapy. CTCs were enumerated with the CellSearch system in 111 metastatic breast and 185 metastatic prostate cancer pat...

journal_title：Translational oncology

authors： Coumans FA,Ligthart ST,Terstappen LW

更新日期：2012-12-01 00:00:00

abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

journal_title：Translational oncology

authors： Stearns ME,Wang M

更新日期：2011-06-01 00:00:00

abstract：:Multiple myeloma (MM) is a very heterogeneous disease, characterized by multiple cytogenetic aberrations on plasma cells (PC) that have been traditionally used to predict the outcome of the disease. A mayor issue on the analysis of PC is the sometimes low infiltration of these cells in the bone marrow that hampers cyt...

journal_title：Translational oncology

authors： Mansilla C,Soria E,Vallejo M,Valiente A,Perez-Juana A,Zabalza A,Hurtado G,Sala F,Ramírez N

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS:The association of AR mRNA expression with clinicopathological features was r...

journal_title：Translational oncology

authors： Sikic D,Wirtz RM,Wach S,Dyrskjøt L,Erben P,Bolenz C,Breyer J,Otto W,Hoadley KA,Lerner SP,Eckstein M,Hartmann A,Keck B

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:To investigate the predictive value of the pre-operative D-dimer and gamma-glutamyltranspeptidase (GGT) for the prognosis in colorectal liver metastases (CRLM) patients after hepatic resection. METHODS:Two hundred and ninety-two patients between December 2008 and December 2016 and 101 patients at our center...

journal_title：Translational oncology

authors： Chen Q,Zhao H,Wu J,Cai J,Li C,Zhao J,Bi X,Li Z,Huang Z,Zhang Y,Cui W,Zhou J

更新日期：2019-07-01 00:00:00

abstract：:The mechanism of action of arsenic trioxide (ATO) has been shown to be complex, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects. Among these mechanisms of action, ATO has been shown to cause acute vascular shutdown and massive tumor necrosis in a murine solid tumor m...

journal_title：Translational oncology

authors： Lee JC,Lee HY,Moon CH,Lee SJ,Lee WH,Cha HJ,Park S,Lee YH,Park HJ,Song HT,Min YJ

更新日期：2013-02-01 00:00:00