hERG1 and HIF-2α Behave as Biomarkers of Positive Response to Bevacizumab in Metastatic Colorectal Cancer Patients.

abstract：OBJECT:Thyroid cancer represents the most frequent malignancy of the endocrine system with an increasing incidence worldwide. Novel imaging techniques are able to further characterize tumors and even predict histopathology features. Texture analysis is an emergent imaging technique to extract extensive data from an rad...

journal_title：Translational oncology

authors： Meyer HJ,Schob S,Höhn AK,Surov A

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To evaluate whether contrast enhancement on cone-beam breast-CT (CBBCT) could aid in discrimination of breast cancer subtypes and receptor status. METHODS:This study included female patients age >40 years with malignant breast lesions identified on contrast-enhanced CBBCT. Contrast enhancement of malignant bre...

journal_title：Translational oncology

authors： Uhlig J,Fischer U,von Fintel E,Stahnke V,Perske C,Lotz J,Wienbeck S

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) ...

journal_title：Translational oncology

authors： Maretty-Kongstad K,Aggerholm-Pedersen N,Keller J,Safwat A

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...

journal_title：Translational oncology

authors： Cuneo KC,Chenevert TL,Ben-Josef E,Feng MU,Greenson JK,Hussain HK,Simeone DM,Schipper MJ,Anderson MA,Zalupski MM,Al-Hawary M,Galban CJ,Rehemtulla A,Feng FY,Lawrence TS,Ross BD

更新日期：2014-10-24 00:00:00

abstract：OBJECTIVE:This study investigated the feasibility of using malignant pleural effusion (MPE) supernatant and paired cell blocks (precipitate) for gene profiling in patients with non-small cell lung cancer (NSCLC) using next-generation sequencing (NGS) technique. METHODS:Stage IV non-squamous NSCLC patients with MPE wer...

journal_title：Translational oncology

authors： Li J,Li X,Wang W,Shao Y,Zhang Y,Song Z

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:This study presented a three-dimensional magnetic resonance (MR)-based method to separate a breast into four quadrants for quantitative measurements of the quadrant breast volume (BV) and density. METHODS:Breast MR images from 58 healthy women were studied. The breast and the fibroglandular tissue were segment...

journal_title：Translational oncology

authors： Fwu PT,Chen JH,Li Y,Chan S,Su MY

更新日期：2015-08-01 00:00:00

abstract：:We study the reproducibility of quantitative imaging features that are used to describe tumor shape, size, and texture from computed tomography (CT) scans of non-small cell lung cancer (NSCLC). CT images are dependent on various scanning factors. We focus on characterizing image features that are reproducible in the p...

journal_title：Translational oncology

authors： Balagurunathan Y,Gu Y,Wang H,Kumar V,Grove O,Hawkins S,Kim J,Goldgof DB,Hall LO,Gatenby RA,Gillies RJ

更新日期：2014-02-01 00:00:00

abstract：:Intestinal commensal bacteria have recently been shown to trigger macrophages to produce diffusible clastogens (or chromosome-breaking factors) through a bystander effect (BSE) that mediates DNA damage and induces chromosomal instability in neighboring cells. Colon macrophages appear central to colon carcinogenesis an...

journal_title：Translational oncology

authors： Yang Y,Wang X,Huycke T,Moore DR,Lightfoot SA,Huycke MM

更新日期：2013-10-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance. In this study, we analyze, for the first time, the complete genomic profile...

journal_title：Translational oncology

authors： Souza-Santos PT,Soares Lima SC,Nicolau-Neto P,Boroni M,Meireles Da Costa N,Brewer L,Menezes AN,Furtado C,Moreira MAM,Seuanez HN,de Almeida Simão T,Ribeiro Pinto LF

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:In gastric adenocarcinoma (GC), the major tumor suppressor genes (TSGs) such as p16, PTEN, Rb, E-cadherin, and p53, may play important roles in various regulatory pathways and in tumor suppression. This study evaluated the loss of heterozygosity (LOH) of microsatellite and protein expression of 5 TSGs and the r...

journal_title：Translational oncology

authors： Choi WH,Lee S,Cho S

更新日期：2018-02-01 00:00:00

abstract：:Tumor cells grow in nutrient- and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering their metabolic pathways. This adaptation process commonly results in a tumor phenotype that displays a high rate of aerobic glycolysis and aggressive tumor characteristics. The glucose regulat...

journal_title：Translational oncology

authors： Mendoza EE,Pocceschi MG,Kong X,Leeper DB,Caro J,Limesand KH,Burd R

更新日期：2012-06-01 00:00:00

abstract：AIM:The Bruton's tyrosine kinase (BTK) inhibitor Ibrutinib (PCI-32765) is effective in patients with multiple myeloma, non-Hodgkin lymphoma and chronic lymphoblastic leukemia. We previously showed that primary cells of children with TCF3-PBX1 positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) express BTK ...

journal_title：Translational oncology

authors： van de Ven C,Boeree A,Stalpers F,Zwaan CM,Den Boer ML

更新日期：2020-10-01 00:00:00

abstract：:Ovarian cancer remains the most frequently lethal of the gynecologic cancers owing to the late detection of this disease. Here, by using human specimens and three mouse models of ovarian cancer, we tested the feasibility of nonlinear imaging approaches, the multiphoton microscopy (MPM) and second harmonic generation (...

journal_title：Translational oncology

authors： Williams RM,Flesken-Nikitin A,Ellenson LH,Connolly DC,Hamilton TC,Nikitin AY,Zipfel WR

更新日期：2010-06-01 00:00:00

abstract：:Therapy-induced senescence (TIS), a cytostatic stress response in cancer cells, is induced inefficiently by current anticancer agents and radiation. The mechanisms that mediate TIS in cancer cells are not well defined. Herein, we characterize a robust senescence response both in vitro and in vivo to the quinone diaziq...

journal_title：Translational oncology

authors： Ewald JA,Jarrard DF

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) in an attempt to identify potential core genes in the pathogenesis of this tumor. METHODS:Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and fi...

journal_title：Translational oncology

authors： Zhu J,Ye J,Zhang L,Xia L,Hu H,Jiang H,Wan Z,Sheng F,Ma Y,Li W,Qian J,Luo C

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:The molecular mechanisms underlying aggressive versus indolent disease are not fully understood. Recent research has implicated a class of molecules known as long noncoding RNAs (lncRNAs) in tumorigenesis and progression of cancer. Our objective was to discover lncRNAs that differentiate aggressive and ind...

journal_title：Translational oncology

authors： Cesnik AJ,Yang B,Truong A,Etheridge T,Spiniello M,Steinbrink MI,Shortreed MR,Frey BL,Jarrard DF,Smith LM

更新日期：2018-06-01 00:00:00

abstract：:The presence of circulating tumor cells (CTCs) in the blood of cancer patients may guide the use of therapy. We investigated how to evaluate a reduction in the number of CTCs after administration of therapy. CTCs were enumerated with the CellSearch system in 111 metastatic breast and 185 metastatic prostate cancer pat...

journal_title：Translational oncology

authors： Coumans FA,Ligthart ST,Terstappen LW

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV) is one of the most prominent risk factors for hepatocellular carcinoma (HCC) development and virus-mediated cases represents more than 80% of HCC in East Asia, where it is endemic. Currently, the HBV status of pathological HCC is not fully clarified, especially by comparison to nontum...

journal_title：Translational oncology

authors： Liu J,Chen S,Zou Z,Tan D,Liu X,Wang X

更新日期：2019-09-01 00:00:00

abstract：:Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic cancer in bone. The objectives of this study were to compare DKK1 ...

journal_title：Translational oncology

authors： Clines KL,Clines GA

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) mutation status is crucial in treatment selection for non-small cell lung cancer (NSCLC) patients; however, the detection materials' availability remains challenging in clinical practice. In this study, we collected surgical resection tissues, lymph node biopsy, and cy...

journal_title：Translational oncology

authors： Han X,Zhang Z,Wu D,Shen Y,Wang S,Wang L,Liu Y,Yang S,Hu X,Feng Y,Sun Y,Shi Y

更新日期：2014-12-01 00:00:00

abstract：:Checkpoint with FHA and RING finger domains (CHFR) was first recognized as an early mitotic checkpoint protein that delayed the cell cycle in response to microtubule-targeting drugs. It is an E3 ubiquitin ligase that ubiquitinates target proteins to direct them to the proteasome for degradation or to alter their activ...

journal_title：Translational oncology

authors： Privette LM,Petty EM

更新日期：2008-07-01 00:00:00

abstract：:Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...

journal_title：Translational oncology

authors： Yang YF,Pan YH,Tian QH,Wu DC,Su SG

更新日期：2018-10-01 00:00:00

abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

journal_title：Translational oncology

authors： Stearns ME,Wang M

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of...

journal_title：Translational oncology

authors： Murrell DH,Zarghami N,Jensen MD,Chambers AF,Wong E,Foster PJ

更新日期：2016-06-01 00:00:00

abstract：:This study aimed to identify novel prognostic biomarker for advanced renal cell carcinoma (RCC) patients treated with anti-PD-1 therapy, using quantitative multi-immunofluorescence (IF) analysis of tumor immunity. Twenty-five consecutive patients who had metastatic or unresectable RCC treated with anti-PD-1 therapy we...

journal_title：Translational oncology

authors： Kato R,Jinnouchi N,Tuyukubo T,Ikarashi D,Matsuura T,Maekawa S,Kato Y,Kanehira M,Takata R,Ishida K,Obara W

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

journal_title：Translational oncology

authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

更新日期：2020-12-01 00:00:00

abstract：:Absent in melanoma 2 (AIM2) as an immune regulator for the regulation of tumor-associated macrophages (TAMs) function is unclear in tumor development. Here, the AIM2 function was investigated in TAMs-mediated malignant behaviors of renal carcinoma. The correlation analysis result showed that the AIM2 expression in TAM...

journal_title：Translational oncology

authors： Chai D,Zhang Z,Shi SY,Qiu D,Zhang C,Wang G,Fang L,Li H,Tian H,Li H,Zheng J

更新日期：2021-01-22 00:00:00

abstract：:Development of novel bioactive compounds against KRAS and/or BRAF mutant colorectal cancer (CRC) is currently an urgent need in oncology. In addition, single or multitarget kinase inhibitors against MEK/ERK and PI3K/AKT pathways are of potential therapeutic advantage. A new compound based on the benzothiophene nucleus...

journal_title：Translational oncology

authors： Goulielmaki M,Assimomytis N,Rozanc J,Taki E,Christodoulou I,Alexopoulos LG,Zoumpourlis V,Pintzas A,Papahatjis D

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS:The association of AR mRNA expression with clinicopathological features was r...

journal_title：Translational oncology

authors： Sikic D,Wirtz RM,Wach S,Dyrskjøt L,Erben P,Bolenz C,Breyer J,Otto W,Hoadley KA,Lerner SP,Eckstein M,Hartmann A,Keck B

更新日期：2019-04-01 00:00:00

abstract：:Wnt signaling has been implicated as a driver of prostate cancer-related osteoblast differentiation, and previous studies have linked modifications in Wnt function with the induction of tumor metastasis. A unique aspect of prostate cancer bone metastases in mouse models is their relative predilection to the hindlimb (...

journal_title：Translational oncology

authors： Wang Y,Singhal U,Qiao Y,Kasputis T,Chung JS,Zhao H,Chammaa F,Belardo JA,Roth TM,Zhang H,Zaslavsky AB,Palapattu GS,Pienta KJ,Chinnaiyan AM,Taichman RS,Cackowski FC,Morgan TM

更新日期：2020-04-01 00:00:00