Abstract:
PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuvant chemoradiation. Surgical specimens were graded according to the percent tumor cell destruction. Apparent diffusion coefficient (ADC) maps were used to generate whole-tumor derived ADC histogram distributions and mean ADC values. The primary objective of the study was to correlate ADC parameters with pathologic and CT response. RESULTS:Ten of the 12 patients enrolled on the study completed chemoradiation and had surgery. Three were found to be unresectable at the time of surgery and no specimen was obtained. Out of the 7 patients who underwent pancreaticoduodenectomy, 3 had a grade III histopathologic response (> 90% tumor cell destruction), 2 had a grade IIB response (51% to 90% tumor cell destruction), 1 had a grade IIA response (11% to 50% tumor cell destruction), and 1 had a grade I response (> 90% viable tumor). Median survival for patients with a grade III response, grade I-II response, and unresectable disease were 25.6, 18.7, and 6.1 months, respectively. There was a significant correlation between pre-treatment mean tumor ADC values and the amount of tumor cell destruction after chemoradiation with a Pearson correlation coefficient of 0.94 (P = .001). Mean pre-treatment ADC was 161 × 10(- 5) mm(2)/s (n = 3) in responding patients (> 90% tumor cell destruction) compared to 125 × 10(- 5) mm(2)/s (n = 4) in non-responding patients (> 10% viable tumor). CT imaging showed no significant change in tumor size in responders or non-responders. CONCLUSIONS:dMRI may be useful to predict response to chemoradiation in pancreatic cancer. In our study, tumors with a low ADC mean value at baseline responded poorly to standard chemoradiation and would be candidates for intensified therapy.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Cuneo KC,Chenevert TL,Ben-Josef E,Feng MU,Greenson JK,Hussain HK,Simeone DM,Schipper MJ,Anderson MA,Zalupski MM,Al-Hawary M,Galban CJ,Rehemtulla A,Feng FY,Lawrence TS,Ross BDdoi
10.1016/j.tranon.2014.07.005subject
Has Abstractpub_date
2014-10-24 00:00:00pages
644-9issue
5issn
1936-5233pii
S1936-5233(14)00078-3journal_volume
7pub_type
杂志文章abstract::DNA damage has been associated with prostate cancer risk. Men who were referred for initial prostate biopsy for elevated prostate-specific antigen or abnormal digital rectal examination are often found with no cancer but have a higher risk of developing prostate cancer than the general population of men in their lifet...
journal_title:Translational oncology
pub_type: 杂志文章
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journal_title:Translational oncology
pub_type: 杂志文章
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abstract:BACKGROUND AND PURPOSE:Breast cancer is now recognized as a clinically heterogeneous disease with a wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether epidemiological and clinicopathologic features are associated with the histological tumor grade of breast carcinomas in Wester...
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章,评审
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.10.006
更新日期:2019-02-01 00:00:00
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章,评审
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.09280
更新日期:2010-02-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2015.11.011
更新日期:2016-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100938
更新日期:2021-01-01 00:00:00
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journal_title:Translational oncology
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更新日期:2020-12-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00