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Angiogenesis and Antiangiogenesis in Triple-Negative Breast cancer.

Abstract：

:Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most important angiogenic factor with proven significance in breast cancer, as it has been assessed in both experimental and clinical studies. Triple-negative breast cancer (TNBC) is a type of breast cancer which lacks estrogen, progesterone, and HER-2/neu receptors. MVD in both basal-like and TNBC is significantly higher than in non-basal-like and non-TNBC. In breast cancer and other malignancies, the development of agents that inhibit tumor angiogenesis has been an active area of investigation. In TNBC, clinical trials combining targeted agents and chemotherapy have failed to show substantial survival improvement. There is evidence that patients with TNBC may have a greater probability of obtaining some kind of clinical efficacy benefit from bevacizumab-based therapy.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Ribatti D,Nico B,Ruggieri S,Tamma R,Simone G,Mangia A

doi

10.1016/j.tranon.2016.07.002

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

453-457

issue

5

issn

1936-5233

pii

S1936-5233(16)30071-7

journal_volume

9

pub_type

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