Abstract:
PURPOSE:In gastric adenocarcinoma (GC), the major tumor suppressor genes (TSGs) such as p16, PTEN, Rb, E-cadherin, and p53, may play important roles in various regulatory pathways and in tumor suppression. This study evaluated the loss of heterozygosity (LOH) of microsatellite and protein expression of 5 TSGs and the results were examined for their correlation with clinicopathological factors. METHODS:LOH analysis was carried out using polymerase chain reactions with 15 polymorphic microsatellite markers of 5 chromosomes containing TSGs in 100 surgically resected tumors. Protein expression was evaluated by immunohistochemistry (IHC). RESULTS:LOH was detected in 83% of GCs. LOH of 9p21, 10q23, 13q14, 16q22, and 17p13 were detected in 26%, 31%, 24%, 22%, and 35% of cases, respectively. Protein expression of p16, PTEN, Rb, E-cadherin, and p53 were found to be 31%, 39%, 28%, 32%, and 46% of cases. Advanced GCs showed significantly higher rates of 17p13 LOH and p53 expression. 9p21 LOH and E-cadherin IHC were correlated with higher tumor grade. Lymph node metastasis was correlated with the LOH of 9p21, 16q22, and 17p13 and IHC of the Rb and p53. A higher stage was correlated with 10q23 and 17p13 in LOH and p53 for IHC. CONCLUSION:These results suggest that LOH and protein expression of various TSGs are important in carcinogenesis and tumor invasion. Additionally, LOH and IHC may be useful clinical indicators for determining the prognosis of patients with GCs. In particular, the 17p13 LOH and p53 for IHC can be applied as simple evaluations in the clinic.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Choi WH,Lee S,Cho Sdoi
10.1016/j.tranon.2017.10.007subject
Has Abstractpub_date
2018-02-01 00:00:00pages
43-55issue
1issn
1936-5233pii
S1936-5233(17)30326-1journal_volume
11pub_type
杂志文章abstract::Wnt signaling has been implicated as a driver of prostate cancer-related osteoblast differentiation, and previous studies have linked modifications in Wnt function with the induction of tumor metastasis. A unique aspect of prostate cancer bone metastases in mouse models is their relative predilection to the hindlimb (...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100747
更新日期:2020-04-01 00:00:00
abstract:AIM:The Bruton's tyrosine kinase (BTK) inhibitor Ibrutinib (PCI-32765) is effective in patients with multiple myeloma, non-Hodgkin lymphoma and chronic lymphoblastic leukemia. We previously showed that primary cells of children with TCF3-PBX1 positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) express BTK ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100817
更新日期:2020-10-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) exon 19 deletion (E19del) is the most common activating mutation in advanced non-small cell lung cancer (NSCLC) and associates with the sensitivity of EGFR tyrosine kinase inhibitors (TKIs) treatment. However, not all mutant patterns of E19del have been well studied for the limi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100791
更新日期:2020-09-01 00:00:00
abstract::BRAFV600-mutated colorectal cancer (CRC) accounts for 8% to 12% of all CRC diagnoses. These tumors are often associated with specific patient features, including right-sided primary tumor location, peritoneal and non-regional lymph node involvement, and poor prognosis. In approximately 30% of cases, a simultaneous mis...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2020.100795
更新日期:2020-09-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized that the three main pr...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2020.100812
更新日期:2020-10-01 00:00:00
abstract::MicroRNAs are endogenous posttranscriptional modulators that negatively control the expression of their target genes and play an important role in the development and progression of many malignancies, including colorectal carcinoma. In particular, expression of microRNA-21 (miR-21) is greatly increased in chemotherapy...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.12397
更新日期:2013-04-01 00:00:00
abstract::Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositid...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.11265
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND AND STUDY AIM:To develop a molecular imaging endoscopic system that eliminates tissue autofluorescence and distinguishes multiple fluorescent markers specifically on the cancerous lesions. METHODS:Newly developed multi-spectral fluorescence endoscope device has the potential to eliminate signal interference...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.10.006
更新日期:2019-02-01 00:00:00
abstract::Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is targeted in the clinic, with successful and remarkable results. The PD-1/PD-Ls axis was shown to be one of the most relevant immunosu...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2020.100811
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:Mechanisms related the crosstalk between adipocytes and colon cancer cells are still not clear. We hypothesize that molecules and adipocytokines generated from the adipose tissue of obese individuals accentuate the effect on the metabolic reprogramming in colon cancer cells, i.e. induce disarray in energy metab...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.07.010
更新日期:2019-11-01 00:00:00
abstract::CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2015.08.003
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) in an attempt to identify potential core genes in the pathogenesis of this tumor. METHODS:Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and fi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.12.006
更新日期:2017-04-01 00:00:00
abstract::A targeted and timely offered treatment can be a benefitting tool for patients with acute promyelocytic leukemia (APML). Current round of study made use of potential morphological and immature fraction-related parameters (cell population data) generated during complete blood cell count (CBC), through artificial neural...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.09.009
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.04.016
更新日期:2014-08-01 00:00:00
abstract::Peritoneal carcinomatosis (PC) of colorectal origin is associated with a poor prognosis. However, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is available for a selected group of PC patients, which significantly increases overall survival rates up to 30%. As a consequence, there is su...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.10220
更新日期:2011-04-01 00:00:00
abstract:INTRODUCTION:The molecular mechanisms underlying aggressive versus indolent disease are not fully understood. Recent research has implicated a class of molecules known as long noncoding RNAs (lncRNAs) in tumorigenesis and progression of cancer. Our objective was to discover lncRNAs that differentiate aggressive and ind...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.04.002
更新日期:2018-06-01 00:00:00
abstract::Elderly patients with esophageal carcinoma may benefit from concurrent chemoradiotherapy (CCRT). However, the optimal concurrent chemotherapy regimen has not been determined. The aim of our study was to assess the efficiency and tolerance of treatment with a concurrent 5-fluorouracil (5-Fu)-based regimen and a taxane-...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.12.008
更新日期:2020-03-01 00:00:00
abstract::Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and mitochondrial DNA (mtDNA) damage, reflects how hypoxic conditions connect to cancer-induced systemi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.09.010
更新日期:2019-01-01 00:00:00
abstract::High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a "nanoimmunotherapy," which combines photothermal therapy (PTT) using CpG oligodeoxynucl...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100823
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory res...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2015.06.006
更新日期:2015-08-01 00:00:00
abstract::Adequately selecting a therapeutic approach for bladder cancer depends on accurate grading and staging. Substantial inaccuracy of clinical staging with bimanual examination, cystoscopy, and transurethral resection of bladder tumor has facilitated the increasing utility of magnetic resonance imaging to evaluate bladder...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2015.04.003
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.01.015
更新日期:2018-04-01 00:00:00
abstract:OBJECT:Thyroid cancer represents the most frequent malignancy of the endocrine system with an increasing incidence worldwide. Novel imaging techniques are able to further characterize tumors and even predict histopathology features. Texture analysis is an emergent imaging technique to extract extensive data from an rad...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.09.003
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) is one of the most prominent risk factors for hepatocellular carcinoma (HCC) development and virus-mediated cases represents more than 80% of HCC in East Asia, where it is endemic. Currently, the HBV status of pathological HCC is not fully clarified, especially by comparison to nontum...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.05.006
更新日期:2019-09-01 00:00:00
abstract::We investigated programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer (HGSOC) and its relationship to tumor infiltrating lymphocytes (TIL) and prognosis. Formalin fixed paraffin embedded (FFPE) samples of 94 HGSOC cases were included in the study. Immuno...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100994
更新日期:2021-02-01 00:00:00
abstract::Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on pr...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2016.05.004
更新日期:2016-08-01 00:00:00
abstract::Checkpoint with FHA and RING finger domains (CHFR) was first recognized as an early mitotic checkpoint protein that delayed the cell cycle in response to microtubule-targeting drugs. It is an E3 ubiquitin ligase that ubiquitinates target proteins to direct them to the proteasome for degradation or to alter their activ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.08109
更新日期:2008-07-01 00:00:00
abstract::Acquired uniparental disomy (aUPD) regions pinpoint homozygousity and monoallelic expressed genes. We analyzed The Cancer Genome Atlas single-nucleotide polymorphism arrays and expression data from oral cavity, oropharynx, and larynx cancers to identify frequency of aUPD in each tumor type and association of aUPD regi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100763
更新日期:2020-05-01 00:00:00
abstract::Anticancer drug efficacy varies because the delivery of drugs within tumors and tumor responses are heterogeneous; however, these features are often more homogenous in vitro. This difference makes it difficult to accurately determine drug efficacy. Therefore, it is important to use living tumor tissues in preclinical ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100764
更新日期:2020-06-01 00:00:00
abstract::Glioblastoma (GBM) with oligodendroglioma component (GBMO) is a newly described GBM subtype in the 2007 World Health Organization classification. However, its biological and genetic characteristics are largely unknown. We investigated the clinicopathological and molecular features of 34 GBMOs and compared the survival...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.10.002
更新日期:2014-12-01 00:00:00