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Role of IGF-1 receptor in radiation response.

Abstract：

:Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. In addition to their traditional roles, IGF-1R activation has been associated with increased radioresistance both in vitro and in vivo, although the molecular mechanisms behind this process are still unclear. Recently, IGF-1R has been associated to new partners as major vault proteins, BCL-2, BAX, or Ku70/80, related to radiochemotherapy resistance, regulation of apoptosis, and nonhomologous end-joining DNA repair. Here, we review these novel associations of IGF-1R trying to explain the resistance to radiotherapy mediated by IGF-1R. Finally, we revised the role of new therapies leading to block the receptor to enhance the efficacy of radiation.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Valenciano A,Henríquez-Hernández LA,Moreno M,Lloret M,Lara PC

doi

10.1593/tlo.11265

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

1-9

issue

1

issn

1936-5233

journal_volume

5

pub_type

杂志文章

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