当前位置： SCI文献检索 > Translational Oncology期刊下所有文献 > Multi-Spectral Fluorescence Imaging of Colon Dysplasia InVivo Using a Multi-Spectral Endoscopy System.

Multi-Spectral Fluorescence Imaging of Colon Dysplasia InVivo Using a Multi-Spectral Endoscopy System.

Abstract：

BACKGROUND AND STUDY AIM:To develop a molecular imaging endoscopic system that eliminates tissue autofluorescence and distinguishes multiple fluorescent markers specifically on the cancerous lesions. METHODS:Newly developed multi-spectral fluorescence endoscope device has the potential to eliminate signal interference due to autofluorescence and multiplex fluorophores in fluorescent probes. The multiplexing capability of the multi-spectral endoscope device was demonstrated in the phantom studies and multi-spectral imaging with endoscopy and macroscopy was performed to analyze fluorescence signals after administration of fluorescent probe that targets cancer in the colon. Because of the limitations in the clinical application using rigid-type small animal endoscope, we developed a flexible channel insert-type fluorescence endoscope, which was validated on the colonoscopy of dummy and porcine model. RESULTS:We measured multiple fluorescent signals simultaneously, and the fluorescence spectra were unmixed to separate the fluorescent signals of each probe, in which multiple fluorescent probes clearly revealed spectral deconvolution at the specific targeting area in the mouse colon. The positive area of fluorescence signal for each probe over the whole polyp was segmented with analyzing software, and showed distinctive patterns and significantly distinguishable values: 0.46 ± 0.04, 0.39 ± 0.08 and 0.73 ± 0.12 for HMRG, CET-553 and TRA-675 probes, respectively. The spectral unmixing was finally demonstrated in the dummy and porcine model, corroborating the targeted multi-spectral fluorescence imaging of colon dysplasia. CONCLUSION:The multi-spectral endoscopy system may allow endoscopists to clearly identify cancerous lesion that has different patterns of various target expression using multiple fluorescent probes.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Bae SM,Bae DJ,Do EJ,Oh G,Yoo SW,Lee GJ,Chae JS,Yun Y,Kim S,Kim KH,Chung E,Kim JK,Hwang SW,Park SH,Yang DH,Ye BD,Byeon JS,Yang SK,Joo J,Kim SY,Myung SJ

doi

10.1016/j.tranon.2018.10.006

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

226-235

issue

2

issn

1936-5233

pii

S1936-5233(18)30289-4

journal_volume

12

pub_type

杂志文章

相关文献

Translational Oncology文献大全
  • Programmed cell death-ligand 2: A neglected but important target in the immune response to cancer?

    abstract：:Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is targeted in the clinic, with successful and remarkable results. The PD-1/PD-Ls axis was shown to be one of the most relevant immunosu...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2020.100811

    authors： Solinas C,Aiello M,Rozali E,Lambertini M,Willard-Gallo K,Migliori E

    更新日期：2020-10-01 00:00:00

  • SPARC Expression Correlates with Tumor Response to Albumin-Bound Paclitaxel in Head and Neck Cancer Patients.

    abstract：:SPARC up-regulation is a poor prognostic factor in head and neck cancer. It was hypothesized that because of a SPARC-albumin interaction, tumoral SPARC facilitates the accumulation of albumin in the tumor and increases the effectiveness of albumin-bound paclitaxel (nab-paclitaxel). This hypothesis was tested by correl...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.09109

    authors： Desai N,Trieu V,Damascelli B,Soon-Shiong P

    更新日期：2009-05-01 00:00:00

  • The association between monocytic myeloid-derived suppressor cells levels and the anti-tumor efficacy of anti-PD-1 therapy in NSCLC patients.

    abstract：:Monocytic myeloid-derived suppressor cells (M-MDSCs), granulocytic MDSC (G-MDSCs) and regulatory T cells (Tregs) inhibit adaptive anti-tumor immunity and undermine the efficacy of anti-PD-1 therapy. However, the impact of anti-PD-1 treatment on these immunosuppressive cells has not been clearly defined in non-small ce...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100865

    authors： Feng J,Chen S,Li S,Wu B,Lu J,Tan L,Li J,Song Y,Shi G,Shi YG,Jiang J

    更新日期：2020-12-01 00:00:00

  • Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas.

    abstract：BACKGROUND:Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD:Various bioinformatics tools were u...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100976

    authors： Ni H,Sun H,Zheng M,Bian T,Liu J,Li X,Zhang J,Liu Y

    更新日期：2021-01-01 00:00:00

  • Prognosis of primary hepatic lymphoma: A US population-based analysis.

    abstract：OBJECTIVE:Primary hepatic lymphoma (PHL) is a rare malignancy with lesions confined to the liver. It is characterized by a large number of monomorphic, medium-sized lymphocytic infiltrates in the hepatic sinusoid. Due to the rarity of this malignancy, our current understanding of PHL is limited. METHODS:We collected i...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100931

    authors： Qiu MJ,Fang XF,Huang ZZ,Li QT,Wang MM,Jiang X,Xiong ZF,Yang SL

    更新日期：2021-01-01 00:00:00

  • Evaluation of potentially predictive markers for anti-angiogenic therapy with sunitinib in recurrent ovarian cancer patients.

    abstract：INTRODUCTION:In ovarian cancer, new therapeutic strategies are needed because the vast majority of patients develop a recurrence and resistance to platinum derivates. Attached to the AGO-OVAR2.11 study investigating the multityrosine kinase inhibitor sunitinib in recurrent platinum refractory ovarian cancers, this tran...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13205

    authors： Bauerschlag DO,Hilpert F,Meier W,Rau J,Meinhold-Heerlein I,Maass N,Dubois A,Sehouli J,Arnold N,Schem C,Oberg HH,Baumann K

    更新日期：2013-06-01 00:00:00

  • Down-regulation of miR-21 Induces Differentiation of Chemoresistant Colon Cancer Cells and Enhances Susceptibility to Therapeutic Regimens.

    abstract：:MicroRNAs are endogenous posttranscriptional modulators that negatively control the expression of their target genes and play an important role in the development and progression of many malignancies, including colorectal carcinoma. In particular, expression of microRNA-21 (miR-21) is greatly increased in chemotherapy...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.12397

    authors： Yu Y,Sarkar FH,Majumdar AP

    更新日期：2013-04-01 00:00:00

  • Loss of PI(4,5)P2 5-Phosphatase A Contributes to Resistance of Human Melanoma Cells to RAF/MEK Inhibitors.

    abstract：:Past studies have shown that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase (PIB5PA), is commonly downregulated or lost in melanomas, which contributes to elevated activation of phosphatidylinositol 3-kinase (PI3K)/Akt in melanoma cells. In this report, we provide evidenc...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13277

    authors： Ye Y,Li Q,Hu WL,Tseng HY,Jin L,Zhang XD,Zhang LJ,Yang S

    更新日期：2013-08-01 00:00:00

  • Measuring KRAS Mutations in Circulating Tumor DNA by Droplet Digital PCR and Next-Generation Sequencing.

    abstract：:Measuring total cell-free DNA (cfDNA) or cancer-specific mutations herein has presented as new tools in aiding the treatment of cancer patients. Studies show that total cfDNA bears prognostic value in metastatic colorectal cancer (mCRC) and that measuring cancer-specific mutations could supplement biopsies. However, l...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.07.013

    authors： Demuth C,Spindler KG,Johansen JS,Pallisgaard N,Nielsen D,Hogdall E,Vittrup B,Sorensen BS

    更新日期：2018-10-01 00:00:00

  • Inhibitor of DNA Binding 2 Inhibits Epithelial-Mesenchymal Transition via Up-Regulation of Notch3 in Breast Cancer.

    abstract：:Breast cancer is the second leading cause of cancer death in women worldwide. Incurable metastatic breast disease presents a major clinical challenge and is the main cause of breast cancer-related death. The epithelial-mesenchymal transition (EMT) is a critical early promoter of metastasis. In the present study, we id...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.07.015

    authors： Wen XF,Chen M,Wu Y,Chen MN,Glogowska A,Klonisch T,Zhang GJ

    更新日期：2018-10-01 00:00:00

  • Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma.

    abstract：:Accumulating evidence indicates that CDK2 promotes hyperproliferation and is associated to poor prognosis in multiple cancer cells. However, the physiological role of CDK2 in GBM and the biological mechanism still remains unclear. In this study, we identified that CDK2 expression was significantly enriched in GBM tumo...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2016.08.007

    authors： Wang J,Yang T,Xu G,Liu H,Ren C,Xie W,Wang M

    更新日期：2016-12-01 00:00:00

  • Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.

    abstract：OBJECTIVE:The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) in an attempt to identify potential core genes in the pathogenesis of this tumor. METHODS:Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and fi...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2016.12.006

    authors： Zhu J,Ye J,Zhang L,Xia L,Hu H,Jiang H,Wan Z,Sheng F,Ma Y,Li W,Qian J,Luo C

    更新日期：2017-04-01 00:00:00

  • CBX1 Indicates Poor Outcomes and Exerts Oncogenic Activity in Hepatocellular Carcinoma.

    abstract：:Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.07.002

    authors： Yang YF,Pan YH,Tian QH,Wu DC,Su SG

    更新日期：2018-10-01 00:00:00

  • Therapeutic relevance of molecular screening program in patients with metastatic sarcoma: Analysis from the ProfiLER 01 trial.

    abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100870

    authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

    更新日期：2020-12-01 00:00:00

  • Activation Status of Receptor Tyrosine Kinases as an Early Predictive Marker of Response to Chemotherapy in Osteosarcoma.

    abstract：:Receptor tyrosine kinases (RTKs) are membrane receptors that play a vital role in various biological processes, in particular, cell survival, cell proliferation, and cell differentiation. These cellular processes are composed of multitiered signaling cascades of kinases starting from ligand binding to extracellular do...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.08.005

    authors： Chaiyawat P,Klangjorhor J,Settakorn J,Champattanachai V,Phanphaisarn A,Teeyakasem P,Svasti J,Pruksakorn D

    更新日期：2017-10-01 00:00:00

  • Nuclear Enolase-1/ MBP-1 expression and its association with the Wnt signaling in epithelial ovarian cancer.

    abstract：BACKGROUND:Enolase-1, primarily known for its role in glucose metabolism, is overexpressed in various cancer entities. In contrast its alternative spliced nuclear isoform MBP-1 acts as a tumor suppressor. The aim of this study is to analyze the prognostic impact of Enolase-1/ MBP-1 and its functional significance in ep...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100910

    authors： Czogalla B,Partenheimer A,Badmann S,Schmoeckel E,Mayr D,Kolben T,Beyer S,Hester A,Burges A,Mahner S,Jeschke U,Trillsch F

    更新日期：2021-01-01 00:00:00

  • TIM3 expression on tumor cells predicts response to anti-PD-1 therapy for renal cancer.

    abstract：:This study aimed to identify novel prognostic biomarker for advanced renal cell carcinoma (RCC) patients treated with anti-PD-1 therapy, using quantitative multi-immunofluorescence (IF) analysis of tumor immunity. Twenty-five consecutive patients who had metastatic or unresectable RCC treated with anti-PD-1 therapy we...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100918

    authors： Kato R,Jinnouchi N,Tuyukubo T,Ikarashi D,Matsuura T,Maekawa S,Kato Y,Kanehira M,Takata R,Ishida K,Obara W

    更新日期：2021-01-01 00:00:00

  • Characterization of long non-coding RNAs and MEF2C-AS1 identified as a novel biomarker in diffuse gastric cancer.

    abstract：:Previous studies proved that long noncoding RNAs (lncRNAs) play important role in human cancer. However, the knowledge of genome scale expression of lncRNAs and their potential biological function in gastric cancer is still lacking. Next generation RNA sequencing (RNA-seq) was performed on tumor tissues and matched ad...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.06.007

    authors： Luo T,Zhao J,Lu Z,Bi J,Pang T,Cui H,Yang B,Li W,Wang Y,Wu S,Xue X

    更新日期：2018-10-01 00:00:00

  • A Validated Prognostic Biomarker Score for Adult Patients with Nonmetastatic Soft Tissue Sarcomas of the Trunk and Extremities.

    abstract：BACKGROUND:The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.09.002

    authors： Maretty-Kongstad K,Aggerholm-Pedersen N,Keller J,Safwat A

    更新日期：2017-12-01 00:00:00

  • Prognosis of Glioblastoma With Oligodendroglioma Component is Associated With the IDH1 Mutation and MGMT Methylation Status.

    abstract：:Glioblastoma (GBM) with oligodendroglioma component (GBMO) is a newly described GBM subtype in the 2007 World Health Organization classification. However, its biological and genetic characteristics are largely unknown. We investigated the clinicopathological and molecular features of 34 GBMOs and compared the survival...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.10.002

    authors： Myung JK,Cho HJ,Kim H,Park CK,Lee SH,Choi SH,Park P,Yoon JM,Park SH

    更新日期：2014-12-01 00:00:00

  • Mutations, Differential Gene Expression, and Chimeric Transcripts in Esophageal Squamous Cell Carcinoma Show High Heterogeneity.

    abstract：:Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance. In this study, we analyze, for the first time, the complete genomic profile...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.08.002

    authors： Souza-Santos PT,Soares Lima SC,Nicolau-Neto P,Boroni M,Meireles Da Costa N,Brewer L,Menezes AN,Furtado C,Moreira MAM,Seuanez HN,de Almeida Simão T,Ribeiro Pinto LF

    更新日期：2018-12-01 00:00:00

  • Phase I trial of radiotherapy concurrent with twice-weekly gemcitabine for head and neck cancer: translation from preclinical investigations aiming to improve the therapeutic ratio.

    abstract：BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.04.016

    authors： Popovtzer A,Normolle D,Worden FP,Prince ME,Chepeha DB,Wolf GT,Bradford CR,Lawrence TS,Eisbruch A

    更新日期：2014-08-01 00:00:00

  • DKK1 and Kremen Expression Predicts the Osteoblastic Response to Bone Metastasis.

    abstract：:Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic cancer in bone. The objectives of this study were to compare DKK1 ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.04.013

    authors： Clines KL,Clines GA

    更新日期：2018-08-01 00:00:00

  • Thioredoxin Reductase 1 Expression and Castration-recurrent Growth of Prostate Cancer.

    abstract：INTRODUCTION:Many genes are differentially expressed between androgen-dependent and androgen-independent prostate cancer (CaP). Differential expression analysis and subtractive hybridization previously identified nine genes expressed in intact mice bearing CWR22 tumors and castrated mice bearing recurrent CWR22 tumors ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.08145

    authors： Singh SS,Li Y,Ford OH,Wrzosek CS,Mehedint DC,Titus MA,Mohler JL

    更新日期：2008-09-01 00:00:00

  • Adipocytes Isolated from Visceral and Subcutaneous Depots of Donors Differing in BMI Crosstalk with Colon Cancer Cells and Modulate their Invasive Phenotype.

    abstract：PURPOSE:Mechanisms related the crosstalk between adipocytes and colon cancer cells are still not clear. We hypothesize that molecules and adipocytokines generated from the adipose tissue of obese individuals accentuate the effect on the metabolic reprogramming in colon cancer cells, i.e. induce disarray in energy metab...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.07.010

    authors： Nimri L,Peri I,Yehuda-Shnaidman E,Schwartz B

    更新日期：2019-11-01 00:00:00

  • Comparison of a Concurrent Fluorouracil-Based Regimen and a Taxane-Based Regimen Combined with Radiotherapy in Elderly Patients with Esophageal Squamous Cell Carcinoma.

    abstract：:Elderly patients with esophageal carcinoma may benefit from concurrent chemoradiotherapy (CCRT). However, the optimal concurrent chemotherapy regimen has not been determined. The aim of our study was to assess the efficiency and tolerance of treatment with a concurrent 5-fluorouracil (5-Fu)-based regimen and a taxane-...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.12.008

    authors： Huang C,Huang D,Zhu Y,Xie G,Wang H,Shi J,Jia B,Yuan Y,Zhang W

    更新日期：2020-03-01 00:00:00

  • Fasting Reduces the Incidence of Delayed-Type Vomiting Associated with Doxorubicin Treatment in Dogs with Lymphoma.

    abstract：:Fasting reduces gastrointestinal cellular proliferation rates through G1 cycle blockade and can promote cellular protection of normal but not cancer cells through altered cell signaling including down-regulation of insulin-like growth factor 1 (IGF-1). Consequently, the purpose of this study was to determine the effec...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.04.014

    authors： Withers SS,Kass PH,Rodriguez CO Jr,Skorupski KA,O'Brien D,Guerrero TA,Sein KD,Rebhun RB

    更新日期：2014-05-12 00:00:00

  • MicroRNA-506-3p increases the response to PARP inhibitors and cisplatin by targeting EZH2/β-catenin in serous ovarian cancers.

    abstract：:Chemo-resistance is an important barrier to effective treatment of ovarian cancer. Poly (ADP-ribose) polymerase (PARP) inhibitors are currently promising targeted drugs used to treat BRCA-mutant ovarian cancer. Ovarian cancer patients with BRCA 1/2 mutations appear to benefit better from PARP inhibitors and chemothera...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100987

    authors： Sun Y,Wu J,Dong X,Zhang J,Meng C,Liu G

    更新日期：2021-02-01 00:00:00

  • Clinicopathologic Factors Related to the Histological Tumor Grade of Breast Cancer in Western China: An Epidemiological Multicenter Study of 8619 Female Patients.

    abstract：BACKGROUND AND PURPOSE:Breast cancer is now recognized as a clinically heterogeneous disease with a wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether epidemiological and clinicopathologic features are associated with the histological tumor grade of breast carcinomas in Wester...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.06.005

    authors： Zheng K,Tan JX,Li F,Li HY,Zeng XH,Ma BL,Ou JH,Li H,Yang SS,Jiang AM,Ni Q,Liu JL,Liu JP,Zheng H,Yue-Yang,Ling R,He JJ,Li ZG,Zeng J,Zou TN,Jiang J,Song ZJ,Liu QL,Ren GS

    更新日期：2018-08-01 00:00:00

  • Biomarker Discovery in Human Prostate Cancer: an Update in Metabolomics Studies.

    abstract：:Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on pr...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2016.05.004

    authors： Lima AR,Bastos Mde L,Carvalho M,Guedes de Pinho P

    更新日期：2016-08-01 00:00:00