Evaluation of potentially predictive markers for anti-angiogenic therapy with sunitinib in recurrent ovarian cancer patients.

abstract：:Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance. In this study, we analyze, for the first time, the complete genomic profile...

journal_title：Translational oncology

authors： Souza-Santos PT,Soares Lima SC,Nicolau-Neto P,Boroni M,Meireles Da Costa N,Brewer L,Menezes AN,Furtado C,Moreira MAM,Seuanez HN,de Almeida Simão T,Ribeiro Pinto LF

更新日期：2018-12-01 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) provide clinical benefits to the lung cancer patients with epidermal growth factor receptor (EGFR) mutations. However, non-invasively determine EGFR mutation status in patients before targeted therapy remains a challenge. This study aimed to develop and validate a nomogram for preoper...

journal_title：Translational oncology

authors： Zhang G,Zhang J,Cao Y,Zhao Z,Li S,Deng L,Zhou J

更新日期：2021-01-01 00:00:00

abstract：:Migration is a complex process that, besides its various physiological functions in embryogenesis and adult tissues, plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the involvement and collaboration of Akt, focal adhesion kinase (FAK), and Src kinases in migration and invasivene...

journal_title：Translational oncology

authors： Turecková J,Vojtechová M,Krausová M,Sloncová E,Korínek V

更新日期：2009-12-01 00:00:00

abstract：:Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...

journal_title：Translational oncology

authors： Lippmann J,Petri K,Fulda S,Liese J

更新日期：2020-08-01 00:00:00

abstract：:Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on pr...

journal_title：Translational oncology

authors： Lima AR,Bastos Mde L,Carvalho M,Guedes de Pinho P

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD:Various bioinformatics tools were u...

journal_title：Translational oncology

authors： Ni H,Sun H,Zheng M,Bian T,Liu J,Li X,Zhang J,Liu Y

更新日期：2021-01-01 00:00:00

abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

journal_title：Translational oncology

authors： Stearns ME,Wang M

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:To develop a new nomogram tool for predicting survival in middle-aged and elderly patients with rectal adenocarcinoma. METHODS:A total of 6,116 patients were randomly assigned in a 7:3 ratio to training and validation cohorts. Univariate and multivariate Cox proportional hazards regression analyses were used...

journal_title：Translational oncology

authors： Liu H,Lv L,Qu Y,Zheng Z,Zhao J,Liu B,Zhang D,Wang H,Zhang J

更新日期：2021-01-01 00:00:00

abstract：:Previous studies proved that long noncoding RNAs (lncRNAs) play important role in human cancer. However, the knowledge of genome scale expression of lncRNAs and their potential biological function in gastric cancer is still lacking. Next generation RNA sequencing (RNA-seq) was performed on tumor tissues and matched ad...

journal_title：Translational oncology

authors： Luo T,Zhao J,Lu Z,Bi J,Pang T,Cui H,Yang B,Li W,Wang Y,Wu S,Xue X

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph ...

journal_title：Translational oncology

authors： Oltedal S,Kørner H,Aasprong OG,Hussain I,Tjensvoll K,Smaaland R,Søreide JA,Søreide K,Lothe RA,Heikkilä R,Gilje B,Nordgård O

更新日期：2018-04-01 00:00:00

abstract：:In HNSCC, protein- and mRNA-expression of the antileukoproteinase SLPI are significantly inverse correlated with HPV-infection suggesting that elevated expression of SLPI protects against HPV-infections. Moreover, SLPI-expression is up-regulated in HNSCC-patients reporting a smoking habit. Here, we investigate the des...

journal_title：Translational oncology

authors： Quabius ES,Loehr J,Haaser D,Günther V,Maass N,Röcken C,Mathiak M,Alkatout I,Hoffmann M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) ...

journal_title：Translational oncology

authors： Maretty-Kongstad K,Aggerholm-Pedersen N,Keller J,Safwat A

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To evaluate whether contrast enhancement on cone-beam breast-CT (CBBCT) could aid in discrimination of breast cancer subtypes and receptor status. METHODS:This study included female patients age >40 years with malignant breast lesions identified on contrast-enhanced CBBCT. Contrast enhancement of malignant bre...

journal_title：Translational oncology

authors： Uhlig J,Fischer U,von Fintel E,Stahnke V,Perske C,Lotz J,Wienbeck S

更新日期：2017-12-01 00:00:00

abstract：:Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositid...

journal_title：Translational oncology

authors： Valenciano A,Henríquez-Hernández LA,Moreno M,Lloret M,Lara PC

更新日期：2012-02-01 00:00:00

abstract：:Despite the weak clinical efficacy of TRAIL death receptor agonists, a search is under way for new agents that more efficiently activate apoptotic signaling. We previously created a TRAIL DR5-selective variant DR5-B without affinity for the DR4, DcR1, DcR2, and OPG receptors and increased proapoptotic activity in tumo...

journal_title：Translational oncology

authors： Yagolovich AV,Artykov AA,Karmakova TA,Vorontsova MS,Pankratov AA,Andreev-Andrievsky AA,Dolgikh DA,Kirpichnikov MP,Gasparian ME

更新日期：2020-04-01 00:00:00

abstract：:Bone is one of the most frequent metastatic sites in non-small cell lung cancer (NSCLC). Osimertinib, with and without bevacizumab (BV), has been investigated on advanced NSCLC patients. However, the efficacy of those drugs on bone metastasis of NSCLC has not been investigated. The human NSCLC cell line H1975, express...

journal_title：Translational oncology

authors： Higuchi T,Sugisawa N,Park JH,Sun Y,Zhu G,Yamamoto N,Hayashi K,Kimura H,Miwa S,Igarashi K,Bouvet M,Singh SR,Tsuchiya H,Hoffman RM

更新日期：2020-10-01 00:00:00

abstract：:Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...

journal_title：Translational oncology

authors： Yang YF,Pan YH,Tian QH,Wu DC,Su SG

更新日期：2018-10-01 00:00:00

abstract：:Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic cancer in bone. The objectives of this study were to compare DKK1 ...

journal_title：Translational oncology

authors： Clines KL,Clines GA

更新日期：2018-08-01 00:00:00

abstract：:Adequately selecting a therapeutic approach for bladder cancer depends on accurate grading and staging. Substantial inaccuracy of clinical staging with bimanual examination, cystoscopy, and transurethral resection of bladder tumor has facilitated the increasing utility of magnetic resonance imaging to evaluate bladder...

journal_title：Translational oncology

authors： Lin WC,Chen JH

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Many genes are differentially expressed between androgen-dependent and androgen-independent prostate cancer (CaP). Differential expression analysis and subtractive hybridization previously identified nine genes expressed in intact mice bearing CWR22 tumors and castrated mice bearing recurrent CWR22 tumors ...

journal_title：Translational oncology

authors： Singh SS,Li Y,Ford OH,Wrzosek CS,Mehedint DC,Titus MA,Mohler JL

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:This study presented a three-dimensional magnetic resonance (MR)-based method to separate a breast into four quadrants for quantitative measurements of the quadrant breast volume (BV) and density. METHODS:Breast MR images from 58 healthy women were studied. The breast and the fibroglandular tissue were segment...

journal_title：Translational oncology

authors： Fwu PT,Chen JH,Li Y,Chan S,Su MY

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:An increase in detection of early-stage asymptomatic lung tumors could increase the overall survival rate of lung cancer patients. A new approach to cancer (pre-)screening focusses on detecting field cancerization instead of the tumor itself. The objective of this study was to investigate the use of optica...

journal_title：Translational oncology

authors： Bugter O,van Brummelen SE,van der Leest KH,Aerts JGJV,Maat APWM,Baatenburg de Jong RJ,Amelink A,Robinson DJ

更新日期：2019-12-01 00:00:00

abstract：:We have recently shown that centrosomal protein 57 (CEP57) is overexpressed in a subset of human prostate cancers. CEP57 is involved in intracellular transport processes, and its overexpression causes mitotic defects as well as abnormal microtubule nucleation and bundling. In the present study, we further characterize...

journal_title：Translational oncology

authors： Mang J,Korzeniewski N,Dietrich D,Sailer V,Tolstov Y,Searcy S,von Hardenberg J,Perner S,Kristiansen G,Marx A,Roth W,Herpel E,Grüllich C,Popeneciu V,Pahernik S,Hadaschik B,Hohenfellner M,Duensing S

更新日期：2015-12-01 00:00:00

abstract：:Phosphatidylserine (PS) is normally intracellular but becomes exposed on the luminal surface of vascular endothelial cells in tumors. It also becomes exposed on tumors cells responding to therapy. In the present study, we optically imaged exposed PS in vivo using PGN635, a novel monoclonal antibody that binds PS. The ...

journal_title：Translational oncology

authors： Zhao D,Stafford JH,Zhou H,Thorpe PE

更新日期：2011-12-01 00:00:00

abstract：:Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active par...

journal_title：Translational oncology

authors： Gyamfi J,Eom M,Koo JS,Choi J

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

journal_title：Translational oncology

authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:In contrast to other studies, our previous study showed that adding induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) significantly worsened the prognosis of patients with stage II nasopharyngeal carcinoma (NPC). However, the population used was small; therefore, there is an urgent need to conf...

journal_title：Translational oncology

authors： Jin T,Zhang Q,Luo DH,Jiang F,Jin QF,Chen YY,Chen XZ,Mao WM

更新日期：2020-01-01 00:00:00

abstract：:Acquired uniparental disomy (aUPD) regions pinpoint homozygousity and monoallelic expressed genes. We analyzed The Cancer Genome Atlas single-nucleotide polymorphism arrays and expression data from oral cavity, oropharynx, and larynx cancers to identify frequency of aUPD in each tumor type and association of aUPD regi...

journal_title：Translational oncology

authors： Tuna M,I Amos C,B Mills G

更新日期：2020-05-01 00:00:00

abstract：:The accumulation of lipids is a hallmark of human clear cell renal cell carcinoma (ccRCC). Advanced ccRCC tumors frequently show increased lipid biosynthesis, but the regulation of lipid metabolism in early stage ccRCC tumors has not been studied. Here, we performed combined transcriptomics and metabolomics on a previ...

journal_title：Translational oncology

authors： van der Mijn JC,Fu L,Khani F,Zhang T,Molina AM,Barbieri CE,Chen Q,Gross SS,Gudas LJ,Nanus DM

更新日期：2020-02-01 00:00:00

abstract：:The mechanism of action of arsenic trioxide (ATO) has been shown to be complex, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects. Among these mechanisms of action, ATO has been shown to cause acute vascular shutdown and massive tumor necrosis in a murine solid tumor m...

journal_title：Translational oncology

authors： Lee JC,Lee HY,Moon CH,Lee SJ,Lee WH,Cha HJ,Park S,Lee YH,Park HJ,Song HT,Min YJ

更新日期：2013-02-01 00:00:00