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Multifaceted Roles of Interleukin-6 in Adipocyte-Breast Cancer Cell Interaction.

Abstract：

:Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active participants in breast cancer progression and response to treatment through autocrine and paracrine interaction with the malignant cells. Adipose tissue is abundant in the breast cancer microenvironment; interactions with cancer cells create cancer-associated adipocytes which produce a variety of adipokines that influence breast cancer initiation, metastasis, angiogenesis, and cachexia. Interleukin (IL)-6 has emerged as key compound significantly produced by breast cancer cells and adipocytes, with the potential of inducing proliferation, epithelial-mesenchymal phenotype, stem cell phenotype, angiogenesis, cachexia, and therapeutic resistance in breast cancer cells. Our aim is to present a brief knowledge of IL-6's role in breast cancer. This review summarizes our current understanding of the breast microenvironment, with emphasis on adipocytes as key players in breast cancer tumorigenesis. The effects of key adipocytes such as leptin, adipokines, TGF-b, and IL-6 are discussed. Finally, we discuss the role of IL-6 in various aspects of cancer progression.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Gyamfi J,Eom M,Koo JS,Choi J

doi

10.1016/j.tranon.2017.12.009

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

275-285

issue

2

issn

1936-5233

pii

S1936-5233(17)30406-0

journal_volume

11

pub_type

杂志文章,评审

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