Abstract:
:Fatty liver disease (hepatosteatosis) is a common early pathology in alcohol-dependent and obese patients. Fatty acid binding protein-4 (FABP4) is normally expressed in adipocytes and macrophages and functions as a regulator of intracellular lipid movement/storage. This study sought to investigate hepatic FABP4 expression and function in alcoholic liver disease (ALD) and hepatocellular carcinoma (HCC). Using chronic ethanol fed mouse models and patient samples FABP4 expression was analyzed. Human HCC cells, and HCC cells transfected to express CYP2E1, were exposed to ethanol and analyzed for FABP4 expression, or exposed to rhFABP4 (in the absence/presence of ERK, p38-MAPK or JNK1/2 inhibitors) and cell proliferation and migration measured. Hepatosteatotic-ALD mouse models exhibited increased hepatic FABP4 mRNA and protein levels, with FABP4 expression confirmed in hepatocytes. In HCC cells, CYP2E1-dependent ethanol metabolism induced FABP4 expression in vitro and exogenous rhFABP4 stimulated proliferation and migration, effects abrogated by ERK and JNK1/2 inhibition. Increased FABP4 was also detected in ALD/ALD-HCC patients, but not patients with viral hepatitis/HCC. Collectively these data demonstrate ethanol metabolism induces hepatic FABP4 expression and FABP4 promotes hepatoma cell proliferation/migration. These data suggest liver-derived FABP4 may be an important paracrine-endocrine factor during hepatic foci expansion and/or hepatoma progression in the underlying setting of ALD.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Attal N,Sullivan MT,Girardi CA,Thompson KJ,McKillop IHdoi
10.1016/j.tranon.2020.100975subject
Has Abstractpub_date
2021-01-01 00:00:00pages
100975issue
1issn
1936-5233pii
S1936-5233(20)30467-8journal_volume
14pub_type
杂志文章abstract:INTRODUCTION:In ovarian cancer, new therapeutic strategies are needed because the vast majority of patients develop a recurrence and resistance to platinum derivates. Attached to the AGO-OVAR2.11 study investigating the multityrosine kinase inhibitor sunitinib in recurrent platinum refractory ovarian cancers, this tran...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.13205
更新日期:2013-06-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) exon 19 deletion (E19del) is the most common activating mutation in advanced non-small cell lung cancer (NSCLC) and associates with the sensitivity of EGFR tyrosine kinase inhibitors (TKIs) treatment. However, not all mutant patterns of E19del have been well studied for the limi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100791
更新日期:2020-09-01 00:00:00
abstract::CRC is a heterogeneous disease due to global molecular alterations, including mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H). Immunotherapy has achieved durable responses in a subset of patients with dMMR-MSI-H metastatic CRC. It has been showed that Loss of ZG16 is highly associated with...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.101003
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.04.006
更新日期:2016-06-01 00:00:00
abstract::MicroRNAs are endogenous posttranscriptional modulators that negatively control the expression of their target genes and play an important role in the development and progression of many malignancies, including colorectal carcinoma. In particular, expression of microRNA-21 (miR-21) is greatly increased in chemotherapy...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.12397
更新日期:2013-04-01 00:00:00
abstract::Mannosyl (alpha-1,6-)-Glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5) is exclusively expressed in gastric carcinoma, and plays an essential role in cancer progression, but no targeted drug is available so far. The potential anti-cancer effect of Hydrogen Sulfide (H2S), has not been widely recognized. It...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.04.008
更新日期:2018-08-01 00:00:00
abstract::BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1. Here, we studied a possible association of BNIP3 expression and the prognosis of patients with renal cell...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.08.008
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Enolase-1, primarily known for its role in glucose metabolism, is overexpressed in various cancer entities. In contrast its alternative spliced nuclear isoform MBP-1 acts as a tumor suppressor. The aim of this study is to analyze the prognostic impact of Enolase-1/ MBP-1 and its functional significance in ep...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100910
更新日期:2021-01-01 00:00:00
abstract:OBJECT:Our purpose was to provide data regarding relationships between different imaging and histopathological parameters in HNSCC. METHODS:MEDLINE library was screened for associations between different imaging parameters and histopathological features in HNSCC up to December 2017. Only papers containing correlation ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.02.004
更新日期:2018-04-01 00:00:00
abstract::Chemo-resistance is an important barrier to effective treatment of ovarian cancer. Poly (ADP-ribose) polymerase (PARP) inhibitors are currently promising targeted drugs used to treat BRCA-mutant ovarian cancer. Ovarian cancer patients with BRCA 1/2 mutations appear to benefit better from PARP inhibitors and chemothera...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100987
更新日期:2021-02-01 00:00:00
abstract::Bone is one of the most frequent metastatic sites in non-small cell lung cancer (NSCLC). Osimertinib, with and without bevacizumab (BV), has been investigated on advanced NSCLC patients. However, the efficacy of those drugs on bone metastasis of NSCLC has not been investigated. The human NSCLC cell line H1975, express...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100826
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.07.005
更新日期:2014-10-24 00:00:00
abstract::The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were e...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.06.002
更新日期:2016-08-01 00:00:00
abstract::Measuring total cell-free DNA (cfDNA) or cancer-specific mutations herein has presented as new tools in aiding the treatment of cancer patients. Studies show that total cfDNA bears prognostic value in metastatic colorectal cancer (mCRC) and that measuring cancer-specific mutations could supplement biopsies. However, l...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.07.013
更新日期:2018-10-01 00:00:00
abstract:AIM:The Bruton's tyrosine kinase (BTK) inhibitor Ibrutinib (PCI-32765) is effective in patients with multiple myeloma, non-Hodgkin lymphoma and chronic lymphoblastic leukemia. We previously showed that primary cells of children with TCF3-PBX1 positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) express BTK ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100817
更新日期:2020-10-01 00:00:00
abstract::Despite the weak clinical efficacy of TRAIL death receptor agonists, a search is under way for new agents that more efficiently activate apoptotic signaling. We previously created a TRAIL DR5-selective variant DR5-B without affinity for the DR4, DcR1, DcR2, and OPG receptors and increased proapoptotic activity in tumo...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100762
更新日期:2020-04-01 00:00:00
abstract::Acquired uniparental disomy (aUPD) regions pinpoint homozygousity and monoallelic expressed genes. We analyzed The Cancer Genome Atlas single-nucleotide polymorphism arrays and expression data from oral cavity, oropharynx, and larynx cancers to identify frequency of aUPD in each tumor type and association of aUPD regi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100763
更新日期:2020-05-01 00:00:00
abstract::Oral mucositis (OM) is a serious side effect of cancer chemotherapy. The pathobiology of oral mucositis remains incompletely understood due to lack of appropriate models which recapitulate the human condition. Existing rodent models are intraperitoneal and require radiation, chemical or mechanical injury to the chemot...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.05.001
更新日期:2017-08-01 00:00:00
abstract::Studies investigating dynamic susceptibility contrast magnetic resonance imaging-determined relative cerebral blood volume (rCBV) maps as a metric of treatment response assessment have generated conflicting results. We evaluated the potential of various analytical techniques to predict survival of patients with glioma...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.13670
更新日期:2013-12-01 00:00:00
abstract::Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active par...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2017.12.009
更新日期:2018-04-01 00:00:00
abstract::Phosphatidylserine (PS) is normally intracellular but becomes exposed on the luminal surface of vascular endothelial cells in tumors. It also becomes exposed on tumors cells responding to therapy. In the present study, we optically imaged exposed PS in vivo using PGN635, a novel monoclonal antibody that binds PS. The ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.11178
更新日期:2011-12-01 00:00:00
abstract::Therapy-induced senescence (TIS), a cytostatic stress response in cancer cells, is induced inefficiently by current anticancer agents and radiation. The mechanisms that mediate TIS in cancer cells are not well defined. Herein, we characterize a robust senescence response both in vitro and in vivo to the quinone diaziq...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.12181
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:To investigate the predictive value of the pre-operative D-dimer and gamma-glutamyltranspeptidase (GGT) for the prognosis in colorectal liver metastases (CRLM) patients after hepatic resection. METHODS:Two hundred and ninety-two patients between December 2008 and December 2016 and 101 patients at our center...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.04.011
更新日期:2019-07-01 00:00:00
abstract::Monocytic myeloid-derived suppressor cells (M-MDSCs), granulocytic MDSC (G-MDSCs) and regulatory T cells (Tregs) inhibit adaptive anti-tumor immunity and undermine the efficacy of anti-PD-1 therapy. However, the impact of anti-PD-1 treatment on these immunosuppressive cells has not been clearly defined in non-small ce...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100865
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To determine the accuracy of a handheld ultrasound-guided optoacoustic tomography (US-OT) probe developed for human deep-tissue imaging in ex vivo assessment of tumor margins postlumpectomy. METHODS:A custom-built two-dimensional (2D) US-OT-handheld probe was used to scan 15 lumpectomy breast specimens. Optoac...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.11.005
更新日期:2020-02-01 00:00:00
abstract:PURPOSE:To prospectively investigate ultrasound-guided diffuse optical tomography (US-guided DOT) in predicting breast cancer response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS:Eighty-eight breast cancer patients, with a total of 93 lesions, were included in our study. Pre- and post-last chemotherapy, s...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.10.011
更新日期:2018-02-01 00:00:00
abstract::Clinical trials using anti-vascular endothelial growth factor /(VEGF) molecules induce a modest improvement in overall survival, measurable in weeks to just a few months, and tumors respond differently to these agents. In this review article, we have exposed some tumor characteristics and processes that may impair the...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2019.04.022
更新日期:2019-07-01 00:00:00
abstract::Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg, has been in clinical trials for treating ASS1-negative tumors. ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.12.003
更新日期:2020-02-01 00:00:00
abstract::This study aimed to identify novel prognostic biomarker for advanced renal cell carcinoma (RCC) patients treated with anti-PD-1 therapy, using quantitative multi-immunofluorescence (IF) analysis of tumor immunity. Twenty-five consecutive patients who had metastatic or unresectable RCC treated with anti-PD-1 therapy we...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100918
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) is one of the most prominent risk factors for hepatocellular carcinoma (HCC) development and virus-mediated cases represents more than 80% of HCC in East Asia, where it is endemic. Currently, the HBV status of pathological HCC is not fully clarified, especially by comparison to nontum...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.05.006
更新日期:2019-09-01 00:00:00