当前位置： SCI文献检索 > Translational Oncology期刊下所有文献 > Colorectal Cancer with Residual Polyp of Origin: A Model of Malignant Transformation.

Colorectal Cancer with Residual Polyp of Origin: A Model of Malignant Transformation.

Abstract：

:The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were evaluated over 10 years at Mayo Clinic, Rochester, MN, and compared their clinical and pathologic characteristics to CRC without remnant polyps (CRC RPO-). Overall survival and disease-free survival overlap with an equivalent hazard ratio between CRC RPO+ and RPO- cases when age, stage, and grade are adjusted. The somatic genomic profile obtained by whole genome sequencing and the gene expression profiles by RNA-seq for CRC RPO+ tumors were compared with that of age -and gender-matched CRC RPO- evaluated by The Cancer Genome Atlas. CRC RPO+ cases were more commonly found with lower-grade, earlier-stage disease than CRC RPO-. However, within the same disease stage and grade, their clinical course is very similar to that of CRC RPO-. The mutation frequencies of commonly mutated genes in CRC are similar between CRC RPO+ and RPO- cases. Likewise, gene expression patterns are indistinguishable between the RPO+ and RPO- cases. We have confirmed that CRC RPO+ is clinically and biologically similar to CRC RPO- and may be utilized as a model of the adenoma to carcinoma transition.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Druliner BR,Rashtak S,Ruan X,Bae T,Vasmatzis N,O'Brien D,Johnson R,Felmlee-Devine D,Washechek-Aletto J,Basu N,Liu H,Smyrk T,Abyzov A,Boardman LA

doi

10.1016/j.tranon.2016.06.002

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

280-6

issue

4

issn

1936-5233

pii

S1936-5233(16)30083-3

journal_volume

9

pub_type

杂志文章

相关文献

Translational Oncology文献大全
  • The Potential Value of Preoperative MRI Texture and Shape Analysis in Grading Meningiomas: A Preliminary Investigation.

    abstract：OBJECT:Preoperative knowledge of meningioma grade is essential for planning treatment and surgery. The purpose of this study was to investigate the diagnostic value of MRI texture and shape analysis in grading meningiomas. METHODS:A surgical database was reviewed to identify meningioma patients who had undergone tumor...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.04.006

    authors： Yan PF,Yan L,Hu TT,Xiao DD,Zhang Z,Zhao HY,Feng J

    更新日期：2017-08-01 00:00:00

  • Combined Selection System to Lower the Cutoff for Plasma Cell Enrichment Applied to iFISH Analysis in Multiple Myeloma.

    abstract：:Multiple myeloma (MM) is a very heterogeneous disease, characterized by multiple cytogenetic aberrations on plasma cells (PC) that have been traditionally used to predict the outcome of the disease. A mayor issue on the analysis of PC is the sometimes low infiltration of these cells in the bone marrow that hampers cyt...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.02.021

    authors： Mansilla C,Soria E,Vallejo M,Valiente A,Perez-Juana A,Zabalza A,Hurtado G,Sala F,Ramírez N

    更新日期：2018-06-01 00:00:00

  • Impact of perfusion map analysis on early survival prediction accuracy in glioma patients.

    abstract：:Studies investigating dynamic susceptibility contrast magnetic resonance imaging-determined relative cerebral blood volume (rCBV) maps as a metric of treatment response assessment have generated conflicting results. We evaluated the potential of various analytical techniques to predict survival of patients with glioma...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13670

    authors： Lemasson B,Chenevert TL,Lawrence TS,Tsien C,Sundgren PC,Meyer CR,Junck L,Boes J,Galbán S,Johnson TD,Rehemtulla A,Ross BD,Galbán CJ

    更新日期：2013-12-01 00:00:00

  • Multifaceted Roles of Interleukin-6 in Adipocyte-Breast Cancer Cell Interaction.

    abstract：:Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active par...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2017.12.009

    authors： Gyamfi J,Eom M,Koo JS,Choi J

    更新日期：2018-04-01 00:00:00

  • The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.

    abstract：:Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch t...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.07.004

    authors： Castillo-Pichardo L,Humphries-Bickley T,De La Parra C,Forestier-Roman I,Martinez-Ferrer M,Hernandez E,Vlaar C,Ferrer-Acosta Y,Washington AV,Cubano LA,Rodriguez-Orengo J,Dharmawardhane S

    更新日期：2014-10-24 00:00:00

  • Inhibitor of DNA Binding 2 Inhibits Epithelial-Mesenchymal Transition via Up-Regulation of Notch3 in Breast Cancer.

    abstract：:Breast cancer is the second leading cause of cancer death in women worldwide. Incurable metastatic breast disease presents a major clinical challenge and is the main cause of breast cancer-related death. The epithelial-mesenchymal transition (EMT) is a critical early promoter of metastasis. In the present study, we id...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.07.015

    authors： Wen XF,Chen M,Wu Y,Chen MN,Glogowska A,Klonisch T,Zhang GJ

    更新日期：2018-10-01 00:00:00

  • CpG-coated prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma.

    abstract：:High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a "nanoimmunotherapy," which combines photothermal therapy (PTT) using CpG oligodeoxynucl...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100823

    authors： Cano-Mejia J,Shukla A,Ledezma DK,Palmer E,Villagra A,Fernandes R

    更新日期：2020-10-01 00:00:00

  • EV20, a Novel Anti-ErbB-3 Humanized Antibody, Promotes ErbB-3 Down-Regulation and Inhibits Tumor Growth In Vivo.

    abstract：:ErbB-3 (HER-3) receptor is involved in tumor progression and resistance to therapy. Development of specific inhibitors impairing the activity of ErbB-3 is an attractive tool for cancer therapeutics. MP-RM-1, a murine monoclonal antibody targeting human ErbB-3, has shown anticancer activity in preclinical models. With ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13475

    authors： Sala G,Rapposelli IG,Ghasemi R,Piccolo E,Traini S,Capone E,Rossi C,Pelliccia A,Di Risio A,D'Egidio M,Tinari N,Muraro R,Iacobelli S,Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO).

    更新日期：2013-12-01 00:00:00

  • Therapeutic relevance of molecular screening program in patients with metastatic sarcoma: Analysis from the ProfiLER 01 trial.

    abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100870

    authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

    更新日期：2020-12-01 00:00:00

  • Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model.

    abstract：:Phosphatidylserine (PS) is normally intracellular but becomes exposed on the luminal surface of vascular endothelial cells in tumors. It also becomes exposed on tumors cells responding to therapy. In the present study, we optically imaged exposed PS in vivo using PGN635, a novel monoclonal antibody that binds PS. The ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.11178

    authors： Zhao D,Stafford JH,Zhou H,Thorpe PE

    更新日期：2011-12-01 00:00:00

  • Glucose metabolism measured by [¹⁸F]fluorodeoxyglucose positron emission tomography is independent of PTEN/AKT status in human colon carcinoma cells.

    abstract：:The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most altered in cancer, leading to a range of cellular responses including enhanced proliferation, survival, and metabolism, and is thus an attractive target for anticancer drug development. Stimulation of the PI3K pathway can be initiated by alterat...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.11118

    authors： Nguyen QD,Perumal M,Waldman TA,Aboagye EO

    更新日期：2011-08-01 00:00:00

  • Arsenic Trioxide as a Vascular Disrupting Agent: Synergistic Effect with Irinotecan on Tumor Growth Delay in a CT26 Allograft Model.

    abstract：:The mechanism of action of arsenic trioxide (ATO) has been shown to be complex, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects. Among these mechanisms of action, ATO has been shown to cause acute vascular shutdown and massive tumor necrosis in a murine solid tumor m...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.12322

    authors： Lee JC,Lee HY,Moon CH,Lee SJ,Lee WH,Cha HJ,Park S,Lee YH,Park HJ,Song HT,Min YJ

    更新日期：2013-02-01 00:00:00

  • Increased Expression of CAP2 Indicates Poor Prognosis in Hepatocellular Carcinoma.

    abstract：:CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.08.003

    authors： Fu J,Li M,Wu DC,Liu LL,Chen SL,Yun JP

    更新日期：2015-10-01 00:00:00

  • Loss of PI(4,5)P2 5-Phosphatase A Contributes to Resistance of Human Melanoma Cells to RAF/MEK Inhibitors.

    abstract：:Past studies have shown that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase (PIB5PA), is commonly downregulated or lost in melanomas, which contributes to elevated activation of phosphatidylinositol 3-kinase (PI3K)/Akt in melanoma cells. In this report, we provide evidenc...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13277

    authors： Ye Y,Li Q,Hu WL,Tseng HY,Jin L,Zhang XD,Zhang LJ,Yang S

    更新日期：2013-08-01 00:00:00

  • Protein anabolism is key to long-term survival in high-grade serous ovarian cancer.

    abstract：:This study aimed to identify the biological processes associated with long-term survival in high-grade serous ovarian cancer (HGSOC). HGSOC cases obtained from The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) database were divided into long-term survivors (LTS) and normal-term survivors (NTS) based on survival cutoffs...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100885

    authors： Wang L,Sun T,Li S,Zhang Z,Jia J,Shan B

    更新日期：2021-01-01 00:00:00

  • Synergistic Effects of the Green Tea Extract Epigallocatechin-3-gallate and Taxane in Eradication of Malignant Human Prostate Tumors.

    abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.10286

    authors： Stearns ME,Wang M

    更新日期：2011-06-01 00:00:00

  • Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas.

    abstract：BACKGROUND:Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD:Various bioinformatics tools were u...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100976

    authors： Ni H,Sun H,Zheng M,Bian T,Liu J,Li X,Zhang J,Liu Y

    更新日期：2021-01-01 00:00:00

  • Quantification of Regional Breast Density in Four Quadrants Using 3D MRI-A Pilot Study.

    abstract：PURPOSE:This study presented a three-dimensional magnetic resonance (MR)-based method to separate a breast into four quadrants for quantitative measurements of the quadrant breast volume (BV) and density. METHODS:Breast MR images from 58 healthy women were studied. The breast and the fibroglandular tissue were segment...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.04.005

    authors： Fwu PT,Chen JH,Li Y,Chan S,Su MY

    更新日期：2015-08-01 00:00:00

  • DPS-2: A Novel Dual MEK/ERK and PI3K/AKT Pathway Inhibitor with Powerful Ex Vivo and In Vivo Anticancer Properties.

    abstract：:Development of novel bioactive compounds against KRAS and/or BRAF mutant colorectal cancer (CRC) is currently an urgent need in oncology. In addition, single or multitarget kinase inhibitors against MEK/ERK and PI3K/AKT pathways are of potential therapeutic advantage. A new compound based on the benzothiophene nucleus...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.04.005

    authors： Goulielmaki M,Assimomytis N,Rozanc J,Taki E,Christodoulou I,Alexopoulos LG,Zoumpourlis V,Pintzas A,Papahatjis D

    更新日期：2019-07-01 00:00:00

  • Development of near-infrared imaging agents for detection of junction adhesion molecule-A protein.

    abstract：INTRODUCTION:Prostate and breast cancer are the most prevalent primary malignant human tumors globally. Prostatectomy and breast conservative surgery remain the most common definitive treatment option for the >500,000 men and women newly diagnosed with localized prostate and breast cancer each year only in the US. Morp...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.101007

    authors： Walker E,Turaga SM,Wang X,Gopalakrishnan R,Shukla S,Basilion JP,Lathia JD

    更新日期：2021-01-06 00:00:00

  • Role of IGF-1 receptor in radiation response.

    abstract：:Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositid...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.11265

    authors： Valenciano A,Henríquez-Hernández LA,Moreno M,Lloret M,Lara PC

    更新日期：2012-02-01 00:00:00

  • Measuring KRAS Mutations in Circulating Tumor DNA by Droplet Digital PCR and Next-Generation Sequencing.

    abstract：:Measuring total cell-free DNA (cfDNA) or cancer-specific mutations herein has presented as new tools in aiding the treatment of cancer patients. Studies show that total cfDNA bears prognostic value in metastatic colorectal cancer (mCRC) and that measuring cancer-specific mutations could supplement biopsies. However, l...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.07.013

    authors： Demuth C,Spindler KG,Johansen JS,Pallisgaard N,Nielsen D,Hogdall E,Vittrup B,Sorensen BS

    更新日期：2018-10-01 00:00:00

  • Prognostic Indicators for Gastrointestinal Stromal Tumors: A Review.

    abstract：:Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized that the three main pr...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2020.100812

    authors： Zhang H,Liu Q

    更新日期：2020-10-01 00:00:00

  • Tumor-suppressor Gene Promoter Hypermethylation in Saliva of Head and Neck Cancer Patients.

    abstract：:Head and neck squamous cell carcinoma (HNSCC) accounts for a bulk of the oral and laryngeal cancers, the majority (70%) of which are associated with smoking and excessive drinking, major known risk factors for the development of HNSCC. In contrast to reports that suggest an inverse relationship between smoking and glo...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.12232

    authors： Ovchinnikov DA,Cooper MA,Pandit P,Coman WB,Cooper-White JJ,Keith P,Wolvetang EJ,Slowey PD,Punyadeera C

    更新日期：2012-10-01 00:00:00

  • Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma.

    abstract：:Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100785

    authors： Lippmann J,Petri K,Fulda S,Liese J

    更新日期：2020-08-01 00:00:00

  • Limitations of Anti-Angiogenic Treatment of Tumors.

    abstract：:Clinical trials using anti-vascular endothelial growth factor /(VEGF) molecules induce a modest improvement in overall survival, measurable in weeks to just a few months, and tumors respond differently to these agents. In this review article, we have exposed some tumor characteristics and processes that may impair the...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2019.04.022

    authors： Ribatti D,Annese T,Ruggieri S,Tamma R,Crivellato E

    更新日期：2019-07-01 00:00:00

  • Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.

    abstract：OBJECTIVE:The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) in an attempt to identify potential core genes in the pathogenesis of this tumor. METHODS:Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and fi...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2016.12.006

    authors： Zhu J,Ye J,Zhang L,Xia L,Hu H,Jiang H,Wan Z,Sheng F,Ma Y,Li W,Qian J,Luo C

    更新日期：2017-04-01 00:00:00

  • Prognosis of Glioblastoma With Oligodendroglioma Component is Associated With the IDH1 Mutation and MGMT Methylation Status.

    abstract：:Glioblastoma (GBM) with oligodendroglioma component (GBMO) is a newly described GBM subtype in the 2007 World Health Organization classification. However, its biological and genetic characteristics are largely unknown. We investigated the clinicopathological and molecular features of 34 GBMOs and compared the survival...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.10.002

    authors： Myung JK,Cho HJ,Kim H,Park CK,Lee SH,Choi SH,Park P,Yoon JM,Park SH

    更新日期：2014-12-01 00:00:00

  • Phase I trial of radiotherapy concurrent with twice-weekly gemcitabine for head and neck cancer: translation from preclinical investigations aiming to improve the therapeutic ratio.

    abstract：BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.04.016

    authors： Popovtzer A,Normolle D,Worden FP,Prince ME,Chepeha DB,Wolf GT,Bradford CR,Lawrence TS,Eisbruch A

    更新日期：2014-08-01 00:00:00

  • Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells.

    abstract：PURPOSE:Angiogenesis plays an important role in pancreas cancer pathobiology. Pancreatic tumor cells secrete vascular endothelial growth factor (VEGF), activating endothelial cell protein kinase C beta (PKCbeta) that phosphorylates GSK3beta to suppress apoptosis and promote endothelial cell proliferation and microvesse...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.08151

    authors： Spalding AC,Zeitlin BD,Wilder-Romans K,Davis ME,Nor JE,Lawrence TS,Ben-Josef E

    更新日期：2008-12-01 00:00:00