当前位置： SCI文献检索 > Translational Oncology期刊下所有文献 > The Potential Value of Preoperative MRI Texture and Shape Analysis in Grading Meningiomas: A Preliminary Investigation.

The Potential Value of Preoperative MRI Texture and Shape Analysis in Grading Meningiomas: A Preliminary Investigation.

Abstract：

OBJECT:Preoperative knowledge of meningioma grade is essential for planning treatment and surgery. The purpose of this study was to investigate the diagnostic value of MRI texture and shape analysis in grading meningiomas. METHODS:A surgical database was reviewed to identify meningioma patients who had undergone tumor resection between January 2015 and December 2016. Preoperative MR images were retrieved and analyzed. Texture and shape analysis was conducted to quantitatively evaluate tumor heterogeneity and morphology. Three machine learning classifiers were trained with these features to build classification models. The performance of the features and classification models was assessed. RESULTS:A total of 131 patients were included in this study: 21 with high-grade meningiomas and 110 with low-grade meningiomas. Three texture features were selected: Horzl_RLNonUni, S(2,2)SumOfSqs, and WavEnHL_s-3; three shape features were selected: GeoFv, GeoW4, and GeoW5b. The Mann-Whitney test indicated that all six features were significantly different between high-grade and low-grade meningiomas. AUC values were generally greater than 0.50 (range, 0.73 to 0.88). Sensitivities and specificities ranged from 47.62% to 90.48% and 69.09% to 96.36%, respectively. Among the nine classification models obtained, the one built by training the SVM classifier with all six features achieved the best performance, with a sensitivity, specificity, diagnostic accuracy, and AUC of 0.86, 0.87, 0.87, and 0.87, respectively. CONCLUSIONS:Texture and shape analysis, especially when combined with a SVM classifier, can provide satisfactory performance in the preoperative determination of meningioma grade and is thus potentially useful for clinical application.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Yan PF,Yan L,Hu TT,Xiao DD,Zhang Z,Zhao HY,Feng J

doi

10.1016/j.tranon.2017.04.006

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

570-577

issue

4

issn

1936-5233

pii

S1936-5233(17)30139-0

journal_volume

10

pub_type

杂志文章

相关文献

Translational Oncology文献大全
  • The Prognostic Relevance of Sentinel Lymph Node Metastases Assessed by PHGR1 mRNA Quantification in Stage I to III Colon Cancer.

    abstract：BACKGROUND:Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.01.015

    authors： Oltedal S,Kørner H,Aasprong OG,Hussain I,Tjensvoll K,Smaaland R,Søreide JA,Søreide K,Lothe RA,Heikkilä R,Gilje B,Nordgård O

    更新日期：2018-04-01 00:00:00

  • Impact of perfusion map analysis on early survival prediction accuracy in glioma patients.

    abstract：:Studies investigating dynamic susceptibility contrast magnetic resonance imaging-determined relative cerebral blood volume (rCBV) maps as a metric of treatment response assessment have generated conflicting results. We evaluated the potential of various analytical techniques to predict survival of patients with glioma...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13670

    authors： Lemasson B,Chenevert TL,Lawrence TS,Tsien C,Sundgren PC,Meyer CR,Junck L,Boes J,Galbán S,Johnson TD,Rehemtulla A,Ross BD,Galbán CJ

    更新日期：2013-12-01 00:00:00

  • The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.

    abstract：:Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch t...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.07.004

    authors： Castillo-Pichardo L,Humphries-Bickley T,De La Parra C,Forestier-Roman I,Martinez-Ferrer M,Hernandez E,Vlaar C,Ferrer-Acosta Y,Washington AV,Cubano LA,Rodriguez-Orengo J,Dharmawardhane S

    更新日期：2014-10-24 00:00:00

  • Tumor Site-Dependent Transport Properties Determine Nanotherapeutics Delivery and Its Efficacy.

    abstract：:Insufficient delivery of systemically administered anticancer drugs to tumors can compromise therapeutic efficacy and develop drug delivery-based therapeutic resistance. Nanotherapeutics such as PEGylated liposomal doxorubicin (PLD) are designed to preferentially accumulate in tumors utilizing enhanced permeation and ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.05.011

    authors： Kai M,Ziemys A,Liu YT,Kojic M,Ferrari M,Yokoi K

    更新日期：2019-09-01 00:00:00

  • Mutations, Differential Gene Expression, and Chimeric Transcripts in Esophageal Squamous Cell Carcinoma Show High Heterogeneity.

    abstract：:Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance. In this study, we analyze, for the first time, the complete genomic profile...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.08.002

    authors： Souza-Santos PT,Soares Lima SC,Nicolau-Neto P,Boroni M,Meireles Da Costa N,Brewer L,Menezes AN,Furtado C,Moreira MAM,Seuanez HN,de Almeida Simão T,Ribeiro Pinto LF

    更新日期：2018-12-01 00:00:00

  • Synergistic Effects of the Green Tea Extract Epigallocatechin-3-gallate and Taxane in Eradication of Malignant Human Prostate Tumors.

    abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.10286

    authors： Stearns ME,Wang M

    更新日期：2011-06-01 00:00:00

  • Fatty acid binding protein-4 promotes alcohol-dependent hepatosteatosis and hepatocellular carcinoma progression.

    abstract：:Fatty liver disease (hepatosteatosis) is a common early pathology in alcohol-dependent and obese patients. Fatty acid binding protein-4 (FABP4) is normally expressed in adipocytes and macrophages and functions as a regulator of intracellular lipid movement/storage. This study sought to investigate hepatic FABP4 expres...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100975

    authors： Attal N,Sullivan MT,Girardi CA,Thompson KJ,McKillop IH

    更新日期：2021-01-01 00:00:00

  • Therapeutic relevance of molecular screening program in patients with metastatic sarcoma: Analysis from the ProfiLER 01 trial.

    abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100870

    authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

    更新日期：2020-12-01 00:00:00

  • Tumor-suppressor Gene Promoter Hypermethylation in Saliva of Head and Neck Cancer Patients.

    abstract：:Head and neck squamous cell carcinoma (HNSCC) accounts for a bulk of the oral and laryngeal cancers, the majority (70%) of which are associated with smoking and excessive drinking, major known risk factors for the development of HNSCC. In contrast to reports that suggest an inverse relationship between smoking and glo...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.12232

    authors： Ovchinnikov DA,Cooper MA,Pandit P,Coman WB,Cooper-White JJ,Keith P,Wolvetang EJ,Slowey PD,Punyadeera C

    更新日期：2012-10-01 00:00:00

  • Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model.

    abstract：:Phosphatidylserine (PS) is normally intracellular but becomes exposed on the luminal surface of vascular endothelial cells in tumors. It also becomes exposed on tumors cells responding to therapy. In the present study, we optically imaged exposed PS in vivo using PGN635, a novel monoclonal antibody that binds PS. The ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.11178

    authors： Zhao D,Stafford JH,Zhou H,Thorpe PE

    更新日期：2011-12-01 00:00:00

  • Increased Expression of CAP2 Indicates Poor Prognosis in Hepatocellular Carcinoma.

    abstract：:CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.08.003

    authors： Fu J,Li M,Wu DC,Liu LL,Chen SL,Yun JP

    更新日期：2015-10-01 00:00:00

  • Utility of Genomic Analysis in Differentiating Synchronous and Metachronous Lung Adenocarcinomas from Primary Adenocarcinomas with Intrapulmonary Metastasis.

    abstract：:Distinguishing synchronous and metachronous primary lung adenocarcinomas from adenocarcinomas with intrapulmonary metastasis is essential for optimal patient management. In this study, multiple lung adenocarcinomas occurring in the same patient were evaluated using comprehensive histopathologic evaluation supplemented...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.02.009

    authors： Saab J,Zia H,Mathew S,Kluk M,Narula N,Fernandes H

    更新日期：2017-06-01 00:00:00

  • Nuclear Enolase-1/ MBP-1 expression and its association with the Wnt signaling in epithelial ovarian cancer.

    abstract：BACKGROUND:Enolase-1, primarily known for its role in glucose metabolism, is overexpressed in various cancer entities. In contrast its alternative spliced nuclear isoform MBP-1 acts as a tumor suppressor. The aim of this study is to analyze the prognostic impact of Enolase-1/ MBP-1 and its functional significance in ep...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100910

    authors： Czogalla B,Partenheimer A,Badmann S,Schmoeckel E,Mayr D,Kolben T,Beyer S,Hester A,Burges A,Mahner S,Jeschke U,Trillsch F

    更新日期：2021-01-01 00:00:00

  • Phase I trial of radiotherapy concurrent with twice-weekly gemcitabine for head and neck cancer: translation from preclinical investigations aiming to improve the therapeutic ratio.

    abstract：BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.04.016

    authors： Popovtzer A,Normolle D,Worden FP,Prince ME,Chepeha DB,Wolf GT,Bradford CR,Lawrence TS,Eisbruch A

    更新日期：2014-08-01 00:00:00

  • Microsatellite Alterations and Protein Expression of 5 Major Tumor Suppressor Genes in Gastric Adenocarcinomas.

    abstract：PURPOSE:In gastric adenocarcinoma (GC), the major tumor suppressor genes (TSGs) such as p16, PTEN, Rb, E-cadherin, and p53, may play important roles in various regulatory pathways and in tumor suppression. This study evaluated the loss of heterozygosity (LOH) of microsatellite and protein expression of 5 TSGs and the r...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.10.007

    authors： Choi WH,Lee S,Cho S

    更新日期：2018-02-01 00:00:00

  • Towards the Optical Detection of Field Cancerization in the Buccal Mucosa of Patients with Lung Cancer.

    abstract：INTRODUCTION:An increase in detection of early-stage asymptomatic lung tumors could increase the overall survival rate of lung cancer patients. A new approach to cancer (pre-)screening focusses on detecting field cancerization instead of the tumor itself. The objective of this study was to investigate the use of optica...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.07.018

    authors： Bugter O,van Brummelen SE,van der Leest KH,Aerts JGJV,Maat APWM,Baatenburg de Jong RJ,Amelink A,Robinson DJ

    更新日期：2019-12-01 00:00:00

  • Extracellular heat shock proteins and cancer: New perspectives.

    abstract：:Heat shock proteins (HSPs) are a large family of molecular chaperones aberrantly expressed in cancer. The expression of HSPs in tumor cells has been shown to be implicated in the regulation of apoptosis, immune responses, angiogenesis and metastasis. Given that extracellular vesicles (EVs) can serve as potential sourc...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2020.100995

    authors： Albakova Z,Siam MKS,Sacitharan PK,Ziganshin RH,Ryazantsev DY,Sapozhnikov AM

    更新日期：2021-02-01 00:00:00

  • Expression and Functional Characterization of the BNIP3 Protein in Renal Cell Carcinomas.

    abstract：:BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1. Here, we studied a possible association of BNIP3 expression and the prognosis of patients with renal cell...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.08.008

    authors： Macher-Goeppinger S,Keith M,Hatiboglu G,Hohenfellner M,Schirmacher P,Roth W,Tagscherer KE

    更新日期：2017-12-01 00:00:00

  • Prognostic Indicators for Gastrointestinal Stromal Tumors: A Review.

    abstract：:Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized that the three main pr...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2020.100812

    authors： Zhang H,Liu Q

    更新日期：2020-10-01 00:00:00

  • Suitability of surgical tumor tissues, biopsy, or cytology samples for epidermal growth factor receptor mutation testing in non-small cell lung carcinoma based on chinese population.

    abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) mutation status is crucial in treatment selection for non-small cell lung cancer (NSCLC) patients; however, the detection materials' availability remains challenging in clinical practice. In this study, we collected surgical resection tissues, lymph node biopsy, and cy...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.10.008

    authors： Han X,Zhang Z,Wu D,Shen Y,Wang S,Wang L,Liu Y,Yang S,Hu X,Feng Y,Sun Y,Shi Y

    更新日期：2014-12-01 00:00:00

  • Hydrogen Sulfide Demonstrates Promising Antitumor Efficacy in Gastric Carcinoma by Targeting MGAT5.

    abstract：:Mannosyl (alpha-1,6-)-Glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5) is exclusively expressed in gastric carcinoma, and plays an essential role in cancer progression, but no targeted drug is available so far. The potential anti-cancer effect of Hydrogen Sulfide (H2S), has not been widely recognized. It...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.04.008

    authors： Wang R,Fan Q,Zhang J,Zhang X,Kang Y,Wang Z

    更新日期：2018-08-01 00:00:00

  • Preoperative C-Reactive Protein/Albumin Ratio Predicts Prognosis of Patients after Curative Resection for Gastric Cancer.

    abstract：BACKGROUND:An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory res...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.06.006

    authors： Liu X,Sun X,Liu J,Kong P,Chen S,Zhan Y,Xu D

    更新日期：2015-08-01 00:00:00

  • Colorectal Cancer with Residual Polyp of Origin: A Model of Malignant Transformation.

    abstract：:The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were e...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2016.06.002

    authors： Druliner BR,Rashtak S,Ruan X,Bae T,Vasmatzis N,O'Brien D,Johnson R,Felmlee-Devine D,Washechek-Aletto J,Basu N,Liu H,Smyrk T,Abyzov A,Boardman LA

    更新日期：2016-08-01 00:00:00

  • Magnetic resonance assessment of response to therapy: tumor change measurement, truth data and error sources.

    abstract：:This article describes methods and issues that are specific to the assessment of change in tumor characteristics as measured using quantitative magnetic resonance (MR) techniques and how this relates to the establishment of quantitative MR imaging (MRI) biomarkers of patient response to therapy. The initial focus is o...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.09241

    authors： Jackson EF,Barboriak DP,Bidaut LM,Meyer CR

    更新日期：2009-12-01 00:00:00

  • CpG-coated prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma.

    abstract：:High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a "nanoimmunotherapy," which combines photothermal therapy (PTT) using CpG oligodeoxynucl...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100823

    authors： Cano-Mejia J,Shukla A,Ledezma DK,Palmer E,Villagra A,Fernandes R

    更新日期：2020-10-01 00:00:00

  • Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer.

    abstract：:DNA damage has been associated with prostate cancer risk. Men who were referred for initial prostate biopsy for elevated prostate-specific antigen or abnormal digital rectal examination are often found with no cancer but have a higher risk of developing prostate cancer than the general population of men in their lifet...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.08217

    authors： Wu JD,Lin DW,Page ST,Lundgren AD,True LD,Plymate SR

    更新日期：2009-03-01 00:00:00

  • The Role of Fibroblasts in Pancreatic Cancer: Extracellular Matrix Versus Paracrine Factors.

    abstract：BACKGROUND AND AIM:Desmoplasia is a characteristic feature and a suspected mechanism of tumor progression in pancreatic ductal adenocarcinoma (PDAC). Main constituents of the stroma involve cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM). The aim of this study was to dissect the interaction of CAFs,...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.04.009

    authors： Bolm L,Cigolla S,Wittel UA,Hopt UT,Keck T,Rades D,Bronsert P,Wellner UF

    更新日期：2017-08-01 00:00:00

  • Enzastaurin, an inhibitor of PKCbeta, Enhances Antiangiogenic Effects and Cytotoxicity of Radiation against Endothelial Cells.

    abstract：PURPOSE:Angiogenesis plays an important role in pancreas cancer pathobiology. Pancreatic tumor cells secrete vascular endothelial growth factor (VEGF), activating endothelial cell protein kinase C beta (PKCbeta) that phosphorylates GSK3beta to suppress apoptosis and promote endothelial cell proliferation and microvesse...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.08151

    authors： Spalding AC,Zeitlin BD,Wilder-Romans K,Davis ME,Nor JE,Lawrence TS,Ben-Josef E

    更新日期：2008-12-01 00:00:00

  • Prediction of cancer-specific survival and overall survival in middle-aged and older patients with rectal adenocarcinoma using a nomogram model.

    abstract：OBJECTIVE:To develop a new nomogram tool for predicting survival in middle-aged and elderly patients with rectal adenocarcinoma. METHODS:A total of 6,116 patients were randomly assigned in a 7:3 ratio to training and validation cohorts. Univariate and multivariate Cox proportional hazards regression analyses were used...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100938

    authors： Liu H,Lv L,Qu Y,Zheng Z,Zhao J,Liu B,Zhang D,Wang H,Zhang J

    更新日期：2021-01-01 00:00:00

  • Chemotherapy Induces Oral Mucositis in Mice Without Additional Noxious Stimuli.

    abstract：:Oral mucositis (OM) is a serious side effect of cancer chemotherapy. The pathobiology of oral mucositis remains incompletely understood due to lack of appropriate models which recapitulate the human condition. Existing rodent models are intraperitoneal and require radiation, chemical or mechanical injury to the chemot...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.05.001

    authors： Bertolini M,Sobue T,Thompson A,Dongari-Bagtzoglou A

    更新日期：2017-08-01 00:00:00