Abstract：
:Insufficient delivery of systemically administered anticancer drugs to tumors can compromise therapeutic efficacy and develop drug delivery-based therapeutic resistance. Nanotherapeutics such as PEGylated liposomal doxorubicin (PLD) are designed to preferentially accumulate in tumors utilizing enhanced permeation and retention effect. However, their antitumor effects and resulting clinical outcomes are modest and heterogeneous among tumors. Here, we aimed to investigate whether the amount and efficacy of PLD delivered to tumors are tumor site dependent. We established orthotopic primary tumor or liver metastases models of murine breast cancer using 4 T1 cells. PLD showed significant therapeutic effects against tumors that grew in primary mammary sites but not in the liver. We found that differences in therapeutic efficacy were not because of the intrinsic biological resistance of cancer cells but rather were associated with tumor site-dependent differences in transport properties, such as the amount of PLD delivery, blood vessel function, relative vascular permeability, and mechanical pressure in tumors. Thus, transport properties in tumor is site dependent and can be used as phenotypic surrogate markers for tumor drug delivery and therapeutic efficacy.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Kai M,Ziemys A,Liu YT,Kojic M,Ferrari M,Yokoi Kdoi
10.1016/j.tranon.2019.05.011subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1196-1205issue
9issn
1936-5233pii
S1936-5233(19)30096-8journal_volume
12pub_type
杂志文章abstract：:The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were e...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2016.06.002
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory res...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2015.06.006
更新日期：2015-08-01 00:00:00
abstract：:Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2020.100785
更新日期：2020-08-01 00:00:00
abstract：:Peritoneal carcinomatosis (PC) of colorectal origin is associated with a poor prognosis. However, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is available for a selected group of PC patients, which significantly increases overall survival rates up to 30%. As a consequence, there is su...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1593/tlo.10220
更新日期：2011-04-01 00:00:00
abstract：:Clinical trials using anti-vascular endothelial growth factor /(VEGF) molecules induce a modest improvement in overall survival, measurable in weeks to just a few months, and tumors respond differently to these agents. In this review article, we have exposed some tumor characteristics and processes that may impair the...
journal_title：Translational oncology
pub_type： 杂志文章,评审
doi：10.1016/j.tranon.2019.04.022
更新日期：2019-07-01 00:00:00
abstract：:Distinguishing synchronous and metachronous primary lung adenocarcinomas from adenocarcinomas with intrapulmonary metastasis is essential for optimal patient management. In this study, multiple lung adenocarcinomas occurring in the same patient were evaluated using comprehensive histopathologic evaluation supplemented...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2017.02.009
更新日期：2017-06-01 00:00:00
abstract：:Head and neck squamous cell carcinoma (HNSCC) accounts for a bulk of the oral and laryngeal cancers, the majority (70%) of which are associated with smoking and excessive drinking, major known risk factors for the development of HNSCC. In contrast to reports that suggest an inverse relationship between smoking and glo...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1593/tlo.12232
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVES:To investigate the predictive value of the pre-operative D-dimer and gamma-glutamyltranspeptidase (GGT) for the prognosis in colorectal liver metastases (CRLM) patients after hepatic resection. METHODS:Two hundred and ninety-two patients between December 2008 and December 2016 and 101 patients at our center...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2019.04.011
更新日期：2019-07-01 00:00:00
abstract：:BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1. Here, we studied a possible association of BNIP3 expression and the prognosis of patients with renal cell...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2017.08.008
更新日期：2017-12-01 00:00:00
abstract：OBJECT:Our purpose was to provide data regarding relationships between different imaging and histopathological parameters in HNSCC. METHODS:MEDLINE library was screened for associations between different imaging parameters and histopathological features in HNSCC up to December 2017. Only papers containing correlation ...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2018.02.004
更新日期：2018-04-01 00:00:00
abstract：INTRODUCTION:The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2016.04.006
更新日期：2016-06-01 00:00:00
abstract：:Migration is a complex process that, besides its various physiological functions in embryogenesis and adult tissues, plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the involvement and collaboration of Akt, focal adhesion kinase (FAK), and Src kinases in migration and invasivene...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1593/tlo.09160
更新日期：2009-12-01 00:00:00
abstract：:Fatty liver disease (hepatosteatosis) is a common early pathology in alcohol-dependent and obese patients. Fatty acid binding protein-4 (FABP4) is normally expressed in adipocytes and macrophages and functions as a regulator of intracellular lipid movement/storage. This study sought to investigate hepatic FABP4 expres...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2020.100975
更新日期：2021-01-01 00:00:00
abstract：:Past studies have shown that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase (PIB5PA), is commonly downregulated or lost in melanomas, which contributes to elevated activation of phosphatidylinositol 3-kinase (PI3K)/Akt in melanoma cells. In this report, we provide evidenc...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1593/tlo.13277
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:In gastric adenocarcinoma (GC), the major tumor suppressor genes (TSGs) such as p16, PTEN, Rb, E-cadherin, and p53, may play important roles in various regulatory pathways and in tumor suppression. This study evaluated the loss of heterozygosity (LOH) of microsatellite and protein expression of 5 TSGs and the r...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2017.10.007
更新日期：2018-02-01 00:00:00
abstract：:Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2018.07.002
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:The aim of this study is to summarize and quantify the current evidence on the therapeutic efficacy of laparoscopic radical nephrectomy (LRN) compared with open radical nephrectomy (ORN) in patients with renal cell carcinoma (RCC) in a meta-analysis. METHODS:Data were collected by searching Pubmed, Embase, ...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2017.03.004
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVES:Recurrence of hepatocellular carcinoma can arise from the primary tumor ("early recurrence") or de novo from tumor formation in a cirrhotic environment ("late recurrence"). We aimed to develop one simple gene expression score applicable in both the tumor and the surrounding liver that can predict the recurre...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2016.02.003
更新日期：2016-04-01 00:00:00
abstract：AIM:The Bruton's tyrosine kinase (BTK) inhibitor Ibrutinib (PCI-32765) is effective in patients with multiple myeloma, non-Hodgkin lymphoma and chronic lymphoblastic leukemia. We previously showed that primary cells of children with TCF3-PBX1 positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) express BTK ...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2020.100817
更新日期：2020-10-01 00:00:00
abstract：:Checkpoint with FHA and RING finger domains (CHFR) was first recognized as an early mitotic checkpoint protein that delayed the cell cycle in response to microtubule-targeting drugs. It is an E3 ubiquitin ligase that ubiquitinates target proteins to direct them to the proteasome for degradation or to alter their activ...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1593/tlo.08109
更新日期：2008-07-01 00:00:00
abstract：:Exosomes are extracellular membrane vesicles of 50- to 130-nm diameter secreted by most tumor cells. Exosomes can mediate the intercellular transfer of proteins and RNAs, including microRNAs (miRNAs), and promote both tumorigenesis and premetastatic niche formation. In this study, we performed exosomal RNA sequencing ...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2017.12.012
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2020.100870
更新日期：2020-12-01 00:00:00
abstract：:Chronic myelogenous leukemia (CML) can be controlled for years with the tyrosine kinase inhibitor imatinib but because imatinib poorly penetrates the blood-brain barrier (BBB), on occasion, the CML clone will thrive and evolve to an accelerated phase in the resulting imatinib sanctuary within the central nervous syste...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1593/tlo.09280
更新日期：2010-02-01 00:00:00
abstract：:Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositid...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1593/tlo.11265
更新日期：2012-02-01 00:00:00
abstract：:This study aimed to identify the biological processes associated with long-term survival in high-grade serous ovarian cancer (HGSOC). HGSOC cases obtained from The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) database were divided into long-term survivors (LTS) and normal-term survivors (NTS) based on survival cutoffs...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2020.100885
更新日期：2021-01-01 00:00:00
abstract：:Multiple myeloma (MM) is a very heterogeneous disease, characterized by multiple cytogenetic aberrations on plasma cells (PC) that have been traditionally used to predict the outcome of the disease. A mayor issue on the analysis of PC is the sometimes low infiltration of these cells in the bone marrow that hampers cyt...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2018.02.021
更新日期：2018-06-01 00:00:00
abstract：:Studies investigating dynamic susceptibility contrast magnetic resonance imaging-determined relative cerebral blood volume (rCBV) maps as a metric of treatment response assessment have generated conflicting results. We evaluated the potential of various analytical techniques to predict survival of patients with glioma...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1593/tlo.13670
更新日期：2013-12-01 00:00:00
abstract：OBJECT:Thyroid cancer represents the most frequent malignancy of the endocrine system with an increasing incidence worldwide. Novel imaging techniques are able to further characterize tumors and even predict histopathology features. Texture analysis is an emergent imaging technique to extract extensive data from an rad...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2017.09.003
更新日期：2017-12-01 00:00:00
abstract：:CRC is a heterogeneous disease due to global molecular alterations, including mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H). Immunotherapy has achieved durable responses in a subset of patients with dMMR-MSI-H metastatic CRC. It has been showed that Loss of ZG16 is highly associated with...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2020.101003
更新日期：2021-02-01 00:00:00
abstract：INTRODUCTION:Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS:The association of AR mRNA expression with clinicopathological features was r...
journal_title：Translational oncology
pub_type： 杂志文章
doi：10.1016/j.tranon.2019.01.005
更新日期：2019-04-01 00:00:00
