Expression and Functional Characterization of the BNIP3 Protein in Renal Cell Carcinomas.

abstract：:Previous studies proved that long noncoding RNAs (lncRNAs) play important role in human cancer. However, the knowledge of genome scale expression of lncRNAs and their potential biological function in gastric cancer is still lacking. Next generation RNA sequencing (RNA-seq) was performed on tumor tissues and matched ad...

journal_title：Translational oncology

authors： Luo T,Zhao J,Lu Z,Bi J,Pang T,Cui H,Yang B,Li W,Wang Y,Wu S,Xue X

更新日期：2018-10-01 00:00:00

abstract：:We study the reproducibility of quantitative imaging features that are used to describe tumor shape, size, and texture from computed tomography (CT) scans of non-small cell lung cancer (NSCLC). CT images are dependent on various scanning factors. We focus on characterizing image features that are reproducible in the p...

journal_title：Translational oncology

authors： Balagurunathan Y,Gu Y,Wang H,Kumar V,Grove O,Hawkins S,Kim J,Goldgof DB,Hall LO,Gatenby RA,Gillies RJ

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:Recurrence of hepatocellular carcinoma can arise from the primary tumor ("early recurrence") or de novo from tumor formation in a cirrhotic environment ("late recurrence"). We aimed to develop one simple gene expression score applicable in both the tumor and the surrounding liver that can predict the recurre...

journal_title：Translational oncology

authors： Dekervel J,Popovic D,van Malenstein H,Windmolders P,Heylen L,Libbrecht L,Bulle A,De Moor B,Van Cutsem E,Nevens F,Verslype C,van Pelt J

更新日期：2016-04-01 00:00:00

abstract：:CRC is a heterogeneous disease due to global molecular alterations, including mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H). Immunotherapy has achieved durable responses in a subset of patients with dMMR-MSI-H metastatic CRC. It has been showed that Loss of ZG16 is highly associated with...

journal_title：Translational oncology

authors： Meng H,Ding Y,Liu E,Li W,Wang L

更新日期：2021-02-01 00:00:00

abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

journal_title：Translational oncology

authors： Stearns ME,Wang M

更新日期：2011-06-01 00:00:00

abstract：:Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on pr...

journal_title：Translational oncology

authors： Lima AR,Bastos Mde L,Carvalho M,Guedes de Pinho P

更新日期：2016-08-01 00:00:00

abstract：:Adequately selecting a therapeutic approach for bladder cancer depends on accurate grading and staging. Substantial inaccuracy of clinical staging with bimanual examination, cystoscopy, and transurethral resection of bladder tumor has facilitated the increasing utility of magnetic resonance imaging to evaluate bladder...

journal_title：Translational oncology

authors： Lin WC,Chen JH

更新日期：2015-06-01 00:00:00

abstract：:Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic cancer in bone. The objectives of this study were to compare DKK1 ...

journal_title：Translational oncology

authors： Clines KL,Clines GA

更新日期：2018-08-01 00:00:00

abstract：OBJECT:Preoperative knowledge of meningioma grade is essential for planning treatment and surgery. The purpose of this study was to investigate the diagnostic value of MRI texture and shape analysis in grading meningiomas. METHODS:A surgical database was reviewed to identify meningioma patients who had undergone tumor...

journal_title：Translational oncology

authors： Yan PF,Yan L,Hu TT,Xiao DD,Zhang Z,Zhao HY,Feng J

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

journal_title：Translational oncology

authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

更新日期：2020-12-01 00:00:00

abstract：:Fasting reduces gastrointestinal cellular proliferation rates through G1 cycle blockade and can promote cellular protection of normal but not cancer cells through altered cell signaling including down-regulation of insulin-like growth factor 1 (IGF-1). Consequently, the purpose of this study was to determine the effec...

journal_title：Translational oncology

authors： Withers SS,Kass PH,Rodriguez CO Jr,Skorupski KA,O'Brien D,Guerrero TA,Sein KD,Rebhun RB

更新日期：2014-05-12 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) mutation status is crucial in treatment selection for non-small cell lung cancer (NSCLC) patients; however, the detection materials' availability remains challenging in clinical practice. In this study, we collected surgical resection tissues, lymph node biopsy, and cy...

journal_title：Translational oncology

authors： Han X,Zhang Z,Wu D,Shen Y,Wang S,Wang L,Liu Y,Yang S,Hu X,Feng Y,Sun Y,Shi Y

更新日期：2014-12-01 00:00:00

abstract：:SPARC up-regulation is a poor prognostic factor in head and neck cancer. It was hypothesized that because of a SPARC-albumin interaction, tumoral SPARC facilitates the accumulation of albumin in the tumor and increases the effectiveness of albumin-bound paclitaxel (nab-paclitaxel). This hypothesis was tested by correl...

journal_title：Translational oncology

authors： Desai N,Trieu V,Damascelli B,Soon-Shiong P

更新日期：2009-05-01 00:00:00

abstract：:CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...

journal_title：Translational oncology

authors： Fu J,Li M,Wu DC,Liu LL,Chen SL,Yun JP

更新日期：2015-10-01 00:00:00

abstract：:Exosomes are extracellular membrane vesicles of 50- to 130-nm diameter secreted by most tumor cells. Exosomes can mediate the intercellular transfer of proteins and RNAs, including microRNAs (miRNAs), and promote both tumorigenesis and premetastatic niche formation. In this study, we performed exosomal RNA sequencing ...

journal_title：Translational oncology

authors： Fu F,Jiang W,Zhou L,Chen Z

更新日期：2018-04-01 00:00:00

abstract：:MicroRNAs are endogenous posttranscriptional modulators that negatively control the expression of their target genes and play an important role in the development and progression of many malignancies, including colorectal carcinoma. In particular, expression of microRNA-21 (miR-21) is greatly increased in chemotherapy...

journal_title：Translational oncology

authors： Yu Y,Sarkar FH,Majumdar AP

更新日期：2013-04-01 00:00:00

abstract：:Multiple myeloma (MM) is a very heterogeneous disease, characterized by multiple cytogenetic aberrations on plasma cells (PC) that have been traditionally used to predict the outcome of the disease. A mayor issue on the analysis of PC is the sometimes low infiltration of these cells in the bone marrow that hampers cyt...

journal_title：Translational oncology

authors： Mansilla C,Soria E,Vallejo M,Valiente A,Perez-Juana A,Zabalza A,Hurtado G,Sala F,Ramírez N

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Primary hepatic lymphoma (PHL) is a rare malignancy with lesions confined to the liver. It is characterized by a large number of monomorphic, medium-sized lymphocytic infiltrates in the hepatic sinusoid. Due to the rarity of this malignancy, our current understanding of PHL is limited. METHODS:We collected i...

journal_title：Translational oncology

authors： Qiu MJ,Fang XF,Huang ZZ,Li QT,Wang MM,Jiang X,Xiong ZF,Yang SL

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...

journal_title：Translational oncology

authors： Cuneo KC,Chenevert TL,Ben-Josef E,Feng MU,Greenson JK,Hussain HK,Simeone DM,Schipper MJ,Anderson MA,Zalupski MM,Al-Hawary M,Galban CJ,Rehemtulla A,Feng FY,Lawrence TS,Ross BD

更新日期：2014-10-24 00:00:00

abstract：:High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a "nanoimmunotherapy," which combines photothermal therapy (PTT) using CpG oligodeoxynucl...

journal_title：Translational oncology

authors： Cano-Mejia J,Shukla A,Ledezma DK,Palmer E,Villagra A,Fernandes R

更新日期：2020-10-01 00:00:00

abstract：:Tumor cells grow in nutrient- and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering their metabolic pathways. This adaptation process commonly results in a tumor phenotype that displays a high rate of aerobic glycolysis and aggressive tumor characteristics. The glucose regulat...

journal_title：Translational oncology

authors： Mendoza EE,Pocceschi MG,Kong X,Leeper DB,Caro J,Limesand KH,Burd R

更新日期：2012-06-01 00:00:00

abstract：:Ovarian cancer remains the most frequently lethal of the gynecologic cancers owing to the late detection of this disease. Here, by using human specimens and three mouse models of ovarian cancer, we tested the feasibility of nonlinear imaging approaches, the multiphoton microscopy (MPM) and second harmonic generation (...

journal_title：Translational oncology

authors： Williams RM,Flesken-Nikitin A,Ellenson LH,Connolly DC,Hamilton TC,Nikitin AY,Zipfel WR

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Many genes are differentially expressed between androgen-dependent and androgen-independent prostate cancer (CaP). Differential expression analysis and subtractive hybridization previously identified nine genes expressed in intact mice bearing CWR22 tumors and castrated mice bearing recurrent CWR22 tumors ...

journal_title：Translational oncology

authors： Singh SS,Li Y,Ford OH,Wrzosek CS,Mehedint DC,Titus MA,Mohler JL

更新日期：2008-09-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most altered in cancer, leading to a range of cellular responses including enhanced proliferation, survival, and metabolism, and is thus an attractive target for anticancer drug development. Stimulation of the PI3K pathway can be initiated by alterat...

journal_title：Translational oncology

authors： Nguyen QD,Perumal M,Waldman TA,Aboagye EO

更新日期：2011-08-01 00:00:00

abstract：:Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositid...

journal_title：Translational oncology

authors： Valenciano A,Henríquez-Hernández LA,Moreno M,Lloret M,Lara PC

更新日期：2012-02-01 00:00:00

abstract：:Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present with advanced disease, many such patients do well. We have attempted identification of biologically indolent tumors within HR+HER2- tumors based on gene expression using...

journal_title：Translational oncology

authors： Prabhu JS,Korlimarla A,Anupama CE,Alexander A,Raghavan R,Kaul R,Desai K,Rajarajan S,Manjunath S,Correa M,Raman R,Kalamdani A,Prasad M,Patil S,Gopinath KS,Srinath BS,Sridhar TS

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory res...

journal_title：Translational oncology

authors： Liu X,Sun X,Liu J,Kong P,Chen S,Zhan Y,Xu D

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:In contrast to other studies, our previous study showed that adding induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) significantly worsened the prognosis of patients with stage II nasopharyngeal carcinoma (NPC). However, the population used was small; therefore, there is an urgent need to conf...

journal_title：Translational oncology

authors： Jin T,Zhang Q,Luo DH,Jiang F,Jin QF,Chen YY,Chen XZ,Mao WM

更新日期：2020-01-01 00:00:00

abstract：:Heat shock proteins (HSPs) are a large family of molecular chaperones aberrantly expressed in cancer. The expression of HSPs in tumor cells has been shown to be implicated in the regulation of apoptosis, immune responses, angiogenesis and metastasis. Given that extracellular vesicles (EVs) can serve as potential sourc...

journal_title：Translational oncology

authors： Albakova Z,Siam MKS,Sacitharan PK,Ziganshin RH,Ryazantsev DY,Sapozhnikov AM

更新日期：2021-02-01 00:00:00

abstract：INTRODUCTION:Prostate and breast cancer are the most prevalent primary malignant human tumors globally. Prostatectomy and breast conservative surgery remain the most common definitive treatment option for the >500,000 men and women newly diagnosed with localized prostate and breast cancer each year only in the US. Morp...

journal_title：Translational oncology

authors： Walker E,Turaga SM,Wang X,Gopalakrishnan R,Shukla S,Basilion JP,Lathia JD

更新日期：2021-01-06 00:00:00