Abstract:
:Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on prostate biopsies; however, this approach can lead to false-positive and false-negative results. Therefore, it is important to discover new biomarkers for the diagnosis of PCa, preferably noninvasive ones. Metabolomics is an approach that allows the analysis of the entire metabolic profile of a biological system. As neoplastic cells have a unique metabolic phenotype related to cancer development and progression, the identification of dysfunctional metabolic pathways using metabolomics can be used to discover cancer biomarkers and therapeutic targets. In this study, we review several metabolomics studies performed in prostatic fluid, blood plasma/serum, urine, tissues and immortalized cultured cell lines with the objective of discovering alterations in the metabolic phenotype of PCa and thus discovering new biomarkers for the diagnosis of PCa. Encouraging results using metabolomics have been reported for PCa, with sarcosine being one of the most promising biomarkers identified to date. However, the use of sarcosine as a PCa biomarker in the clinic remains a controversial issue within the scientific community. Beyond sarcosine, other metabolites are considered to be biomarkers for PCa, but they still need clinical validation. Despite the lack of metabolomics biomarkers reaching clinical practice, metabolomics proved to be a powerful tool in the discovery of new biomarkers for PCa detection.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Lima AR,Bastos Mde L,Carvalho M,Guedes de Pinho Pdoi
10.1016/j.tranon.2016.05.004subject
Has Abstractpub_date
2016-08-01 00:00:00pages
357-70issue
4issn
1936-5233pii
S1936-5233(16)30051-1journal_volume
9pub_type
杂志文章,评审abstract::Measuring total cell-free DNA (cfDNA) or cancer-specific mutations herein has presented as new tools in aiding the treatment of cancer patients. Studies show that total cfDNA bears prognostic value in metastatic colorectal cancer (mCRC) and that measuring cancer-specific mutations could supplement biopsies. However, l...
journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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doi:10.1593/tlo.13670
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章,评审
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.10.011
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.09.010
更新日期:2019-01-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2016.10.003
更新日期:2017-02-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.08.007
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.02.003
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.07.004
更新日期:2014-10-24 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.12.002
更新日期:2017-04-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.05.001
更新日期:2017-08-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.04.005
更新日期:2019-07-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.10286
更新日期:2011-06-01 00:00:00