Tumor-suppressor Gene Promoter Hypermethylation in Saliva of Head and Neck Cancer Patients.

abstract：INTRODUCTION:In ovarian cancer, new therapeutic strategies are needed because the vast majority of patients develop a recurrence and resistance to platinum derivates. Attached to the AGO-OVAR2.11 study investigating the multityrosine kinase inhibitor sunitinib in recurrent platinum refractory ovarian cancers, this tran...

journal_title：Translational oncology

authors： Bauerschlag DO,Hilpert F,Meier W,Rau J,Meinhold-Heerlein I,Maass N,Dubois A,Sehouli J,Arnold N,Schem C,Oberg HH,Baumann K

更新日期：2013-06-01 00:00:00

abstract：:Liver cancers in children are rare representing only 1.1% of malignancies, with an annual incidence rate of 1.5 cases per million. Hepatoblastoma and hepatocellular carcinomas are the most common malignancies of the liver occurring in young people aged 15 years or younger. Molecular basis of both tumors are still uncl...

journal_title：Translational oncology

authors： Magrelli A,Azzalin G,Salvatore M,Viganotti M,Tosto F,Colombo T,Devito R,Di Masi A,Antoccia A,Lorenzetti S,Maranghi F,Mantovani A,Tanzarella C,Macino G,Taruscio D

更新日期：2009-08-18 00:00:00

abstract：OBJECT:Our purpose was to provide data regarding relationships between different imaging and histopathological parameters in HNSCC. METHODS:MEDLINE library was screened for associations between different imaging parameters and histopathological features in HNSCC up to December 2017. Only papers containing correlation ...

journal_title：Translational oncology

authors： Surov A,Meyer HJ,Wienke A

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Breast cancer is now recognized as a clinically heterogeneous disease with a wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether epidemiological and clinicopathologic features are associated with the histological tumor grade of breast carcinomas in Wester...

journal_title：Translational oncology

authors： Zheng K,Tan JX,Li F,Li HY,Zeng XH,Ma BL,Ou JH,Li H,Yang SS,Jiang AM,Ni Q,Liu JL,Liu JP,Zheng H,Yue-Yang,Ling R,He JJ,Li ZG,Zeng J,Zou TN,Jiang J,Song ZJ,Liu QL,Ren GS

更新日期：2018-08-01 00:00:00

abstract：:We study the reproducibility of quantitative imaging features that are used to describe tumor shape, size, and texture from computed tomography (CT) scans of non-small cell lung cancer (NSCLC). CT images are dependent on various scanning factors. We focus on characterizing image features that are reproducible in the p...

journal_title：Translational oncology

authors： Balagurunathan Y,Gu Y,Wang H,Kumar V,Grove O,Hawkins S,Kim J,Goldgof DB,Hall LO,Gatenby RA,Gillies RJ

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph ...

journal_title：Translational oncology

authors： Oltedal S,Kørner H,Aasprong OG,Hussain I,Tjensvoll K,Smaaland R,Søreide JA,Søreide K,Lothe RA,Heikkilä R,Gilje B,Nordgård O

更新日期：2018-04-01 00:00:00

abstract：:Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic cancer in bone. The objectives of this study were to compare DKK1 ...

journal_title：Translational oncology

authors： Clines KL,Clines GA

更新日期：2018-08-01 00:00:00

abstract：:This study aimed to identify the biological processes associated with long-term survival in high-grade serous ovarian cancer (HGSOC). HGSOC cases obtained from The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) database were divided into long-term survivors (LTS) and normal-term survivors (NTS) based on survival cutoffs...

journal_title：Translational oncology

authors： Wang L,Sun T,Li S,Zhang Z,Jia J,Shan B

更新日期：2021-01-01 00:00:00

abstract：:Prostate cancer (CaP) is the most commonly diagnosed and the second leading cause of death from cancer in males in USA. Prostate orthotopic mouse model has been widely used to study human CaP in preclinical settings. Measurement of changes in tumor size obtained from noninvasive diagnostic images is a standard method ...

journal_title：Translational oncology

authors： Ni J,Cozzi P,Hung TT,Hao J,Graham P,Li Y

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND AIM:Desmoplasia is a characteristic feature and a suspected mechanism of tumor progression in pancreatic ductal adenocarcinoma (PDAC). Main constituents of the stroma involve cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM). The aim of this study was to dissect the interaction of CAFs,...

journal_title：Translational oncology

authors： Bolm L,Cigolla S,Wittel UA,Hopt UT,Keck T,Rades D,Bronsert P,Wellner UF

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Prostate and breast cancer are the most prevalent primary malignant human tumors globally. Prostatectomy and breast conservative surgery remain the most common definitive treatment option for the >500,000 men and women newly diagnosed with localized prostate and breast cancer each year only in the US. Morp...

journal_title：Translational oncology

authors： Walker E,Turaga SM,Wang X,Gopalakrishnan R,Shukla S,Basilion JP,Lathia JD

更新日期：2021-01-06 00:00:00

abstract：:SPARC up-regulation is a poor prognostic factor in head and neck cancer. It was hypothesized that because of a SPARC-albumin interaction, tumoral SPARC facilitates the accumulation of albumin in the tumor and increases the effectiveness of albumin-bound paclitaxel (nab-paclitaxel). This hypothesis was tested by correl...

journal_title：Translational oncology

authors： Desai N,Trieu V,Damascelli B,Soon-Shiong P

更新日期：2009-05-01 00:00:00

abstract：:Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active par...

journal_title：Translational oncology

authors： Gyamfi J,Eom M,Koo JS,Choi J

更新日期：2018-04-01 00:00:00

abstract：:BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1. Here, we studied a possible association of BNIP3 expression and the prognosis of patients with renal cell...

journal_title：Translational oncology

authors： Macher-Goeppinger S,Keith M,Hatiboglu G,Hohenfellner M,Schirmacher P,Roth W,Tagscherer KE

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Many genes are differentially expressed between androgen-dependent and androgen-independent prostate cancer (CaP). Differential expression analysis and subtractive hybridization previously identified nine genes expressed in intact mice bearing CWR22 tumors and castrated mice bearing recurrent CWR22 tumors ...

journal_title：Translational oncology

authors： Singh SS,Li Y,Ford OH,Wrzosek CS,Mehedint DC,Titus MA,Mohler JL

更新日期：2008-09-01 00:00:00

abstract：:Peritoneal carcinomatosis (PC) of colorectal origin is associated with a poor prognosis. However, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is available for a selected group of PC patients, which significantly increases overall survival rates up to 30%. As a consequence, there is su...

journal_title：Translational oncology

authors： van Oosten M,Crane LM,Bart J,van Leeuwen FW,van Dam GM

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:This study investigated the feasibility of using malignant pleural effusion (MPE) supernatant and paired cell blocks (precipitate) for gene profiling in patients with non-small cell lung cancer (NSCLC) using next-generation sequencing (NGS) technique. METHODS:Stage IV non-squamous NSCLC patients with MPE wer...

journal_title：Translational oncology

authors： Li J,Li X,Wang W,Shao Y,Zhang Y,Song Z

更新日期：2020-08-01 00:00:00

abstract：:DNA damage has been associated with prostate cancer risk. Men who were referred for initial prostate biopsy for elevated prostate-specific antigen or abnormal digital rectal examination are often found with no cancer but have a higher risk of developing prostate cancer than the general population of men in their lifet...

journal_title：Translational oncology

authors： Wu JD,Lin DW,Page ST,Lundgren AD,True LD,Plymate SR

更新日期：2009-03-01 00:00:00

abstract：:Glioblastoma (GBM) with oligodendroglioma component (GBMO) is a newly described GBM subtype in the 2007 World Health Organization classification. However, its biological and genetic characteristics are largely unknown. We investigated the clinicopathological and molecular features of 34 GBMOs and compared the survival...

journal_title：Translational oncology

authors： Myung JK,Cho HJ,Kim H,Park CK,Lee SH,Choi SH,Park P,Yoon JM,Park SH

更新日期：2014-12-01 00:00:00

abstract：OBJECT:Thyroid cancer represents the most frequent malignancy of the endocrine system with an increasing incidence worldwide. Novel imaging techniques are able to further characterize tumors and even predict histopathology features. Texture analysis is an emergent imaging technique to extract extensive data from an rad...

journal_title：Translational oncology

authors： Meyer HJ,Schob S,Höhn AK,Surov A

更新日期：2017-12-01 00:00:00

abstract：:Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch t...

journal_title：Translational oncology

authors： Castillo-Pichardo L,Humphries-Bickley T,De La Parra C,Forestier-Roman I,Martinez-Ferrer M,Hernandez E,Vlaar C,Ferrer-Acosta Y,Washington AV,Cubano LA,Rodriguez-Orengo J,Dharmawardhane S

更新日期：2014-10-24 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance. In this study, we analyze, for the first time, the complete genomic profile...

journal_title：Translational oncology

authors： Souza-Santos PT,Soares Lima SC,Nicolau-Neto P,Boroni M,Meireles Da Costa N,Brewer L,Menezes AN,Furtado C,Moreira MAM,Seuanez HN,de Almeida Simão T,Ribeiro Pinto LF

更新日期：2018-12-01 00:00:00

abstract：:Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...

journal_title：Translational oncology

authors： Lippmann J,Petri K,Fulda S,Liese J

更新日期：2020-08-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized that the three main pr...

journal_title：Translational oncology

authors： Zhang H,Liu Q

更新日期：2020-10-01 00:00:00

abstract：:BRAFV600-mutated colorectal cancer (CRC) accounts for 8% to 12% of all CRC diagnoses. These tumors are often associated with specific patient features, including right-sided primary tumor location, peritoneal and non-regional lymph node involvement, and poor prognosis. In approximately 30% of cases, a simultaneous mis...

journal_title：Translational oncology

authors： Roviello G,D'Angelo A,Petrioli R,Roviello F,Cianchi F,Nobili S,Mini E,Lavacchi D

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:In gastric adenocarcinoma (GC), the major tumor suppressor genes (TSGs) such as p16, PTEN, Rb, E-cadherin, and p53, may play important roles in various regulatory pathways and in tumor suppression. This study evaluated the loss of heterozygosity (LOH) of microsatellite and protein expression of 5 TSGs and the r...

journal_title：Translational oncology

authors： Choi WH,Lee S,Cho S

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Recurrence of hepatocellular carcinoma can arise from the primary tumor ("early recurrence") or de novo from tumor formation in a cirrhotic environment ("late recurrence"). We aimed to develop one simple gene expression score applicable in both the tumor and the surrounding liver that can predict the recurre...

journal_title：Translational oncology

authors： Dekervel J,Popovic D,van Malenstein H,Windmolders P,Heylen L,Libbrecht L,Bulle A,De Moor B,Van Cutsem E,Nevens F,Verslype C,van Pelt J

更新日期：2016-04-01 00:00:00

abstract：:Clinical trials using anti-vascular endothelial growth factor /(VEGF) molecules induce a modest improvement in overall survival, measurable in weeks to just a few months, and tumors respond differently to these agents. In this review article, we have exposed some tumor characteristics and processes that may impair the...

journal_title：Translational oncology

authors： Ribatti D,Annese T,Ruggieri S,Tamma R,Crivellato E

更新日期：2019-07-01 00:00:00

abstract：:Anticancer drug efficacy varies because the delivery of drugs within tumors and tumor responses are heterogeneous; however, these features are often more homogenous in vitro. This difference makes it difficult to accurately determine drug efficacy. Therefore, it is important to use living tumor tissues in preclinical ...

journal_title：Translational oncology

authors： Gonda K,Negishi H,Takano-Kasuya M,Kitamura N,Furusawa N,Nakano Y,Hamada Y,Tokunaga M,Higuchi H,Tada H,Ishida T

更新日期：2020-06-01 00:00:00

abstract：:Monocytic myeloid-derived suppressor cells (M-MDSCs), granulocytic MDSC (G-MDSCs) and regulatory T cells (Tregs) inhibit adaptive anti-tumor immunity and undermine the efficacy of anti-PD-1 therapy. However, the impact of anti-PD-1 treatment on these immunosuppressive cells has not been clearly defined in non-small ce...

journal_title：Translational oncology

authors： Feng J,Chen S,Li S,Wu B,Lu J,Tan L,Li J,Song Y,Shi G,Shi YG,Jiang J

更新日期：2020-12-01 00:00:00