Abstract:
:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ∼3 nM, and ∼6 nM, for EGCG, paclitaxel and docetaxel, respectively. Isobolograms generated from the data clearly indicated that EGCG in combination with paclitaxel or docetaxel had an additive effect in blocking tumor cell growth. EGCG combined with taxane also had an additive effect to increase the expression of apoptotic genes, (p53, p73, p21, and caspase 3) and the percent apoptosis observed in vitro and in tumor modeling studies in severe combined immunodeficient mice. The tumor modeling studies clearly showed that EGCG plus taxane injected intraperitoneally (i.p.) induced a significant increase in apoptosis rates (TUNEL assays) and eliminated preexisting tumors generated from PC-3ML cells implanted i.p., increasing disease-free survival rates to greater than 90%. More importantly, the combination therapy (i.p. biweekly) blocked metastases after intravenous injection of PC-3ML cells through the tail vein. In mice treated with EGCG plus taxane, the disease-free survival rates increased from 0% (in untreated mice) to more than 70% to 80% in treated mice. Taken together, these data demonstrate for the first time that EGCG in combination with taxane may provide a novel therapeutic treatment of advanced prostate cancer.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Stearns ME,Wang Mdoi
10.1593/tlo.10286subject
Has Abstractpub_date
2011-06-01 00:00:00pages
147-56issue
3issn
1936-5233journal_volume
4pub_type
杂志文章abstract::Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100785
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS:The association of AR mRNA expression with clinicopathological features was r...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.01.005
更新日期:2019-04-01 00:00:00
abstract::SPARC up-regulation is a poor prognostic factor in head and neck cancer. It was hypothesized that because of a SPARC-albumin interaction, tumoral SPARC facilitates the accumulation of albumin in the tumor and increases the effectiveness of albumin-bound paclitaxel (nab-paclitaxel). This hypothesis was tested by correl...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.09109
更新日期:2009-05-01 00:00:00
abstract::This study aimed to identify novel prognostic biomarker for advanced renal cell carcinoma (RCC) patients treated with anti-PD-1 therapy, using quantitative multi-immunofluorescence (IF) analysis of tumor immunity. Twenty-five consecutive patients who had metastatic or unresectable RCC treated with anti-PD-1 therapy we...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100918
更新日期:2021-01-01 00:00:00
abstract:OBJECT:Preoperative knowledge of meningioma grade is essential for planning treatment and surgery. The purpose of this study was to investigate the diagnostic value of MRI texture and shape analysis in grading meningiomas. METHODS:A surgical database was reviewed to identify meningioma patients who had undergone tumor...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.04.006
更新日期:2017-08-01 00:00:00
abstract::Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.07.002
更新日期:2018-10-01 00:00:00
abstract::We study the reproducibility of quantitative imaging features that are used to describe tumor shape, size, and texture from computed tomography (CT) scans of non-small cell lung cancer (NSCLC). CT images are dependent on various scanning factors. We focus on characterizing image features that are reproducible in the p...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.13844
更新日期:2014-02-01 00:00:00
abstract::ErbB-3 (HER-3) receptor is involved in tumor progression and resistance to therapy. Development of specific inhibitors impairing the activity of ErbB-3 is an attractive tool for cancer therapeutics. MP-RM-1, a murine monoclonal antibody targeting human ErbB-3, has shown anticancer activity in preclinical models. With ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.13475
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD:Various bioinformatics tools were u...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100976
更新日期:2021-01-01 00:00:00
abstract:INTRODUCTION:Many genes are differentially expressed between androgen-dependent and androgen-independent prostate cancer (CaP). Differential expression analysis and subtractive hybridization previously identified nine genes expressed in intact mice bearing CWR22 tumors and castrated mice bearing recurrent CWR22 tumors ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.08145
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:In gastric adenocarcinoma (GC), the major tumor suppressor genes (TSGs) such as p16, PTEN, Rb, E-cadherin, and p53, may play important roles in various regulatory pathways and in tumor suppression. This study evaluated the loss of heterozygosity (LOH) of microsatellite and protein expression of 5 TSGs and the r...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.10.007
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS:Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-ech...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2015.03.002
更新日期:2015-06-01 00:00:00
abstract::Despite the weak clinical efficacy of TRAIL death receptor agonists, a search is under way for new agents that more efficiently activate apoptotic signaling. We previously created a TRAIL DR5-selective variant DR5-B without affinity for the DR4, DcR1, DcR2, and OPG receptors and increased proapoptotic activity in tumo...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100762
更新日期:2020-04-01 00:00:00
abstract::Chemo-resistance is an important barrier to effective treatment of ovarian cancer. Poly (ADP-ribose) polymerase (PARP) inhibitors are currently promising targeted drugs used to treat BRCA-mutant ovarian cancer. Ovarian cancer patients with BRCA 1/2 mutations appear to benefit better from PARP inhibitors and chemothera...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100987
更新日期:2021-02-01 00:00:00
abstract::Measuring total cell-free DNA (cfDNA) or cancer-specific mutations herein has presented as new tools in aiding the treatment of cancer patients. Studies show that total cfDNA bears prognostic value in metastatic colorectal cancer (mCRC) and that measuring cancer-specific mutations could supplement biopsies. However, l...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.07.013
更新日期:2018-10-01 00:00:00
abstract::Peritoneal carcinomatosis (PC) of colorectal origin is associated with a poor prognosis. However, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is available for a selected group of PC patients, which significantly increases overall survival rates up to 30%. As a consequence, there is su...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.10220
更新日期:2011-04-01 00:00:00
abstract::Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch t...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.07.004
更新日期:2014-10-24 00:00:00
abstract:PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.07.005
更新日期:2014-10-24 00:00:00
abstract::Development of novel bioactive compounds against KRAS and/or BRAF mutant colorectal cancer (CRC) is currently an urgent need in oncology. In addition, single or multitarget kinase inhibitors against MEK/ERK and PI3K/AKT pathways are of potential therapeutic advantage. A new compound based on the benzothiophene nucleus...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.04.005
更新日期:2019-07-01 00:00:00
abstract::Polo-like kinase 1 (PLK1) plays an important role in the initiation, maintenance, and completion of mitosis. Dysfunction of PLK1 may promote cancerous transformation and drive its progression. PLK1 overexpression has been found in a variety of human cancers and was associated with poor prognoses in cancers. Many studi...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2016.10.003
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.09.002
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:Prostate and breast cancer are the most prevalent primary malignant human tumors globally. Prostatectomy and breast conservative surgery remain the most common definitive treatment option for the >500,000 men and women newly diagnosed with localized prostate and breast cancer each year only in the US. Morp...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.101007
更新日期:2021-01-06 00:00:00
abstract:PURPOSE:Angiogenesis plays an important role in pancreas cancer pathobiology. Pancreatic tumor cells secrete vascular endothelial growth factor (VEGF), activating endothelial cell protein kinase C beta (PKCbeta) that phosphorylates GSK3beta to suppress apoptosis and promote endothelial cell proliferation and microvesse...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.08151
更新日期:2008-12-01 00:00:00
abstract::This article describes methods and issues that are specific to the assessment of change in tumor characteristics as measured using quantitative magnetic resonance (MR) techniques and how this relates to the establishment of quantitative MR imaging (MRI) biomarkers of patient response to therapy. The initial focus is o...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.09241
更新日期:2009-12-01 00:00:00
abstract::Tyrosine kinase inhibitors (TKIs) provide clinical benefits to the lung cancer patients with epidermal growth factor receptor (EGFR) mutations. However, non-invasively determine EGFR mutation status in patients before targeted therapy remains a challenge. This study aimed to develop and validate a nomogram for preoper...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100954
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Enolase-1, primarily known for its role in glucose metabolism, is overexpressed in various cancer entities. In contrast its alternative spliced nuclear isoform MBP-1 acts as a tumor suppressor. The aim of this study is to analyze the prognostic impact of Enolase-1/ MBP-1 and its functional significance in ep...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100910
更新日期:2021-01-01 00:00:00
abstract::Mannosyl (alpha-1,6-)-Glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5) is exclusively expressed in gastric carcinoma, and plays an essential role in cancer progression, but no targeted drug is available so far. The potential anti-cancer effect of Hydrogen Sulfide (H2S), has not been widely recognized. It...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.04.008
更新日期:2018-08-01 00:00:00
abstract::Liver cancers in children are rare representing only 1.1% of malignancies, with an annual incidence rate of 1.5 cases per million. Hepatoblastoma and hepatocellular carcinomas are the most common malignancies of the liver occurring in young people aged 15 years or younger. Molecular basis of both tumors are still uncl...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.09124
更新日期:2009-08-18 00:00:00
abstract::Epidermal growth factor receptor (EGFR) exon 19 deletion (E19del) is the most common activating mutation in advanced non-small cell lung cancer (NSCLC) and associates with the sensitivity of EGFR tyrosine kinase inhibitors (TKIs) treatment. However, not all mutant patterns of E19del have been well studied for the limi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100791
更新日期:2020-09-01 00:00:00
abstract::Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present with advanced disease, many such patients do well. We have attempted identification of biologically indolent tumors within HR+HER2- tumors based on gene expression using...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.04.011
更新日期:2017-08-01 00:00:00