EV20, a Novel Anti-ErbB-3 Humanized Antibody, Promotes ErbB-3 Down-Regulation and Inhibits Tumor Growth In Vivo.

abstract：:Acquired uniparental disomy (aUPD) regions pinpoint homozygousity and monoallelic expressed genes. We analyzed The Cancer Genome Atlas single-nucleotide polymorphism arrays and expression data from oral cavity, oropharynx, and larynx cancers to identify frequency of aUPD in each tumor type and association of aUPD regi...

journal_title：Translational oncology

authors： Tuna M,I Amos C,B Mills G

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis. METHODS:A retrospective, multicenter study on 80 surgical samples from mCRC patients treated in first line with bevaciz...

journal_title：Translational oncology

authors： Iorio J,Lastraioli E,Tofani L,Petroni G,Antonuzzo L,Messerini L,Perrone G,Caputo D,Francesconi M,Amato MM,Cadei M,Arcangeli G,Villanacci V,Boni L,Coppola R,Di Costanzo F,Arcangeli A

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Primary hepatic lymphoma (PHL) is a rare malignancy with lesions confined to the liver. It is characterized by a large number of monomorphic, medium-sized lymphocytic infiltrates in the hepatic sinusoid. Due to the rarity of this malignancy, our current understanding of PHL is limited. METHODS:We collected i...

journal_title：Translational oncology

authors： Qiu MJ,Fang XF,Huang ZZ,Li QT,Wang MM,Jiang X,Xiong ZF,Yang SL

更新日期：2021-01-01 00:00:00

abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

journal_title：Translational oncology

authors： Stearns ME,Wang M

更新日期：2011-06-01 00:00:00

abstract：:Monocytic myeloid-derived suppressor cells (M-MDSCs), granulocytic MDSC (G-MDSCs) and regulatory T cells (Tregs) inhibit adaptive anti-tumor immunity and undermine the efficacy of anti-PD-1 therapy. However, the impact of anti-PD-1 treatment on these immunosuppressive cells has not been clearly defined in non-small ce...

journal_title：Translational oncology

authors： Feng J,Chen S,Li S,Wu B,Lu J,Tan L,Li J,Song Y,Shi G,Shi YG,Jiang J

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS:The association of AR mRNA expression with clinicopathological features was r...

journal_title：Translational oncology

authors： Sikic D,Wirtz RM,Wach S,Dyrskjøt L,Erben P,Bolenz C,Breyer J,Otto W,Hoadley KA,Lerner SP,Eckstein M,Hartmann A,Keck B

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:To prospectively investigate ultrasound-guided diffuse optical tomography (US-guided DOT) in predicting breast cancer response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS:Eighty-eight breast cancer patients, with a total of 93 lesions, were included in our study. Pre- and post-last chemotherapy, s...

journal_title：Translational oncology

authors： Zhi W,Liu G,Chang C,Miao A,Zhu X,Xie L,Zhou J

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To determine the accuracy of a handheld ultrasound-guided optoacoustic tomography (US-OT) probe developed for human deep-tissue imaging in ex vivo assessment of tumor margins postlumpectomy. METHODS:A custom-built two-dimensional (2D) US-OT-handheld probe was used to scan 15 lumpectomy breast specimens. Optoac...

journal_title：Translational oncology

authors： Goh Y,Balasundaram G,Moothanchery M,Attia A,Li X,Lim HQ,Burton NC,Qiu Y,Putti TC,Chan CW,Iau P,Buhari SA,Hartman M,Tang SW,Ng CWQ,Chan YH,Pool FJ,Pillay P,Chua W,Kapur J,Jagmohan P,Sterling E,Quek ST,Olivo M

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...

journal_title：Translational oncology

authors： Cuneo KC,Chenevert TL,Ben-Josef E,Feng MU,Greenson JK,Hussain HK,Simeone DM,Schipper MJ,Anderson MA,Zalupski MM,Al-Hawary M,Galban CJ,Rehemtulla A,Feng FY,Lawrence TS,Ross BD

更新日期：2014-10-24 00:00:00

abstract：:Accumulating evidence indicates that CDK2 promotes hyperproliferation and is associated to poor prognosis in multiple cancer cells. However, the physiological role of CDK2 in GBM and the biological mechanism still remains unclear. In this study, we identified that CDK2 expression was significantly enriched in GBM tumo...

journal_title：Translational oncology

authors： Wang J,Yang T,Xu G,Liu H,Ren C,Xie W,Wang M

更新日期：2016-12-01 00:00:00

abstract：:This article describes methods and issues that are specific to the assessment of change in tumor characteristics as measured using quantitative magnetic resonance (MR) techniques and how this relates to the establishment of quantitative MR imaging (MRI) biomarkers of patient response to therapy. The initial focus is o...

journal_title：Translational oncology

authors： Jackson EF,Barboriak DP,Bidaut LM,Meyer CR

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Mechanisms related the crosstalk between adipocytes and colon cancer cells are still not clear. We hypothesize that molecules and adipocytokines generated from the adipose tissue of obese individuals accentuate the effect on the metabolic reprogramming in colon cancer cells, i.e. induce disarray in energy metab...

journal_title：Translational oncology

authors： Nimri L,Peri I,Yehuda-Shnaidman E,Schwartz B

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) ...

journal_title：Translational oncology

authors： Maretty-Kongstad K,Aggerholm-Pedersen N,Keller J,Safwat A

更新日期：2017-12-01 00:00:00

abstract：:DNA damage has been associated with prostate cancer risk. Men who were referred for initial prostate biopsy for elevated prostate-specific antigen or abnormal digital rectal examination are often found with no cancer but have a higher risk of developing prostate cancer than the general population of men in their lifet...

journal_title：Translational oncology

authors： Wu JD,Lin DW,Page ST,Lundgren AD,True LD,Plymate SR

更新日期：2009-03-01 00:00:00

abstract：:A targeted and timely offered treatment can be a benefitting tool for patients with acute promyelocytic leukemia (APML). Current round of study made use of potential morphological and immature fraction-related parameters (cell population data) generated during complete blood cell count (CBC), through artificial neural...

journal_title：Translational oncology

authors： Haider RZ,Ujjan IU,Shamsi TS

更新日期：2020-01-01 00:00:00

abstract：:SPARC up-regulation is a poor prognostic factor in head and neck cancer. It was hypothesized that because of a SPARC-albumin interaction, tumoral SPARC facilitates the accumulation of albumin in the tumor and increases the effectiveness of albumin-bound paclitaxel (nab-paclitaxel). This hypothesis was tested by correl...

journal_title：Translational oncology

authors： Desai N,Trieu V,Damascelli B,Soon-Shiong P

更新日期：2009-05-01 00:00:00

abstract：:We investigated programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer (HGSOC) and its relationship to tumor infiltrating lymphocytes (TIL) and prognosis. Formalin fixed paraffin embedded (FFPE) samples of 94 HGSOC cases were included in the study. Immuno...

journal_title：Translational oncology

authors： Baş Y,Koç N,Helvacı K,Koçak C,Akdeniz R,Şahin HHK

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...

journal_title：Translational oncology

authors： Popovtzer A,Normolle D,Worden FP,Prince ME,Chepeha DB,Wolf GT,Bradford CR,Lawrence TS,Eisbruch A

更新日期：2014-08-01 00:00:00

abstract：:We have recently shown that centrosomal protein 57 (CEP57) is overexpressed in a subset of human prostate cancers. CEP57 is involved in intracellular transport processes, and its overexpression causes mitotic defects as well as abnormal microtubule nucleation and bundling. In the present study, we further characterize...

journal_title：Translational oncology

authors： Mang J,Korzeniewski N,Dietrich D,Sailer V,Tolstov Y,Searcy S,von Hardenberg J,Perner S,Kristiansen G,Marx A,Roth W,Herpel E,Grüllich C,Popeneciu V,Pahernik S,Hadaschik B,Hohenfellner M,Duensing S

更新日期：2015-12-01 00:00:00

abstract：:Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg, has been in clinical trials for treating ASS1-negative tumors. ...

journal_title：Translational oncology

authors： Kuo MT,Long Y,Tsai WB,Li YY,Chen HHW,Feun LG,Savaraj N

更新日期：2020-02-01 00:00:00

abstract：:Insufficient delivery of systemically administered anticancer drugs to tumors can compromise therapeutic efficacy and develop drug delivery-based therapeutic resistance. Nanotherapeutics such as PEGylated liposomal doxorubicin (PLD) are designed to preferentially accumulate in tumors utilizing enhanced permeation and ...

journal_title：Translational oncology

authors： Kai M,Ziemys A,Liu YT,Kojic M,Ferrari M,Yokoi K

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:To investigate the predictive value of the pre-operative D-dimer and gamma-glutamyltranspeptidase (GGT) for the prognosis in colorectal liver metastases (CRLM) patients after hepatic resection. METHODS:Two hundred and ninety-two patients between December 2008 and December 2016 and 101 patients at our center...

journal_title：Translational oncology

authors： Chen Q,Zhao H,Wu J,Cai J,Li C,Zhao J,Bi X,Li Z,Huang Z,Zhang Y,Cui W,Zhou J

更新日期：2019-07-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most altered in cancer, leading to a range of cellular responses including enhanced proliferation, survival, and metabolism, and is thus an attractive target for anticancer drug development. Stimulation of the PI3K pathway can be initiated by alterat...

journal_title：Translational oncology

authors： Nguyen QD,Perumal M,Waldman TA,Aboagye EO

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of...

journal_title：Translational oncology

authors： Murrell DH,Zarghami N,Jensen MD,Chambers AF,Wong E,Foster PJ

更新日期：2016-06-01 00:00:00

abstract：:Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is targeted in the clinic, with successful and remarkable results. The PD-1/PD-Ls axis was shown to be one of the most relevant immunosu...

journal_title：Translational oncology

authors： Solinas C,Aiello M,Rozali E,Lambertini M,Willard-Gallo K,Migliori E

更新日期：2020-10-01 00:00:00

abstract：:Ovarian cancer remains the most frequently lethal of the gynecologic cancers owing to the late detection of this disease. Here, by using human specimens and three mouse models of ovarian cancer, we tested the feasibility of nonlinear imaging approaches, the multiphoton microscopy (MPM) and second harmonic generation (...

journal_title：Translational oncology

authors： Williams RM,Flesken-Nikitin A,Ellenson LH,Connolly DC,Hamilton TC,Nikitin AY,Zipfel WR

更新日期：2010-06-01 00:00:00

abstract：:Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present with advanced disease, many such patients do well. We have attempted identification of biologically indolent tumors within HR+HER2- tumors based on gene expression using...

journal_title：Translational oncology

authors： Prabhu JS,Korlimarla A,Anupama CE,Alexander A,Raghavan R,Kaul R,Desai K,Rajarajan S,Manjunath S,Correa M,Raman R,Kalamdani A,Prasad M,Patil S,Gopinath KS,Srinath BS,Sridhar TS

更新日期：2017-08-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance. In this study, we analyze, for the first time, the complete genomic profile...

journal_title：Translational oncology

authors： Souza-Santos PT,Soares Lima SC,Nicolau-Neto P,Boroni M,Meireles Da Costa N,Brewer L,Menezes AN,Furtado C,Moreira MAM,Seuanez HN,de Almeida Simão T,Ribeiro Pinto LF

更新日期：2018-12-01 00:00:00

abstract：:Oral mucositis (OM) is a serious side effect of cancer chemotherapy. The pathobiology of oral mucositis remains incompletely understood due to lack of appropriate models which recapitulate the human condition. Existing rodent models are intraperitoneal and require radiation, chemical or mechanical injury to the chemot...

journal_title：Translational oncology

authors： Bertolini M,Sobue T,Thompson A,Dongari-Bagtzoglou A

更新日期：2017-08-01 00:00:00

abstract：:Bone is one of the most frequent metastatic sites in non-small cell lung cancer (NSCLC). Osimertinib, with and without bevacizumab (BV), has been investigated on advanced NSCLC patients. However, the efficacy of those drugs on bone metastasis of NSCLC has not been investigated. The human NSCLC cell line H1975, express...

journal_title：Translational oncology

authors： Higuchi T,Sugisawa N,Park JH,Sun Y,Zhu G,Yamamoto N,Hayashi K,Kimura H,Miwa S,Igarashi K,Bouvet M,Singh SR,Tsuchiya H,Hoffman RM

更新日期：2020-10-01 00:00:00