Abstract:
:Bone is one of the most frequent metastatic sites in non-small cell lung cancer (NSCLC). Osimertinib, with and without bevacizumab (BV), has been investigated on advanced NSCLC patients. However, the efficacy of those drugs on bone metastasis of NSCLC has not been investigated. The human NSCLC cell line H1975, expressing red fluorescent protein (H1975-RFP), was orthotopically injected to the tibia of nude mice. The established mouse models were randomized into four treatment groups of nine mice: Control; BV alone; osimertinib alone; osimertinib and BV combination. The tumors were observed by non-invasive fluorescence imaging. Osimertinib, with or without BV, caused tumor regression, increased mouse survival, and bone remodeling in the bone metastasis models. These results suggest that osimertinib is a promising clinical option for NSCLS patients with bone metastasis.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Higuchi T,Sugisawa N,Park JH,Sun Y,Zhu G,Yamamoto N,Hayashi K,Kimura H,Miwa S,Igarashi K,Bouvet M,Singh SR,Tsuchiya H,Hoffman RMdoi
10.1016/j.tranon.2020.100826subject
Has Abstractpub_date
2020-10-01 00:00:00pages
100826issue
10issn
1936-5233pii
S1936-5233(20)30318-1journal_volume
13pub_type
杂志文章abstract::Accumulating evidence indicates that CDK2 promotes hyperproliferation and is associated to poor prognosis in multiple cancer cells. However, the physiological role of CDK2 in GBM and the biological mechanism still remains unclear. In this study, we identified that CDK2 expression was significantly enriched in GBM tumo...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.08.007
更新日期:2016-12-01 00:00:00
abstract::Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most importan...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2016.07.002
更新日期:2016-10-01 00:00:00
abstract::Therapy-induced senescence (TIS), a cytostatic stress response in cancer cells, is induced inefficiently by current anticancer agents and radiation. The mechanisms that mediate TIS in cancer cells are not well defined. Herein, we characterize a robust senescence response both in vitro and in vivo to the quinone diaziq...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.12181
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:To determine the accuracy of a handheld ultrasound-guided optoacoustic tomography (US-OT) probe developed for human deep-tissue imaging in ex vivo assessment of tumor margins postlumpectomy. METHODS:A custom-built two-dimensional (2D) US-OT-handheld probe was used to scan 15 lumpectomy breast specimens. Optoac...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.11.005
更新日期:2020-02-01 00:00:00
abstract::High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a "nanoimmunotherapy," which combines photothermal therapy (PTT) using CpG oligodeoxynucl...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100823
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:The present study compared the effect of combination therapy using human apolipoprotein(a) kringle V (rhLK8) to conventional chemotherapy with paclitaxel for human ovarian carcinoma producing high or low levels of vascular endothelial growth factor (VEGF). MATERIALS AND METHODS:Human ovarian carcinoma cel...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.04.005
更新日期:2014-06-17 00:00:00
abstract::Heat shock proteins (HSPs) are a large family of molecular chaperones aberrantly expressed in cancer. The expression of HSPs in tumor cells has been shown to be implicated in the regulation of apoptosis, immune responses, angiogenesis and metastasis. Given that extracellular vesicles (EVs) can serve as potential sourc...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2020.100995
更新日期:2021-02-01 00:00:00
abstract:OBJECT:Thyroid cancer represents the most frequent malignancy of the endocrine system with an increasing incidence worldwide. Novel imaging techniques are able to further characterize tumors and even predict histopathology features. Texture analysis is an emergent imaging technique to extract extensive data from an rad...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.09.003
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To evaluate whether contrast enhancement on cone-beam breast-CT (CBBCT) could aid in discrimination of breast cancer subtypes and receptor status. METHODS:This study included female patients age >40 years with malignant breast lesions identified on contrast-enhanced CBBCT. Contrast enhancement of malignant bre...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.08.010
更新日期:2017-12-01 00:00:00
abstract::The mechanism of action of arsenic trioxide (ATO) has been shown to be complex, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects. Among these mechanisms of action, ATO has been shown to cause acute vascular shutdown and massive tumor necrosis in a murine solid tumor m...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.12322
更新日期:2013-02-01 00:00:00
abstract::CRC is a heterogeneous disease due to global molecular alterations, including mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H). Immunotherapy has achieved durable responses in a subset of patients with dMMR-MSI-H metastatic CRC. It has been showed that Loss of ZG16 is highly associated with...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.101003
更新日期:2021-02-01 00:00:00
abstract::CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2015.08.003
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.09.002
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND STUDY AIM:To develop a molecular imaging endoscopic system that eliminates tissue autofluorescence and distinguishes multiple fluorescent markers specifically on the cancerous lesions. METHODS:Newly developed multi-spectral fluorescence endoscope device has the potential to eliminate signal interference...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.10.006
更新日期:2019-02-01 00:00:00
abstract::Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active par...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2017.12.009
更新日期:2018-04-01 00:00:00
abstract::Glioblastoma (GBM) with oligodendroglioma component (GBMO) is a newly described GBM subtype in the 2007 World Health Organization classification. However, its biological and genetic characteristics are largely unknown. We investigated the clinicopathological and molecular features of 34 GBMOs and compared the survival...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.10.002
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To prospectively investigate ultrasound-guided diffuse optical tomography (US-guided DOT) in predicting breast cancer response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS:Eighty-eight breast cancer patients, with a total of 93 lesions, were included in our study. Pre- and post-last chemotherapy, s...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.10.011
更新日期:2018-02-01 00:00:00
abstract::Tumor cells grow in nutrient- and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering their metabolic pathways. This adaptation process commonly results in a tumor phenotype that displays a high rate of aerobic glycolysis and aggressive tumor characteristics. The glucose regulat...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.11319
更新日期:2012-06-01 00:00:00
abstract::Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100785
更新日期:2020-08-01 00:00:00
abstract:OBJECT:Preoperative knowledge of meningioma grade is essential for planning treatment and surgery. The purpose of this study was to investigate the diagnostic value of MRI texture and shape analysis in grading meningiomas. METHODS:A surgical database was reviewed to identify meningioma patients who had undergone tumor...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.04.006
更新日期:2017-08-01 00:00:00
abstract::Adequately selecting a therapeutic approach for bladder cancer depends on accurate grading and staging. Substantial inaccuracy of clinical staging with bimanual examination, cystoscopy, and transurethral resection of bladder tumor has facilitated the increasing utility of magnetic resonance imaging to evaluate bladder...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2015.04.003
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis. METHODS:A retrospective, multicenter study on 80 surgical samples from mCRC patients treated in first line with bevaciz...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.01.001
更新日期:2020-03-01 00:00:00
abstract::Despite the weak clinical efficacy of TRAIL death receptor agonists, a search is under way for new agents that more efficiently activate apoptotic signaling. We previously created a TRAIL DR5-selective variant DR5-B without affinity for the DR4, DcR1, DcR2, and OPG receptors and increased proapoptotic activity in tumo...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100762
更新日期:2020-04-01 00:00:00
abstract::The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were e...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.06.002
更新日期:2016-08-01 00:00:00
abstract::Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present with advanced disease, many such patients do well. We have attempted identification of biologically indolent tumors within HR+HER2- tumors based on gene expression using...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.04.011
更新日期:2017-08-01 00:00:00
abstract::Acquired uniparental disomy (aUPD) regions pinpoint homozygousity and monoallelic expressed genes. We analyzed The Cancer Genome Atlas single-nucleotide polymorphism arrays and expression data from oral cavity, oropharynx, and larynx cancers to identify frequency of aUPD in each tumor type and association of aUPD regi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100763
更新日期:2020-05-01 00:00:00
abstract::Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is targeted in the clinic, with successful and remarkable results. The PD-1/PD-Ls axis was shown to be one of the most relevant immunosu...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2020.100811
更新日期:2020-10-01 00:00:00
abstract::The phosphoinositide 3-kinase (PI3K) signaling pathway is one of the most altered in cancer, leading to a range of cellular responses including enhanced proliferation, survival, and metabolism, and is thus an attractive target for anticancer drug development. Stimulation of the PI3K pathway can be initiated by alterat...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.11118
更新日期:2011-08-01 00:00:00
abstract::Measuring total cell-free DNA (cfDNA) or cancer-specific mutations herein has presented as new tools in aiding the treatment of cancer patients. Studies show that total cfDNA bears prognostic value in metastatic colorectal cancer (mCRC) and that measuring cancer-specific mutations could supplement biopsies. However, l...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.07.013
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Epidermal growth factor receptor (EGFR) mutation status is crucial in treatment selection for non-small cell lung cancer (NSCLC) patients; however, the detection materials' availability remains challenging in clinical practice. In this study, we collected surgical resection tissues, lymph node biopsy, and cy...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.10.008
更新日期:2014-12-01 00:00:00