Abstract:
PURPOSE:To evaluate whether contrast enhancement on cone-beam breast-CT (CBBCT) could aid in discrimination of breast cancer subtypes and receptor status. METHODS:This study included female patients age >40 years with malignant breast lesions identified on contrast-enhanced CBBCT. Contrast enhancement of malignant breast lesions was standardized to breast fat tissue contrast enhancement. All breast lesions were approved via image-guided biopsy or surgery. Immunohistochemical staining was conducted for expression of estrogen (ER), progesterone (PR), human epidermal growth factor receptor-2 (HER2) and Ki-67 index. Contrast enhancement of breast lesions was correlated with immunohistochemical breast cancer subtypes (Luminal A, Luminal B, HER2 positive, triple negative), receptor status and Ki-67 expression. RESULTS:Highest contrast enhancement was seen for Luminal A lesions (93.6 HU) compared to Luminal B lesions (47.6 HU, P=.002), HER2 positive lesions (83.5 HU, P=.359) and triple negative lesions (45.3 HU, P=.005). Contrast enhancement of HER2 positive lesions was higher than Luminal B lesions (P=.044) and triple negative lesions (P=.039). No significant difference was evident between Luminal B and triple negative lesions (P=.439). Lesions with high Ki-67 index showed lower contrast enhancement than those with low Ki-67 index (P=.0043). ER, PR and HER2 positive lesions demonstrated higher contrast enhancement than their receptor negative counterparts, although differences did not reach statistical significance (P=.1714; P=.3603; P=.2166). CONCLUSIONS:Contrast enhancement of malignant breast lesions on CBBCT correlates with immunohistochemical subtype and proliferative potential. Thereby, CBBCT might aid in selecting individualized treatment strategies for breast cancer patients based on pre-operative imaging.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Uhlig J,Fischer U,von Fintel E,Stahnke V,Perske C,Lotz J,Wienbeck Sdoi
10.1016/j.tranon.2017.08.010subject
Has Abstractpub_date
2017-12-01 00:00:00pages
904-910issue
6issn
1936-5233pii
S1936-5233(17)30295-4journal_volume
10pub_type
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100826
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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doi:10.1016/j.tranon.2020.100762
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100747
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.08217
更新日期:2009-03-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.02.021
更新日期:2018-06-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.07.005
更新日期:2014-10-24 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.08.005
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doi:10.1016/j.tranon.2020.100976
更新日期:2021-01-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
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journal_title:Translational oncology
pub_type: 杂志文章,评审
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.09.003
更新日期:2017-12-01 00:00:00