Abstract:
:The purpose of this study was to investigate the usefulness of photoacoustic imaging (PAI) for spatiotemporal mapping of tumor hemodynamics in a rabbit model of head and neck carcinoma. Shope cottontail rabbit papilloma virus associated VX2 carcinomas were established in adult male New Zealand White rabbits (n = 9) by surgical transplantation of tumor tissue in the neck. Noninvasive PAI with co-registered ultrasound (US) was performed to longitudinally monitor tumor growth, oxygen saturation (%sO2), and hemoglobin concentration (HbT). PAI findings were validated with Doppler sonography measures of percent vascularity (PV). Differences in tumor volumes, %sO2, HbT, and PV values over time were analyzed using repeated-measures analysis of variance with multiple comparisons. Two-tailed Spearman correlation analysis was performed to determine the correlation coefficient (r) for comparisons between %sO2, HbT, and tumor volume. US revealed a significant (P < .0001) increase in tumor volume over the 3-week period from 549 ± 260 mm3 on day 7 to 5055 ± 438 mm3 at 21 days postimplantation. Consistent with this aggressive tumor growth, PAI revealed a significant (P < .05) and progressive reduction in %sO2 from day 7 (37.6 ± 7.4%) to day 21 (9.5 ± 2.1%). Corresponding Doppler images also showed a decrease in PV over time. PAI revealed considerable intratumoral spatial heterogeneity with the tumor rim showing two- to three-fold higher %sO2 values compared to the core. Noninvasive PAI based on endogenous contrast provides a label-free method for longitudinal monitoring of temporal changes and spatial heterogeneity in thick head and neck tumors.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Rich LJ,Sexton S,Curtin L,Seshadri Mdoi
10.1016/j.tranon.2017.08.004subject
Has Abstractpub_date
2017-10-01 00:00:00pages
839-845issue
5issn
1936-5233pii
S1936-5233(17)30231-0journal_volume
10pub_type
杂志文章abstract:BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.04.016
更新日期:2014-08-01 00:00:00
abstract::Multiple myeloma (MM) is a very heterogeneous disease, characterized by multiple cytogenetic aberrations on plasma cells (PC) that have been traditionally used to predict the outcome of the disease. A mayor issue on the analysis of PC is the sometimes low infiltration of these cells in the bone marrow that hampers cyt...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.02.021
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:In contrast to other studies, our previous study showed that adding induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) significantly worsened the prognosis of patients with stage II nasopharyngeal carcinoma (NPC). However, the population used was small; therefore, there is an urgent need to conf...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.08.007
更新日期:2020-01-01 00:00:00
abstract::Receptor tyrosine kinases (RTKs) are membrane receptors that play a vital role in various biological processes, in particular, cell survival, cell proliferation, and cell differentiation. These cellular processes are composed of multitiered signaling cascades of kinases starting from ligand binding to extracellular do...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.08.005
更新日期:2017-10-01 00:00:00
abstract::Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on pr...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2016.05.004
更新日期:2016-08-01 00:00:00
abstract::Wnt signaling has been implicated as a driver of prostate cancer-related osteoblast differentiation, and previous studies have linked modifications in Wnt function with the induction of tumor metastasis. A unique aspect of prostate cancer bone metastases in mouse models is their relative predilection to the hindlimb (...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100747
更新日期:2020-04-01 00:00:00
abstract::We investigated programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer (HGSOC) and its relationship to tumor infiltrating lymphocytes (TIL) and prognosis. Formalin fixed paraffin embedded (FFPE) samples of 94 HGSOC cases were included in the study. Immuno...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100994
更新日期:2021-02-01 00:00:00
abstract::A targeted and timely offered treatment can be a benefitting tool for patients with acute promyelocytic leukemia (APML). Current round of study made use of potential morphological and immature fraction-related parameters (cell population data) generated during complete blood cell count (CBC), through artificial neural...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.09.009
更新日期:2020-01-01 00:00:00
abstract::CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2015.08.003
更新日期:2015-10-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) are potentially malignancies that can occur anywhere in the digestive tract. Tyrosine kinase inhibitors (TKIs) such as imatinib have proven effective since the discovery of KIT and PDGFRA. The current version of NCNN, ESMO and EURACAN guidelines recognized that the three main pr...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2020.100812
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:An increase in detection of early-stage asymptomatic lung tumors could increase the overall survival rate of lung cancer patients. A new approach to cancer (pre-)screening focusses on detecting field cancerization instead of the tumor itself. The objective of this study was to investigate the use of optica...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.07.018
更新日期:2019-12-01 00:00:00
abstract::Peritoneal carcinomatosis (PC) of colorectal origin is associated with a poor prognosis. However, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is available for a selected group of PC patients, which significantly increases overall survival rates up to 30%. As a consequence, there is su...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.10220
更新日期:2011-04-01 00:00:00
abstract::Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is targeted in the clinic, with successful and remarkable results. The PD-1/PD-Ls axis was shown to be one of the most relevant immunosu...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2020.100811
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:This study investigated the feasibility of using malignant pleural effusion (MPE) supernatant and paired cell blocks (precipitate) for gene profiling in patients with non-small cell lung cancer (NSCLC) using next-generation sequencing (NGS) technique. METHODS:Stage IV non-squamous NSCLC patients with MPE wer...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100784
更新日期:2020-08-01 00:00:00
abstract::Fatty liver disease (hepatosteatosis) is a common early pathology in alcohol-dependent and obese patients. Fatty acid binding protein-4 (FABP4) is normally expressed in adipocytes and macrophages and functions as a regulator of intracellular lipid movement/storage. This study sought to investigate hepatic FABP4 expres...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100975
更新日期:2021-01-01 00:00:00
abstract::Bone is one of the most frequent metastatic sites in non-small cell lung cancer (NSCLC). Osimertinib, with and without bevacizumab (BV), has been investigated on advanced NSCLC patients. However, the efficacy of those drugs on bone metastasis of NSCLC has not been investigated. The human NSCLC cell line H1975, express...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100826
更新日期:2020-10-01 00:00:00
abstract::Migration is a complex process that, besides its various physiological functions in embryogenesis and adult tissues, plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the involvement and collaboration of Akt, focal adhesion kinase (FAK), and Src kinases in migration and invasivene...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.09160
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV) is one of the most prominent risk factors for hepatocellular carcinoma (HCC) development and virus-mediated cases represents more than 80% of HCC in East Asia, where it is endemic. Currently, the HBV status of pathological HCC is not fully clarified, especially by comparison to nontum...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.05.006
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Oral squamous cell carcinoma (OSCC) remains a challenging cancer to treat despite all the advances of the last 50 years. Kallikrein 5 (KLK5) is among the serine proteases implicated in OSCC development. However, whether the activity of KLK5 promotes carcinogenesis is still controversial. Moreover, knowledge ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100970
更新日期:2021-01-01 00:00:00
abstract::Therapy-induced senescence (TIS), a cytostatic stress response in cancer cells, is induced inefficiently by current anticancer agents and radiation. The mechanisms that mediate TIS in cancer cells are not well defined. Herein, we characterize a robust senescence response both in vitro and in vivo to the quinone diaziq...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.12181
更新日期:2012-08-01 00:00:00
abstract::Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present with advanced disease, many such patients do well. We have attempted identification of biologically indolent tumors within HR+HER2- tumors based on gene expression using...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.04.011
更新日期:2017-08-01 00:00:00
abstract::Studies investigating dynamic susceptibility contrast magnetic resonance imaging-determined relative cerebral blood volume (rCBV) maps as a metric of treatment response assessment have generated conflicting results. We evaluated the potential of various analytical techniques to predict survival of patients with glioma...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.13670
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD:Various bioinformatics tools were u...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100976
更新日期:2021-01-01 00:00:00
abstract::Chronic myelogenous leukemia (CML) can be controlled for years with the tyrosine kinase inhibitor imatinib but because imatinib poorly penetrates the blood-brain barrier (BBB), on occasion, the CML clone will thrive and evolve to an accelerated phase in the resulting imatinib sanctuary within the central nervous syste...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.09280
更新日期:2010-02-01 00:00:00
abstract:INTRODUCTION:Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS:The association of AR mRNA expression with clinicopathological features was r...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.01.005
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:To prospectively investigate ultrasound-guided diffuse optical tomography (US-guided DOT) in predicting breast cancer response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS:Eighty-eight breast cancer patients, with a total of 93 lesions, were included in our study. Pre- and post-last chemotherapy, s...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.10.011
更新日期:2018-02-01 00:00:00
abstract::Chemo-resistance is an important barrier to effective treatment of ovarian cancer. Poly (ADP-ribose) polymerase (PARP) inhibitors are currently promising targeted drugs used to treat BRCA-mutant ovarian cancer. Ovarian cancer patients with BRCA 1/2 mutations appear to benefit better from PARP inhibitors and chemothera...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100987
更新日期:2021-02-01 00:00:00
abstract::Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg, has been in clinical trials for treating ASS1-negative tumors. ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.12.003
更新日期:2020-02-01 00:00:00
abstract::This study aimed to identify the biological processes associated with long-term survival in high-grade serous ovarian cancer (HGSOC). HGSOC cases obtained from The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) database were divided into long-term survivors (LTS) and normal-term survivors (NTS) based on survival cutoffs...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100885
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis. METHODS:A retrospective, multicenter study on 80 surgical samples from mCRC patients treated in first line with bevaciz...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.01.001
更新日期:2020-03-01 00:00:00