Abstract:
:CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistochemistry (IHC) revealed that CAP2 was markedly up-regulated in 77.3% of HCC cases. High CAP2 expression, defined by the median score of IHC, was present in 53.3% of the patients. Kaplan-Meier analysis indicated that high CAP2 expression was associated with poor overall survival (P < .0001), disease-free survival (P = .013) and recurrence probability (P = .004) in a training cohort of 312 HCC patients. The prognostic implication of CAP2 in HCC was further confirmed in a validation cohort of 208 HCC patients and by stratified survival analysis. Multiple Cox regression analysis indicated CAP2 as an independent predictor for overall survival (hazard ratio (HR) = 1.615, 95% confidence interval: 1.345-1.938, P < .001). Collectively, we conclude that CAP2 is increased in HCC and is a novel unfavorable biomarker for prognostic prediction for patients with this deadly disease.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Fu J,Li M,Wu DC,Liu LL,Chen SL,Yun JPdoi
10.1016/j.tranon.2015.08.003subject
Has Abstractpub_date
2015-10-01 00:00:00pages
400-406issue
5issn
1936-5233pii
S1936-5233(15)00070-4journal_volume
8pub_type
杂志文章abstract::SPARC up-regulation is a poor prognostic factor in head and neck cancer. It was hypothesized that because of a SPARC-albumin interaction, tumoral SPARC facilitates the accumulation of albumin in the tumor and increases the effectiveness of albumin-bound paclitaxel (nab-paclitaxel). This hypothesis was tested by correl...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.09109
更新日期:2009-05-01 00:00:00
abstract::Elderly patients with esophageal carcinoma may benefit from concurrent chemoradiotherapy (CCRT). However, the optimal concurrent chemotherapy regimen has not been determined. The aim of our study was to assess the efficiency and tolerance of treatment with a concurrent 5-fluorouracil (5-Fu)-based regimen and a taxane-...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.12.008
更新日期:2020-03-01 00:00:00
abstract::The presence of circulating tumor cells (CTCs) in the blood of cancer patients may guide the use of therapy. We investigated how to evaluate a reduction in the number of CTCs after administration of therapy. CTCs were enumerated with the CellSearch system in 111 metastatic breast and 185 metastatic prostate cancer pat...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.12247
更新日期:2012-12-01 00:00:00
abstract:OBJECT:Thyroid cancer represents the most frequent malignancy of the endocrine system with an increasing incidence worldwide. Novel imaging techniques are able to further characterize tumors and even predict histopathology features. Texture analysis is an emergent imaging technique to extract extensive data from an rad...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.09.003
更新日期:2017-12-01 00:00:00
abstract:OBJECT:Our purpose was to provide data regarding relationships between different imaging and histopathological parameters in HNSCC. METHODS:MEDLINE library was screened for associations between different imaging parameters and histopathological features in HNSCC up to December 2017. Only papers containing correlation ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.02.004
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Angiogenesis plays an important role in pancreas cancer pathobiology. Pancreatic tumor cells secrete vascular endothelial growth factor (VEGF), activating endothelial cell protein kinase C beta (PKCbeta) that phosphorylates GSK3beta to suppress apoptosis and promote endothelial cell proliferation and microvesse...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.08151
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The aim of this study is to summarize and quantify the current evidence on the therapeutic efficacy of laparoscopic radical nephrectomy (LRN) compared with open radical nephrectomy (ORN) in patients with renal cell carcinoma (RCC) in a meta-analysis. METHODS:Data were collected by searching Pubmed, Embase, ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.03.004
更新日期:2017-08-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR) exon 19 deletion (E19del) is the most common activating mutation in advanced non-small cell lung cancer (NSCLC) and associates with the sensitivity of EGFR tyrosine kinase inhibitors (TKIs) treatment. However, not all mutant patterns of E19del have been well studied for the limi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100791
更新日期:2020-09-01 00:00:00
abstract::Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.07.002
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Breast cancer is now recognized as a clinically heterogeneous disease with a wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether epidemiological and clinicopathologic features are associated with the histological tumor grade of breast carcinomas in Wester...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.06.005
更新日期:2018-08-01 00:00:00
abstract::Polo-like kinase 1 (PLK1) plays an important role in the initiation, maintenance, and completion of mitosis. Dysfunction of PLK1 may promote cancerous transformation and drive its progression. PLK1 overexpression has been found in a variety of human cancers and was associated with poor prognoses in cancers. Many studi...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2016.10.003
更新日期:2017-02-01 00:00:00
abstract::Distinguishing synchronous and metachronous primary lung adenocarcinomas from adenocarcinomas with intrapulmonary metastasis is essential for optimal patient management. In this study, multiple lung adenocarcinomas occurring in the same patient were evaluated using comprehensive histopathologic evaluation supplemented...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.02.009
更新日期:2017-06-01 00:00:00
abstract::CRC is a heterogeneous disease due to global molecular alterations, including mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H). Immunotherapy has achieved durable responses in a subset of patients with dMMR-MSI-H metastatic CRC. It has been showed that Loss of ZG16 is highly associated with...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.101003
更新日期:2021-02-01 00:00:00
abstract::Glioblastoma (GBM) with oligodendroglioma component (GBMO) is a newly described GBM subtype in the 2007 World Health Organization classification. However, its biological and genetic characteristics are largely unknown. We investigated the clinicopathological and molecular features of 34 GBMOs and compared the survival...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.10.002
更新日期:2014-12-01 00:00:00
abstract::We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.10286
更新日期:2011-06-01 00:00:00
abstract::Acquired uniparental disomy (aUPD) regions pinpoint homozygousity and monoallelic expressed genes. We analyzed The Cancer Genome Atlas single-nucleotide polymorphism arrays and expression data from oral cavity, oropharynx, and larynx cancers to identify frequency of aUPD in each tumor type and association of aUPD regi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100763
更新日期:2020-05-01 00:00:00
abstract::Adequately selecting a therapeutic approach for bladder cancer depends on accurate grading and staging. Substantial inaccuracy of clinical staging with bimanual examination, cystoscopy, and transurethral resection of bladder tumor has facilitated the increasing utility of magnetic resonance imaging to evaluate bladder...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2015.04.003
更新日期:2015-06-01 00:00:00
abstract::We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the gingivobuccal complex (GBC). We find that the genomic and transcriptomic profiles of leukoplakia resemble those observed in later stages of OSCC and ...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.03.008
更新日期:2017-06-01 00:00:00
abstract::Studies investigating dynamic susceptibility contrast magnetic resonance imaging-determined relative cerebral blood volume (rCBV) maps as a metric of treatment response assessment have generated conflicting results. We evaluated the potential of various analytical techniques to predict survival of patients with glioma...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.13670
更新日期:2013-12-01 00:00:00
abstract:INTRODUCTION:The present study compared the effect of combination therapy using human apolipoprotein(a) kringle V (rhLK8) to conventional chemotherapy with paclitaxel for human ovarian carcinoma producing high or low levels of vascular endothelial growth factor (VEGF). MATERIALS AND METHODS:Human ovarian carcinoma cel...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2014.04.005
更新日期:2014-06-17 00:00:00
abstract::Mannosyl (alpha-1,6-)-Glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5) is exclusively expressed in gastric carcinoma, and plays an essential role in cancer progression, but no targeted drug is available so far. The potential anti-cancer effect of Hydrogen Sulfide (H2S), has not been widely recognized. It...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.04.008
更新日期:2018-08-01 00:00:00
abstract:INTRODUCTION:An increase in detection of early-stage asymptomatic lung tumors could increase the overall survival rate of lung cancer patients. A new approach to cancer (pre-)screening focusses on detecting field cancerization instead of the tumor itself. The objective of this study was to investigate the use of optica...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.07.018
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Mechanisms related the crosstalk between adipocytes and colon cancer cells are still not clear. We hypothesize that molecules and adipocytokines generated from the adipose tissue of obese individuals accentuate the effect on the metabolic reprogramming in colon cancer cells, i.e. induce disarray in energy metab...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.07.010
更新日期:2019-11-01 00:00:00
abstract::Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most importan...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2016.07.002
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis. METHODS:A retrospective, multicenter study on 80 surgical samples from mCRC patients treated in first line with bevaciz...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.01.001
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:Primary hepatic lymphoma (PHL) is a rare malignancy with lesions confined to the liver. It is characterized by a large number of monomorphic, medium-sized lymphocytic infiltrates in the hepatic sinusoid. Due to the rarity of this malignancy, our current understanding of PHL is limited. METHODS:We collected i...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100931
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) in an attempt to identify potential core genes in the pathogenesis of this tumor. METHODS:Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and fi...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.12.006
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2016.04.006
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS:Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-ech...
journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2015.03.002
更新日期:2015-06-01 00:00:00
abstract::Breast cancer is the most common malignancy in women worldwide, with a developmental process spanning decades. The malignant cells recruit a variety of cells including fibroblasts, endothelial cells, immune cells, and adipocytes, creating the tumor microenvironment. The tumor microenvironment has emerged as active par...
journal_title:Translational oncology
pub_type: 杂志文章,评审
doi:10.1016/j.tranon.2017.12.009
更新日期:2018-04-01 00:00:00