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Interpretation of changes in circulating tumor cell counts.

Abstract：

:The presence of circulating tumor cells (CTCs) in the blood of cancer patients may guide the use of therapy. We investigated how to evaluate a reduction in the number of CTCs after administration of therapy. CTCs were enumerated with the CellSearch system in 111 metastatic breast and 185 metastatic prostate cancer patients before start of a new line of chemotherapy and after initiation of therapy. Different means to express changes in CTC counts were evaluated with respect to overall survival (OS). A static CTC cutoff is the best method to determine whether a therapy is effective. This is exemplified by the highest Cox hazard ratio of 2.1 for OS; three methods to express relative differences performed worse. A lookup table is provided from which the significance of a change in CTCs can be derived. The aim of therapy should be the elimination of all CTCs. A period of 10 to 12 weeks of therapy is needed to reach the treatment effect on CTCs.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Coumans FA,Ligthart ST,Terstappen LW

doi

10.1593/tlo.12247

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

486-91

issue

6

issn

1936-5233

journal_volume

5

pub_type

杂志文章

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