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Programmed cell death-ligand 2: A neglected but important target in the immune response to cancer?

Abstract：

:Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is targeted in the clinic, with successful and remarkable results. The PD-1/PD-Ls axis was shown to be one of the most relevant immunosuppressive pathways in the immune microenvironment, and blocking this interaction gave rise to an impressive clinical benefit in a broad variety of solid and hematological malignancies. Although PD-L2 has been historically considered a minor ligand, it binds to PD-1 with a two- to six-fold higher affinity as compared to PD-L1. PD-L2 can be expressed by immune, stromal, or tumor cells. The aims of this narrative review are to summarize PD-L2 biology in the physiological responses of the immune system and its role, expression, and clinical significance in cancer.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Solinas C,Aiello M,Rozali E,Lambertini M,Willard-Gallo K,Migliori E

doi

10.1016/j.tranon.2020.100811

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

100811

issue

10

issn

1936-5233

pii

S1936-5233(20)30303-X

journal_volume

13

pub_type

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