当前位置： SCI文献检索 > Translational Oncology期刊下所有文献 > Inhibitor of DNA Binding 2 Inhibits Epithelial-Mesenchymal Transition via Up-Regulation of Notch3 in Breast Cancer.

Inhibitor of DNA Binding 2 Inhibits Epithelial-Mesenchymal Transition via Up-Regulation of Notch3 in Breast Cancer.

Abstract：

:Breast cancer is the second leading cause of cancer death in women worldwide. Incurable metastatic breast disease presents a major clinical challenge and is the main cause of breast cancer-related death. The epithelial-mesenchymal transition (EMT) is a critical early promoter of metastasis. In the present study, we identified a novel role for the inhibitor of DNA binding 2 (Id2), a member of the basic helix-loop-helix protein family, during the EMT of breast cancer. Expression of Id2 was positively correlated with Notch3 in breast cancer cells. Low expression of Id2 and Notch3 was associated with worse distant metastasis-free survival in breast cancer patients. The present study revealed that Id2 activated Notch3 expression by blocking E2A binding to an E-box motif in the Notch3 promoter. The Id2-mediated up-regulation of Notch3 expression at both the mRNA and protein levels resulted in an attenuated EMT, which was associated with reduced motility and matrix invasion of ER-positive and -negative human breast cancer cells and the emergence of E-cadherin expression and reduction in the mesenchymal marker vimentin in triple-negative breast cancer cells. In summary, our findings identified Id2 as a suppressor of the EMT and positive transcriptional regulator of Notch3 in breast cancer. Id2 and Notch3 may serve as novel prognostic markers in a subpopulation of ER-positive breast cancer patients.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Wen XF,Chen M,Wu Y,Chen MN,Glogowska A,Klonisch T,Zhang GJ

doi

10.1016/j.tranon.2018.07.015

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1259-1270

issue

5

issn

1936-5233

pii

S1936-5233(18)30166-9

journal_volume

11

pub_type

杂志文章

相关文献

Translational Oncology文献大全
  • Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.

    abstract：OBJECTIVE:The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) in an attempt to identify potential core genes in the pathogenesis of this tumor. METHODS:Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and fi...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2016.12.006

    authors： Zhu J,Ye J,Zhang L,Xia L,Hu H,Jiang H,Wan Z,Sheng F,Ma Y,Li W,Qian J,Luo C

    更新日期：2017-04-01 00:00:00

  • Absent in melanoma 2-mediating M1 macrophages facilitate tumor rejection in renal carcinoma.

    abstract：:Absent in melanoma 2 (AIM2) as an immune regulator for the regulation of tumor-associated macrophages (TAMs) function is unclear in tumor development. Here, the AIM2 function was investigated in TAMs-mediated malignant behaviors of renal carcinoma. The correlation analysis result showed that the AIM2 expression in TAM...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2021.101018

    authors： Chai D,Zhang Z,Shi SY,Qiu D,Zhang C,Wang G,Fang L,Li H,Tian H,Li H,Zheng J

    更新日期：2021-01-22 00:00:00

  • Prognosis of primary hepatic lymphoma: A US population-based analysis.

    abstract：OBJECTIVE:Primary hepatic lymphoma (PHL) is a rare malignancy with lesions confined to the liver. It is characterized by a large number of monomorphic, medium-sized lymphocytic infiltrates in the hepatic sinusoid. Due to the rarity of this malignancy, our current understanding of PHL is limited. METHODS:We collected i...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100931

    authors： Qiu MJ,Fang XF,Huang ZZ,Li QT,Wang MM,Jiang X,Xiong ZF,Yang SL

    更新日期：2021-01-01 00:00:00

  • Impact of perfusion map analysis on early survival prediction accuracy in glioma patients.

    abstract：:Studies investigating dynamic susceptibility contrast magnetic resonance imaging-determined relative cerebral blood volume (rCBV) maps as a metric of treatment response assessment have generated conflicting results. We evaluated the potential of various analytical techniques to predict survival of patients with glioma...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13670

    authors： Lemasson B,Chenevert TL,Lawrence TS,Tsien C,Sundgren PC,Meyer CR,Junck L,Boes J,Galbán S,Johnson TD,Rehemtulla A,Ross BD,Galbán CJ

    更新日期：2013-12-01 00:00:00

  • Preoperative C-Reactive Protein/Albumin Ratio Predicts Prognosis of Patients after Curative Resection for Gastric Cancer.

    abstract：BACKGROUND:An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory res...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.06.006

    authors： Liu X,Sun X,Liu J,Kong P,Chen S,Zhan Y,Xu D

    更新日期：2015-08-01 00:00:00

  • Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma.

    abstract：:The accumulation of lipids is a hallmark of human clear cell renal cell carcinoma (ccRCC). Advanced ccRCC tumors frequently show increased lipid biosynthesis, but the regulation of lipid metabolism in early stage ccRCC tumors has not been studied. Here, we performed combined transcriptomics and metabolomics on a previ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.10.015

    authors： van der Mijn JC,Fu L,Khani F,Zhang T,Molina AM,Barbieri CE,Chen Q,Gross SS,Gudas LJ,Nanus DM

    更新日期：2020-02-01 00:00:00

  • Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma.

    abstract：:Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100785

    authors： Lippmann J,Petri K,Fulda S,Liese J

    更新日期：2020-08-01 00:00:00

  • Protein anabolism is key to long-term survival in high-grade serous ovarian cancer.

    abstract：:This study aimed to identify the biological processes associated with long-term survival in high-grade serous ovarian cancer (HGSOC). HGSOC cases obtained from The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) database were divided into long-term survivors (LTS) and normal-term survivors (NTS) based on survival cutoffs...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100885

    authors： Wang L,Sun T,Li S,Zhang Z,Jia J,Shan B

    更新日期：2021-01-01 00:00:00

  • Tumor Site-Dependent Transport Properties Determine Nanotherapeutics Delivery and Its Efficacy.

    abstract：:Insufficient delivery of systemically administered anticancer drugs to tumors can compromise therapeutic efficacy and develop drug delivery-based therapeutic resistance. Nanotherapeutics such as PEGylated liposomal doxorubicin (PLD) are designed to preferentially accumulate in tumors utilizing enhanced permeation and ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.05.011

    authors： Kai M,Ziemys A,Liu YT,Kojic M,Ferrari M,Yokoi K

    更新日期：2019-09-01 00:00:00

  • Spatiotemporal Optoacoustic Mapping of Tumor Hemodynamics in a Clinically Relevant Orthotopic Rabbit Model of Head and Neck Cancer.

    abstract：:The purpose of this study was to investigate the usefulness of photoacoustic imaging (PAI) for spatiotemporal mapping of tumor hemodynamics in a rabbit model of head and neck carcinoma. Shope cottontail rabbit papilloma virus associated VX2 carcinomas were established in adult male New Zealand White rabbits (n = 9) by...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.08.004

    authors： Rich LJ,Sexton S,Curtin L,Seshadri M

    更新日期：2017-10-01 00:00:00

  • Wnt Signaling Drives Prostate Cancer Bone Metastatic Tropism and Invasion.

    abstract：:Wnt signaling has been implicated as a driver of prostate cancer-related osteoblast differentiation, and previous studies have linked modifications in Wnt function with the induction of tumor metastasis. A unique aspect of prostate cancer bone metastases in mouse models is their relative predilection to the hindlimb (...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100747

    authors： Wang Y,Singhal U,Qiao Y,Kasputis T,Chung JS,Zhao H,Chammaa F,Belardo JA,Roth TM,Zhang H,Zaslavsky AB,Palapattu GS,Pienta KJ,Chinnaiyan AM,Taichman RS,Cackowski FC,Morgan TM

    更新日期：2020-04-01 00:00:00

  • Smoking-Induced SLPI Expression Hinders HPV Infections Also in Squamous Cell Carcinomas of the Vulva.

    abstract：:In HNSCC, protein- and mRNA-expression of the antileukoproteinase SLPI are significantly inverse correlated with HPV-infection suggesting that elevated expression of SLPI protects against HPV-infections. Moreover, SLPI-expression is up-regulated in HNSCC-patients reporting a smoking habit. Here, we investigate the des...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.09.004

    authors： Quabius ES,Loehr J,Haaser D,Günther V,Maass N,Röcken C,Mathiak M,Alkatout I,Hoffmann M

    更新日期：2019-01-01 00:00:00

  • Chromosomal Alterations and Gene Expression Changes Associated with the Progression of Leukoplakia to Advanced Gingivobuccal Cancer.

    abstract：:We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the gingivobuccal complex (GBC). We find that the genomic and transcriptomic profiles of leukoplakia resemble those observed in later stages of OSCC and ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.03.008

    authors： Bhosale PG,Cristea S,Ambatipudi S,Desai RS,Kumar R,Patil A,Kane S,Borges AM,Schäffer AA,Beerenwinkel N,Mahimkar MB

    更新日期：2017-06-01 00:00:00

  • Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer.

    abstract：:DNA damage has been associated with prostate cancer risk. Men who were referred for initial prostate biopsy for elevated prostate-specific antigen or abnormal digital rectal examination are often found with no cancer but have a higher risk of developing prostate cancer than the general population of men in their lifet...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.08217

    authors： Wu JD,Lin DW,Page ST,Lundgren AD,True LD,Plymate SR

    更新日期：2009-03-01 00:00:00

  • Prognostic Significance and Functional Role of CEP57 in Prostate Cancer.

    abstract：:We have recently shown that centrosomal protein 57 (CEP57) is overexpressed in a subset of human prostate cancers. CEP57 is involved in intracellular transport processes, and its overexpression causes mitotic defects as well as abnormal microtubule nucleation and bundling. In the present study, we further characterize...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.11.004

    authors： Mang J,Korzeniewski N,Dietrich D,Sailer V,Tolstov Y,Searcy S,von Hardenberg J,Perner S,Kristiansen G,Marx A,Roth W,Herpel E,Grüllich C,Popeneciu V,Pahernik S,Hadaschik B,Hohenfellner M,Duensing S

    更新日期：2015-12-01 00:00:00

  • Strategies for high-resolution imaging of epithelial ovarian cancer by laparoscopic nonlinear microscopy.

    abstract：:Ovarian cancer remains the most frequently lethal of the gynecologic cancers owing to the late detection of this disease. Here, by using human specimens and three mouse models of ovarian cancer, we tested the feasibility of nonlinear imaging approaches, the multiphoton microscopy (MPM) and second harmonic generation (...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.09310

    authors： Williams RM,Flesken-Nikitin A,Ellenson LH,Connolly DC,Hamilton TC,Nikitin AY,Zipfel WR

    更新日期：2010-06-01 00:00:00

  • Pitfalls and Limitations of Diffusion-Weighted Magnetic Resonance Imaging in the Diagnosis of Urinary Bladder Cancer.

    abstract：:Adequately selecting a therapeutic approach for bladder cancer depends on accurate grading and staging. Substantial inaccuracy of clinical staging with bimanual examination, cystoscopy, and transurethral resection of bladder tumor has facilitated the increasing utility of magnetic resonance imaging to evaluate bladder...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2015.04.003

    authors： Lin WC,Chen JH

    更新日期：2015-06-01 00:00:00

  • Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients.

    abstract：OBJECTIVES:This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS:Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-ech...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.03.002

    authors： Jafari-Khouzani K,Emblem KE,Kalpathy-Cramer J,Bjørnerud A,Vangel MG,Gerstner ER,Schmainda KM,Paynabar K,Wu O,Wen PY,Batchelor T,Rosen B,Stufflebeam SM

    更新日期：2015-06-01 00:00:00

  • Focal adhesion kinase functions as an akt downstream target in migration of colorectal cancer cells.

    abstract：:Migration is a complex process that, besides its various physiological functions in embryogenesis and adult tissues, plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the involvement and collaboration of Akt, focal adhesion kinase (FAK), and Src kinases in migration and invasivene...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.09160

    authors： Turecková J,Vojtechová M,Krausová M,Sloncová E,Korínek V

    更新日期：2009-12-01 00:00:00

  • MRI Texture Analysis Reflects Histopathology Parameters in Thyroid Cancer - A First Preliminary Study.

    abstract：OBJECT:Thyroid cancer represents the most frequent malignancy of the endocrine system with an increasing incidence worldwide. Novel imaging techniques are able to further characterize tumors and even predict histopathology features. Texture analysis is an emergent imaging technique to extract extensive data from an rad...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.09.003

    authors： Meyer HJ,Schob S,Höhn AK,Surov A

    更新日期：2017-12-01 00:00:00

  • Concurrent Chemoradiotherapy With or Without Induction Chemotherapy for Patients with Stage II Nasopharyngeal Carcinoma: An Update.

    abstract：PURPOSE:In contrast to other studies, our previous study showed that adding induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) significantly worsened the prognosis of patients with stage II nasopharyngeal carcinoma (NPC). However, the population used was small; therefore, there is an urgent need to conf...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.08.007

    authors： Jin T,Zhang Q,Luo DH,Jiang F,Jin QF,Chen YY,Chen XZ,Mao WM

    更新日期：2020-01-01 00:00:00

  • Role of IGF-1 receptor in radiation response.

    abstract：:Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositid...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.11265

    authors： Valenciano A,Henríquez-Hernández LA,Moreno M,Lloret M,Lara PC

    更新日期：2012-02-01 00:00:00

  • Acquired Uniparental Disomy Regions Are Associated with Disease Outcome in Patients with Oral Cavity and Oropharynx But Not Larynx Cancers.

    abstract：:Acquired uniparental disomy (aUPD) regions pinpoint homozygousity and monoallelic expressed genes. We analyzed The Cancer Genome Atlas single-nucleotide polymorphism arrays and expression data from oral cavity, oropharynx, and larynx cancers to identify frequency of aUPD in each tumor type and association of aUPD regi...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100763

    authors： Tuna M,I Amos C,B Mills G

    更新日期：2020-05-01 00:00:00

  • SPARC Expression Correlates with Tumor Response to Albumin-Bound Paclitaxel in Head and Neck Cancer Patients.

    abstract：:SPARC up-regulation is a poor prognostic factor in head and neck cancer. It was hypothesized that because of a SPARC-albumin interaction, tumoral SPARC facilitates the accumulation of albumin in the tumor and increases the effectiveness of albumin-bound paclitaxel (nab-paclitaxel). This hypothesis was tested by correl...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.09109

    authors： Desai N,Trieu V,Damascelli B,Soon-Shiong P

    更新日期：2009-05-01 00:00:00

  • Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer.

    abstract：:BRAFV600-mutated colorectal cancer (CRC) accounts for 8% to 12% of all CRC diagnoses. These tumors are often associated with specific patient features, including right-sided primary tumor location, peritoneal and non-regional lymph node involvement, and poor prognosis. In approximately 30% of cases, a simultaneous mis...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2020.100795

    authors： Roviello G,D'Angelo A,Petrioli R,Roviello F,Cianchi F,Nobili S,Mini E,Lavacchi D

    更新日期：2020-09-01 00:00:00

  • hERG1 and HIF-2α Behave as Biomarkers of Positive Response to Bevacizumab in Metastatic Colorectal Cancer Patients.

    abstract：BACKGROUND:In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis. METHODS:A retrospective, multicenter study on 80 surgical samples from mCRC patients treated in first line with bevaciz...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.01.001

    authors： Iorio J,Lastraioli E,Tofani L,Petroni G,Antonuzzo L,Messerini L,Perrone G,Caputo D,Francesconi M,Amato MM,Cadei M,Arcangeli G,Villanacci V,Boni L,Coppola R,Di Costanzo F,Arcangeli A

    更新日期：2020-03-01 00:00:00

  • CBX1 Indicates Poor Outcomes and Exerts Oncogenic Activity in Hepatocellular Carcinoma.

    abstract：:Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.07.002

    authors： Yang YF,Pan YH,Tian QH,Wu DC,Su SG

    更新日期：2018-10-01 00:00:00

  • Hydrogen Sulfide Demonstrates Promising Antitumor Efficacy in Gastric Carcinoma by Targeting MGAT5.

    abstract：:Mannosyl (alpha-1,6-)-Glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5) is exclusively expressed in gastric carcinoma, and plays an essential role in cancer progression, but no targeted drug is available so far. The potential anti-cancer effect of Hydrogen Sulfide (H2S), has not been widely recognized. It...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.04.008

    authors： Wang R,Fan Q,Zhang J,Zhang X,Kang Y,Wang Z

    更新日期：2018-08-01 00:00:00

  • Increased Expression of CAP2 Indicates Poor Prognosis in Hepatocellular Carcinoma.

    abstract：:CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.08.003

    authors： Fu J,Li M,Wu DC,Liu LL,Chen SL,Yun JP

    更新日期：2015-10-01 00:00:00

  • Molecular Characteristics and Clinical Outcomes of EGFR Exon 19 C-Helix Deletion in Non-Small Cell Lung Cancer and Response to EGFR TKIs.

    abstract：:Epidermal growth factor receptor (EGFR) exon 19 deletion (E19del) is the most common activating mutation in advanced non-small cell lung cancer (NSCLC) and associates with the sensitivity of EGFR tyrosine kinase inhibitors (TKIs) treatment. However, not all mutant patterns of E19del have been well studied for the limi...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100791

    authors： Xu CW,Lei L,Wang WX,Lin L,Zhu YC,Wang H,Miao LY,Wang LP,Zhuang W,Fang MY,Lv TF,Song Y

    更新日期：2020-09-01 00:00:00