Preoperative C-Reactive Protein/Albumin Ratio Predicts Prognosis of Patients after Curative Resection for Gastric Cancer.

abstract：BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...

journal_title：Translational oncology

authors： Popovtzer A,Normolle D,Worden FP,Prince ME,Chepeha DB,Wolf GT,Bradford CR,Lawrence TS,Eisbruch A

更新日期：2014-08-01 00:00:00

abstract：:Monocytic myeloid-derived suppressor cells (M-MDSCs), granulocytic MDSC (G-MDSCs) and regulatory T cells (Tregs) inhibit adaptive anti-tumor immunity and undermine the efficacy of anti-PD-1 therapy. However, the impact of anti-PD-1 treatment on these immunosuppressive cells has not been clearly defined in non-small ce...

journal_title：Translational oncology

authors： Feng J,Chen S,Li S,Wu B,Lu J,Tan L,Li J,Song Y,Shi G,Shi YG,Jiang J

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND STUDY AIM:To develop a molecular imaging endoscopic system that eliminates tissue autofluorescence and distinguishes multiple fluorescent markers specifically on the cancerous lesions. METHODS:Newly developed multi-spectral fluorescence endoscope device has the potential to eliminate signal interference...

journal_title：Translational oncology

authors： Bae SM,Bae DJ,Do EJ,Oh G,Yoo SW,Lee GJ,Chae JS,Yun Y,Kim S,Kim KH,Chung E,Kim JK,Hwang SW,Park SH,Yang DH,Ye BD,Byeon JS,Yang SK,Joo J,Kim SY,Myung SJ

更新日期：2019-02-01 00:00:00

abstract：:Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...

journal_title：Translational oncology

authors： Yang YF,Pan YH,Tian QH,Wu DC,Su SG

更新日期：2018-10-01 00:00:00

abstract：:Despite the weak clinical efficacy of TRAIL death receptor agonists, a search is under way for new agents that more efficiently activate apoptotic signaling. We previously created a TRAIL DR5-selective variant DR5-B without affinity for the DR4, DcR1, DcR2, and OPG receptors and increased proapoptotic activity in tumo...

journal_title：Translational oncology

authors： Yagolovich AV,Artykov AA,Karmakova TA,Vorontsova MS,Pankratov AA,Andreev-Andrievsky AA,Dolgikh DA,Kirpichnikov MP,Gasparian ME

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS:Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-ech...

journal_title：Translational oncology

authors： Jafari-Khouzani K,Emblem KE,Kalpathy-Cramer J,Bjørnerud A,Vangel MG,Gerstner ER,Schmainda KM,Paynabar K,Wu O,Wen PY,Batchelor T,Rosen B,Stufflebeam SM

更新日期：2015-06-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) can be controlled for years with the tyrosine kinase inhibitor imatinib but because imatinib poorly penetrates the blood-brain barrier (BBB), on occasion, the CML clone will thrive and evolve to an accelerated phase in the resulting imatinib sanctuary within the central nervous syste...

journal_title：Translational oncology

authors： Kast RE,Focosi D

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:In gastric adenocarcinoma (GC), the major tumor suppressor genes (TSGs) such as p16, PTEN, Rb, E-cadherin, and p53, may play important roles in various regulatory pathways and in tumor suppression. This study evaluated the loss of heterozygosity (LOH) of microsatellite and protein expression of 5 TSGs and the r...

journal_title：Translational oncology

authors： Choi WH,Lee S,Cho S

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Prostate and breast cancer are the most prevalent primary malignant human tumors globally. Prostatectomy and breast conservative surgery remain the most common definitive treatment option for the >500,000 men and women newly diagnosed with localized prostate and breast cancer each year only in the US. Morp...

journal_title：Translational oncology

authors： Walker E,Turaga SM,Wang X,Gopalakrishnan R,Shukla S,Basilion JP,Lathia JD

更新日期：2021-01-06 00:00:00

abstract：:A targeted and timely offered treatment can be a benefitting tool for patients with acute promyelocytic leukemia (APML). Current round of study made use of potential morphological and immature fraction-related parameters (cell population data) generated during complete blood cell count (CBC), through artificial neural...

journal_title：Translational oncology

authors： Haider RZ,Ujjan IU,Shamsi TS

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV) is one of the most prominent risk factors for hepatocellular carcinoma (HCC) development and virus-mediated cases represents more than 80% of HCC in East Asia, where it is endemic. Currently, the HBV status of pathological HCC is not fully clarified, especially by comparison to nontum...

journal_title：Translational oncology

authors： Liu J,Chen S,Zou Z,Tan D,Liu X,Wang X

更新日期：2019-09-01 00:00:00

abstract：:Fatty liver disease (hepatosteatosis) is a common early pathology in alcohol-dependent and obese patients. Fatty acid binding protein-4 (FABP4) is normally expressed in adipocytes and macrophages and functions as a regulator of intracellular lipid movement/storage. This study sought to investigate hepatic FABP4 expres...

journal_title：Translational oncology

authors： Attal N,Sullivan MT,Girardi CA,Thompson KJ,McKillop IH

更新日期：2021-01-01 00:00:00

abstract：:Insufficient delivery of systemically administered anticancer drugs to tumors can compromise therapeutic efficacy and develop drug delivery-based therapeutic resistance. Nanotherapeutics such as PEGylated liposomal doxorubicin (PLD) are designed to preferentially accumulate in tumors utilizing enhanced permeation and ...

journal_title：Translational oncology

authors： Kai M,Ziemys A,Liu YT,Kojic M,Ferrari M,Yokoi K

更新日期：2019-09-01 00:00:00

abstract：INTRODUCTION:Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS:The association of AR mRNA expression with clinicopathological features was r...

journal_title：Translational oncology

authors： Sikic D,Wirtz RM,Wach S,Dyrskjøt L,Erben P,Bolenz C,Breyer J,Otto W,Hoadley KA,Lerner SP,Eckstein M,Hartmann A,Keck B

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) ...

journal_title：Translational oncology

authors： Maretty-Kongstad K,Aggerholm-Pedersen N,Keller J,Safwat A

更新日期：2017-12-01 00:00:00

abstract：:Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic cancer in bone. The objectives of this study were to compare DKK1 ...

journal_title：Translational oncology

authors： Clines KL,Clines GA

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) mutation status is crucial in treatment selection for non-small cell lung cancer (NSCLC) patients; however, the detection materials' availability remains challenging in clinical practice. In this study, we collected surgical resection tissues, lymph node biopsy, and cy...

journal_title：Translational oncology

authors： Han X,Zhang Z,Wu D,Shen Y,Wang S,Wang L,Liu Y,Yang S,Hu X,Feng Y,Sun Y,Shi Y

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD:Various bioinformatics tools were u...

journal_title：Translational oncology

authors： Ni H,Sun H,Zheng M,Bian T,Liu J,Li X,Zhang J,Liu Y

更新日期：2021-01-01 00:00:00

abstract：:We investigated programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer (HGSOC) and its relationship to tumor infiltrating lymphocytes (TIL) and prognosis. Formalin fixed paraffin embedded (FFPE) samples of 94 HGSOC cases were included in the study. Immuno...

journal_title：Translational oncology

authors： Baş Y,Koç N,Helvacı K,Koçak C,Akdeniz R,Şahin HHK

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) in an attempt to identify potential core genes in the pathogenesis of this tumor. METHODS:Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and fi...

journal_title：Translational oncology

authors： Zhu J,Ye J,Zhang L,Xia L,Hu H,Jiang H,Wan Z,Sheng F,Ma Y,Li W,Qian J,Luo C

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Immunotherapy using dendritic cell (DC) vaccine has the potential to overcome the bottleneck of cancer therapy. METHODS:We engineered Lewis lung cancer cells (LLCs) and bone marrow-derived DCs to express tumor-associated antigen (TAA) ovalbumin (OVA) via lentiviral vector plasmid encoding OVA gene. We then ...

journal_title：Translational oncology

authors： Jiang T,Chen X,Zhou W,Fan G,Zhao P,Ren S,Zhou C,Zhang J

更新日期：2017-04-01 00:00:00

abstract：:We study the reproducibility of quantitative imaging features that are used to describe tumor shape, size, and texture from computed tomography (CT) scans of non-small cell lung cancer (NSCLC). CT images are dependent on various scanning factors. We focus on characterizing image features that are reproducible in the p...

journal_title：Translational oncology

authors： Balagurunathan Y,Gu Y,Wang H,Kumar V,Grove O,Hawkins S,Kim J,Goldgof DB,Hall LO,Gatenby RA,Gillies RJ

更新日期：2014-02-01 00:00:00

abstract：:Studies investigating dynamic susceptibility contrast magnetic resonance imaging-determined relative cerebral blood volume (rCBV) maps as a metric of treatment response assessment have generated conflicting results. We evaluated the potential of various analytical techniques to predict survival of patients with glioma...

journal_title：Translational oncology

authors： Lemasson B,Chenevert TL,Lawrence TS,Tsien C,Sundgren PC,Meyer CR,Junck L,Boes J,Galbán S,Johnson TD,Rehemtulla A,Ross BD,Galbán CJ

更新日期：2013-12-01 00:00:00

abstract：:DNA damage has been associated with prostate cancer risk. Men who were referred for initial prostate biopsy for elevated prostate-specific antigen or abnormal digital rectal examination are often found with no cancer but have a higher risk of developing prostate cancer than the general population of men in their lifet...

journal_title：Translational oncology

authors： Wu JD,Lin DW,Page ST,Lundgren AD,True LD,Plymate SR

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:This study investigated the feasibility of using malignant pleural effusion (MPE) supernatant and paired cell blocks (precipitate) for gene profiling in patients with non-small cell lung cancer (NSCLC) using next-generation sequencing (NGS) technique. METHODS:Stage IV non-squamous NSCLC patients with MPE wer...

journal_title：Translational oncology

authors： Li J,Li X,Wang W,Shao Y,Zhang Y,Song Z

更新日期：2020-08-01 00:00:00

abstract：:The accumulation of lipids is a hallmark of human clear cell renal cell carcinoma (ccRCC). Advanced ccRCC tumors frequently show increased lipid biosynthesis, but the regulation of lipid metabolism in early stage ccRCC tumors has not been studied. Here, we performed combined transcriptomics and metabolomics on a previ...

journal_title：Translational oncology

authors： van der Mijn JC,Fu L,Khani F,Zhang T,Molina AM,Barbieri CE,Chen Q,Gross SS,Gudas LJ,Nanus DM

更新日期：2020-02-01 00:00:00

abstract：:Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present with advanced disease, many such patients do well. We have attempted identification of biologically indolent tumors within HR+HER2- tumors based on gene expression using...

journal_title：Translational oncology

authors： Prabhu JS,Korlimarla A,Anupama CE,Alexander A,Raghavan R,Kaul R,Desai K,Rajarajan S,Manjunath S,Correa M,Raman R,Kalamdani A,Prasad M,Patil S,Gopinath KS,Srinath BS,Sridhar TS

更新日期：2017-08-01 00:00:00

abstract：:Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most importan...

journal_title：Translational oncology

authors： Ribatti D,Nico B,Ruggieri S,Tamma R,Simone G,Mangia A

更新日期：2016-10-01 00:00:00

abstract：OBJECT:Thyroid cancer represents the most frequent malignancy of the endocrine system with an increasing incidence worldwide. Novel imaging techniques are able to further characterize tumors and even predict histopathology features. Texture analysis is an emergent imaging technique to extract extensive data from an rad...

journal_title：Translational oncology

authors： Meyer HJ,Schob S,Höhn AK,Surov A

更新日期：2017-12-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor is of foremost relevance. In this study, we analyze, for the first time, the complete genomic profile...

journal_title：Translational oncology

authors： Souza-Santos PT,Soares Lima SC,Nicolau-Neto P,Boroni M,Meireles Da Costa N,Brewer L,Menezes AN,Furtado C,Moreira MAM,Seuanez HN,de Almeida Simão T,Ribeiro Pinto LF

更新日期：2018-12-01 00:00:00