Abstract:
BACKGROUND:Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD:Various bioinformatics tools were used to explore the role of the STAT family in HNSC. RESULT:The mRNA levels of STAT1/2/4/5A/6 were significantly upregulated in HNSC tissues. The levels of STAT1/2/4/5A/6 could be used for the detection of HNSC. HNSC patients with a high level of STAT5A had a poor overall survival and relapse-free survival. A moderate to high correlation was obtained between the STAT family and HNSC. Genetic alteration revealed that STAT1/2/3/4/5A/5B/6 were altered in 6%, 5%, 7%, 8%, 6%, 6%, and 4% of the queried TCGA HNSC samples, respectively. Immune infiltrations analysis suggested a significant association between STAT5A expression and abundance of specific immune cells. Further, copy number alteration of STAT5A could certainly inhibit infiltration level. Moreover, a close correlation was obtained between STAT5A level and the expression of immune markers in HNSC. Several kinase targets and transcription factor targets of STAT5A in HNSC were also identified. Enrichment analysis suggested that STAT5A and co-expression genes were mainly responsible for adaptive immune response, T cell activation, cytokine-cytokine receptor interaction, chemokine signaling pathway, cell-adhesion molecules, and ribosome and RNA transport. CONCLUSION:Our results provided additional data for the expression and clinical significance of the STAT family in HNSC, and further study should be performed to verify these.
journal_name
Transl Oncoljournal_title
Translational oncologyauthors
Ni H,Sun H,Zheng M,Bian T,Liu J,Li X,Zhang J,Liu Ydoi
10.1016/j.tranon.2020.100976subject
Has Abstractpub_date
2021-01-01 00:00:00pages
100976issue
1issn
1936-5233pii
S1936-5233(20)30468-Xjournal_volume
14pub_type
杂志文章abstract::Receptor tyrosine kinases (RTKs) are membrane receptors that play a vital role in various biological processes, in particular, cell survival, cell proliferation, and cell differentiation. These cellular processes are composed of multitiered signaling cascades of kinases starting from ligand binding to extracellular do...
journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章,评审
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.12.008
更新日期:2020-03-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.11178
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.04.008
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journal_title:Translational oncology
pub_type: 杂志文章
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journal_title:Translational oncology
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2019.04.005
更新日期:2019-07-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2020.100987
更新日期:2021-02-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.02.004
更新日期:2018-04-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2017.10.007
更新日期:2018-02-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1593/tlo.08145
更新日期:2008-09-01 00:00:00
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journal_title:Translational oncology
pub_type: 杂志文章
doi:10.1016/j.tranon.2018.07.015
更新日期:2018-10-01 00:00:00