Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.

abstract：:Liver cancers in children are rare representing only 1.1% of malignancies, with an annual incidence rate of 1.5 cases per million. Hepatoblastoma and hepatocellular carcinomas are the most common malignancies of the liver occurring in young people aged 15 years or younger. Molecular basis of both tumors are still uncl...

journal_title：Translational oncology

authors： Magrelli A,Azzalin G,Salvatore M,Viganotti M,Tosto F,Colombo T,Devito R,Di Masi A,Antoccia A,Lorenzetti S,Maranghi F,Mantovani A,Tanzarella C,Macino G,Taruscio D

更新日期：2009-08-18 00:00:00

abstract：:Bone is one of the most frequent metastatic sites in non-small cell lung cancer (NSCLC). Osimertinib, with and without bevacizumab (BV), has been investigated on advanced NSCLC patients. However, the efficacy of those drugs on bone metastasis of NSCLC has not been investigated. The human NSCLC cell line H1975, express...

journal_title：Translational oncology

authors： Higuchi T,Sugisawa N,Park JH,Sun Y,Zhu G,Yamamoto N,Hayashi K,Kimura H,Miwa S,Igarashi K,Bouvet M,Singh SR,Tsuchiya H,Hoffman RM

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND AND AIM:Desmoplasia is a characteristic feature and a suspected mechanism of tumor progression in pancreatic ductal adenocarcinoma (PDAC). Main constituents of the stroma involve cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM). The aim of this study was to dissect the interaction of CAFs,...

journal_title：Translational oncology

authors： Bolm L,Cigolla S,Wittel UA,Hopt UT,Keck T,Rades D,Bronsert P,Wellner UF

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The aim of this study is to summarize and quantify the current evidence on the therapeutic efficacy of laparoscopic radical nephrectomy (LRN) compared with open radical nephrectomy (ORN) in patients with renal cell carcinoma (RCC) in a meta-analysis. METHODS:Data were collected by searching Pubmed, Embase, ...

journal_title：Translational oncology

authors： Liu G,Ma Y,Wang S,Han X,Gao D

更新日期：2017-08-01 00:00:00

abstract：:Fatty liver disease (hepatosteatosis) is a common early pathology in alcohol-dependent and obese patients. Fatty acid binding protein-4 (FABP4) is normally expressed in adipocytes and macrophages and functions as a regulator of intracellular lipid movement/storage. This study sought to investigate hepatic FABP4 expres...

journal_title：Translational oncology

authors： Attal N,Sullivan MT,Girardi CA,Thompson KJ,McKillop IH

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To develop a new nomogram tool for predicting survival in middle-aged and elderly patients with rectal adenocarcinoma. METHODS:A total of 6,116 patients were randomly assigned in a 7:3 ratio to training and validation cohorts. Univariate and multivariate Cox proportional hazards regression analyses were used...

journal_title：Translational oncology

authors： Liu H,Lv L,Qu Y,Zheng Z,Zhao J,Liu B,Zhang D,Wang H,Zhang J

更新日期：2021-01-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) exon 19 deletion (E19del) is the most common activating mutation in advanced non-small cell lung cancer (NSCLC) and associates with the sensitivity of EGFR tyrosine kinase inhibitors (TKIs) treatment. However, not all mutant patterns of E19del have been well studied for the limi...

journal_title：Translational oncology

authors： Xu CW,Lei L,Wang WX,Lin L,Zhu YC,Wang H,Miao LY,Wang LP,Zhuang W,Fang MY,Lv TF,Song Y

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To determine the accuracy of a handheld ultrasound-guided optoacoustic tomography (US-OT) probe developed for human deep-tissue imaging in ex vivo assessment of tumor margins postlumpectomy. METHODS:A custom-built two-dimensional (2D) US-OT-handheld probe was used to scan 15 lumpectomy breast specimens. Optoac...

journal_title：Translational oncology

authors： Goh Y,Balasundaram G,Moothanchery M,Attia A,Li X,Lim HQ,Burton NC,Qiu Y,Putti TC,Chan CW,Iau P,Buhari SA,Hartman M,Tang SW,Ng CWQ,Chan YH,Pool FJ,Pillay P,Chua W,Kapur J,Jagmohan P,Sterling E,Quek ST,Olivo M

更新日期：2020-02-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) can be controlled for years with the tyrosine kinase inhibitor imatinib but because imatinib poorly penetrates the blood-brain barrier (BBB), on occasion, the CML clone will thrive and evolve to an accelerated phase in the resulting imatinib sanctuary within the central nervous syste...

journal_title：Translational oncology

authors： Kast RE,Focosi D

更新日期：2010-02-01 00:00:00

abstract：:We investigated programmed cell death 1 (PD-1) / programmed cell death ligand 1 (PD-L1) expression in high grade serous ovarian cancer (HGSOC) and its relationship to tumor infiltrating lymphocytes (TIL) and prognosis. Formalin fixed paraffin embedded (FFPE) samples of 94 HGSOC cases were included in the study. Immuno...

journal_title：Translational oncology

authors： Baş Y,Koç N,Helvacı K,Koçak C,Akdeniz R,Şahin HHK

更新日期：2021-02-01 00:00:00

abstract：:Previous studies proved that long noncoding RNAs (lncRNAs) play important role in human cancer. However, the knowledge of genome scale expression of lncRNAs and their potential biological function in gastric cancer is still lacking. Next generation RNA sequencing (RNA-seq) was performed on tumor tissues and matched ad...

journal_title：Translational oncology

authors： Luo T,Zhao J,Lu Z,Bi J,Pang T,Cui H,Yang B,Li W,Wang Y,Wu S,Xue X

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of...

journal_title：Translational oncology

authors： Murrell DH,Zarghami N,Jensen MD,Chambers AF,Wong E,Foster PJ

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Regional lymph node (LN) metastasis is a strong and well-established prognostic factor in colon cancer, and recent data suggest a prognostic value of detecting micrometastases and isolated tumor cells in regional LNs. The aim of the study was to investigate the clinical relevance of detecting sentinel lymph ...

journal_title：Translational oncology

authors： Oltedal S,Kørner H,Aasprong OG,Hussain I,Tjensvoll K,Smaaland R,Søreide JA,Søreide K,Lothe RA,Heikkilä R,Gilje B,Nordgård O

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) mutation status is crucial in treatment selection for non-small cell lung cancer (NSCLC) patients; however, the detection materials' availability remains challenging in clinical practice. In this study, we collected surgical resection tissues, lymph node biopsy, and cy...

journal_title：Translational oncology

authors： Han X,Zhang Z,Wu D,Shen Y,Wang S,Wang L,Liu Y,Yang S,Hu X,Feng Y,Sun Y,Shi Y

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...

journal_title：Translational oncology

authors： Popovtzer A,Normolle D,Worden FP,Prince ME,Chepeha DB,Wolf GT,Bradford CR,Lawrence TS,Eisbruch A

更新日期：2014-08-01 00:00:00

abstract：:A targeted and timely offered treatment can be a benefitting tool for patients with acute promyelocytic leukemia (APML). Current round of study made use of potential morphological and immature fraction-related parameters (cell population data) generated during complete blood cell count (CBC), through artificial neural...

journal_title：Translational oncology

authors： Haider RZ,Ujjan IU,Shamsi TS

更新日期：2020-01-01 00:00:00

abstract：:Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is targeted in the clinic, with successful and remarkable results. The PD-1/PD-Ls axis was shown to be one of the most relevant immunosu...

journal_title：Translational oncology

authors： Solinas C,Aiello M,Rozali E,Lambertini M,Willard-Gallo K,Migliori E

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:An increase in detection of early-stage asymptomatic lung tumors could increase the overall survival rate of lung cancer patients. A new approach to cancer (pre-)screening focusses on detecting field cancerization instead of the tumor itself. The objective of this study was to investigate the use of optica...

journal_title：Translational oncology

authors： Bugter O,van Brummelen SE,van der Leest KH,Aerts JGJV,Maat APWM,Baatenburg de Jong RJ,Amelink A,Robinson DJ

更新日期：2019-12-01 00:00:00

abstract：:Anticancer drug efficacy varies because the delivery of drugs within tumors and tumor responses are heterogeneous; however, these features are often more homogenous in vitro. This difference makes it difficult to accurately determine drug efficacy. Therefore, it is important to use living tumor tissues in preclinical ...

journal_title：Translational oncology

authors： Gonda K,Negishi H,Takano-Kasuya M,Kitamura N,Furusawa N,Nakano Y,Hamada Y,Tokunaga M,Higuchi H,Tada H,Ishida T

更新日期：2020-06-01 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death in women worldwide. Incurable metastatic breast disease presents a major clinical challenge and is the main cause of breast cancer-related death. The epithelial-mesenchymal transition (EMT) is a critical early promoter of metastasis. In the present study, we id...

journal_title：Translational oncology

authors： Wen XF,Chen M,Wu Y,Chen MN,Glogowska A,Klonisch T,Zhang GJ

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...

journal_title：Translational oncology

authors： Cuneo KC,Chenevert TL,Ben-Josef E,Feng MU,Greenson JK,Hussain HK,Simeone DM,Schipper MJ,Anderson MA,Zalupski MM,Al-Hawary M,Galban CJ,Rehemtulla A,Feng FY,Lawrence TS,Ross BD

更新日期：2014-10-24 00:00:00

abstract：:Chemo-resistance is an important barrier to effective treatment of ovarian cancer. Poly (ADP-ribose) polymerase (PARP) inhibitors are currently promising targeted drugs used to treat BRCA-mutant ovarian cancer. Ovarian cancer patients with BRCA 1/2 mutations appear to benefit better from PARP inhibitors and chemothera...

journal_title：Translational oncology

authors： Sun Y,Wu J,Dong X,Zhang J,Meng C,Liu G

更新日期：2021-02-01 00:00:00

abstract：INTRODUCTION:Prostate and breast cancer are the most prevalent primary malignant human tumors globally. Prostatectomy and breast conservative surgery remain the most common definitive treatment option for the >500,000 men and women newly diagnosed with localized prostate and breast cancer each year only in the US. Morp...

journal_title：Translational oncology

authors： Walker E,Turaga SM,Wang X,Gopalakrishnan R,Shukla S,Basilion JP,Lathia JD

更新日期：2021-01-06 00:00:00

abstract：:Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present with advanced disease, many such patients do well. We have attempted identification of biologically indolent tumors within HR+HER2- tumors based on gene expression using...

journal_title：Translational oncology

authors： Prabhu JS,Korlimarla A,Anupama CE,Alexander A,Raghavan R,Kaul R,Desai K,Rajarajan S,Manjunath S,Correa M,Raman R,Kalamdani A,Prasad M,Patil S,Gopinath KS,Srinath BS,Sridhar TS

更新日期：2017-08-01 00:00:00

abstract：:Wnt signaling has been implicated as a driver of prostate cancer-related osteoblast differentiation, and previous studies have linked modifications in Wnt function with the induction of tumor metastasis. A unique aspect of prostate cancer bone metastases in mouse models is their relative predilection to the hindlimb (...

journal_title：Translational oncology

authors： Wang Y,Singhal U,Qiao Y,Kasputis T,Chung JS,Zhao H,Chammaa F,Belardo JA,Roth TM,Zhang H,Zaslavsky AB,Palapattu GS,Pienta KJ,Chinnaiyan AM,Taichman RS,Cackowski FC,Morgan TM

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:In contrast to other studies, our previous study showed that adding induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) significantly worsened the prognosis of patients with stage II nasopharyngeal carcinoma (NPC). However, the population used was small; therefore, there is an urgent need to conf...

journal_title：Translational oncology

authors： Jin T,Zhang Q,Luo DH,Jiang F,Jin QF,Chen YY,Chen XZ,Mao WM

更新日期：2020-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) accounts for a bulk of the oral and laryngeal cancers, the majority (70%) of which are associated with smoking and excessive drinking, major known risk factors for the development of HNSCC. In contrast to reports that suggest an inverse relationship between smoking and glo...

journal_title：Translational oncology

authors： Ovchinnikov DA,Cooper MA,Pandit P,Coman WB,Cooper-White JJ,Keith P,Wolvetang EJ,Slowey PD,Punyadeera C

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

journal_title：Translational oncology

authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

更新日期：2020-12-01 00:00:00

abstract：:Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...

journal_title：Translational oncology

authors： Yang YF,Pan YH,Tian QH,Wu DC,Su SG

更新日期：2018-10-01 00:00:00

abstract：:The JNK and P38α pathways play an important role in the sensitivity and outcomes of chemotherapy. We hypothesize that functional single nucleotide polymorphisms (SNPs) of genes of these pathways modulate outcomes of patients with advanced non-small cell lung cancer (NSCLC) treated with first-line platinum-based chemot...

journal_title：Translational oncology

authors： Jia M,Xu Y,Zhu M,Wang M,Sun M,Qian J,Chang J,Wei Q

更新日期：2016-12-01 00:00:00