The Role of Fibroblasts in Pancreatic Cancer: Extracellular Matrix Versus Paracrine Factors.

abstract：:The JNK and P38α pathways play an important role in the sensitivity and outcomes of chemotherapy. We hypothesize that functional single nucleotide polymorphisms (SNPs) of genes of these pathways modulate outcomes of patients with advanced non-small cell lung cancer (NSCLC) treated with first-line platinum-based chemot...

journal_title：Translational oncology

authors： Jia M,Xu Y,Zhu M,Wang M,Sun M,Qian J,Chang J,Wei Q

更新日期：2016-12-01 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) are membrane receptors that play a vital role in various biological processes, in particular, cell survival, cell proliferation, and cell differentiation. These cellular processes are composed of multitiered signaling cascades of kinases starting from ligand binding to extracellular do...

journal_title：Translational oncology

authors： Chaiyawat P,Klangjorhor J,Settakorn J,Champattanachai V,Phanphaisarn A,Teeyakasem P,Svasti J,Pruksakorn D

更新日期：2017-10-01 00:00:00

abstract：:Chemo-resistance is an important barrier to effective treatment of ovarian cancer. Poly (ADP-ribose) polymerase (PARP) inhibitors are currently promising targeted drugs used to treat BRCA-mutant ovarian cancer. Ovarian cancer patients with BRCA 1/2 mutations appear to benefit better from PARP inhibitors and chemothera...

journal_title：Translational oncology

authors： Sun Y,Wu J,Dong X,Zhang J,Meng C,Liu G

更新日期：2021-02-01 00:00:00

abstract：:Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most importan...

journal_title：Translational oncology

authors： Ribatti D,Nico B,Ruggieri S,Tamma R,Simone G,Mangia A

更新日期：2016-10-01 00:00:00

abstract：:Anticancer drug efficacy varies because the delivery of drugs within tumors and tumor responses are heterogeneous; however, these features are often more homogenous in vitro. This difference makes it difficult to accurately determine drug efficacy. Therefore, it is important to use living tumor tissues in preclinical ...

journal_title：Translational oncology

authors： Gonda K,Negishi H,Takano-Kasuya M,Kitamura N,Furusawa N,Nakano Y,Hamada Y,Tokunaga M,Higuchi H,Tada H,Ishida T

更新日期：2020-06-01 00:00:00

abstract：:Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on pr...

journal_title：Translational oncology

authors： Lima AR,Bastos Mde L,Carvalho M,Guedes de Pinho P

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS:Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-ech...

journal_title：Translational oncology

authors： Jafari-Khouzani K,Emblem KE,Kalpathy-Cramer J,Bjørnerud A,Vangel MG,Gerstner ER,Schmainda KM,Paynabar K,Wu O,Wen PY,Batchelor T,Rosen B,Stufflebeam SM

更新日期：2015-06-01 00:00:00

abstract：:Tumor cells grow in nutrient- and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering their metabolic pathways. This adaptation process commonly results in a tumor phenotype that displays a high rate of aerobic glycolysis and aggressive tumor characteristics. The glucose regulat...

journal_title：Translational oncology

authors： Mendoza EE,Pocceschi MG,Kong X,Leeper DB,Caro J,Limesand KH,Burd R

更新日期：2012-06-01 00:00:00

abstract：:The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were e...

journal_title：Translational oncology

authors： Druliner BR,Rashtak S,Ruan X,Bae T,Vasmatzis N,O'Brien D,Johnson R,Felmlee-Devine D,Washechek-Aletto J,Basu N,Liu H,Smyrk T,Abyzov A,Boardman LA

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory res...

journal_title：Translational oncology

authors： Liu X,Sun X,Liu J,Kong P,Chen S,Zhan Y,Xu D

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To prospectively investigate ultrasound-guided diffuse optical tomography (US-guided DOT) in predicting breast cancer response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS:Eighty-eight breast cancer patients, with a total of 93 lesions, were included in our study. Pre- and post-last chemotherapy, s...

journal_title：Translational oncology

authors： Zhi W,Liu G,Chang C,Miao A,Zhu X,Xie L,Zhou J

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:In ovarian cancer, new therapeutic strategies are needed because the vast majority of patients develop a recurrence and resistance to platinum derivates. Attached to the AGO-OVAR2.11 study investigating the multityrosine kinase inhibitor sunitinib in recurrent platinum refractory ovarian cancers, this tran...

journal_title：Translational oncology

authors： Bauerschlag DO,Hilpert F,Meier W,Rau J,Meinhold-Heerlein I,Maass N,Dubois A,Sehouli J,Arnold N,Schem C,Oberg HH,Baumann K

更新日期：2013-06-01 00:00:00

abstract：:Development of novel bioactive compounds against KRAS and/or BRAF mutant colorectal cancer (CRC) is currently an urgent need in oncology. In addition, single or multitarget kinase inhibitors against MEK/ERK and PI3K/AKT pathways are of potential therapeutic advantage. A new compound based on the benzothiophene nucleus...

journal_title：Translational oncology

authors： Goulielmaki M,Assimomytis N,Rozanc J,Taki E,Christodoulou I,Alexopoulos LG,Zoumpourlis V,Pintzas A,Papahatjis D

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To develop a new nomogram tool for predicting survival in middle-aged and elderly patients with rectal adenocarcinoma. METHODS:A total of 6,116 patients were randomly assigned in a 7:3 ratio to training and validation cohorts. Univariate and multivariate Cox proportional hazards regression analyses were used...

journal_title：Translational oncology

authors： Liu H,Lv L,Qu Y,Zheng Z,Zhao J,Liu B,Zhang D,Wang H,Zhang J

更新日期：2021-01-01 00:00:00

abstract：:Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositid...

journal_title：Translational oncology

authors： Valenciano A,Henríquez-Hernández LA,Moreno M,Lloret M,Lara PC

更新日期：2012-02-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) accounts for a bulk of the oral and laryngeal cancers, the majority (70%) of which are associated with smoking and excessive drinking, major known risk factors for the development of HNSCC. In contrast to reports that suggest an inverse relationship between smoking and glo...

journal_title：Translational oncology

authors： Ovchinnikov DA,Cooper MA,Pandit P,Coman WB,Cooper-White JJ,Keith P,Wolvetang EJ,Slowey PD,Punyadeera C

更新日期：2012-10-01 00:00:00

abstract：:Oral mucositis (OM) is a serious side effect of cancer chemotherapy. The pathobiology of oral mucositis remains incompletely understood due to lack of appropriate models which recapitulate the human condition. Existing rodent models are intraperitoneal and require radiation, chemical or mechanical injury to the chemot...

journal_title：Translational oncology

authors： Bertolini M,Sobue T,Thompson A,Dongari-Bagtzoglou A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Breast cancer is now recognized as a clinically heterogeneous disease with a wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether epidemiological and clinicopathologic features are associated with the histological tumor grade of breast carcinomas in Wester...

journal_title：Translational oncology

authors： Zheng K,Tan JX,Li F,Li HY,Zeng XH,Ma BL,Ou JH,Li H,Yang SS,Jiang AM,Ni Q,Liu JL,Liu JP,Zheng H,Yue-Yang,Ling R,He JJ,Li ZG,Zeng J,Zou TN,Jiang J,Song ZJ,Liu QL,Ren GS

更新日期：2018-08-01 00:00:00

abstract：:Insufficient delivery of systemically administered anticancer drugs to tumors can compromise therapeutic efficacy and develop drug delivery-based therapeutic resistance. Nanotherapeutics such as PEGylated liposomal doxorubicin (PLD) are designed to preferentially accumulate in tumors utilizing enhanced permeation and ...

journal_title：Translational oncology

authors： Kai M,Ziemys A,Liu YT,Kojic M,Ferrari M,Yokoi K

更新日期：2019-09-01 00:00:00

abstract：:Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...

journal_title：Translational oncology

authors： Lippmann J,Petri K,Fulda S,Liese J

更新日期：2020-08-01 00:00:00

abstract：:Migration is a complex process that, besides its various physiological functions in embryogenesis and adult tissues, plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the involvement and collaboration of Akt, focal adhesion kinase (FAK), and Src kinases in migration and invasivene...

journal_title：Translational oncology

authors： Turecková J,Vojtechová M,Krausová M,Sloncová E,Korínek V

更新日期：2009-12-01 00:00:00

abstract：:The presence of circulating tumor cells (CTCs) in the blood of cancer patients may guide the use of therapy. We investigated how to evaluate a reduction in the number of CTCs after administration of therapy. CTCs were enumerated with the CellSearch system in 111 metastatic breast and 185 metastatic prostate cancer pat...

journal_title：Translational oncology

authors： Coumans FA,Ligthart ST,Terstappen LW

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:This study presented a three-dimensional magnetic resonance (MR)-based method to separate a breast into four quadrants for quantitative measurements of the quadrant breast volume (BV) and density. METHODS:Breast MR images from 58 healthy women were studied. The breast and the fibroglandular tissue were segment...

journal_title：Translational oncology

authors： Fwu PT,Chen JH,Li Y,Chan S,Su MY

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS:The association of AR mRNA expression with clinicopathological features was r...

journal_title：Translational oncology

authors： Sikic D,Wirtz RM,Wach S,Dyrskjøt L,Erben P,Bolenz C,Breyer J,Otto W,Hoadley KA,Lerner SP,Eckstein M,Hartmann A,Keck B

更新日期：2019-04-01 00:00:00

abstract：:Exosomes are extracellular membrane vesicles of 50- to 130-nm diameter secreted by most tumor cells. Exosomes can mediate the intercellular transfer of proteins and RNAs, including microRNAs (miRNAs), and promote both tumorigenesis and premetastatic niche formation. In this study, we performed exosomal RNA sequencing ...

journal_title：Translational oncology

authors： Fu F,Jiang W,Zhou L,Chen Z

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

journal_title：Translational oncology

authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:The present study aimed to explore the expression profiles of circular RNAs (circRNAs) in glioblastoma multiforme (GBM) in an attempt to identify potential core genes in the pathogenesis of this tumor. METHODS:Differentially expressed circRNAs were screened between tumor tissues from five GBM patients and fi...

journal_title：Translational oncology

authors： Zhu J,Ye J,Zhang L,Xia L,Hu H,Jiang H,Wan Z,Sheng F,Ma Y,Li W,Qian J,Luo C

更新日期：2017-04-01 00:00:00

abstract：:Absent in melanoma 2 (AIM2) as an immune regulator for the regulation of tumor-associated macrophages (TAMs) function is unclear in tumor development. Here, the AIM2 function was investigated in TAMs-mediated malignant behaviors of renal carcinoma. The correlation analysis result showed that the AIM2 expression in TAM...

journal_title：Translational oncology

authors： Chai D,Zhang Z,Shi SY,Qiu D,Zhang C,Wang G,Fang L,Li H,Tian H,Li H,Zheng J

更新日期：2021-01-22 00:00:00

abstract：:Measuring total cell-free DNA (cfDNA) or cancer-specific mutations herein has presented as new tools in aiding the treatment of cancer patients. Studies show that total cfDNA bears prognostic value in metastatic colorectal cancer (mCRC) and that measuring cancer-specific mutations could supplement biopsies. However, l...

journal_title：Translational oncology

authors： Demuth C,Spindler KG,Johansen JS,Pallisgaard N,Nielsen D,Hogdall E,Vittrup B,Sorensen BS

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...

journal_title：Translational oncology

authors： Cuneo KC,Chenevert TL,Ben-Josef E,Feng MU,Greenson JK,Hussain HK,Simeone DM,Schipper MJ,Anderson MA,Zalupski MM,Al-Hawary M,Galban CJ,Rehemtulla A,Feng FY,Lawrence TS,Ross BD

更新日期：2014-10-24 00:00:00