Characterization of long non-coding RNAs and MEF2C-AS1 identified as a novel biomarker in diffuse gastric cancer.

abstract：:Distinguishing synchronous and metachronous primary lung adenocarcinomas from adenocarcinomas with intrapulmonary metastasis is essential for optimal patient management. In this study, multiple lung adenocarcinomas occurring in the same patient were evaluated using comprehensive histopathologic evaluation supplemented...

journal_title：Translational oncology

authors： Saab J,Zia H,Mathew S,Kluk M,Narula N,Fernandes H

更新日期：2017-06-01 00:00:00

abstract：:Heat shock proteins (HSPs) are a large family of molecular chaperones aberrantly expressed in cancer. The expression of HSPs in tumor cells has been shown to be implicated in the regulation of apoptosis, immune responses, angiogenesis and metastasis. Given that extracellular vesicles (EVs) can serve as potential sourc...

journal_title：Translational oncology

authors： Albakova Z,Siam MKS,Sacitharan PK,Ziganshin RH,Ryazantsev DY,Sapozhnikov AM

更新日期：2021-02-01 00:00:00

abstract：:The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were e...

journal_title：Translational oncology

authors： Druliner BR,Rashtak S,Ruan X,Bae T,Vasmatzis N,O'Brien D,Johnson R,Felmlee-Devine D,Washechek-Aletto J,Basu N,Liu H,Smyrk T,Abyzov A,Boardman LA

更新日期：2016-08-01 00:00:00

abstract：:Oral mucositis (OM) is a serious side effect of cancer chemotherapy. The pathobiology of oral mucositis remains incompletely understood due to lack of appropriate models which recapitulate the human condition. Existing rodent models are intraperitoneal and require radiation, chemical or mechanical injury to the chemot...

journal_title：Translational oncology

authors： Bertolini M,Sobue T,Thompson A,Dongari-Bagtzoglou A

更新日期：2017-08-01 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death in women worldwide. Incurable metastatic breast disease presents a major clinical challenge and is the main cause of breast cancer-related death. The epithelial-mesenchymal transition (EMT) is a critical early promoter of metastasis. In the present study, we id...

journal_title：Translational oncology

authors： Wen XF,Chen M,Wu Y,Chen MN,Glogowska A,Klonisch T,Zhang GJ

更新日期：2018-10-01 00:00:00

abstract：:We present an integrative genome-wide analysis that can be used to predict the risk of progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the gingivobuccal complex (GBC). We find that the genomic and transcriptomic profiles of leukoplakia resemble those observed in later stages of OSCC and ...

journal_title：Translational oncology

authors： Bhosale PG,Cristea S,Ambatipudi S,Desai RS,Kumar R,Patil A,Kane S,Borges AM,Schäffer AA,Beerenwinkel N,Mahimkar MB

更新日期：2017-06-01 00:00:00

abstract：:Ovarian cancer remains the most frequently lethal of the gynecologic cancers owing to the late detection of this disease. Here, by using human specimens and three mouse models of ovarian cancer, we tested the feasibility of nonlinear imaging approaches, the multiphoton microscopy (MPM) and second harmonic generation (...

journal_title：Translational oncology

authors： Williams RM,Flesken-Nikitin A,Ellenson LH,Connolly DC,Hamilton TC,Nikitin AY,Zipfel WR

更新日期：2010-06-01 00:00:00

abstract：:Past studies have shown that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase (PIB5PA), is commonly downregulated or lost in melanomas, which contributes to elevated activation of phosphatidylinositol 3-kinase (PI3K)/Akt in melanoma cells. In this report, we provide evidenc...

journal_title：Translational oncology

authors： Ye Y,Li Q,Hu WL,Tseng HY,Jin L,Zhang XD,Zhang LJ,Yang S

更新日期：2013-08-01 00:00:00

abstract：:The mechanism of action of arsenic trioxide (ATO) has been shown to be complex, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects. Among these mechanisms of action, ATO has been shown to cause acute vascular shutdown and massive tumor necrosis in a murine solid tumor m...

journal_title：Translational oncology

authors： Lee JC,Lee HY,Moon CH,Lee SJ,Lee WH,Cha HJ,Park S,Lee YH,Park HJ,Song HT,Min YJ

更新日期：2013-02-01 00:00:00

abstract：:Development of novel bioactive compounds against KRAS and/or BRAF mutant colorectal cancer (CRC) is currently an urgent need in oncology. In addition, single or multitarget kinase inhibitors against MEK/ERK and PI3K/AKT pathways are of potential therapeutic advantage. A new compound based on the benzothiophene nucleus...

journal_title：Translational oncology

authors： Goulielmaki M,Assimomytis N,Rozanc J,Taki E,Christodoulou I,Alexopoulos LG,Zoumpourlis V,Pintzas A,Papahatjis D

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...

journal_title：Translational oncology

authors： Cuneo KC,Chenevert TL,Ben-Josef E,Feng MU,Greenson JK,Hussain HK,Simeone DM,Schipper MJ,Anderson MA,Zalupski MM,Al-Hawary M,Galban CJ,Rehemtulla A,Feng FY,Lawrence TS,Ross BD

更新日期：2014-10-24 00:00:00

abstract：:Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch t...

journal_title：Translational oncology

authors： Castillo-Pichardo L,Humphries-Bickley T,De La Parra C,Forestier-Roman I,Martinez-Ferrer M,Hernandez E,Vlaar C,Ferrer-Acosta Y,Washington AV,Cubano LA,Rodriguez-Orengo J,Dharmawardhane S

更新日期：2014-10-24 00:00:00

abstract：:BRAFV600-mutated colorectal cancer (CRC) accounts for 8% to 12% of all CRC diagnoses. These tumors are often associated with specific patient features, including right-sided primary tumor location, peritoneal and non-regional lymph node involvement, and poor prognosis. In approximately 30% of cases, a simultaneous mis...

journal_title：Translational oncology

authors： Roviello G,D'Angelo A,Petrioli R,Roviello F,Cianchi F,Nobili S,Mini E,Lavacchi D

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:The molecular mechanisms underlying aggressive versus indolent disease are not fully understood. Recent research has implicated a class of molecules known as long noncoding RNAs (lncRNAs) in tumorigenesis and progression of cancer. Our objective was to discover lncRNAs that differentiate aggressive and ind...

journal_title：Translational oncology

authors： Cesnik AJ,Yang B,Truong A,Etheridge T,Spiniello M,Steinbrink MI,Shortreed MR,Frey BL,Jarrard DF,Smith LM

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Enolase-1, primarily known for its role in glucose metabolism, is overexpressed in various cancer entities. In contrast its alternative spliced nuclear isoform MBP-1 acts as a tumor suppressor. The aim of this study is to analyze the prognostic impact of Enolase-1/ MBP-1 and its functional significance in ep...

journal_title：Translational oncology

authors： Czogalla B,Partenheimer A,Badmann S,Schmoeckel E,Mayr D,Kolben T,Beyer S,Hester A,Burges A,Mahner S,Jeschke U,Trillsch F

更新日期：2021-01-01 00:00:00

abstract：AIM:The Bruton's tyrosine kinase (BTK) inhibitor Ibrutinib (PCI-32765) is effective in patients with multiple myeloma, non-Hodgkin lymphoma and chronic lymphoblastic leukemia. We previously showed that primary cells of children with TCF3-PBX1 positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL) express BTK ...

journal_title：Translational oncology

authors： van de Ven C,Boeree A,Stalpers F,Zwaan CM,Den Boer ML

更新日期：2020-10-01 00:00:00

abstract：:CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...

journal_title：Translational oncology

authors： Fu J,Li M,Wu DC,Liu LL,Chen SL,Yun JP

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability is compromised by a common inability to adjust for important confounders. The aim of this study was to determine the prognostic value of pretreatment biomarkers on disease-specific survival (DSS) ...

journal_title：Translational oncology

authors： Maretty-Kongstad K,Aggerholm-Pedersen N,Keller J,Safwat A

更新日期：2017-12-01 00:00:00

abstract：:Anticancer drug efficacy varies because the delivery of drugs within tumors and tumor responses are heterogeneous; however, these features are often more homogenous in vitro. This difference makes it difficult to accurately determine drug efficacy. Therefore, it is important to use living tumor tissues in preclinical ...

journal_title：Translational oncology

authors： Gonda K,Negishi H,Takano-Kasuya M,Kitamura N,Furusawa N,Nakano Y,Hamada Y,Tokunaga M,Higuchi H,Tada H,Ishida T

更新日期：2020-06-01 00:00:00

abstract：:Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...

journal_title：Translational oncology

authors： Lippmann J,Petri K,Fulda S,Liese J

更新日期：2020-08-01 00:00:00

abstract：:Dysregulation of chromobox proteins contributes to the progression of human diseases. CBX1 has been implicated in epigenetic control of chromatin structure and gene expression, but its role in human cancers remains largely unknown. Here we show that CBX1 exhibits oncogenic activities in hepatocellular carcinoma (HCC) ...

journal_title：Translational oncology

authors： Yang YF,Pan YH,Tian QH,Wu DC,Su SG

更新日期：2018-10-01 00:00:00

abstract：:Despite the weak clinical efficacy of TRAIL death receptor agonists, a search is under way for new agents that more efficiently activate apoptotic signaling. We previously created a TRAIL DR5-selective variant DR5-B without affinity for the DR4, DcR1, DcR2, and OPG receptors and increased proapoptotic activity in tumo...

journal_title：Translational oncology

authors： Yagolovich AV,Artykov AA,Karmakova TA,Vorontsova MS,Pankratov AA,Andreev-Andrievsky AA,Dolgikh DA,Kirpichnikov MP,Gasparian ME

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:In ovarian cancer, new therapeutic strategies are needed because the vast majority of patients develop a recurrence and resistance to platinum derivates. Attached to the AGO-OVAR2.11 study investigating the multityrosine kinase inhibitor sunitinib in recurrent platinum refractory ovarian cancers, this tran...

journal_title：Translational oncology

authors： Bauerschlag DO,Hilpert F,Meier W,Rau J,Meinhold-Heerlein I,Maass N,Dubois A,Sehouli J,Arnold N,Schem C,Oberg HH,Baumann K

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Many genes are differentially expressed between androgen-dependent and androgen-independent prostate cancer (CaP). Differential expression analysis and subtractive hybridization previously identified nine genes expressed in intact mice bearing CWR22 tumors and castrated mice bearing recurrent CWR22 tumors ...

journal_title：Translational oncology

authors： Singh SS,Li Y,Ford OH,Wrzosek CS,Mehedint DC,Titus MA,Mohler JL

更新日期：2008-09-01 00:00:00

abstract：:Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic cancer in bone. The objectives of this study were to compare DKK1 ...

journal_title：Translational oncology

authors： Clines KL,Clines GA

更新日期：2018-08-01 00:00:00

abstract：:Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current screening techniques are based on the measurement of serum prostate specific antigen (PSA) levels and digital rectal examination. A decisive diagnosis of PCa is based on pr...

journal_title：Translational oncology

authors： Lima AR,Bastos Mde L,Carvalho M,Guedes de Pinho P

更新日期：2016-08-01 00:00:00

abstract：:The accumulation of lipids is a hallmark of human clear cell renal cell carcinoma (ccRCC). Advanced ccRCC tumors frequently show increased lipid biosynthesis, but the regulation of lipid metabolism in early stage ccRCC tumors has not been studied. Here, we performed combined transcriptomics and metabolomics on a previ...

journal_title：Translational oncology

authors： van der Mijn JC,Fu L,Khani F,Zhang T,Molina AM,Barbieri CE,Chen Q,Gross SS,Gudas LJ,Nanus DM

更新日期：2020-02-01 00:00:00

abstract：:Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and mitochondrial DNA (mtDNA) damage, reflects how hypoxic conditions connect to cancer-induced systemi...

journal_title：Translational oncology

authors： Bousquet PA,Meltzer S,Sønstevold L,Esbensen Y,Dueland S,Flatmark K,Sitter B,Bathen TF,Seierstad T,Redalen KR,Eide L,Ree AH

更新日期：2019-01-01 00:00:00

abstract：:Glioblastoma (GBM) with oligodendroglioma component (GBMO) is a newly described GBM subtype in the 2007 World Health Organization classification. However, its biological and genetic characteristics are largely unknown. We investigated the clinicopathological and molecular features of 34 GBMOs and compared the survival...

journal_title：Translational oncology

authors： Myung JK,Cho HJ,Kim H,Park CK,Lee SH,Choi SH,Park P,Yoon JM,Park SH

更新日期：2014-12-01 00:00:00

abstract：:This article describes methods and issues that are specific to the assessment of change in tumor characteristics as measured using quantitative magnetic resonance (MR) techniques and how this relates to the establishment of quantitative MR imaging (MRI) biomarkers of patient response to therapy. The initial focus is o...

journal_title：Translational oncology

authors： Jackson EF,Barboriak DP,Bidaut LM,Meyer CR

更新日期：2009-12-01 00:00:00