ZG16 regulates PD-L1 expression and promotes local immunity in colon cancer.

abstract：:Programmed cell death-ligand 2 (PD-L2) is one of the two ligands of the programmed cell death-1 (PD-1) receptor, an inhibitory protein mainly expressed on activated immune cells that is targeted in the clinic, with successful and remarkable results. The PD-1/PD-Ls axis was shown to be one of the most relevant immunosu...

journal_title：Translational oncology

authors： Solinas C,Aiello M,Rozali E,Lambertini M,Willard-Gallo K,Migliori E

更新日期：2020-10-01 00:00:00

abstract：:Despite the weak clinical efficacy of TRAIL death receptor agonists, a search is under way for new agents that more efficiently activate apoptotic signaling. We previously created a TRAIL DR5-selective variant DR5-B without affinity for the DR4, DcR1, DcR2, and OPG receptors and increased proapoptotic activity in tumo...

journal_title：Translational oncology

authors： Yagolovich AV,Artykov AA,Karmakova TA,Vorontsova MS,Pankratov AA,Andreev-Andrievsky AA,Dolgikh DA,Kirpichnikov MP,Gasparian ME

更新日期：2020-04-01 00:00:00

abstract：:The purpose of this study was to investigate the usefulness of photoacoustic imaging (PAI) for spatiotemporal mapping of tumor hemodynamics in a rabbit model of head and neck carcinoma. Shope cottontail rabbit papilloma virus associated VX2 carcinomas were established in adult male New Zealand White rabbits (n = 9) by...

journal_title：Translational oncology

authors： Rich LJ,Sexton S,Curtin L,Seshadri M

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Angiogenesis plays an important role in pancreas cancer pathobiology. Pancreatic tumor cells secrete vascular endothelial growth factor (VEGF), activating endothelial cell protein kinase C beta (PKCbeta) that phosphorylates GSK3beta to suppress apoptosis and promote endothelial cell proliferation and microvesse...

journal_title：Translational oncology

authors： Spalding AC,Zeitlin BD,Wilder-Romans K,Davis ME,Nor JE,Lawrence TS,Ben-Josef E

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:In the current study we examined the ability of diffusion MRI (dMRI) to predict pathologic response in pancreatic cancer patients receiving neoadjuvant chemoradiation. METHODS:We performed a prospective pilot study of dMRI in patients with resectable pancreatic cancer. Patients underwent dMRI prior to neoadjuv...

journal_title：Translational oncology

authors： Cuneo KC,Chenevert TL,Ben-Josef E,Feng MU,Greenson JK,Hussain HK,Simeone DM,Schipper MJ,Anderson MA,Zalupski MM,Al-Hawary M,Galban CJ,Rehemtulla A,Feng FY,Lawrence TS,Ross BD

更新日期：2014-10-24 00:00:00

abstract：OBJECTIVES:This study evaluates the repeatability of brain perfusion using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with a variety of post-processing methods. METHODS:Thirty-two patients with newly diagnosed glioblastoma were recruited. On a 3-T MRI using a dual-echo, gradient-echo spin-ech...

journal_title：Translational oncology

authors： Jafari-Khouzani K,Emblem KE,Kalpathy-Cramer J,Bjørnerud A,Vangel MG,Gerstner ER,Schmainda KM,Paynabar K,Wu O,Wen PY,Batchelor T,Rosen B,Stufflebeam SM

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Immunotherapy using dendritic cell (DC) vaccine has the potential to overcome the bottleneck of cancer therapy. METHODS:We engineered Lewis lung cancer cells (LLCs) and bone marrow-derived DCs to express tumor-associated antigen (TAA) ovalbumin (OVA) via lentiviral vector plasmid encoding OVA gene. We then ...

journal_title：Translational oncology

authors： Jiang T,Chen X,Zhou W,Fan G,Zhao P,Ren S,Zhou C,Zhang J

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Advanced sarcoma is a group of heterogeneous disease with poor prognosis and poor efficacy of medical treatment. They represent a promising group of tumors to assess molecular-based therapy (MBT) strategy. PATIENTS AND METHODS:Genomic profiles of patients with advanced sarcoma included in the ProfiLER progr...

journal_title：Translational oncology

authors： Arnaud-Coffin P,Brahmi M,Vanacker H,Eberst L,Tredan O,Attignon V,Pissaloux D,Sohier E,Cassier P,Garin G,Pérol D,Blay JY,Dufresne A

更新日期：2020-12-01 00:00:00

abstract：:BNIP3 (Bcl-2/adenovirus E1B 19-kDa interacting protein 3) is a BH3-only protein that regulates apoptosis and autophagy. BNIP3 plays also an important role in hypoxia-induced cell response and is regulated by HIF1. Here, we studied a possible association of BNIP3 expression and the prognosis of patients with renal cell...

journal_title：Translational oncology

authors： Macher-Goeppinger S,Keith M,Hatiboglu G,Hohenfellner M,Schirmacher P,Roth W,Tagscherer KE

更新日期：2017-12-01 00:00:00

abstract：:Ferroptosis, a newly discovered form of cell death mediated by reactive oxygen species (ROS) and lipid peroxidation, has recently been shown to have an impact on various cancer types; however, so far there are only few studies about its role in hepatocellular carcinoma (HCC). The delicate equilibrium of ROS in cancer ...

journal_title：Translational oncology

authors： Lippmann J,Petri K,Fulda S,Liese J

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Breast cancer is now recognized as a clinically heterogeneous disease with a wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether epidemiological and clinicopathologic features are associated with the histological tumor grade of breast carcinomas in Wester...

journal_title：Translational oncology

authors： Zheng K,Tan JX,Li F,Li HY,Zeng XH,Ma BL,Ou JH,Li H,Yang SS,Jiang AM,Ni Q,Liu JL,Liu JP,Zheng H,Yue-Yang,Ling R,He JJ,Li ZG,Zeng J,Zou TN,Jiang J,Song ZJ,Liu QL,Ren GS

更新日期：2018-08-01 00:00:00

abstract：:Migration is a complex process that, besides its various physiological functions in embryogenesis and adult tissues, plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the involvement and collaboration of Akt, focal adhesion kinase (FAK), and Src kinases in migration and invasivene...

journal_title：Translational oncology

authors： Turecková J,Vojtechová M,Krausová M,Sloncová E,Korínek V

更新日期：2009-12-01 00:00:00

abstract：:The accumulation of lipids is a hallmark of human clear cell renal cell carcinoma (ccRCC). Advanced ccRCC tumors frequently show increased lipid biosynthesis, but the regulation of lipid metabolism in early stage ccRCC tumors has not been studied. Here, we performed combined transcriptomics and metabolomics on a previ...

journal_title：Translational oncology

authors： van der Mijn JC,Fu L,Khani F,Zhang T,Molina AM,Barbieri CE,Chen Q,Gross SS,Gudas LJ,Nanus DM

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To develop a new nomogram tool for predicting survival in middle-aged and elderly patients with rectal adenocarcinoma. METHODS:A total of 6,116 patients were randomly assigned in a 7:3 ratio to training and validation cohorts. Univariate and multivariate Cox proportional hazards regression analyses were used...

journal_title：Translational oncology

authors： Liu H,Lv L,Qu Y,Zheng Z,Zhao J,Liu B,Zhang D,Wang H,Zhang J

更新日期：2021-01-01 00:00:00

abstract：:Fasting reduces gastrointestinal cellular proliferation rates through G1 cycle blockade and can promote cellular protection of normal but not cancer cells through altered cell signaling including down-regulation of insulin-like growth factor 1 (IGF-1). Consequently, the purpose of this study was to determine the effec...

journal_title：Translational oncology

authors： Withers SS,Kass PH,Rodriguez CO Jr,Skorupski KA,O'Brien D,Guerrero TA,Sein KD,Rebhun RB

更新日期：2014-05-12 00:00:00

abstract：BACKGROUND:Once-weekly gemcitabine concurrent with radiotherapy was highly effective in the treatment of head and neck cancer (HNC) but limited by high mucosal toxicity. Pre-clinical investigations suggested that delivering gemcitabine at substantially lower doses twice weekly during radiotherapy improved the therapeut...

journal_title：Translational oncology

authors： Popovtzer A,Normolle D,Worden FP,Prince ME,Chepeha DB,Wolf GT,Bradford CR,Lawrence TS,Eisbruch A

更新日期：2014-08-01 00:00:00

abstract：:Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most importan...

journal_title：Translational oncology

authors： Ribatti D,Nico B,Ruggieri S,Tamma R,Simone G,Mangia A

更新日期：2016-10-01 00:00:00

abstract：:Elderly patients with esophageal carcinoma may benefit from concurrent chemoradiotherapy (CCRT). However, the optimal concurrent chemotherapy regimen has not been determined. The aim of our study was to assess the efficiency and tolerance of treatment with a concurrent 5-fluorouracil (5-Fu)-based regimen and a taxane-...

journal_title：Translational oncology

authors： Huang C,Huang D,Zhu Y,Xie G,Wang H,Shi J,Jia B,Yuan Y,Zhang W

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:An elevated preoperative C-reactive protein/albumin (CRP/Alb) ratio has been reported to be associated with a poor prognosis for hepatocellular carcinoma. The aim of the present study was to investigate the prognostic value of the preoperative CRP/Alb ratio and compare it with other systemic inflammatory res...

journal_title：Translational oncology

authors： Liu X,Sun X,Liu J,Kong P,Chen S,Zhan Y,Xu D

更新日期：2015-08-01 00:00:00

abstract：:Distinguishing synchronous and metachronous primary lung adenocarcinomas from adenocarcinomas with intrapulmonary metastasis is essential for optimal patient management. In this study, multiple lung adenocarcinomas occurring in the same patient were evaluated using comprehensive histopathologic evaluation supplemented...

journal_title：Translational oncology

authors： Saab J,Zia H,Mathew S,Kluk M,Narula N,Fernandes H

更新日期：2017-06-01 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death in women worldwide. Incurable metastatic breast disease presents a major clinical challenge and is the main cause of breast cancer-related death. The epithelial-mesenchymal transition (EMT) is a critical early promoter of metastasis. In the present study, we id...

journal_title：Translational oncology

authors： Wen XF,Chen M,Wu Y,Chen MN,Glogowska A,Klonisch T,Zhang GJ

更新日期：2018-10-01 00:00:00

abstract：:Hormone receptor positive (HR+) breast cancers are a heterogeneous class with differential prognosis. Although more than half of Indian women present with advanced disease, many such patients do well. We have attempted identification of biologically indolent tumors within HR+HER2- tumors based on gene expression using...

journal_title：Translational oncology

authors： Prabhu JS,Korlimarla A,Anupama CE,Alexander A,Raghavan R,Kaul R,Desai K,Rajarajan S,Manjunath S,Correa M,Raman R,Kalamdani A,Prasad M,Patil S,Gopinath KS,Srinath BS,Sridhar TS

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To prospectively investigate ultrasound-guided diffuse optical tomography (US-guided DOT) in predicting breast cancer response to neoadjuvant chemotherapy (NAC). MATERIALS AND METHODS:Eighty-eight breast cancer patients, with a total of 93 lesions, were included in our study. Pre- and post-last chemotherapy, s...

journal_title：Translational oncology

authors： Zhi W,Liu G,Chang C,Miao A,Zhu X,Xie L,Zhou J

更新日期：2018-02-01 00:00:00

abstract：:Phosphatidylserine (PS) is normally intracellular but becomes exposed on the luminal surface of vascular endothelial cells in tumors. It also becomes exposed on tumors cells responding to therapy. In the present study, we optically imaged exposed PS in vivo using PGN635, a novel monoclonal antibody that binds PS. The ...

journal_title：Translational oncology

authors： Zhao D,Stafford JH,Zhou H,Thorpe PE

更新日期：2011-12-01 00:00:00

abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

journal_title：Translational oncology

authors： Stearns ME,Wang M

更新日期：2011-06-01 00:00:00

abstract：:Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch t...

journal_title：Translational oncology

authors： Castillo-Pichardo L,Humphries-Bickley T,De La Parra C,Forestier-Roman I,Martinez-Ferrer M,Hernandez E,Vlaar C,Ferrer-Acosta Y,Washington AV,Cubano LA,Rodriguez-Orengo J,Dharmawardhane S

更新日期：2014-10-24 00:00:00

abstract：:Liver cancers in children are rare representing only 1.1% of malignancies, with an annual incidence rate of 1.5 cases per million. Hepatoblastoma and hepatocellular carcinomas are the most common malignancies of the liver occurring in young people aged 15 years or younger. Molecular basis of both tumors are still uncl...

journal_title：Translational oncology

authors： Magrelli A,Azzalin G,Salvatore M,Viganotti M,Tosto F,Colombo T,Devito R,Di Masi A,Antoccia A,Lorenzetti S,Maranghi F,Mantovani A,Tanzarella C,Macino G,Taruscio D

更新日期：2009-08-18 00:00:00

abstract：:This study aimed to identify novel prognostic biomarker for advanced renal cell carcinoma (RCC) patients treated with anti-PD-1 therapy, using quantitative multi-immunofluorescence (IF) analysis of tumor immunity. Twenty-five consecutive patients who had metastatic or unresectable RCC treated with anti-PD-1 therapy we...

journal_title：Translational oncology

authors： Kato R,Jinnouchi N,Tuyukubo T,Ikarashi D,Matsuura T,Maekawa S,Kato Y,Kanehira M,Takata R,Ishida K,Obara W

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Recurrence of hepatocellular carcinoma can arise from the primary tumor ("early recurrence") or de novo from tumor formation in a cirrhotic environment ("late recurrence"). We aimed to develop one simple gene expression score applicable in both the tumor and the surrounding liver that can predict the recurre...

journal_title：Translational oncology

authors： Dekervel J,Popovic D,van Malenstein H,Windmolders P,Heylen L,Libbrecht L,Bulle A,De Moor B,Van Cutsem E,Nevens F,Verslype C,van Pelt J

更新日期：2016-04-01 00:00:00

abstract：:This study aimed to identify the biological processes associated with long-term survival in high-grade serous ovarian cancer (HGSOC). HGSOC cases obtained from The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) database were divided into long-term survivors (LTS) and normal-term survivors (NTS) based on survival cutoffs...

journal_title：Translational oncology

authors： Wang L,Sun T,Li S,Zhang Z,Jia J,Shan B

更新日期：2021-01-01 00:00:00