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Clinicopathologic Factors Related to the Histological Tumor Grade of Breast Cancer in Western China: An Epidemiological Multicenter Study of 8619 Female Patients.

Abstract：

BACKGROUND AND PURPOSE:Breast cancer is now recognized as a clinically heterogeneous disease with a wide spectrum of epidemiological and clinicopathologic features. We aimed to evaluate whether epidemiological and clinicopathologic features are associated with the histological tumor grade of breast carcinomas in Western China. METHODS:We retrospectively collected data from the Western China Clinical Cooperation Group and assessed associations between clinicopathologic factors and histological tumor grade in 8619 female breast cancer patients. Patients were divided into two groups: Group I (tumor grade I/II) and Group II (tumor grade III). Univariable analysis and multivariable logistic regression models were used to analyze the relationships between clinicopathologic factors and tumor grade. RESULTS:Patients presenting with positive axillary lymph nodes, large tumor size (>2 cm), lymphovascular invasion, hormone receptor negativity, human epidermal growth factor receptor 2 (HER-2) positivity, and triple negativity tended to have an increased risk of a high tumor grade. However, the number of pregnancies or births was inversely correlated with the risk of a high tumor grade. In addition, patients presenting with grade III tumors were more likely to receive aggressive treatment, such as adjuvant chemotherapy, anti-HER-2 therapy, and level III axillary lymph node dissection. CONCLUSIONS:Our results suggested that several clinicopathologic factors were associated with high tumor grade of breast cancer patients in Western China.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Zheng K,Tan JX,Li F,Li HY,Zeng XH,Ma BL,Ou JH,Li H,Yang SS,Jiang AM,Ni Q,Liu JL,Liu JP,Zheng H,Yue-Yang,Ling R,He JJ,Li ZG,Zeng J,Zou TN,Jiang J,Song ZJ,Liu QL,Ren GS

doi

10.1016/j.tranon.2018.06.005

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

1023-1033

issue

4

issn

1936-5233

pii

S1936-5233(18)30170-0

journal_volume

11

pub_type

杂志文章

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