当前位置： SCI文献检索 > Translational Oncology期刊下所有文献 > Limitations of Anti-Angiogenic Treatment of Tumors.

Limitations of Anti-Angiogenic Treatment of Tumors.

Abstract：

:Clinical trials using anti-vascular endothelial growth factor /(VEGF) molecules induce a modest improvement in overall survival, measurable in weeks to just a few months, and tumors respond differently to these agents. In this review article, we have exposed some tumor characteristics and processes that may impair the effectiveness of anti-angiogenic approaches, including genotypic changes on endothelial cells, the vascular normalization phenomenon, and the vasculogenic mimicry. The usage of anti-angiogenic molecules leads to hypoxic tumor microenvironment which enhances tumor invasiveness. The role of tumor-infiltrating cells, including tumor associated macrophages and fibroblasts (TAMs and TAFs) in the therapeutic response to anti-angiogenic settings was also highlighted. Finally, among the new therapeutic approaches to target tumor vasculature, anti-PD-1 or anti-PD-L1 therapy sensitizing and prolonging the efficacy of anti-angiogenic therapy, have been discussed.

journal_name

Transl Oncol

journal_title

Translational oncology

authors

Ribatti D,Annese T,Ruggieri S,Tamma R,Crivellato E

doi

10.1016/j.tranon.2019.04.022

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

981-986

issue

7

issn

1936-5233

pii

S1936-5233(19)30152-4

journal_volume

12

pub_type

杂志文章,评审

相关文献

Translational Oncology文献大全
  • Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas.

    abstract：BACKGROUND:Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD:Various bioinformatics tools were u...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100976

    authors： Ni H,Sun H,Zheng M,Bian T,Liu J,Li X,Zhang J,Liu Y

    更新日期：2021-01-01 00:00:00

  • CpG-coated prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma.

    abstract：:High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a "nanoimmunotherapy," which combines photothermal therapy (PTT) using CpG oligodeoxynucl...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100823

    authors： Cano-Mejia J,Shukla A,Ledezma DK,Palmer E,Villagra A,Fernandes R

    更新日期：2020-10-01 00:00:00

  • Protein anabolism is key to long-term survival in high-grade serous ovarian cancer.

    abstract：:This study aimed to identify the biological processes associated with long-term survival in high-grade serous ovarian cancer (HGSOC). HGSOC cases obtained from The Cancer Genome Atlas Ovarian Cancer (TCGA-OV) database were divided into long-term survivors (LTS) and normal-term survivors (NTS) based on survival cutoffs...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100885

    authors： Wang L,Sun T,Li S,Zhang Z,Jia J,Shan B

    更新日期：2021-01-01 00:00:00

  • Increased Expression of CAP2 Indicates Poor Prognosis in Hepatocellular Carcinoma.

    abstract：:CAP2 has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. Here, we show that CAP2 expression is much higher in HCC tissues than that in paracarcinoma tissues, at both mRNA and protein levels. Data of immunohistoche...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.08.003

    authors： Fu J,Li M,Wu DC,Liu LL,Chen SL,Yun JP

    更新日期：2015-10-01 00:00:00

  • A Global Risk Score (GRS) to Simultaneously Predict Early and Late Tumor Recurrence Risk after Resection of Hepatocellular Carcinoma.

    abstract：OBJECTIVES:Recurrence of hepatocellular carcinoma can arise from the primary tumor ("early recurrence") or de novo from tumor formation in a cirrhotic environment ("late recurrence"). We aimed to develop one simple gene expression score applicable in both the tumor and the surrounding liver that can predict the recurre...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2016.02.003

    authors： Dekervel J,Popovic D,van Malenstein H,Windmolders P,Heylen L,Libbrecht L,Bulle A,De Moor B,Van Cutsem E,Nevens F,Verslype C,van Pelt J

    更新日期：2016-04-01 00:00:00

  • Role of IGF-1 receptor in radiation response.

    abstract：:Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositid...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.11265

    authors： Valenciano A,Henríquez-Hernández LA,Moreno M,Lloret M,Lara PC

    更新日期：2012-02-01 00:00:00

  • Evaluation of potentially predictive markers for anti-angiogenic therapy with sunitinib in recurrent ovarian cancer patients.

    abstract：INTRODUCTION:In ovarian cancer, new therapeutic strategies are needed because the vast majority of patients develop a recurrence and resistance to platinum derivates. Attached to the AGO-OVAR2.11 study investigating the multityrosine kinase inhibitor sunitinib in recurrent platinum refractory ovarian cancers, this tran...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13205

    authors： Bauerschlag DO,Hilpert F,Meier W,Rau J,Meinhold-Heerlein I,Maass N,Dubois A,Sehouli J,Arnold N,Schem C,Oberg HH,Baumann K

    更新日期：2013-06-01 00:00:00

  • hERG1 and HIF-2α Behave as Biomarkers of Positive Response to Bevacizumab in Metastatic Colorectal Cancer Patients.

    abstract：BACKGROUND:In search of novel biomarkers of response to bevacizumab in metastatic colorectal cancer (mCRC), we analyzed the expression and prognostic role of several proteins related to angiogenesis. METHODS:A retrospective, multicenter study on 80 surgical samples from mCRC patients treated in first line with bevaciz...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.01.001

    authors： Iorio J,Lastraioli E,Tofani L,Petroni G,Antonuzzo L,Messerini L,Perrone G,Caputo D,Francesconi M,Amato MM,Cadei M,Arcangeli G,Villanacci V,Boni L,Coppola R,Di Costanzo F,Arcangeli A

    更新日期：2020-03-01 00:00:00

  • Nomogram based on preoperative CT imaging predicts the EGFR mutation status in lung adenocarcinoma.

    abstract：:Tyrosine kinase inhibitors (TKIs) provide clinical benefits to the lung cancer patients with epidermal growth factor receptor (EGFR) mutations. However, non-invasively determine EGFR mutation status in patients before targeted therapy remains a challenge. This study aimed to develop and validate a nomogram for preoper...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100954

    authors： Zhang G,Zhang J,Cao Y,Zhao Z,Li S,Deng L,Zhou J

    更新日期：2021-01-01 00:00:00

  • Magnetic resonance assessment of response to therapy: tumor change measurement, truth data and error sources.

    abstract：:This article describes methods and issues that are specific to the assessment of change in tumor characteristics as measured using quantitative magnetic resonance (MR) techniques and how this relates to the establishment of quantitative MR imaging (MRI) biomarkers of patient response to therapy. The initial focus is o...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.09241

    authors： Jackson EF,Barboriak DP,Bidaut LM,Meyer CR

    更新日期：2009-12-01 00:00:00

  • Selecting Potential Targetable Biomarkers for Imaging Purposes in Colorectal Cancer Using TArget Selection Criteria (TASC): A Novel Target Identification Tool.

    abstract：:Peritoneal carcinomatosis (PC) of colorectal origin is associated with a poor prognosis. However, cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is available for a selected group of PC patients, which significantly increases overall survival rates up to 30%. As a consequence, there is su...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.10220

    authors： van Oosten M,Crane LM,Bart J,van Leeuwen FW,van Dam GM

    更新日期：2011-04-01 00:00:00

  • The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.

    abstract：:Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch t...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2014.07.004

    authors： Castillo-Pichardo L,Humphries-Bickley T,De La Parra C,Forestier-Roman I,Martinez-Ferrer M,Hernandez E,Vlaar C,Ferrer-Acosta Y,Washington AV,Cubano LA,Rodriguez-Orengo J,Dharmawardhane S

    更新日期：2014-10-24 00:00:00

  • CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis.

    abstract：:Checkpoint with FHA and RING finger domains (CHFR) was first recognized as an early mitotic checkpoint protein that delayed the cell cycle in response to microtubule-targeting drugs. It is an E3 ubiquitin ligase that ubiquitinates target proteins to direct them to the proteasome for degradation or to alter their activ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.08109

    authors： Privette LM,Petty EM

    更新日期：2008-07-01 00:00:00

  • Focal adhesion kinase functions as an akt downstream target in migration of colorectal cancer cells.

    abstract：:Migration is a complex process that, besides its various physiological functions in embryogenesis and adult tissues, plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the involvement and collaboration of Akt, focal adhesion kinase (FAK), and Src kinases in migration and invasivene...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.09160

    authors： Turecková J,Vojtechová M,Krausová M,Sloncová E,Korínek V

    更新日期：2009-12-01 00:00:00

  • Can Imaging Parameters Provide Information Regarding Histopathology in Head and Neck Squamous Cell Carcinoma? A Meta-Analysis.

    abstract：OBJECT:Our purpose was to provide data regarding relationships between different imaging and histopathological parameters in HNSCC. METHODS:MEDLINE library was screened for associations between different imaging parameters and histopathological features in HNSCC up to December 2017. Only papers containing correlation ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.02.004

    authors： Surov A,Meyer HJ,Wienke A

    更新日期：2018-04-01 00:00:00

  • Molecular Characteristics and Clinical Outcomes of EGFR Exon 19 C-Helix Deletion in Non-Small Cell Lung Cancer and Response to EGFR TKIs.

    abstract：:Epidermal growth factor receptor (EGFR) exon 19 deletion (E19del) is the most common activating mutation in advanced non-small cell lung cancer (NSCLC) and associates with the sensitivity of EGFR tyrosine kinase inhibitors (TKIs) treatment. However, not all mutant patterns of E19del have been well studied for the limi...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2020.100791

    authors： Xu CW,Lei L,Wang WX,Lin L,Zhu YC,Wang H,Miao LY,Wang LP,Zhuang W,Fang MY,Lv TF,Song Y

    更新日期：2020-09-01 00:00:00

  • Chemotherapy Induces Oral Mucositis in Mice Without Additional Noxious Stimuli.

    abstract：:Oral mucositis (OM) is a serious side effect of cancer chemotherapy. The pathobiology of oral mucositis remains incompletely understood due to lack of appropriate models which recapitulate the human condition. Existing rodent models are intraperitoneal and require radiation, chemical or mechanical injury to the chemot...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2017.05.001

    authors： Bertolini M,Sobue T,Thompson A,Dongari-Bagtzoglou A

    更新日期：2017-08-01 00:00:00

  • Arsenic Trioxide as a Vascular Disrupting Agent: Synergistic Effect with Irinotecan on Tumor Growth Delay in a CT26 Allograft Model.

    abstract：:The mechanism of action of arsenic trioxide (ATO) has been shown to be complex, influencing numerous signal transduction pathways and resulting in a vast range of cellular effects. Among these mechanisms of action, ATO has been shown to cause acute vascular shutdown and massive tumor necrosis in a murine solid tumor m...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.12322

    authors： Lee JC,Lee HY,Moon CH,Lee SJ,Lee WH,Cha HJ,Park S,Lee YH,Park HJ,Song HT,Min YJ

    更新日期：2013-02-01 00:00:00

  • Comparison of a Concurrent Fluorouracil-Based Regimen and a Taxane-Based Regimen Combined with Radiotherapy in Elderly Patients with Esophageal Squamous Cell Carcinoma.

    abstract：:Elderly patients with esophageal carcinoma may benefit from concurrent chemoradiotherapy (CCRT). However, the optimal concurrent chemotherapy regimen has not been determined. The aim of our study was to assess the efficiency and tolerance of treatment with a concurrent 5-fluorouracil (5-Fu)-based regimen and a taxane-...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.12.008

    authors： Huang C,Huang D,Zhu Y,Xie G,Wang H,Shi J,Jia B,Yuan Y,Zhang W

    更新日期：2020-03-01 00:00:00

  • Monitoring Prostate Tumor Growth in an Orthotopic Mouse Model Using Three-Dimensional Ultrasound Imaging Technique.

    abstract：:Prostate cancer (CaP) is the most commonly diagnosed and the second leading cause of death from cancer in males in USA. Prostate orthotopic mouse model has been widely used to study human CaP in preclinical settings. Measurement of changes in tumor size obtained from noninvasive diagnostic images is a standard method ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2015.11.011

    authors： Ni J,Cozzi P,Hung TT,Hao J,Graham P,Li Y

    更新日期：2016-02-01 00:00:00

  • Angiogenesis and Antiangiogenesis in Triple-Negative Breast cancer.

    abstract：:Several data support a central role for angiogenesis in breast cancer growth and metastasis. Observational studies have demonstrated that microvascular density (MVD) is a prognostic factor in invasive breast cancer, whereas others reached the opposite conclusion. Vascular endothelial growth factor is the most importan...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2016.07.002

    authors： Ribatti D,Nico B,Ruggieri S,Tamma R,Simone G,Mangia A

    更新日期：2016-10-01 00:00:00

  • Synergistic Effects of the Green Tea Extract Epigallocatechin-3-gallate and Taxane in Eradication of Malignant Human Prostate Tumors.

    abstract：:We have examined whether epigallocatechin-3-gallate (EGCG), and extract of green tea, in combination with taxane (i.e., paclitaxel and docetaxel), exerts a synergistic activity in blocking human prostate PC-3ML tumor cell growth in vitro and in vivo. Growth assays in vitro revealed that the IC(50) values were ∼30 µM, ...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.10286

    authors： Stearns ME,Wang M

    更新日期：2011-06-01 00:00:00

  • Adipocytes Isolated from Visceral and Subcutaneous Depots of Donors Differing in BMI Crosstalk with Colon Cancer Cells and Modulate their Invasive Phenotype.

    abstract：PURPOSE:Mechanisms related the crosstalk between adipocytes and colon cancer cells are still not clear. We hypothesize that molecules and adipocytokines generated from the adipose tissue of obese individuals accentuate the effect on the metabolic reprogramming in colon cancer cells, i.e. induce disarray in energy metab...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2019.07.010

    authors： Nimri L,Peri I,Yehuda-Shnaidman E,Schwartz B

    更新日期：2019-11-01 00:00:00

  • Colorectal Cancer with Residual Polyp of Origin: A Model of Malignant Transformation.

    abstract：:The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were e...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2016.06.002

    authors： Druliner BR,Rashtak S,Ruan X,Bae T,Vasmatzis N,O'Brien D,Johnson R,Felmlee-Devine D,Washechek-Aletto J,Basu N,Liu H,Smyrk T,Abyzov A,Boardman LA

    更新日期：2016-08-01 00:00:00

  • Hydrogen Sulfide Demonstrates Promising Antitumor Efficacy in Gastric Carcinoma by Targeting MGAT5.

    abstract：:Mannosyl (alpha-1,6-)-Glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (MGAT5) is exclusively expressed in gastric carcinoma, and plays an essential role in cancer progression, but no targeted drug is available so far. The potential anti-cancer effect of Hydrogen Sulfide (H2S), has not been widely recognized. It...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1016/j.tranon.2018.04.008

    authors： Wang R,Fan Q,Zhang J,Zhang X,Kang Y,Wang Z

    更新日期：2018-08-01 00:00:00

  • Reproducibility and Prognosis of Quantitative Features Extracted from CT Images.

    abstract：:We study the reproducibility of quantitative imaging features that are used to describe tumor shape, size, and texture from computed tomography (CT) scans of non-small cell lung cancer (NSCLC). CT images are dependent on various scanning factors. We focus on characterizing image features that are reproducible in the p...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13844

    authors： Balagurunathan Y,Gu Y,Wang H,Kumar V,Grove O,Hawkins S,Kim J,Goldgof DB,Hall LO,Gatenby RA,Gillies RJ

    更新日期：2014-02-01 00:00:00

  • Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer.

    abstract：:BRAFV600-mutated colorectal cancer (CRC) accounts for 8% to 12% of all CRC diagnoses. These tumors are often associated with specific patient features, including right-sided primary tumor location, peritoneal and non-regional lymph node involvement, and poor prognosis. In approximately 30% of cases, a simultaneous mis...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2020.100795

    authors： Roviello G,D'Angelo A,Petrioli R,Roviello F,Cianchi F,Nobili S,Mini E,Lavacchi D

    更新日期：2020-09-01 00:00:00

  • Loss of PI(4,5)P2 5-Phosphatase A Contributes to Resistance of Human Melanoma Cells to RAF/MEK Inhibitors.

    abstract：:Past studies have shown that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase (PIB5PA), is commonly downregulated or lost in melanomas, which contributes to elevated activation of phosphatidylinositol 3-kinase (PI3K)/Akt in melanoma cells. In this report, we provide evidenc...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.13277

    authors： Ye Y,Li Q,Hu WL,Tseng HY,Jin L,Zhang XD,Zhang LJ,Yang S

    更新日期：2013-08-01 00:00:00

  • Three paths to better tyrosine kinase inhibition behind the blood-brain barrier in treating chronic myelogenous leukemia and glioblastoma with imatinib.

    abstract：:Chronic myelogenous leukemia (CML) can be controlled for years with the tyrosine kinase inhibitor imatinib but because imatinib poorly penetrates the blood-brain barrier (BBB), on occasion, the CML clone will thrive and evolve to an accelerated phase in the resulting imatinib sanctuary within the central nervous syste...

    journal_title：Translational oncology

    pub_type： 杂志文章

    doi：10.1593/tlo.09280

    authors： Kast RE,Focosi D

    更新日期：2010-02-01 00:00:00

  • Extracellular heat shock proteins and cancer: New perspectives.

    abstract：:Heat shock proteins (HSPs) are a large family of molecular chaperones aberrantly expressed in cancer. The expression of HSPs in tumor cells has been shown to be implicated in the regulation of apoptosis, immune responses, angiogenesis and metastasis. Given that extracellular vesicles (EVs) can serve as potential sourc...

    journal_title：Translational oncology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tranon.2020.100995

    authors： Albakova Z,Siam MKS,Sacitharan PK,Ziganshin RH,Ryazantsev DY,Sapozhnikov AM

    更新日期：2021-02-01 00:00:00