Abstract:
:In this study, we explore the functional role of striatal cholinergic interneurons, hereinafter referred to as tonically active neurons (TANs), via computational modeling; specifically, we investigate the mechanistic relationship between TAN activity and dopamine variations and how changes in this relationship affect reinforcement learning in the striatum. TANs pause their tonic firing activity after excitatory stimuli from thalamic and cortical neurons in response to a sensory event or reward information. During the pause striatal dopamine concentration excursions are observed. However, functional interactions between the TAN pause and striatal dopamine release are poorly understood. Here we propose a TAN activity-dopamine relationship model and demonstrate that the TAN pause is likely a time window to gate phasic dopamine release and dopamine variations reciprocally modulate the TAN pause duration. Furthermore, this model is integrated into our previously published model of reward-based motor adaptation to demonstrate how phasic dopamine release is gated by the TAN pause to deliver reward information for reinforcement learning in a timely manner. We also show how TAN-dopamine interactions are affected by striatal dopamine deficiency to produce poor performance of motor adaptation.
journal_name
Front Neural Circuitsjournal_title
Frontiers in neural circuitsauthors
Kim T,Capps RA,Hamade KC,Barnett WH,Todorov DI,Latash EM,Markin SN,Rybak IA,Molkov YIdoi
10.3389/fncir.2019.00010subject
Has Abstractpub_date
2019-02-21 00:00:00pages
10issn
1662-5110journal_volume
13pub_type
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