Abstract:
:We have carried out a Gal4 enhancer trap screen in zebrafish, and have generated 184 stable transgenic lines with interesting expression patterns throughout the nervous system. Of these, three display clear expression in the tectum, each with a distinguishable and stereotyped distribution of Gal4 expressing cells. Detailed morphological analysis of single cells, using a genetic "Golgi-like" labelling method, revealed four common cell types (superficial, periventricular, shallow periventricular, and radial glial), along with a range of other less common neurons. The shallow periventricular (PV) and a subset of the PV neurons are tectal efferent neurons that target various parts of the reticular formation. We find that it is specifically PV neurons with dendrites in the deep tectal neuropil that target the reticular formation. This indicates that these neurons receive the tectum's highly processed visual information (which is fed from the superficial retinorecipient layers), and relay it to premotor regions. Our results show that the larval tectum, both broadly and at the single cell level, strongly resembles a miniature version of its adult counterpart, and that it has all of the necessary anatomical characteristics to inform motor responses based on sensory input. We also demonstrate that mosaic expression of GFP in Gal4 enhancer trap lines can be used to describe the types and abundance of cells in an expression pattern, including the architectures of individual neurons. Such detailed anatomical descriptions will be an important part of future efforts to describe the functions of discrete tectal circuits in the generation of behavior.
journal_name
Front Neural Circuitsjournal_title
Frontiers in neural circuitsauthors
Scott EK,Baier Hdoi
10.3389/neuro.04.013.2009subject
Has Abstractpub_date
2009-10-09 00:00:00pages
13issn
1662-5110journal_volume
3pub_type
杂志文章abstract::In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2014.00093
更新日期:2014-08-05 00:00:00
abstract::Recent studies using primary neuronal cultures have revealed important roles of the microRNA pathway in the regulation of neuronal development and morphology. For example, miR-134 is involved in dendritogenesis and spine development in hippocampal neurons by regulating local mRNA translation in dendrites. The in vivo ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/neuro.04.016.2009
更新日期:2010-01-12 00:00:00
abstract::Recently, by using a combination of two viral vectors, we developed a technique for pathway-selective and reversible synaptic transmission blockade, and successfully induced a behavioral deficit of dexterous hand movements in macaque monkeys by affecting a population of spinal interneurons. To explore the capacity of ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00162
更新日期:2013-10-11 00:00:00
abstract::The human cerebral cortex is highly convoluted as convex gyri and concave sulci. In the past decades, extensive studies have consistently revealed substantial differences between gyri and sulci in terms of genetics, anatomy, morphology, axonal fiber connections, and function. Although interesting findings have been re...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00036
更新日期:2019-05-15 00:00:00
abstract::Complex motor behaviors are thought to be coordinated by networks of brain nuclei that may control different elementary motor programs. Transparent zebrafish larvae offer the opportunity to analyze the functional organization of motor control networks by optical manipulations of neuronal activity during behavior. We e...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00067
更新日期:2013-04-17 00:00:00
abstract::Since the discovery of grid cells in rat entorhinal cortex, many models of their hexagonally arrayed spatial firing fields have been suggested. We review the models and organize them according to the mechanisms they use to encode position, update the positional code, read it out in the spatial grid pattern, and learn ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00016
更新日期:2012-04-18 00:00:00
abstract::Genetic programs controlling ontogeny drive many of the essential connectivity patterns within the brain. Yet it is activity, derived from the experience of interacting with the world, that sculpts the precise circuitry of the central nervous system. Such experience-dependent plasticity has been observed throughout th...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2014.00123
更新日期:2014-10-02 00:00:00
abstract::Cortical sensory systems are active with rich patterns of activity during sleep and under light anesthesia. Remarkably, this activity shares many characteristics with those present when the awake brain responds to sensory stimuli. We review two specific forms of such activity: slow-wave activity (SWA) in the adult bra...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00103
更新日期:2016-12-21 00:00:00
abstract::Caspase-3 is a cysteine protease that is most commonly associated with cell death. Recent studies have shown additional roles in mediating cell differentiation, cell proliferation and development of cell morphology. We investigated the role of caspase-3 in the development of chick auditory brainstem nuclei during embr...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00084
更新日期:2016-10-24 00:00:00
abstract::A fluorescent voltage sensor protein "Flare" was created from a Kv1.4 potassium channel with YFP situated to report voltage-induced conformational changes in vivo. The RNA virus Sindbis introduced Flare into neurons in the binocular region of visual cortex in rat. Injection sites were selected based on intrinsic optic...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00015
更新日期:2012-03-22 00:00:00
abstract::The trace amines (TAs), tryptamine, tyramine, and β-phenylethylamine, are synthesized from precursor amino acids via aromatic-L-amino acid decarboxylase (AADC). We explored their role in the neuromodulation of neonatal rat spinal cord motor circuits. We first showed that the spinal cord contains the substrates for TA ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2014.00134
更新日期:2014-11-07 00:00:00
abstract::Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic motor responses, but the functional connectome of limbic structures in the diencephalon that control locomotion is not well known. The A11 region, within the posterior diencephalon has been postulated to contribute to motor funct...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00086
更新日期:2018-10-11 00:00:00
abstract::Water-homeostasis is a fundamental physiological process for terrestrial life. In vertebrates, thirst drives water intake, but the neuronal circuits that connect the physiology of water regulation with emotional context are poorly understood. Vasopressin (VP) is a prominent messenger in this circuit, as well as L-glut...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00013
更新日期:2016-03-31 00:00:00
abstract::Acetylcholine and the activation of muscarinic receptors influence the activity of neural networks generating locomotor behavior in the mammalian spinal cord. Using electrical stimulations of the ventral commissure, we show that commissural muscarinic (CM) depolarizations could be induced in lumbar motoneurons. We pro...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2011.00015
更新日期:2011-11-04 00:00:00
abstract::Neuronal activity is dominated by synaptic inputs from excitatory or inhibitory neural circuits. With the development of in vivo patch-clamp recording, especially in vivo voltage-clamp recording, researchers can not only directly measure neuronal activity, such as spiking responses or membrane potential dynamics, but ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2015.00023
更新日期:2015-05-22 00:00:00
abstract::Lateral neuronal interactions are known to play important roles in sensory information processing. A center-on surround-off local circuit arrangement has been shown to play a role in mediating contrast enhancement in the visual, auditory, and somatosensory systems. The lateral connectivity and the influence of those c...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00034
更新日期:2012-05-31 00:00:00
abstract::Recent advances in imaging tools are inspiring zebrafish researchers to tackle ever more ambitious questions in the neurosciences. Behaviorally fundamental conserved neural networks can now be potentially studied using zebrafish from a brain-wide scale to molecular resolution. In this perspective, we offer a roadmap b...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2013.00076
更新日期:2013-04-24 00:00:00
abstract::The delay eyeblink conditioning (EBC) is a cerebellum-dependent type of associative motor learning. However, the exact roles played by the various cerebellar synapses, as well as the underlying molecular mechanisms, remain to be determined. It is also unclear whether long-term potentiation (LTP) or long-term depressio...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00180
更新日期:2013-11-15 00:00:00
abstract::Optogenetic stimulation of the mouse cortex can be used to generate motor maps that are similar to maps derived from electrode-based stimulation. Here we present a refined set of procedures for repeated light-based motor mapping in ChR2-expressing mice implanted with a bilateral thinned-skull chronic window and a chro...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00123
更新日期:2013-07-25 00:00:00
abstract::Driven by the increasing channel count of neural probes, there is much effort being directed to creating increasingly scalable electrophysiology data acquisition (DAQ) systems. However, all such systems still rely on personal computers for data storage, and thus are limited by the bandwidth and cost of the computers, ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00046
更新日期:2015-09-01 00:00:00
abstract::Every higher-order association cortex receives a variety of synaptic signals from different regions of the brain. How these cortical networks are capable of differentially responding to these various extrinsic synaptic inputs remains unclear. To address this issue, we studied how the basolateral amygdala (BLA) and the...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00069
更新日期:2012-09-19 00:00:00
abstract::[This corrects the article on p. 33 in vol. 8, PMID: 24782714.]. ...
journal_title:Frontiers in neural circuits
pub_type: 已发布勘误
doi:10.3389/fncir.2014.00142
更新日期:2014-12-02 00:00:00
abstract::Open-source software development has skyrocketed in part due to community tools like github.com, which allows publication of code as well as the ability to create branches and push accepted modifications back to the original repository. As the number and size of EM-based datasets increases, the connectomics community ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00005
更新日期:2019-02-05 00:00:00
abstract::Genetic labeling of neurons with a specific response feature is an emerging technology for precise dissection of brain circuits that are functionally heterogeneous at the single-cell level. While immediate early gene mapping has been widely used for decades to identify brain regions which are activated by external sti...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2014.00037
更新日期:2014-04-23 00:00:00
abstract::The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confound...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00101
更新日期:2016-12-15 00:00:00
abstract::MRI has been extensively used in neurodegenerative disorders, such as Alzheimer's disease (AD), frontal-temporal dementia (FTD), mild cognitive impairment (MCI), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). MRI is important for monitoring the neurodegenerative components...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2018.00114
更新日期:2019-01-07 00:00:00
abstract::Local field potentials (LFPs) in cortex reflect synchronous fluctuations in the synaptic activity of local populations of neurons. The power of high frequency (>30 Hz) oscillations in LFPs is locked to the phase of low frequency (<30 Hz) oscillations, an effect known as phase-amplitude coupling (PAC). While PAC has be...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00082
更新日期:2015-12-22 00:00:00
abstract::Spike-timing dependent plasticity (STDP) is a biologically constrained unsupervised form of learning that potentiates or depresses synaptic connections based on the precise timing of pre-synaptic and post-synaptic firings. The effects of on-going STDP on the topology of evolving model neural networks were assessed in ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00070
更新日期:2013-04-18 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) is a public health problem worldwide. There is increasing interest in using non-invasive therapies such as repetitive transcranial magnetic stimulation (rTMS) to treat MDD. However, the changes induced by rTMS on neural circuits remain poorly characterized. The present study a...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00050
更新日期:2016-07-29 00:00:00
abstract::The parahippocampal areas including the subiculum, pre- and parasubiculum, and notably the entorhinal cortex (EC) are intimately involved in the generation of limbic seizures in temporal lobe epilepsy. We investigated changes in the expression of 10 major GABAA receptor subunit mRNAs in subfields of the ventral hippoc...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2013.00142
更新日期:2013-09-18 00:00:00