Abstract:
:Spike-timing dependent plasticity (STDP) is a biologically constrained unsupervised form of learning that potentiates or depresses synaptic connections based on the precise timing of pre-synaptic and post-synaptic firings. The effects of on-going STDP on the topology of evolving model neural networks were assessed in 50 unique simulations which modeled 2 h of activity. After a period of stabilization, a number of global and local topological features were monitored periodically to quantify on-going changes in network structure. Global topological features included the total number of remaining synapses, average synaptic strengths, and average number of synapses per neuron (degree). Under a range of different input regimes and initial network configurations, each network maintained a robust and highly stable global structure across time. Local topology was monitored by assessing state changes of all three-neuron subgraphs (triads) present in the networks. Overall counts and the range of triad configurations varied little across the simulations; however, a substantial set of individual triads continued to undergo rapid state changes and revealed a dynamic local topology. In addition, specific small-world properties also fluctuated across time. These findings suggest that on-going STDP provides an efficient means of selecting and maintaining a stable yet flexible network organization.
journal_name
Front Neural Circuitsjournal_title
Frontiers in neural circuitsauthors
Stone DB,Tesche CDdoi
10.3389/fncir.2013.00070subject
Has Abstractpub_date
2013-04-18 00:00:00pages
70issn
1662-5110journal_volume
7pub_type
杂志文章abstract::The firing rates of neurons in primate motor cortex have been related to multiple parameters of voluntary movement. This finding has been corroborated by stimulation-based studies that have mapped complex movements in rodent and primate motor cortex. However, it has been difficult to link the movement tuning of a neur...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00127
更新日期:2013-01-18 00:00:00
abstract::Research efforts over the past decades have unraveled both genetic and environmental factors, which contribute to the development of autism spectrum disorders (ASD). It is, to date, largely unknown how different underlying causes result in a common phenotype. However, the individual course of development and the diffe...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00006
更新日期:2019-02-22 00:00:00
abstract::Neuronal activity is dominated by synaptic inputs from excitatory or inhibitory neural circuits. With the development of in vivo patch-clamp recording, especially in vivo voltage-clamp recording, researchers can not only directly measure neuronal activity, such as spiking responses or membrane potential dynamics, but ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2015.00023
更新日期:2015-05-22 00:00:00
abstract::Two-photon imaging has become a useful tool for optical monitoring of neural circuits, but it requires high laser power and serial scanning of each pixel in a sample. This results in slow imaging rates, limiting the measurements of fast signals such as neuronal activity. To improve the speed and signal-to-noise ratio ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/neuro.04.006.2009
更新日期:2009-07-06 00:00:00
abstract::Mitral and tufted cells (MTCs) of the mammalian olfactory bulb are connected via dendrodendritic synapses with inhibitory interneurons in the external plexiform layer. The range, spatial layout, and temporal properties of inhibitory interactions between MTCs mediated by inhibitory interneurons remain unclear. Therefor...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00015
更新日期:2016-03-22 00:00:00
abstract::Parental migration has caused millions of children left behind, especially in China and India. Left-behind children (LBC) have a high risk of mental disorders and may present negative life outcomes in the future. However, little is known whether there are cerebral structural alterations in LBC in relative to those wit...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00033
更新日期:2019-05-08 00:00:00
abstract::mRNP granules at adult central synapses are postulated to regulate local mRNA translation and synapse plasticity. However, they are very poorly characterized in vivo. Here, in Drosophila olfactory synapses, we present early observations and characterization of candidate synaptic mRNP particles, one of which contains a...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2010.00121
更新日期:2010-11-03 00:00:00
abstract::Cortical sensory systems are active with rich patterns of activity during sleep and under light anesthesia. Remarkably, this activity shares many characteristics with those present when the awake brain responds to sensory stimuli. We review two specific forms of such activity: slow-wave activity (SWA) in the adult bra...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00103
更新日期:2016-12-21 00:00:00
abstract::The nematode Caenorhabditis elegans is an ideal organism for studying neural plasticity and animal behaviors. A total of 302 neurons of a C. elegans hermaphrodite have been classified into 118 neuronal groups. This simple neural circuit provides a solid basis for understanding the mechanisms of the brains of higher an...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2013.00187
更新日期:2013-11-28 00:00:00
abstract::Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to be synthesized and released from GABAergic neurons in the brain. However, recent studies have shown that not only neurons but also astrocytes contain a considerable amount of GABA that can be released and activate GABA receptors ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2014.00141
更新日期:2014-12-17 00:00:00
abstract::How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat. Spectral and tempor...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00062
更新日期:2012-09-27 00:00:00
abstract::"Dye-coupling", whole-mount immunohistochemistry for gap junction channel protein connexin 35 (Cx35), and freeze-fracture replica immunogold labeling (FRIL) reveal an abundance of electrical synapses/gap junctions at glutamatergic mixed synapses in the 14th spinal segment that innervates the adult male gonopodium of W...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2014.00066
更新日期:2014-06-26 00:00:00
abstract::Recent studies using primary neuronal cultures have revealed important roles of the microRNA pathway in the regulation of neuronal development and morphology. For example, miR-134 is involved in dendritogenesis and spine development in hippocampal neurons by regulating local mRNA translation in dendrites. The in vivo ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/neuro.04.016.2009
更新日期:2010-01-12 00:00:00
abstract::We investigate the importance of the degree of peripheral or central target differentiation for mouse auditory afferent navigation to the organ of Corti and auditory nuclei in three different mouse models: first, a mouse in which the differentiation of hair cells, but not central auditory nuclei neurons is compromised...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2017.00025
更新日期:2017-04-13 00:00:00
abstract::Complex spatial representations in the hippocampal formation and related cortical areas require input from the head direction system. However, a recurrent finding is that behavior apparently supported by these spatial representations does not appear to require input from generative head direction regions, i.e., latera...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00060
更新日期:2019-09-13 00:00:00
abstract::The primary (S1) and secondary (S2) somatosensory cortices project to several trigeminal sensory nuclei. One putative function of these corticofugal projections is the gating of sensory transmission through the trigeminal principal nucleus (Pr5), and some have proposed that S1 and S2 project differentially to the spin...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00053
更新日期:2015-09-30 00:00:00
abstract::The assembly of neural circuits involves multiple sequential steps such as the specification of cell-types, their migration to proper brain locations, morphological and physiological differentiation, and the formation and maturation of synaptic connections. This intricate and often prolonged process is guided by elabo...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00037
更新日期:2012-06-26 00:00:00
abstract::Genetic labeling of neurons with a specific response feature is an emerging technology for precise dissection of brain circuits that are functionally heterogeneous at the single-cell level. While immediate early gene mapping has been widely used for decades to identify brain regions which are activated by external sti...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2014.00037
更新日期:2014-04-23 00:00:00
abstract::Many studies have demonstrated that vestibular sensory input is important for spatial learning and memory. However, it has been unclear what contributions the different parts of the vestibular system - the semi-circular canals and otoliths - make to these processes. The advent of mutant otolith-deficient mice has made...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2019.00066
更新日期:2019-10-18 00:00:00
abstract::Defensive behavioral responses are essential for survival in threating situations. The superior colliculus (SC) has been implicated in the generation of defensive behaviors elicited by visual, tactile and auditory stimuli. Furthermore, substantia nigra pars reticulata (SNr) neurons are known to exert a modulatory effe...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00036
更新日期:2018-05-07 00:00:00
abstract::Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic motor responses, but the functional connectome of limbic structures in the diencephalon that control locomotion is not well known. The A11 region, within the posterior diencephalon has been postulated to contribute to motor funct...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00086
更新日期:2018-10-11 00:00:00
abstract::The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region's dedicated function is also expre...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2018.00083
更新日期:2018-10-10 00:00:00
abstract::Recent evidence suggests that parallel synapses from the same axonal branch onto the same dendritic branch have almost identical strength. It has been proposed that this alignment is only possible through learning rules that integrate activity over long time spans. However, learning mechanisms such as spike-timing-dep...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00090
更新日期:2016-01-13 00:00:00
abstract::Every higher-order association cortex receives a variety of synaptic signals from different regions of the brain. How these cortical networks are capable of differentially responding to these various extrinsic synaptic inputs remains unclear. To address this issue, we studied how the basolateral amygdala (BLA) and the...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00069
更新日期:2012-09-19 00:00:00
abstract::In drug users, drug-related cues alone can induce dopamine release in the dorsal striatum. Instructive cues activate inputs to the striatum from both dopaminergic and cholinergic neurons, which are thought to work together to support motor learning and motivated behaviors. Imbalances in these neuromodulatory influence...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2014.00057
更新日期:2014-05-28 00:00:00
abstract::[This corrects the article DOI: 10.3389/fncir.2018.00028.]. ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,已发布勘误
doi:10.3389/fncir.2018.00080
更新日期:2018-09-25 00:00:00
abstract::Focal cortical dysplasias (FCDs) are a common cause of brain seizures and are often associated with intractable epilepsy. Here we evaluated aberrant brain neurophysiology in an in vivo mouse model of FCD induced by neonatal freeze lesions (FLs) to the right cortical hemisphere (near S1). Linear multi-electrode arrays ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00093
更新日期:2016-11-10 00:00:00
abstract::We have carried out a Gal4 enhancer trap screen in zebrafish, and have generated 184 stable transgenic lines with interesting expression patterns throughout the nervous system. Of these, three display clear expression in the tectum, each with a distinguishable and stereotyped distribution of Gal4 expressing cells. Det...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/neuro.04.013.2009
更新日期:2009-10-09 00:00:00
abstract::Recording of identified neuronal network activity using genetically encoded calcium indicators (GECIs) requires labeling that is cell type-specific and bright enough for the detection of functional signals. However, specificity and strong expression are often not achievable using the same promoter. Here we present a c...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00049
更新日期:2012-07-31 00:00:00
abstract::The medial part of the olfactory tubercle (OT) is a brain structure located at the interface of the reward and olfactory system. It is closely related to pheromone-rewards, natural reinforcement, addiction and many other behaviors. However, the structure of the anatomic circuitry of the medial part of the OT is still ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2017.00052
更新日期:2017-07-28 00:00:00