解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Many studies have demonstrated that vestibular sensory input is important for spatial learning and memory. However, it has been unclear what contributions the different parts of the vestibular system - the semi-circular canals and otoliths - make to these processes. The advent of mutant otolith-deficient mice has made...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2019.00066
更新日期:2019-10-18 00:00:00
abstract::Complex spatial representations in the hippocampal formation and related cortical areas require input from the head direction system. However, a recurrent finding is that behavior apparently supported by these spatial representations does not appear to require input from generative head direction regions, i.e., latera...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00060
更新日期:2019-09-13 00:00:00
abstract::The human cerebral cortex is highly convoluted as convex gyri and concave sulci. In the past decades, extensive studies have consistently revealed substantial differences between gyri and sulci in terms of genetics, anatomy, morphology, axonal fiber connections, and function. Although interesting findings have been re...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00036
更新日期:2019-05-15 00:00:00
abstract::Parental migration has caused millions of children left behind, especially in China and India. Left-behind children (LBC) have a high risk of mental disorders and may present negative life outcomes in the future. However, little is known whether there are cerebral structural alterations in LBC in relative to those wit...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00033
更新日期:2019-05-08 00:00:00
abstract::Both abnormalities of resting-state cerebral blood flow (CBF) and functional connectivity in Wilson's disease (WD) have been identified by several studies. Whether the coupling of CBF and functional connectivity is imbalanced in WD remains largely unknown. To assess this possibility, 27 patients with WD and 27 sex- an...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00025
更新日期:2019-04-18 00:00:00
abstract::Research efforts over the past decades have unraveled both genetic and environmental factors, which contribute to the development of autism spectrum disorders (ASD). It is, to date, largely unknown how different underlying causes result in a common phenotype. However, the individual course of development and the diffe...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00006
更新日期:2019-02-22 00:00:00
abstract::In this study, we explore the functional role of striatal cholinergic interneurons, hereinafter referred to as tonically active neurons (TANs), via computational modeling; specifically, we investigate the mechanistic relationship between TAN activity and dopamine variations and how changes in this relationship affect ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00010
更新日期:2019-02-21 00:00:00
abstract::Open-source software development has skyrocketed in part due to community tools like github.com, which allows publication of code as well as the ability to create branches and push accepted modifications back to the original repository. As the number and size of EM-based datasets increases, the connectomics community ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2019.00005
更新日期:2019-02-05 00:00:00
abstract::Methods of functional connectivity are applied ubiquitously in studies involving non-invasive whole-brain signals, but may be not optimal for exploring the propagation of the steady-state responses, which are strong oscillatory patterns of neurodynamics evoked by periodic stimulation. In our study, we explore a functi...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00118
更新日期:2019-01-15 00:00:00
abstract::The goal of sensory neuroscience is to understand how the brain creates its myriad of representations of the world, and uses these representations to produce perception and behavior. Circuits of neurons in spatially segregated regions of brain tissue have distinct functional specializations, and these regions are conn...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00115
更新日期:2019-01-09 00:00:00
abstract::MRI has been extensively used in neurodegenerative disorders, such as Alzheimer's disease (AD), frontal-temporal dementia (FTD), mild cognitive impairment (MCI), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). MRI is important for monitoring the neurodegenerative components...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2018.00114
更新日期:2019-01-07 00:00:00
abstract::The central vocal pathway of the African clawed frog, Xenopus laevis, is a powerful vertebrate model to understand mechanisms underlying central pattern generation. However, fast and efficient methods of introducing exogenous genes into the neurons of adult X. laevis are currently not available. Here, we systematicall...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00092
更新日期:2018-10-26 00:00:00
abstract::Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic motor responses, but the functional connectome of limbic structures in the diencephalon that control locomotion is not well known. The A11 region, within the posterior diencephalon has been postulated to contribute to motor funct...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00086
更新日期:2018-10-11 00:00:00
abstract::The brain contains a large diversity of unique cell types that use specific genetic programs to control development and instruct the intricate wiring of sensory, motor, and cognitive brain regions. In addition to their cellular diversity and specialized connectivity maps, each region's dedicated function is also expre...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2018.00083
更新日期:2018-10-10 00:00:00
abstract::[This corrects the article DOI: 10.3389/fncir.2018.00028.]. ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,已发布勘误
doi:10.3389/fncir.2018.00080
更新日期:2018-09-25 00:00:00
abstract::Defensive behavioral responses are essential for survival in threating situations. The superior colliculus (SC) has been implicated in the generation of defensive behaviors elicited by visual, tactile and auditory stimuli. Furthermore, substantia nigra pars reticulata (SNr) neurons are known to exert a modulatory effe...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00036
更新日期:2018-05-07 00:00:00
abstract::Serotonin (5-HT) selectively excites subpopulations of pyramidal neurons in the neocortex via activation of 5-HT2A (2A) receptors coupled to Gq subtype G-protein alpha subunits. Gq-mediated excitatory responses have been attributed primarily to suppression of potassium conductances, including those mediated by KV7 pot...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2018.00002
更新日期:2018-01-18 00:00:00
abstract::Homeostatic regulation of REM sleep drive, as measured by an increase in the number of REM sleep transitions, plays a key role in neuronal and behavioral plasticity (i.e., learning and memory). Deficits in REM sleep homeostatic drive (RSHD) are implicated in the development of many neuropsychiatric disorders. Yet, the...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2017.00063
更新日期:2017-09-14 00:00:00
abstract::The medial part of the olfactory tubercle (OT) is a brain structure located at the interface of the reward and olfactory system. It is closely related to pheromone-rewards, natural reinforcement, addiction and many other behaviors. However, the structure of the anatomic circuitry of the medial part of the OT is still ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2017.00052
更新日期:2017-07-28 00:00:00
abstract::We investigate the importance of the degree of peripheral or central target differentiation for mouse auditory afferent navigation to the organ of Corti and auditory nuclei in three different mouse models: first, a mouse in which the differentiation of hair cells, but not central auditory nuclei neurons is compromised...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2017.00025
更新日期:2017-04-13 00:00:00
abstract::Cortical sensory systems are active with rich patterns of activity during sleep and under light anesthesia. Remarkably, this activity shares many characteristics with those present when the awake brain responds to sensory stimuli. We review two specific forms of such activity: slow-wave activity (SWA) in the adult bra...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00103
更新日期:2016-12-21 00:00:00
abstract::The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confound...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00101
更新日期:2016-12-15 00:00:00
abstract::Focal cortical dysplasias (FCDs) are a common cause of brain seizures and are often associated with intractable epilepsy. Here we evaluated aberrant brain neurophysiology in an in vivo mouse model of FCD induced by neonatal freeze lesions (FLs) to the right cortical hemisphere (near S1). Linear multi-electrode arrays ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00093
更新日期:2016-11-10 00:00:00
abstract::Caspase-3 is a cysteine protease that is most commonly associated with cell death. Recent studies have shown additional roles in mediating cell differentiation, cell proliferation and development of cell morphology. We investigated the role of caspase-3 in the development of chick auditory brainstem nuclei during embr...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00084
更新日期:2016-10-24 00:00:00
abstract::The ability of light to cause pain is paradoxical. The retina detects light but is devoid of nociceptors while the trigeminal sensory ganglia (TG) contain nociceptors but not photoreceptors. Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) are thought to mediate light-induced pain but...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00060
更新日期:2016-08-10 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) is a public health problem worldwide. There is increasing interest in using non-invasive therapies such as repetitive transcranial magnetic stimulation (rTMS) to treat MDD. However, the changes induced by rTMS on neural circuits remain poorly characterized. The present study a...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00050
更新日期:2016-07-29 00:00:00
abstract::The perirhinal (PER) and entorhinal cortex (EC) receive input from the agranular insular cortex (AiP) and the subcortical lateral amygdala (LA) and the main output area is the hippocampus. Information transfer through the PER/EC network however, is not always guaranteed. It is hypothesized that this network actively r...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00044
更新日期:2016-06-14 00:00:00
abstract::The most typical and well known inhibitory action in the cortical microcircuit is a strong inhibition on the target neuron by axo-somatic synapses. However, it has become clear that synaptic inhibition in the cortex is much more diverse and complicated. Firstly, at least ten or more inhibitory non-pyramidal cell subty...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2016.00027
更新日期:2016-04-25 00:00:00
abstract::Water-homeostasis is a fundamental physiological process for terrestrial life. In vertebrates, thirst drives water intake, but the neuronal circuits that connect the physiology of water regulation with emotional context are poorly understood. Vasopressin (VP) is a prominent messenger in this circuit, as well as L-glut...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00013
更新日期:2016-03-31 00:00:00
abstract::Mitral and tufted cells (MTCs) of the mammalian olfactory bulb are connected via dendrodendritic synapses with inhibitory interneurons in the external plexiform layer. The range, spatial layout, and temporal properties of inhibitory interactions between MTCs mediated by inhibitory interneurons remain unclear. Therefor...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00015
更新日期:2016-03-22 00:00:00
abstract::Short-term synaptic plasticity (STP) sets the sensitivity of a synapse to incoming activity and determines the temporal patterns that it best transmits. In "driver" thalamocortical (TC) synaptic populations, STP is dominated by depression during stimulation from rest. However, during ongoing stimulation, lemniscal TC ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2016.00009
更新日期:2016-02-23 00:00:00
abstract::How complex natural sounds are represented by the main converging center of the auditory midbrain, the central inferior colliculus, is an open question. We applied neural discrimination to determine the variation of detailed encoding of individual vocalizations across the best frequency gradient of the central inferio...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00091
更新日期:2016-02-01 00:00:00
abstract::In the mammalian central nervous system, most sensory information passes through primary sensory thalamic nuclei, however the consequence of this remains unclear. Various propositions exist, likening the thalamus to a gate, or a high pass filter. Here, using a simple leaky integrate and fire model based on physiologic...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00089
更新日期:2016-01-14 00:00:00
abstract::Recent evidence suggests that parallel synapses from the same axonal branch onto the same dendritic branch have almost identical strength. It has been proposed that this alignment is only possible through learning rules that integrate activity over long time spans. However, learning mechanisms such as spike-timing-dep...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00090
更新日期:2016-01-13 00:00:00
abstract::Local field potentials (LFPs) in cortex reflect synchronous fluctuations in the synaptic activity of local populations of neurons. The power of high frequency (>30 Hz) oscillations in LFPs is locked to the phase of low frequency (<30 Hz) oscillations, an effect known as phase-amplitude coupling (PAC). While PAC has be...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00082
更新日期:2015-12-22 00:00:00
abstract::The primary (S1) and secondary (S2) somatosensory cortices project to several trigeminal sensory nuclei. One putative function of these corticofugal projections is the gating of sensory transmission through the trigeminal principal nucleus (Pr5), and some have proposed that S1 and S2 project differentially to the spin...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00053
更新日期:2015-09-30 00:00:00
abstract::Driven by the increasing channel count of neural probes, there is much effort being directed to creating increasingly scalable electrophysiology data acquisition (DAQ) systems. However, all such systems still rely on personal computers for data storage, and thus are limited by the bandwidth and cost of the computers, ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2015.00046
更新日期:2015-09-01 00:00:00
abstract::Neuronal activity is dominated by synaptic inputs from excitatory or inhibitory neural circuits. With the development of in vivo patch-clamp recording, especially in vivo voltage-clamp recording, researchers can not only directly measure neuronal activity, such as spiking responses or membrane potential dynamics, but ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2015.00023
更新日期:2015-05-22 00:00:00
abstract::Multiple components of "γ-oscillations" between 30-170 Hz in the CA1 region of the hippocampus have been described, based on their coherence with oscillations in other brain regions and on their cross-frequency coupling with local θ-oscillations. However, it remains unclear whether the different sub-bands are generate...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2014.00150
更新日期:2015-01-12 00:00:00
abstract::Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to be synthesized and released from GABAergic neurons in the brain. However, recent studies have shown that not only neurons but also astrocytes contain a considerable amount of GABA that can be released and activate GABA receptors ...
journal_title:Frontiers in neural circuits
pub_type: 杂志文章,评审
doi:10.3389/fncir.2014.00141
更新日期:2014-12-17 00:00:00