Optogenetic Activation of A11 Region Increases Motor Activity.

Abstract:

:Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic motor responses, but the functional connectome of limbic structures in the diencephalon that control locomotion is not well known. The A11 region, within the posterior diencephalon has been postulated to contribute to motor function and control of pain. Here we show that the A11 region initiates movement. Photostimulation of channelrhodopsin 2 (ChR2) transfected neurons in A11 slice preparations showed that neurons could follow stimulation at frequencies of 20 Hz. Our data show that photostimulation of ChR2 transfected neurons in the A11 region enhances motor activity often leading to locomotion. Using vGluT2-reporter and vGAT-reporter mice we show that the A11 tyrosine hydroxylase positive (TH) dopaminergic neurons are vGluT2 and vGAT negative. We find that in addition to dopaminergic neurons within the A11 region, there is another neuronal subtype which expresses the monoenzymatic aromatic L-amino acid decarboxylase (AADC), but not TH, a key enzyme involved in the synthesis of catecholamines including dopamine. This monoaminergic-based motor circuit may be involved in the control of motor behavior as part of a broader diencephalic motor region.

journal_name

Front Neural Circuits

authors

Koblinger K,Jean-Xavier C,Sharma S,Füzesi T,Young L,Eaton SEA,Kwok CHT,Bains JS,Whelan PJ

doi

10.3389/fncir.2018.00086

subject

Has Abstract

pub_date

2018-10-11 00:00:00

pages

86

issn

1662-5110

journal_volume

12

pub_type

杂志文章
  • Corrigendum: "The role of prefrontal catecholamines in attention and working memory".

    abstract::[This corrects the article on p. 33 in vol. 8, PMID: 24782714.]. ...

    journal_title:Frontiers in neural circuits

    pub_type: 已发布勘误

    doi:10.3389/fncir.2014.00142

    authors: Noudoost B,Clark KL

    更新日期:2014-12-02 00:00:00

  • Imaging zebrafish neural circuitry from whole brain to synapse.

    abstract::Recent advances in imaging tools are inspiring zebrafish researchers to tackle ever more ambitious questions in the neurosciences. Behaviorally fundamental conserved neural networks can now be potentially studied using zebrafish from a brain-wide scale to molecular resolution. In this perspective, we offer a roadmap b...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章,评审

    doi:10.3389/fncir.2013.00076

    authors: Leung LC,Wang GX,Mourrain P

    更新日期:2013-04-24 00:00:00

  • Peripheral Sensory Neurons Expressing Melanopsin Respond to Light.

    abstract::The ability of light to cause pain is paradoxical. The retina detects light but is devoid of nociceptors while the trigeminal sensory ganglia (TG) contain nociceptors but not photoreceptors. Melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) are thought to mediate light-induced pain but...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2016.00060

    authors: Matynia A,Nguyen E,Sun X,Blixt FW,Parikh S,Kessler J,Pérez de Sevilla Müller L,Habib S,Kim P,Wang ZZ,Rodriguez A,Charles A,Nusinowitz S,Edvinsson L,Barnes S,Brecha NC,Gorin MB

    更新日期:2016-08-10 00:00:00

  • GABA as a rising gliotransmitter.

    abstract::Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to be synthesized and released from GABAergic neurons in the brain. However, recent studies have shown that not only neurons but also astrocytes contain a considerable amount of GABA that can be released and activate GABA receptors ...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章,评审

    doi:10.3389/fncir.2014.00141

    authors: Yoon BE,Lee CJ

    更新日期:2014-12-17 00:00:00

  • Spiral Ganglion Neuron Projection Development to the Hindbrain in Mice Lacking Peripheral and/or Central Target Differentiation.

    abstract::We investigate the importance of the degree of peripheral or central target differentiation for mouse auditory afferent navigation to the organ of Corti and auditory nuclei in three different mouse models: first, a mouse in which the differentiation of hair cells, but not central auditory nuclei neurons is compromised...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2017.00025

    authors: Elliott KL,Kersigo J,Pan N,Jahan I,Fritzsch B

    更新日期:2017-04-13 00:00:00

  • Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons.

    abstract::"Dye-coupling", whole-mount immunohistochemistry for gap junction channel protein connexin 35 (Cx35), and freeze-fracture replica immunogold labeling (FRIL) reveal an abundance of electrical synapses/gap junctions at glutamatergic mixed synapses in the 14th spinal segment that innervates the adult male gonopodium of W...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2014.00066

    authors: Serrano-Velez JL,Rodriguez-Alvarado M,Torres-Vazquez II,Fraser SE,Yasumura T,Vanderpool KG,Rash JE,Rosa-Molinar E

    更新日期:2014-06-26 00:00:00

  • DVID: Distributed Versioned Image-Oriented Dataservice.

    abstract::Open-source software development has skyrocketed in part due to community tools like github.com, which allows publication of code as well as the ability to create branches and push accepted modifications back to the original repository. As the number and size of EM-based datasets increases, the connectomics community ...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2019.00005

    authors: Katz WT,Plaza SM

    更新日期:2019-02-05 00:00:00

  • Spatiotemporal characteristics and pharmacological modulation of multiple gamma oscillations in the CA1 region of the hippocampus.

    abstract::Multiple components of "γ-oscillations" between 30-170 Hz in the CA1 region of the hippocampus have been described, based on their coherence with oscillations in other brain regions and on their cross-frequency coupling with local θ-oscillations. However, it remains unclear whether the different sub-bands are generate...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2014.00150

    authors: Balakrishnan S,Pearce RA

    更新日期:2015-01-12 00:00:00

  • Manganese Enhanced MRI for Use in Studying Neurodegenerative Diseases.

    abstract::MRI has been extensively used in neurodegenerative disorders, such as Alzheimer's disease (AD), frontal-temporal dementia (FTD), mild cognitive impairment (MCI), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). MRI is important for monitoring the neurodegenerative components...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章,评审

    doi:10.3389/fncir.2018.00114

    authors: Saar G,Koretsky AP

    更新日期:2019-01-07 00:00:00

  • Method and software for using m-sequences to characterize parallel components of higher-order visual tracking behavior in Drosophila.

    abstract::A moving visual figure may contain first-order signals defined by variation in mean luminance, as well as second-order signals defined by constant mean luminance and variation in luminance envelope, or higher-order signals that cannot be estimated by taking higher moments of the luminance distribution. Separating thes...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2014.00130

    authors: Aptekar JW,Keles MF,Mongeau JM,Lu PM,Frye MA,Shoemaker PA

    更新日期:2014-10-31 00:00:00

  • A direct-to-drive neural data acquisition system.

    abstract::Driven by the increasing channel count of neural probes, there is much effort being directed to creating increasingly scalable electrophysiology data acquisition (DAQ) systems. However, all such systems still rely on personal computers for data storage, and thus are limited by the bandwidth and cost of the computers, ...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2015.00046

    authors: Kinney JP,Bernstein JG,Meyer AJ,Barber JB,Bolivar M,Newbold B,Scholvin J,Moore-Kochlacs C,Wentz CT,Kopell NJ,Boyden ES

    更新日期:2015-09-01 00:00:00

  • Corticofugal projection patterns of whisker sensorimotor cortex to the sensory trigeminal nuclei.

    abstract::The primary (S1) and secondary (S2) somatosensory cortices project to several trigeminal sensory nuclei. One putative function of these corticofugal projections is the gating of sensory transmission through the trigeminal principal nucleus (Pr5), and some have proposed that S1 and S2 project differentially to the spin...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2015.00053

    authors: Smith JB,Watson GD,Alloway KD,Schwarz C,Chakrabarti S

    更新日期:2015-09-30 00:00:00

  • Why Isn't the Head Direction System Necessary for Direction? Lessons From the Lateral Mammillary Nuclei.

    abstract::Complex spatial representations in the hippocampal formation and related cortical areas require input from the head direction system. However, a recurrent finding is that behavior apparently supported by these spatial representations does not appear to require input from generative head direction regions, i.e., latera...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2019.00060

    authors: Dillingham CM,Vann SD

    更新日期:2019-09-13 00:00:00

  • Developmental Coordination of Gene Expression between Synaptic Partners During GABAergic Circuit Assembly in Cerebellar Cortex.

    abstract::The assembly of neural circuits involves multiple sequential steps such as the specification of cell-types, their migration to proper brain locations, morphological and physiological differentiation, and the formation and maturation of synaptic connections. This intricate and often prolonged process is guided by elabo...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2012.00037

    authors: Paul A,Cai Y,Atwal GS,Huang ZJ

    更新日期:2012-06-26 00:00:00

  • The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons.

    abstract::mRNP granules at adult central synapses are postulated to regulate local mRNA translation and synapse plasticity. However, they are very poorly characterized in vivo. Here, in Drosophila olfactory synapses, we present early observations and characterization of candidate synaptic mRNP particles, one of which contains a...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2010.00121

    authors: Hillebrand J,Pan K,Kokaram A,Barbee S,Parker R,Ramaswami M

    更新日期:2010-11-03 00:00:00

  • Two-photon scanning microscopy of in vivo sensory responses of cortical neurons genetically encoded with a fluorescent voltage sensor in rat.

    abstract::A fluorescent voltage sensor protein "Flare" was created from a Kv1.4 potassium channel with YFP situated to report voltage-induced conformational changes in vivo. The RNA virus Sindbis introduced Flare into neurons in the binocular region of visual cortex in rat. Injection sites were selected based on intrinsic optic...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2012.00015

    authors: Ahrens KF,Heider B,Lee H,Isacoff EY,Siegel RM

    更新日期:2012-03-22 00:00:00

  • The Growing Evidence for the Importance of the Otoliths in Spatial Memory.

    abstract::Many studies have demonstrated that vestibular sensory input is important for spatial learning and memory. However, it has been unclear what contributions the different parts of the vestibular system - the semi-circular canals and otoliths - make to these processes. The advent of mutant otolith-deficient mice has made...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章,评审

    doi:10.3389/fncir.2019.00066

    authors: Smith PF

    更新日期:2019-10-18 00:00:00

  • Local Field Potentials: Myths and Misunderstandings.

    abstract::The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confound...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章,评审

    doi:10.3389/fncir.2016.00101

    authors: Herreras O

    更新日期:2016-12-15 00:00:00

  • Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing.

    abstract::How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat. Spectral and tempor...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2012.00062

    authors: Chen C,Rodriguez FC,Read HL,Escabí MA

    更新日期:2012-09-27 00:00:00

  • Improved methods for chronic light-based motor mapping in mice: automated movement tracking with accelerometers, and chronic EEG recording in a bilateral thin-skull preparation.

    abstract::Optogenetic stimulation of the mouse cortex can be used to generate motor maps that are similar to maps derived from electrode-based stimulation. Here we present a refined set of procedures for repeated light-based motor mapping in ChR2-expressing mice implanted with a bilateral thinned-skull chronic window and a chro...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2013.00123

    authors: Silasi G,Boyd JD,Ledue J,Murphy TH

    更新日期:2013-07-25 00:00:00

  • Two-photon imaging with diffractive optical elements.

    abstract::Two-photon imaging has become a useful tool for optical monitoring of neural circuits, but it requires high laser power and serial scanning of each pixel in a sample. This results in slow imaging rates, limiting the measurements of fast signals such as neuronal activity. To improve the speed and signal-to-noise ratio ...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/neuro.04.006.2009

    authors: Watson BO,Nikolenko V,Yuste R

    更新日期:2009-07-06 00:00:00

  • Young and intense: FoxP2 immunoreactivity in Area X varies with age, song stereotypy, and singing in male zebra finches.

    abstract::FOXP2 is a transcription factor functionally relevant for learned vocalizations in humans and songbirds. In songbirds, FoxP2 mRNA expression in the medium spiny neurons of the basal ganglia song nucleus Area X is developmentally regulated and varies with singing conditions in different social contexts. How individual ...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2013.00024

    authors: Thompson CK,Schwabe F,Schoof A,Mendoza E,Gampe J,Rochefort C,Scharff C

    更新日期:2013-02-28 00:00:00

  • Multiple embryonic origins of nitric oxide synthase-expressing GABAergic neurons of the neocortex.

    abstract::CORTICAL GABAERGIC INTERNEURONS IN RODENTS ORIGINATE IN THREE SUBCORTICAL REGIONS: the medial ganglionic eminence (MGE), the lateral/caudal ganglionic eminence (LGE/CGE), and the preoptic area (POA). Each of these neuroepithelial precursor domains contributes different interneuron subtypes to the cortex. Neuronal NOS ...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2012.00065

    authors: Magno L,Oliveira MG,Mucha M,Rubin AN,Kessaris N

    更新日期:2012-09-24 00:00:00

  • Center-surround vs. distance-independent lateral connectivity in the olfactory bulb.

    abstract::Lateral neuronal interactions are known to play important roles in sensory information processing. A center-on surround-off local circuit arrangement has been shown to play a role in mediating contrast enhancement in the visual, auditory, and somatosensory systems. The lateral connectivity and the influence of those c...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2012.00034

    authors: Kim DH,Chang AY,McTavish TS,Patel HK,Willhite DC

    更新日期:2012-05-31 00:00:00

  • Precise Synaptic Efficacy Alignment Suggests Potentiation Dominated Learning.

    abstract::Recent evidence suggests that parallel synapses from the same axonal branch onto the same dendritic branch have almost identical strength. It has been proposed that this alignment is only possible through learning rules that integrate activity over long time spans. However, learning mechanisms such as spike-timing-dep...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2015.00090

    authors: Hartmann C,Miner DC,Triesch J

    更新日期:2016-01-13 00:00:00

  • Cortical modulation of auditory processing in the midbrain.

    abstract::In addition to their ascending pathways that originate at the receptor cells, all sensory systems are characterized by extensive descending projections. Although the size of these connections often outweighs those that carry information in the ascending auditory pathway, we still have a relatively poor understanding o...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2012.00114

    authors: Bajo VM,King AJ

    更新日期:2013-01-03 00:00:00

  • Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson's Disease.

    abstract::Both abnormalities of resting-state cerebral blood flow (CBF) and functional connectivity in Wilson's disease (WD) have been identified by several studies. Whether the coupling of CBF and functional connectivity is imbalanced in WD remains largely unknown. To assess this possibility, 27 patients with WD and 27 sex- an...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2019.00025

    authors: Hu S,Wu H,Xu C,Wang A,Wang Y,Shen T,Huang F,Kan H,Li C

    更新日期:2019-04-18 00:00:00

  • Attention Decreases Phase-Amplitude Coupling, Enhancing Stimulus Discriminability in Cortical Area MT.

    abstract::Local field potentials (LFPs) in cortex reflect synchronous fluctuations in the synaptic activity of local populations of neurons. The power of high frequency (>30 Hz) oscillations in LFPs is locked to the phase of low frequency (<30 Hz) oscillations, an effect known as phase-amplitude coupling (PAC). While PAC has be...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2015.00082

    authors: Esghaei M,Daliri MR,Treue S

    更新日期:2015-12-22 00:00:00

  • Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds.

    abstract::In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章,评审

    doi:10.3389/fncir.2014.00093

    authors: Puig MV,Rose J,Schmidt R,Freund N

    更新日期:2014-08-05 00:00:00

  • Fish in the matrix: motor learning in a virtual world.

    abstract::One of the large remaining challenges in the field of zebrafish neuroscience is the establishment of techniques and preparations that permit the recording and perturbation of neural activity in animals that can interact meaningfully with the environment. Since it is very difficult to do this in freely behaving zebrafi...

    journal_title:Frontiers in neural circuits

    pub_type: 杂志文章

    doi:10.3389/fncir.2012.00125

    authors: Engert F

    更新日期:2013-01-25 00:00:00