Abstract:
:Research efforts over the past decades have unraveled both genetic and environmental factors, which contribute to the development of autism spectrum disorders (ASD). It is, to date, largely unknown how different underlying causes result in a common phenotype. However, the individual course of development and the different comorbidities might reflect the heterogeneous genetic and non-genetic contributions. Therefore, it is reasonable to identify commonalities and differences in models of these disorders at the different hierarchical levels of brain function, including genetics/environment, cellular/synaptic functions, brain regions, connectivity, and behavior. To that end, we investigated Shank3 transgenic mouse lines and compared them with a prenatal zinc-deficient (PZD) mouse model of ASD at the level of brain structural alterations in an 11,7 T small animal magnetic resonance imaging (MRI). Animals were measured at 4 and 9 weeks of age. We identified a decreased total brain volume (TBV) and hippocampal size of Shank3-/- mice but a convergent increase of basal ganglia (striatum and globus pallidus) in most mouse lines. Moreover, Shank3 transgenic mice had smaller thalami, whereas PZD mice had this region enlarged. Intriguingly, Shank3 heterozygous knockout mice mostly showed minor abnormalities to full knockouts, which might reflect the importance of proper Shank3 dosage in neuronal cells. Most reported volume changes seemed to be more pronounced at younger age. Our results indicate both convergent and divergent brain region abnormalities in genetic and non-genetic models of ASD. These alterations of brain structures might be mirrored in the reported behavior of both models, which have not been assessed in this study.
journal_name
Front Neural Circuitsjournal_title
Frontiers in neural circuitsauthors
Schoen M,Asoglu H,Bauer HF,Müller HP,Abaei A,Sauer AK,Zhang R,Song TJ,Bockmann J,Kassubek J,Rasche V,Grabrucker AM,Boeckers TMdoi
10.3389/fncir.2019.00006subject
Has Abstractpub_date
2019-02-22 00:00:00pages
6issn
1662-5110journal_volume
13pub_type
杂志文章abstract::Recent advances in imaging tools are inspiring zebrafish researchers to tackle ever more ambitious questions in the neurosciences. Behaviorally fundamental conserved neural networks can now be potentially studied using zebrafish from a brain-wide scale to molecular resolution. In this perspective, we offer a roadmap b...
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abstract::Spike-timing dependent plasticity (STDP) is a biologically constrained unsupervised form of learning that potentiates or depresses synaptic connections based on the precise timing of pre-synaptic and post-synaptic firings. The effects of on-going STDP on the topology of evolving model neural networks were assessed in ...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2017-09-14 00:00:00
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doi:10.3389/fncir.2012.00114
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journal_title:Frontiers in neural circuits
pub_type: 杂志文章
doi:10.3389/fncir.2012.00015
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journal_title:Frontiers in neural circuits
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pub_type: 杂志文章,评审
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abstract:BACKGROUND:Major depressive disorder (MDD) is a public health problem worldwide. There is increasing interest in using non-invasive therapies such as repetitive transcranial magnetic stimulation (rTMS) to treat MDD. However, the changes induced by rTMS on neural circuits remain poorly characterized. The present study a...
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doi:10.3389/fncir.2016.00050
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